{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T22:12:08Z","timestamp":1790201528998,"version":"4.1.0"},"reference-count":63,"publisher":"Elsevier BV","issue":"7","license":[{"start":{"date-parts":[[2015,4,1]],"date-time":"2015-04-01T00:00:00Z","timestamp":1427846400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2015,4,1]],"date-time":"2015-04-01T00:00:00Z","timestamp":1427846400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bioorganic & Medicinal Chemistry Letters"],"published-print":{"date-parts":[[2015,4]]},"DOI":"10.1016\/j.bmcl.2015.02.046","type":"journal-article","created":{"date-parts":[[2015,2,27]],"date-time":"2015-02-27T20:46:53Z","timestamp":1425070013000},"page":"1385-1389","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":119,"title":["The zinc coordination pattern in the \u03b7-carbonic anhydrase from Plasmodium falciparum is different from all other carbonic anhydrase genetic families"],"prefix":"10.1016","volume":"25","author":[{"given":"Giuseppina","family":"De Simone","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Di Fiore","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clemente","family":"Capasso","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudiu T.","family":"Supuran","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bmcl.2015.02.046_b0005","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1517\/13543776.2013.778245","volume":"23","author":"Capasso","year":"2013","journal-title":"Expert Opin. Ther. Pat."},{"key":"10.1016\/j.bmcl.2015.02.046_b0010","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1007\/978-94-007-7359-2_15","volume":"75","author":"McKenna","year":"2014","journal-title":"Subcell. Biochem."},{"key":"10.1016\/j.bmcl.2015.02.046_b0015","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1517\/13543776.2013.778246","volume":"23","author":"Supuran","year":"2013","journal-title":"Expert Opin. Ther. Pat."},{"key":"10.1016\/j.bmcl.2015.02.046_b0020","doi-asserted-by":"crossref","first-page":"1437","DOI":"10.1016\/j.bmc.2012.10.024","volume":"21","author":"Bertucci","year":"2013","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.bmcl.2015.02.046_b0025","doi-asserted-by":"crossref","first-page":"831","DOI":"10.2174\/092986712799034824","volume":"19","author":"Supuran","year":"2012","journal-title":"Curr. Med. Chem."},{"key":"10.1016\/j.bmcl.2015.02.046_b0030","doi-asserted-by":"crossref","first-page":"759","DOI":"10.3109\/14756366.2012.672983","volume":"27","author":"Supuran","year":"2012","journal-title":"J. Enzyme Inhib. Med. Chem."},{"key":"10.1016\/j.bmcl.2015.02.046_b0035","doi-asserted-by":"crossref","first-page":"1667","DOI":"10.1016\/j.bmc.2014.01.026","volume":"22","author":"Vullo","year":"2014","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.bmcl.2015.02.046_b0040","doi-asserted-by":"crossref","first-page":"4402","DOI":"10.1016\/j.bmcl.2014.08.014","volume":"24","author":"Vullo","year":"2014","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.bmcl.2015.02.046_b0045","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/j.bmcl.2013.11.021","volume":"24","author":"Vullo","year":"2014","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.bmcl.2015.02.046_b0050","doi-asserted-by":"crossref","first-page":"2939","DOI":"10.1016\/j.bmc.2014.04.006","volume":"22","author":"Nishimori","year":"2014","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.bmcl.2015.02.046_b0055","doi-asserted-by":"crossref","first-page":"146","DOI":"10.3109\/14756366.2012.761608","volume":"29","author":"Migliardini","year":"2014","journal-title":"J. Enzyme Inhib. Med. Chem."},{"key":"10.1016\/j.bmcl.2015.02.046_b0060","doi-asserted-by":"crossref","first-page":"52","DOI":"10.3109\/14756366.2013.877897","volume":"30","author":"Alafeefy","year":"2015","journal-title":"J. Enzyme Inhib. Med. Chem."