{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T09:04:10Z","timestamp":1781773450368,"version":"3.54.5"},"reference-count":27,"publisher":"Elsevier BV","issue":"16","license":[{"start":{"date-parts":[[2016,8,1]],"date-time":"2016-08-01T00:00:00Z","timestamp":1470009600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2016,8,1]],"date-time":"2016-08-01T00:00:00Z","timestamp":1470009600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bioorganic &amp; Medicinal Chemistry Letters"],"published-print":{"date-parts":[[2016,8]]},"DOI":"10.1016\/j.bmcl.2016.07.024","type":"journal-article","created":{"date-parts":[[2016,7,10]],"date-time":"2016-07-10T01:18:16Z","timestamp":1468113496000},"page":"3850-3854","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"title":["Ligand binding cooperativity: Bioisosteric replacement of C O with SO2 among thrombin inhibitors"],"prefix":"10.1016","volume":"26","author":[{"given":"Ahmed M.","family":"Said","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David G.","family":"Hangauer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bmcl.2016.07.024_b0005","series-title":"Bioisosteres in Medicinal Chemistry","year":"2012"},{"key":"10.1016\/j.bmcl.2016.07.024_b0010","series-title":"The Practice of Medicinal Chemistry","author":"Ciapetti","year":"2008"},{"key":"10.1016\/j.bmcl.2016.07.024_b0015","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1002\/minf.201000019","volume":"29","author":"Langdon","year":"2010","journal-title":"Mol. Inf."},{"key":"10.1016\/j.bmcl.2016.07.024_b0020","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1016\/j.drudis.2006.02.006","volume":"11","author":"Wermuth","year":"2006","journal-title":"Drug Discovery Today"},{"key":"10.1016\/j.bmcl.2016.07.024_b0025","doi-asserted-by":"crossref","first-page":"2315","DOI":"10.1021\/jm401609a","volume":"57","author":"Nasief","year":"2014","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bmcl.2016.07.024_b0030","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1017\/S0033583506004240","volume":"38","author":"Whitesides","year":"2005","journal-title":"Q. Rev. Biophys."},{"key":"10.1016\/j.bmcl.2016.07.024_b0035","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1021\/ar9600087","volume":"29","author":"Lemieux","year":"1996","journal-title":"Acc. Chem. Res."},{"key":"10.1016\/j.bmcl.2016.07.024_b0040","doi-asserted-by":"crossref","first-page":"1326","DOI":"10.1073\/pnas.1016793108","volume":"108","author":"Wang","year":"2011","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.bmcl.2016.07.024_b0045","doi-asserted-by":"crossref","first-page":"1192","DOI":"10.1016\/j.bbagen.2010.06.009","volume":"1800","author":"Englert","year":"2010","journal-title":"Biochem. Biophys. Acta"},{"key":"10.1016\/j.bmcl.2016.07.024_b0050","doi-asserted-by":"crossref","first-page":"17889","DOI":"10.1073\/pnas.1114107108","volume":"108","author":"Snyder","year":"2011","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.bmcl.2016.07.024_b0055","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.1021\/jm0003992","volume":"44","author":"Stahl","year":"2001","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bmcl.2016.07.024_b0060","doi-asserted-by":"crossref","first-page":"6596","DOI":"10.1002\/anie.200300644","volume":"43","author":"Williams","year":"2004","journal-title":"Angew. Chem., Int. Ed."},{"key":"10.1016\/j.bmcl.2016.07.024_b0065","doi-asserted-by":"crossref","first-page":"5912","DOI":"10.1021\/jm050362n","volume":"49","author":"Warren","year":"2005","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bmcl.2016.07.024_b0070","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.1021\/ci9000053","volume":"49","author":"Cheng","year":"2009","journal-title":"J. Chem. Inf. Model."},{"key":"10.1016\/j.bmcl.2016.07.024_b0075","doi-asserted-by":"crossref","first-page":"2287","DOI":"10.1021\/jm0203783","volume":"46","author":"Wang","year":"2003","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bmcl.2016.07.024_b0080","doi-asserted-by":"crossref","first-page":"1700","DOI":"10.1021\/ci500080q","volume":"54","author":"Li","year":"2014","journal-title":"J. Chem. Inf. Model."},{"key":"10.1016\/j.bmcl.2016.07.024_b0085","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1016\/j.ejmech.2015.03.059","volume":"96","author":"Said","year":"2015","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.bmcl.2016.07.024_b0090","doi-asserted-by":"crossref","first-page":"2126","DOI":"10.1021\/jm9016416","volume":"53","author":"Muley","year":"2010","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bmcl.2016.07.024_b0095","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1016\/j.ejmech.2014.11.056","volume":"90","author":"Nasief","year":"2015","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.bmcl.2016.07.024_b0100","series-title":"ProQuest","author":"Khayat","year":"2013"},{"key":"10.1016\/j.bmcl.2016.07.024_b0105","doi-asserted-by":"crossref","first-page":"3180","DOI":"10.1021\/ci200319e","volume":"51","author":"Kuhn","year":"2011","journal-title":"J. Chem. Inf. Model."},{"key":"10.1016\/j.bmcl.2016.07.024_b0110","first-page":"137","volume":"19","author":"Williams","year":"2003","journal-title":"Methods Princ. Med. Chem."},{"key":"10.1016\/j.bmcl.2016.07.024_b0115","doi-asserted-by":"crossref","first-page":"5061","DOI":"10.1021\/jm100112j","volume":"53","author":"Bissantz","year":"2010","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bmcl.2016.07.024_b0120","doi-asserted-by":"crossref","first-page":"2708","DOI":"10.1021\/jm8011849","volume":"52","author":"Nilsson","year":"2009","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bmcl.2016.07.024_b0125","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1111\/j.1432-1033.1992.tb16916.x","volume":"206","author":"Stubbs","year":"1992","journal-title":"Eur. J. Biochem."},{"key":"10.1016\/j.bmcl.2016.07.024_b0130","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/0049-3848(89)90232-6","volume":"54","author":"Sturzebecher","year":"1989","journal-title":"Thromb. Res."},{"key":"10.1016\/j.bmcl.2016.07.024_b0135","doi-asserted-by":"crossref","first-page":"3099","DOI":"10.1016\/0006-2952(73)90196-2","volume":"22","author":"Cheng","year":"1973","journal-title":"Biochem. Pharmacol."}],"container-title":["Bioorganic &amp; Medicinal Chemistry Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0960894X16307375?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0960894X16307375?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,18]],"date-time":"2025-10-18T07:11:12Z","timestamp":1760771472000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0960894X16307375"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,8]]},"references-count":27,"journal-issue":{"issue":"16","published-print":{"date-parts":[[2016,8]]}},"alternative-id":["S0960894X16307375"],"URL":"https:\/\/doi.org\/10.1016\/j.bmcl.2016.07.024","relation":{},"ISSN":["0960-894X"],"issn-type":[{"value":"0960-894X","type":"print"}],"subject":[],"published":{"date-parts":[[2016,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Ligand binding cooperativity: Bioisosteric replacement of CO with SO2 among thrombin inhibitors","name":"articletitle","label":"Article Title"},{"value":"Bioorganic & Medicinal Chemistry Letters","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bmcl.2016.07.024","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}