{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T17:40:35Z","timestamp":1787161235561,"version":"build-2736575974"},"reference-count":26,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2016,3,1]],"date-time":"2016-03-01T00:00:00Z","timestamp":1456790400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2016,3,1]],"date-time":"2016-03-01T00:00:00Z","timestamp":1456790400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100002428","name":"Fonds zur F\u00f6rderung der Wissenschaftlichen Forschung","doi-asserted-by":"crossref","award":["P 24815-B21"],"award-info":[{"award-number":["P 24815-B21"]}],"id":[{"id":"10.13039\/501100002428","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bioorganic &amp; Medicinal Chemistry Letters"],"published-print":{"date-parts":[[2016,3]]},"DOI":"10.1016\/j.bmcl.2016.01.059","type":"journal-article","created":{"date-parts":[[2016,1,21]],"date-time":"2016-01-21T22:45:22Z","timestamp":1453416322000},"page":"1438-1442","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":18,"title":["Synthesis of C-5a-chain extended derivatives of 4-epi-isofagomine: Powerful \u03b2-galactosidase inhibitors and low concentration activators of GM1-gangliosidosis-related human lysosomal \u03b2-galactosidase"],"prefix":"10.1016","volume":"26","author":[{"given":"Martin","family":"Thonhofer","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick","family":"Weber","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andres Gonzalez","family":"Santana","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roland","family":"Fischer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bettina M.","family":"Pabst","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eduard","family":"Paschke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Schalli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arnold E.","family":"St\u00fctz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marion","family":"Tschernutter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Werner","family":"Windischhofer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen G.","family":"Withers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bmcl.2016.01.059_b0005","series-title":"Iminosugars\u2014From Synthesis to Therapeutic Applications","year":"2007"},{"key":"10.1016\/j.bmcl.2016.01.059_b0010","series-title":"Iminosugars as Glycosidase Inhibitors","year":"1999"},{"key":"10.1016\/j.bmcl.2016.01.059_b0015","doi-asserted-by":"crossref","first-page":"750","DOI":"10.1002\/(SICI)1521-3773(19990315)38:6<750::AID-ANIE750>3.0.CO;2-6","volume":"38","author":"Heightman","year":"1999","journal-title":"Angew. Chem., Int. Ed."},{"key":"10.1016\/j.bmcl.2016.01.059_b0020","doi-asserted-by":"crossref","first-page":"1778","DOI":"10.1002\/anie.199417781","volume":"33","author":"Jespersen","year":"1994","journal-title":"Angew. Chem., Int. Ed. Engl."},{"key":"10.1016\/j.bmcl.2016.01.059_b0025","doi-asserted-by":"crossref","first-page":"13449","DOI":"10.1016\/S0040-4020(01)89351-0","volume":"50","author":"Jespersen","year":"1994","journal-title":"Tetrahedron"},{"key":"10.1016\/j.bmcl.2016.01.059_b0030","doi-asserted-by":"crossref","first-page":"7450","DOI":"10.1002\/anie.200502662","volume":"44","author":"Zhu","year":"2005","journal-title":"Angew. Chem., Int. Ed."},{"key":"10.1016\/j.bmcl.2016.01.059_b0035","doi-asserted-by":"crossref","first-page":"2151","DOI":"10.1002\/cbic.201100332","volume":"12","author":"Hill","year":"2011","journal-title":"ChemBioChem"},{"key":"10.1016\/j.bmcl.2016.01.059_b0040","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1146\/annurev-med-122313-085916","volume":"66","author":"Parenti","year":"2015","journal-title":"Ann. Rev. Med."},{"key":"10.1016\/j.bmcl.2016.01.059_b0045","doi-asserted-by":"crossref","first-page":"145","DOI":"10.2183\/pjab.90.145","volume":"90","author":"Suzuki","year":"2014","journal-title":"Proc. Jap. Acad., Ser. B: Phys. Biol. Sci."},{"key":"10.1016\/j.bmcl.2016.01.059_b0050","doi-asserted-by":"crossref","first-page":"15912","DOI":"10.1073\/pnas.2536657100","volume":"100","author":"Matsuda","year":"2003","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.bmcl.2016.01.059_b0055","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1002\/humu.21516","volume":"32","author":"Higaki","year":"2011","journal-title":"Hum. Mutat."