{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T07:59:31Z","timestamp":1777535971176,"version":"3.51.4"},"reference-count":23,"publisher":"Elsevier BV","issue":"20","license":[{"start":{"date-parts":[[2015,10,1]],"date-time":"2015-10-01T00:00:00Z","timestamp":1443657600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2015,10,1]],"date-time":"2015-10-01T00:00:00Z","timestamp":1443657600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R24 DA018055"],"award-info":[{"award-number":["R24 DA018055"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bioorganic & Medicinal Chemistry Letters"],"published-print":{"date-parts":[[2015,10]]},"DOI":"10.1016\/j.bmcl.2015.08.023","type":"journal-article","created":{"date-parts":[[2015,8,14]],"date-time":"2015-08-14T05:53:45Z","timestamp":1439531625000},"page":"4677-4682","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":29,"title":["Synthesis and anti-cancer potential of the positional isomers of NOSH-aspirin (NBS-1120) a dual nitric oxide and hydrogen sulfide releasing hybrid"],"prefix":"10.1016","volume":"25","author":[{"given":"Federica","family":"Vannini","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew C.","family":"MacKessack-Leitch","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erin K.","family":"Eschbach","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mitali","family":"Chattopadhyay","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ravinder","family":"Kodela","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Khosrow","family":"Kashfi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.bmcl.2015.08.023_b0005","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1038\/nrc1477","volume":"4","author":"Mueller","year":"2004","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.bmcl.2015.08.023_b0010","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1038\/nature07205","volume":"454","author":"Mantovani","year":"2008","journal-title":"Nature"},{"key":"10.1016\/j.bmcl.2015.08.023_b0015","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1056\/NEJMoa021735","volume":"348","author":"Baron","year":"2003","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.bmcl.2015.08.023_b0020","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1016\/S0016-5085(03)00887-4","volume":"125","author":"Benamouzig","year":"2003","journal-title":"Gastroenterology"},{"key":"10.1016\/j.bmcl.2015.08.023_b0025","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1093\/jnci\/dji173","volume":"97","author":"Jacobs","year":"2005","journal-title":"J. Natl Cancer Inst."},{"key":"10.1016\/j.bmcl.2015.08.023_b0030","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1056\/NEJMoa021633","volume":"348","author":"Sandler","year":"2003","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.bmcl.2015.08.023_b0035","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1002\/0470856734.ch2","volume":"256","author":"Thun","year":"2006","journal-title":"Novartis Found. Symp."},{"key":"10.1016\/j.bmcl.2015.08.023_b0040","doi-asserted-by":"crossref","first-page":"1602","DOI":"10.1016\/S0140-6736(11)61720-0","volume":"379","author":"Rothwell","year":"2012","journal-title":"Lancet"},{"key":"10.1016\/j.bmcl.2015.08.023_b0045","doi-asserted-by":"crossref","first-page":"1591","DOI":"10.1016\/S0140-6736(12)60209-8","volume":"379","author":"Rothwell","year":"2012","journal-title":"Lancet"},{"key":"10.1016\/j.bmcl.2015.08.023_b0050","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/S1054-3589(08)57002-5","volume":"57","author":"Kashfi","year":"2009","journal-title":"Adv. Pharmacol."},{"key":"10.1016\/j.bmcl.2015.08.023_b0055","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1021\/ml300002m","volume":"8","author":"Kodela","year":"2012","journal-title":"J. Med. Chem. Lett."},{"key":"10.1016\/j.bmcl.2015.08.023_b0060","doi-asserted-by":"crossref","DOI":"10.1039\/c3md00185g","volume":"4","author":"Kodela","year":"2013","journal-title":"Medchemcomm"},{"key":"10.1016\/j.bmcl.2015.08.023_b0065","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.niox.2014.05.014","volume":"41","author":"Lo Faro","year":"2014","journal-title":"Nitric Oxide"},{"key":"10.1016\/j.bmcl.2015.08.023_b0070","doi-asserted-by":"crossref","first-page":"G341","DOI":"10.1152\/ajpgi.2000.279.2.G341","volume":"279","author":"Ma","year":"2000","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"10.1016\/j.bmcl.2015.08.023_b0075","doi-asserted-by":"crossref","first-page":"1210","DOI":"10.1053\/j.gastro.2005.07.060","volume":"129","author":"Fiorucci","year":"2005","journal-title":"Gastroenterology"},{"key":"10.1016\/j.bmcl.2015.08.023_b0080","doi-asserted-by":"crossref","first-page":"S-596","DOI":"10.1016\/S0016-5085(13)62197-6","volume":"144","author":"Nia","year":"2013","journal-title":"Gastroenterology"},{"key":"10.1016\/j.bmcl.2015.08.023_b0085","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1016\/j.bbrc.2012.02.051","volume":"419","author":"Chattopadhyay","year":"2012","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.bmcl.2015.08.023_b0090","doi-asserted-by":"crossref","first-page":"1724","DOI":"10.1002\/glia.22553","volume":"61","author":"Lee","year":"2013","journal-title":"Glia"},{"key":"10.1016\/j.bmcl.2015.08.023_b0095","first-page":"e00133 p1","volume":"3","author":"Fonesca","year":"2015","journal-title":"Pharmacol. Res. Perspect."},{"key":"10.1016\/j.bmcl.2015.08.023_b0125","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/0006-2952(96)00181-5","volume":"52","author":"Hanif","year":"1996","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.bmcl.2015.08.023_b0140","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1126\/science.270.5234.296","volume":"270","author":"Sundaresan","year":"1995","journal-title":"Science"},{"key":"10.1016\/j.bmcl.2015.08.023_b0145","doi-asserted-by":"crossref","first-page":"15038","DOI":"10.1073\/pnas.0601945103","volume":"103","author":"Robinson","year":"2006","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.bmcl.2015.08.023_b0150","first-page":"289","volume":"106","author":"Klaunig","year":"1998","journal-title":"Environ. Health Perspect."}],"container-title":["Bioorganic & Medicinal Chemistry Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0960894X15008586?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0960894X15008586?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,18]],"date-time":"2025-10-18T07:02:57Z","timestamp":1760770977000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0960894X15008586"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,10]]},"references-count":23,"journal-issue":{"issue":"20","published-print":{"date-parts":[[2015,10]]}},"alternative-id":["S0960894X15008586"],"URL":"https:\/\/doi.org\/10.1016\/j.bmcl.2015.08.023","relation":{},"ISSN":["0960-894X"],"issn-type":[{"value":"0960-894X","type":"print"}],"subject":[],"published":{"date-parts":[[2015,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Synthesis and anti-cancer potential of the positional isomers of NOSH-aspirin (NBS-1120) a dual nitric oxide and hydrogen sulfide releasing hybrid","name":"articletitle","label":"Article Title"},{"value":"Bioorganic & Medicinal Chemistry Letters","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bmcl.2015.08.023","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}