{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T22:23:57Z","timestamp":1773181437193,"version":"3.50.1"},"reference-count":55,"publisher":"Elsevier BV","issue":"17","license":[{"start":{"date-parts":[[2016,9,1]],"date-time":"2016-09-01T00:00:00Z","timestamp":1472688000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2016,9,1]],"date-time":"2016-09-01T00:00:00Z","timestamp":1472688000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100004901","name":"FAPEMIG","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004901","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"CNPq","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002322","name":"CAPES","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bioorganic & Medicinal Chemistry Letters"],"published-print":{"date-parts":[[2016,9]]},"DOI":"10.1016\/j.bmcl.2016.07.058","type":"journal-article","created":{"date-parts":[[2016,7,26]],"date-time":"2016-07-26T07:18:19Z","timestamp":1469517499000},"page":"4197-4204","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":12,"title":["In vitro evaluation of the schistosomicidal effect of the extracts, fractions and major 3-hydroxy-2,6-dialkyl-substituted piperidine alkaloids from the flowers of Senna spectabilis (Fabaceae)"],"prefix":"10.1016","volume":"26","author":[{"given":"Andre\u00edsa Teixeira","family":"de Castro","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aline Pereira","family":"Castro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matheus Siqueira","family":"Silva","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Isabella Maria Monteiro","family":"de Souza","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raquel Lopes","family":"Martins-Souza","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniela Aparecida","family":"Chagas-Paula","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luiz Felipe Leomil","family":"Coelho","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vanderlan","family":"da Silva Bolzani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcos","family":"Pivatto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"suffix":"Junior","given":"Claudio","family":"Viegas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcos Jos\u00e9","family":"Marques","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.bmcl.2016.07.058_b0005","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.exppara.2012.06.005","volume":"132","author":"Oliveira","year":"2012","journal-title":"Exp. Parasitol."},{"key":"10.1016\/j.bmcl.2016.07.058_b0010","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/S2222-1808(13)60018-3","volume":"3","author":"Silva","year":"2013","journal-title":"Asian Pacific J. Trop. Dis."},{"key":"10.1016\/j.bmcl.2016.07.058_b0015","unstructured":"WHO, Schistosomiasis, WHO, World Health Organization, 2014."},{"key":"10.1016\/j.bmcl.2016.07.058_b0020","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1017\/S0022149X10000258","volume":"85","author":"Rapado","year":"2011","journal-title":"J. Helminthol."},{"key":"10.1016\/j.bmcl.2016.07.058_b0025","doi-asserted-by":"crossref","first-page":"1018","DOI":"10.1056\/NEJMra064142","volume":"357","author":"Hotez","year":"2007","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.bmcl.2016.07.058_b0030","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1590\/S0036-46652011000300007","volume":"53","author":"Mantawy","year":"2011","journal-title":"Rev. Inst. Med. Trop. Sao Paulo"},{"key":"10.1016\/j.bmcl.2016.07.058_b0035","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1007\/s00436-012-2871-4","volume":"111","author":"Abdel-Hafeez","year":"2012","journal-title":"Parasitol. Res."},{"key":"10.1016\/j.bmcl.2016.07.058_b0040","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1016\/j.exppara.2010.08.021","volume":"127","author":"De Moraes","year":"2011","journal-title":"Exp. Parasitol."},{"key":"10.1016\/j.bmcl.2016.07.058_b0045","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.exppara.2014.02.010","volume":"139","author":"Oliveira","year":"2014","journal-title":"Exp. Parasitol."},{"key":"10.1016\/j.bmcl.2016.07.058_b0050","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2014\/941318","author":"Fabri","year":"2014","journal-title":"Biomed. Res. Int."},{"key":"10.1016\/j.bmcl.2016.07.058_b0055","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2014\/460342","author":"Godinho","year":"2014","journal-title":"Sci. World J."},{"key":"10.1016\/j.bmcl.2016.07.058_b0060","first-page":"1","volume":"5","author":"Carrara","year":"2013","journal-title":"J. Helminthol."