},{"key":"10.1016\/j.bmcl.2016.01.059_b0060","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1039\/C4MD00270A","volume":"6","author":"Kuno","year":"2015","journal-title":"Med. Chem. Commun."},{"key":"10.1016\/j.bmcl.2016.01.059_b0065","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1038\/mt.2012.263","volume":"21","author":"Takai","year":"2013","journal-title":"Mol. Ther."},{"key":"10.1016\/j.bmcl.2016.01.059_b0070","doi-asserted-by":"crossref","first-page":"4398","DOI":"10.1021\/jo500328u","volume":"79","author":"Siriwardena","year":"2014","journal-title":"J. Org. Chem."},{"key":"10.1016\/j.bmcl.2016.01.059_b0075","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1046\/j.1471-4159.2004.02381.x","volume":"89","author":"Kasperzyk","year":"2004","journal-title":"J. Neurochem."},{"key":"10.1016\/j.bmcl.2016.01.059_b0080","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/j.ymgme.2012.06.007","volume":"107","author":"Rigat","year":"2012","journal-title":"Mol. Genet. Metab."},{"key":"10.1016\/j.bmcl.2016.01.059_b0085","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1016\/j.ymgme.2010.03.019","volume":"100","author":"Fantur","year":"2010","journal-title":"Mol. Genet. Metab."},{"key":"10.1016\/j.bmcl.2016.01.059_b0090","doi-asserted-by":"crossref","first-page":"2026","DOI":"10.1002\/cbic.201000192","volume":"11","author":"Schitter","year":"2010","journal-title":"ChemBioChem"},{"key":"10.1016\/j.bmcl.2016.01.059_b0095","doi-asserted-by":"crossref","first-page":"14560","DOI":"10.1074\/jbc.M113.529529","volume":"289","author":"Suzuki","year":"2014","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bmcl.2016.01.059_b0100","doi-asserted-by":"crossref","first-page":"3007","DOI":"10.1021\/ja973443k","volume":"120","author":"Ichikawa","year":"1998","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.bmcl.2016.01.059_b0105","doi-asserted-by":"crossref","first-page":"4903","DOI":"10.1016\/j.tetlet.2004.04.121","volume":"45","author":"Xie","year":"2004","journal-title":"Tetrahedron Lett."},{"key":"10.1016\/j.bmcl.2016.01.059_b0110","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1007\/s10545-011-9409-2","volume":"35","author":"Fantur","year":"2012","journal-title":"J. Inherit. Metab. Dis."},{"key":"10.1016\/j.bmcl.2016.01.059_b0120","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/S0957-4166(02)00047-2","volume":"13","author":"Sharma","year":"2002","journal-title":"Tetrahedron: Asymmetry"},{"key":"10.1016\/j.bmcl.2016.01.059_b0125","doi-asserted-by":"crossref","first-page":"4142","DOI":"10.1039\/b810817j","volume":"6","author":"Sharma","year":"2008","journal-title":"Org. Biomol. Chem."},{"key":"10.1016\/j.bmcl.2016.01.059_b0135","doi-asserted-by":"crossref","first-page":"5555","DOI":"10.1002\/ejoc.201001045","author":"Chan","year":"2010","journal-title":"Eur. J. Org. Chem."},{"key":"10.1016\/j.bmcl.2016.01.059_b0145","first-page":"7","volume":"3","author":"Suzuki","year":"2009","journal-title":"Perspect. Med. Chem."}],"container-title":["Bioorganic &amp; Medicinal Chemistry Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0960894X16300610?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0960894X16300610?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,18]],"date-time":"2025-10-18T07:04:52Z","timestamp":1760771092000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0960894X16300610"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,3]]},"references-count":26,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2016,3]]}},"alternative-id":["S0960894X16300610"],"URL":"https:\/\/doi.org\/10.1016\/j.bmcl.2016.01.059","relation":{},"ISSN":["0960-894X"],"issn-type":[{"value":"0960-894X","type":"print"}],"subject":[],"published":{"date-parts":[[2016,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Synthesis of C-5a-chain extended derivatives of 4-epi-isofagomine: Powerful \u03b2-galactosidase inhibitors and low concentration activators of GM1-gangliosidosis-related human lysosomal \u03b2-galactosidase","name":"articletitle","label":"Article Title"},{"value":"Bioorganic & Medicinal Chemistry Letters","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bmcl.2016.01.059","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2016 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}