},{"key":"10.1016\/j.bmcl.2015.02.046_b0065","doi-asserted-by":"crossref","first-page":"6706","DOI":"10.1016\/j.bmcl.2013.10.037","volume":"23","author":"Vullo","year":"2013","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.bmcl.2015.02.046_b0070","doi-asserted-by":"crossref","first-page":"1534","DOI":"10.1016\/j.bmc.2012.07.024","volume":"21","author":"Vullo","year":"2013","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.bmcl.2015.02.046_b0075","doi-asserted-by":"crossref","first-page":"1761","DOI":"10.1021\/jm4000616","volume":"56","author":"Pan","year":"2013","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bmcl.2015.02.046_b0080","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1016\/j.bmcl.2012.10.103","volume":"23","author":"Nishimori","year":"2013","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.bmcl.2015.02.046_h0085","doi-asserted-by":"crossref","first-page":"1150","DOI":"10.1107\/S0907444913007208","volume":"69","author":"Di Fiore","year":"2013","journal-title":"Acta Crystallogr. D Biol. Crystallogr."},{"key":"10.1016\/j.bmcl.2015.02.046_h0090","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1006\/jmbi.1998.2077","volume":"283","author":"Huang","year":"1998","journal-title":"J. Mol. Biol."},{"key":"10.1016\/j.bmcl.2015.02.046_h0095","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1002\/prot.340160104","volume":"16","author":"Eriksson","year":"1993","journal-title":"Proteins"},{"key":"10.1016\/j.bmcl.2015.02.046_h0100","doi-asserted-by":"crossref","first-page":"1042","DOI":"10.1016\/j.febslet.2011.03.001","volume":"585","author":"Cuesta-Seijo","year":"2011","journal-title":"FEBS Lett."},{"key":"10.1016\/j.bmcl.2015.02.046_h0105","doi-asserted-by":"crossref","first-page":"7493","DOI":"10.1073\/pnas.0502829102","volume":"102","author":"Premkumar","year":"2005","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.bmcl.2015.02.046_b0090","doi-asserted-by":"crossref","first-page":"25","DOI":"10.4103\/2229-5070.129156","volume":"4","author":"Jeremiah","year":"2014","journal-title":"Trop. Parasitol."},{"key":"10.1016\/j.bmcl.2015.02.046_b0095","author":"Fan","year":"2013","journal-title":"BMJ Case Rep."},{"key":"10.1016\/j.bmcl.2015.02.046_b0100","doi-asserted-by":"crossref","first-page":"e2012013","DOI":"10.4084\/mjhid.2012.013","volume":"4","author":"Antinori","year":"2012","journal-title":"Mediterr. J. Hematol. Infect. Dis."},{"key":"10.1016\/j.bmcl.2015.02.046_b0105","doi-asserted-by":"crossref","first-page":"1407","DOI":"10.1007\/s00108-011-2928-y","volume":"52","author":"Burchard","year":"2011","journal-title":"Internist (Berl)"},{"key":"10.1016\/j.bmcl.2015.02.046_b0110","first-page":"56","volume":"18","author":"Sabbatani","year":"2010","journal-title":"Infez. Med."},{"key":"10.1016\/j.bmcl.2015.02.046_b0115","doi-asserted-by":"crossref","first-page":"4389","DOI":"10.1016\/j.bmcl.2014.08.015","volume":"24","author":"Del Prete","year":"2014","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.bmcl.2015.02.046_b0120","doi-asserted-by":"crossref","first-page":"4421","DOI":"10.1021\/cr200176r","volume":"112","author":"Alterio","year":"2012","journal-title":"Chem. Rev."},{"key":"10.1016\/j.bmcl.2015.02.046_b0125","doi-asserted-by":"crossref","first-page":"3246","DOI":"10.2174\/138161210793429841","volume":"16","author":"Supuran","year":"2010","journal-title":"Curr. Pharm. Des."},{"key":"10.1016\/j.bmcl.2015.02.046_b0130","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1517\/14728214.13.2.383","volume":"13","author":"Supuran","year":"2008","journal-title":"Expert Opin. Emerging Drugs"},{"key":"10.1016\/j.bmcl.2015.02.046_b0135","doi-asserted-by":"crossref","first-page":"655","DOI":"10.2174\/138161208783877820","volume":"14","author":"De Simone","year":"2008","journal-title":"Curr. Pharm. Des."