{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,18]],"date-time":"2026-01-18T14:18:10Z","timestamp":1768745890759,"version":"3.49.0"},"reference-count":34,"publisher":"Elsevier BV","issue":"22","license":[{"start":{"date-parts":[[2014,11,1]],"date-time":"2014-11-01T00:00:00Z","timestamp":1414800000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2014,11,1]],"date-time":"2014-11-01T00:00:00Z","timestamp":1414800000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100003407","name":"Ministero dell\u2019Istruzione, dell\u2019Universit\u00e0 e della Ricerca","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003407","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010739","name":"Universit\u00e0 degli Studi di Camerino","doi-asserted-by":"publisher","award":["FAR 2011\/12 STI000044"],"award-info":[{"award-number":["FAR 2011\/12 STI000044"]}],"id":[{"id":"10.13039\/501100010739","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bioorganic & Medicinal Chemistry Letters"],"published-print":{"date-parts":[[2014,11]]},"DOI":"10.1016\/j.bmcl.2014.09.046","type":"journal-article","created":{"date-parts":[[2014,9,28]],"date-time":"2014-09-28T13:01:34Z","timestamp":1411909294000},"page":"5304-5309","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"title":["From the covalent linkage of drugs to novel inhibitors of ribonucleotide reductase: Synthesis and biological evaluation of valproic esters of 3\u2032-C-methyladenosine"],"prefix":"10.1016","volume":"24","author":[{"given":"Riccardo","family":"Petrelli","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria","family":"Meli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patrizia","family":"Vita","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ilaria","family":"Torquati","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arianna","family":"Ferro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Munender","family":"Vodnala","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Natale","family":"D\u2019Alessandro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manlio","family":"Tolomeo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fabio","family":"Del Bello","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Praveen","family":"Kusumanchi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Palmarisa","family":"Franchetti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mario","family":"Grifantini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiremagalur N.","family":"Jayaram","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anders","family":"Hofer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Loredana","family":"Cappellacci","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.bmcl.2014.09.046_b0005","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1002\/jcb.22185","volume":"107","author":"Marks","year":"2009","journal-title":"J. Cell. Biochem."},{"key":"10.1016\/j.bmcl.2014.09.046_b0010","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1186\/1756-8722-2-22","volume":"2","author":"Cang","year":"2009","journal-title":"J. Hematol. Oncol."},{"key":"10.1016\/j.bmcl.2014.09.046_b0015","doi-asserted-by":"crossref","first-page":"5459","DOI":"10.1200\/JCO.2009.22.1291","volume":"27","author":"Lane","year":"2009","journal-title":"J. Clin. Oncol."},{"key":"10.1016\/j.bmcl.2014.09.046_b0020","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1002\/med.20169","volume":"30","author":"Zhang","year":"2010","journal-title":"Med. Res. Rev."},{"key":"10.1016\/j.bmcl.2014.09.046_b0025","doi-asserted-by":"crossref","first-page":"475","DOI":"10.2174\/092986712798918842","volume":"19","author":"Ai","year":"2012","journal-title":"Curr. Med. Chem."},{"key":"10.1016\/j.bmcl.2014.09.046_b0030","doi-asserted-by":"crossref","first-page":"1911","DOI":"10.2165\/11315680-000000000-00000","volume":"69","author":"Ma","year":"2009","journal-title":"Drugs"},{"key":"10.1016\/j.bmcl.2014.09.046_b0035","doi-asserted-by":"crossref","first-page":"5950","DOI":"10.1016\/j.bmc.2010.06.081","volume":"18","author":"Chen","year":"2010","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.bmcl.2014.09.046_b0040","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.1517\/13543784.2010.510514","volume":"19","author":"Marks","year":"2010","journal-title":"Exp. Opin. Invest. Drugs"},{"key":"10.1016\/j.bmcl.2014.09.046_b0045","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/j.exphem.2012.10.013","volume":"3","author":"Amaru Calzada","year":"2013","journal-title":"Exp. Hematol."},{"key":"10.1016\/j.bmcl.2014.09.046_b0050","first-page":"723","volume":"5","author":"Wilson","year":"1996","journal-title":"Bailliere\u2019s Clin. Neurol."},{"key":"10.1016\/j.bmcl.2014.09.046_b0055","doi-asserted-by":"crossref","first-page":"6969","DOI":"10.1093\/emboj\/20.24.6969","volume":"24","author":"G\u00f6ttlicher","year":"2001","journal-title":"EMBO J."},{"key":"10.1016\/j.bmcl.2014.09.046_b0060","doi-asserted-by":"crossref","first-page":"36734","DOI":"10.1074\/jbc.M101287200","volume":"276","author":"Phiel","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bmcl.2014.09.046_b0065","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.1158\/0008-5472.CAN-03-0799","volume":"64","author":"Gurvich","year":"2004","journal-title":"Cancer Res."},{"key":"10.1016\/j.bmcl.2014.09.046_b0070","doi-asserted-by":"crossref","first-page":"1912","DOI":"10.1158\/1535-7163.MCT-05-0184","volume":"4","author":"Li","year":"2005","journal-title":"Mol. Cancer Ther."