},{"key":"10.1016\/j.bmcl.2015.02.046_b0140","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.1016\/j.bmcl.2012.12.009","volume":"23","author":"Akdemir","year":"2013","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.bmcl.2015.02.046_b0145","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.bmc.2013.11.042","volume":"22","author":"Alafeefy","year":"2014","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.bmcl.2015.02.046_b0150","author":"Capasso","year":"2014","journal-title":"J. Enzyme Inhib. Med. Chem."},{"key":"10.1016\/j.bmcl.2015.02.046_b0155","doi-asserted-by":"crossref","first-page":"826","DOI":"10.1021\/ml500192a","volume":"5","author":"Ceruso","year":"2014","journal-title":"ACS Med. Chem. Lett."},{"key":"10.1016\/j.bmcl.2015.02.046_b0160","doi-asserted-by":"crossref","first-page":"5630","DOI":"10.1016\/j.bmcl.2012.06.106","volume":"22","author":"De Luca","year":"2012","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.bmcl.2015.02.046_b0165","doi-asserted-by":"crossref","first-page":"23","DOI":"10.3109\/14756366.2012.747197","volume":"29","author":"Del Prete","year":"2014","journal-title":"J. Enzyme Inhib. Med. Chem."},{"key":"10.1016\/j.bmcl.2015.02.046_b0170","doi-asserted-by":"crossref","first-page":"532","DOI":"10.3109\/14756366.2013.822371","volume":"29","author":"Del Prete","year":"2014","journal-title":"J. Enzyme Inhib. Med. Chem."},{"key":"10.1016\/j.bmcl.2015.02.046_b0175","doi-asserted-by":"crossref","first-page":"4067","DOI":"10.1016\/j.bmcl.2013.05.063","volume":"23","author":"Del Prete","year":"2013","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.bmcl.2015.02.046_b0180","doi-asserted-by":"crossref","first-page":"4537","DOI":"10.1016\/j.bmc.2014.07.048","volume":"22","author":"Del Prete","year":"2014","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.bmcl.2015.02.046_b0185","doi-asserted-by":"crossref","first-page":"7142","DOI":"10.1016\/j.bmcl.2012.09.065","volume":"22","author":"Vullo","year":"2012","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.bmcl.2015.02.046_b0190","doi-asserted-by":"crossref","first-page":"1232","DOI":"10.1016\/j.biochi.2012.02.013","volume":"94","author":"Alterio","year":"2012","journal-title":"Biochimie"},{"key":"10.1016\/j.bmcl.2015.02.046_b0195","doi-asserted-by":"crossref","first-page":"4745","DOI":"10.1016\/j.bmcl.2010.06.139","volume":"20","author":"Viparelli","year":"2010","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.bmcl.2015.02.046_b0200","doi-asserted-by":"crossref","first-page":"3467","DOI":"10.1016\/j.bmcl.2010.05.009","volume":"20","author":"Supuran","year":"2010","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.bmcl.2015.02.046_b0205","doi-asserted-by":"crossref","first-page":"379","DOI":"10.3109\/14756366.2013.787422","volume":"29","author":"Capasso","year":"2014","journal-title":"J. Enzyme Inhib. Med. Chem."},{"key":"10.1016\/j.bmcl.2015.02.046_b0210","doi-asserted-by":"crossref","first-page":"1465","DOI":"10.1016\/j.bmc.2012.09.047","volume":"21","author":"De Luca","year":"2013","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.bmcl.2015.02.046_b0215","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1080\/14756360410001689577","volume":"19","author":"Reungprapavut","year":"2004","journal-title":"J. Enzyme Inhib. Med. Chem."},{"key":"10.1016\/j.bmcl.2015.02.046_b0220","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1016\/S0020-7519(01)00172-2","volume":"31","author":"Krungkrai","year":"2001","journal-title":"Int. J. Parasitol."},{"key":"10.1016\/j.bmcl.2015.02.046_b0225","doi-asserted-by":"crossref","first-page":"631","DOI":"10.2174\/138161208783877901","volume":"14","author":"Krungkrai","year":"2008","journal-title":"Curr. Pharm. Des."