},{"key":"10.1016\/j.bmcl.2014.09.046_b0075","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1002\/med.20027","volume":"25","author":"Blaheta","year":"2005","journal-title":"Med. Res. Rev."},{"key":"10.1016\/j.bmcl.2014.09.046_b0080","doi-asserted-by":"crossref","first-page":"1423","DOI":"10.1517\/14728222.2013.840293","volume":"12","author":"Shao","year":"2013","journal-title":"Expert Opin. Ther. Targets"},{"key":"10.1016\/j.bmcl.2014.09.046_b0085","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1111\/j.1365-2141.2008.07426.x","volume":"144","author":"Bouzar","year":"2009","journal-title":"Br. J. Haematol."},{"key":"10.1016\/j.bmcl.2014.09.046_b0090","doi-asserted-by":"crossref","first-page":"31","DOI":"10.18632\/oncotarget.430","volume":"1","author":"Stauber","year":"2012","journal-title":"Oncotarget"},{"key":"10.1016\/j.bmcl.2014.09.046_b0095","doi-asserted-by":"crossref","first-page":"732","DOI":"10.1038\/sj.onc.1210677","volume":"27","author":"Kramer","year":"2008","journal-title":"Oncogene"},{"key":"10.1016\/j.bmcl.2014.09.046_b0100","doi-asserted-by":"crossref","first-page":"4983","DOI":"10.1021\/jm048944c","volume":"48","author":"Franchetti","year":"2005","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bmcl.2014.09.046_b0105","doi-asserted-by":"crossref","first-page":"1088","DOI":"10.1135\/cccc20061088","volume":"71","author":"Cappellacci","year":"2006","journal-title":"Collect. Czech. Chem. Commun."},{"key":"10.1016\/j.bmcl.2014.09.046_b0110","doi-asserted-by":"crossref","first-page":"4260","DOI":"10.1021\/jm800205c","volume":"51","author":"Cappellacci","year":"2008","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bmcl.2014.09.046_b0115","doi-asserted-by":"crossref","first-page":"1499","DOI":"10.1016\/j.ejmech.2011.01.055","volume":"46","author":"Cappellacci","year":"2011","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.bmcl.2014.09.046_b0120","doi-asserted-by":"crossref","first-page":"1427","DOI":"10.3892\/ijo.2011.943","volume":"38","author":"Meli","year":"2011","journal-title":"Int. J. Oncol."},{"key":"10.1016\/j.bmcl.2014.09.046_b0125","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.jinorgbio.2014.07.004","volume":"15","author":"Novohradsky","year":"2014","journal-title":"J. Inorg. Biochem."},{"key":"10.1016\/j.bmcl.2014.09.046_b0130","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1080\/15257770802088787","volume":"27","author":"Cappellacci","year":"2008","journal-title":"Nucleosides, Nucleotides, Nucleic Acids"},{"key":"10.1016\/j.bmcl.2014.09.046_b0135","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1093\/jac\/dkm011","volume":"59","author":"Rossi","year":"2007","journal-title":"J. Antimicrob. Chemother."},{"key":"10.1016\/j.bmcl.2014.09.046_b0140","doi-asserted-by":"crossref","first-page":"1550","DOI":"10.1021\/jm049408n","volume":"48","author":"Cappellacci","year":"2005","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bmcl.2014.09.046_b0145","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1016\/j.ctrv.2007.11.003","volume":"3","author":"Duenas-Gonzalez","year":"2008","journal-title":"Cancer Treat. Rev."},{"key":"10.1016\/j.bmcl.2014.09.046_b0150","doi-asserted-by":"crossref","first-page":"2045","DOI":"10.1016\/j.bmc.2005.01.007","volume":"13","author":"Franchetti","year":"2005","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.bmcl.2014.09.046_b0155","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1007\/s10822-005-8694-y","volume":"19","author":"Tetko","year":"2005","journal-title":"J. Comput. Aided Mol. Des."},{"key":"10.1016\/j.bmcl.2014.09.046_b0160","doi-asserted-by":"crossref","first-page":"33021","DOI":"10.1074\/jbc.M005337200","volume":"275","author":"Reichard","year":"2000","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bmcl.2014.09.046_b0165","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1038\/nsmb.2007","volume":"18","author":"Fairman","year":"2011","journal-title":"Nat. Struct. Mol. Biol."},{"key":"10.1016\/j.bmcl.2014.09.046_b0170","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1042\/bj1370143","volume":"137","author":"Cornish-Bowden","year":"1974","journal-title":"Biochem. J."}],"container-title":["Bioorganic & Medicinal Chemistry Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0960894X14009895?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0960894X14009895?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,18]],"date-time":"2025-10-18T06:56:51Z","timestamp":1760770611000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0960894X14009895"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,11]]},"references-count":34,"journal-issue":{"issue":"22","published-print":{"date-parts":[[2014,11]]}},"alternative-id":["S0960894X14009895"],"URL":"https:\/\/doi.org\/10.1016\/j.bmcl.2014.09.046","relation":{},"ISSN":["0960-894X"],"issn-type":[{"value":"0960-894X","type":"print"}],"subject":[],"published":{"date-parts":[[2014,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"From the covalent linkage of drugs to novel inhibitors of ribonucleotide reductase: Synthesis and biological evaluation of valproic esters of 3\u2032-C-methyladenosine","name":"articletitle","label":"Article Title"},{"value":"Bioorganic & Medicinal Chemistry Letters","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bmcl.2014.09.046","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 Elsevier Ltd. Published by Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}