},{"key":"10.1016\/j.bmcl.2015.02.046_b0230","doi-asserted-by":"crossref","first-page":"5466","DOI":"10.1016\/j.bmcl.2008.09.030","volume":"18","author":"Krungkrai","year":"2008","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.bmcl.2015.02.046_b0235","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1016\/j.bmc.2004.10.015","volume":"13","author":"Krungkrai","year":"2005","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.bmcl.2015.02.046_b0240","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1016\/j.bmc.2014.12.009","volume":"23","author":"Vullo","year":"2015","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.bmcl.2015.02.046_b0245","author":"Supuran","year":"2014","journal-title":"Expert Opin. Ther. Targets"},{"key":"10.1016\/j.bmcl.2015.02.046_b0250","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.jinorgbio.2011.11.017","volume":"111","author":"De Simone","year":"2012","journal-title":"J. Inorg. Biochem."},{"key":"10.1016\/j.bmcl.2015.02.046_b0255","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1016\/j.bbapap.2009.07.027","volume":"1804","author":"De Simone","year":"2010","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.bmcl.2015.02.046_b0260","doi-asserted-by":"crossref","first-page":"15780","DOI":"10.1021\/bi971296x","volume":"36","author":"Lesburg","year":"1997","journal-title":"Biochemistry"},{"key":"10.1016\/j.bmcl.2015.02.046_b0265","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1038\/nprot.2009.2","volume":"4","author":"Kelley","year":"2009","journal-title":"Nat. Protocols"},{"key":"10.1016\/j.bmcl.2015.02.046_b0270","doi-asserted-by":"crossref","first-page":"2607","DOI":"10.1107\/S1399004714016526","volume":"70","author":"James","year":"2014","journal-title":"Acta Crystallogr. D"},{"key":"10.1016\/j.bmcl.2015.02.046_h0295","doi-asserted-by":"crossref","first-page":"18782","DOI":"10.1074\/jbc.M414348200","volume":"280","author":"Suarez Covarrubias","year":"2005","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bmcl.2015.02.046_h0300","doi-asserted-by":"crossref","first-page":"4993","DOI":"10.1074\/jbc.M510756200","volume":"281","author":"Covarrubias","year":"2006","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bmcl.2015.02.046_b0280","doi-asserted-by":"crossref","first-page":"894","DOI":"10.1107\/S0907444911032884","volume":"67","author":"Suzuki","year":"2011","journal-title":"Acta Crystallogr. D"},{"key":"10.1016\/j.bmcl.2015.02.046_b0285","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1038\/nature09442","volume":"467","author":"Liu","year":"2010","journal-title":"Nature"},{"key":"10.1016\/j.bmcl.2015.02.046_b0290","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1097\/QCO.0b013e3283558780","volume":"25","author":"Cox-Singh","year":"2012","journal-title":"Curr. Opin. Infect. Dis."}],"container-title":["Bioorganic & Medicinal Chemistry Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0960894X15001663?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0960894X15001663?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,18]],"date-time":"2025-10-18T06:59:47Z","timestamp":1760770787000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0960894X15001663"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,4]]},"references-count":63,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2015,4]]}},"alternative-id":["S0960894X15001663"],"URL":"https:\/\/doi.org\/10.1016\/j.bmcl.2015.02.046","relation":{},"ISSN":["0960-894X"],"issn-type":[{"value":"0960-894X","type":"print"}],"subject":[],"published":{"date-parts":[[2015,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The zinc coordination pattern in the \u03b7-carbonic anhydrase from Plasmodium falciparum is different from all other carbonic anhydrase genetic families","name":"articletitle","label":"Article Title"},{"value":"Bioorganic & Medicinal Chemistry Letters","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bmcl.2015.02.046","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}