},{"key":"10.1016\/j.bmcl.2016.07.058_b0065","doi-asserted-by":"crossref","first-page":"12771","DOI":"10.3390\/molecules171112771","volume":"17","author":"Wink","year":"2012","journal-title":"Molecules"},{"key":"10.1016\/j.bmcl.2016.07.058_b0070","doi-asserted-by":"crossref","first-page":"232","DOI":"10.4103\/0975-1483.83772","volume":"3","author":"Silva","year":"2011","journal-title":"J. Young Pharm."},{"key":"10.1016\/j.bmcl.2016.07.058_b0075","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/j.phymed.2013.09.024","volume":"21","author":"Albuquerque Melo","year":"2014","journal-title":"Phytomedicine"},{"key":"10.1016\/j.bmcl.2016.07.058_b0080","doi-asserted-by":"crossref","first-page":"510","DOI":"10.3923\/ijp.2010.510.514","volume":"6","author":"Krishnan","year":"2010","journal-title":"Int. J. Pharmacol."},{"key":"10.1016\/j.bmcl.2016.07.058_b0085","doi-asserted-by":"crossref","first-page":"l 232","DOI":"10.4103\/0975-1483.83772","volume":"3","author":"Silva","year":"2011","journal-title":"J. Young Pharm."},{"key":"10.1016\/j.bmcl.2016.07.058_b0090","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1055\/s-2003-43201","volume":"69","author":"Alexandre-Moreira","year":"2003","journal-title":"Planta Med."},{"key":"10.1016\/j.bmcl.2016.07.058_b0095","doi-asserted-by":"crossref","first-page":"2026","DOI":"10.1021\/np070312g","volume":"70","author":"Viegas","year":"2007","journal-title":"J. Nat. Prod."},{"key":"10.1016\/j.bmcl.2016.07.058_b0100","first-page":"38","volume":"2","author":"Silva","year":"2010","journal-title":"Rev. Virtual Qu\u00edmica"},{"key":"10.1016\/j.bmcl.2016.07.058_b0105","doi-asserted-by":"crossref","first-page":"10292","DOI":"10.3390\/molecules170910292","volume":"17","author":"Jothy","year":"2012","journal-title":"Molecules"},{"key":"10.1016\/j.bmcl.2016.07.058_b0110","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1016\/j.neuropharm.2011.10.002","volume":"62","author":"Silva","year":"2012","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.bmcl.2016.07.058_b0115","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/j.fitote.2010.10.007","volume":"82","author":"Oliveira Silva","year":"2011","journal-title":"Fitoterapia"},{"key":"10.1016\/j.bmcl.2016.07.058_b0120","doi-asserted-by":"crossref","first-page":"1431","DOI":"10.1590\/S0103-50532005000800023","volume":"16","author":"Pivatto","year":"2005","journal-title":"J. Braz. Chem. Soc."},{"key":"10.1016\/j.bmcl.2016.07.058_b0125","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1017\/S0031182000086248","volume":"55","author":"Smithers","year":"1965","journal-title":"Parasitology"},{"key":"10.1016\/j.bmcl.2016.07.058_b0130","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1055\/s-0035-1545927","volume":"81","author":"Castro","year":"2015","journal-title":"Planta Med."},{"key":"10.1016\/j.bmcl.2016.07.058_b0135","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1016\/j.ijpara.2004.05.001","volume":"34","author":"Cioli","year":"2004","journal-title":"Int. J. Parasitol."},{"key":"10.1016\/j.bmcl.2016.07.058_b0140","doi-asserted-by":"crossref","first-page":"1197","DOI":"10.1007\/s00436-008-1311-y","volume":"104","author":"Magalh\u00e3es","year":"2009","journal-title":"Parasitol. Res."},{"key":"10.1016\/j.bmcl.2016.07.058_b0145","doi-asserted-by":"crossref","first-page":"1440","DOI":"10.1128\/AAC.01537-06","volume":"51","author":"Xiao","year":"2007","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.bmcl.2016.07.058_b0150","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1016\/j.ijpara.2013.01.007","volume":"43","author":"El-Beshbishi","year":"2013","journal-title":"Int. J. Parasitol."},{"key":"10.1016\/j.bmcl.2016.07.058_b0155","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1007\/s00436-009-1674-8","volume":"106","author":"Magalh\u00e3es","year":"2010","journal-title":"Parasitol. Res."},{"key":"10.1016\/j.bmcl.2016.07.058_b0160","doi-asserted-by":"crossref","first-page":"32","DOI":"10.3947\/ic.2013.45.1.32","volume":"45","author":"Chai","year":"2013","journal-title":"Infect Chemother."},{"key":"10.1016\/j.bmcl.2016.07.058_b0165","doi-asserted-by":"crossref","first-page":"701","DOI":"10.4155\/fmc.15.11","volume":"7","author":"Cupit","year":"2015","journal-title":"Future Med. Chem."},{"key":"10.1016\/j.bmcl.2016.07.058_b0170","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1016\/0014-4894(85)90074-8","volume":"216","author":"Ercoli","year":"1985","journal-title":"Exp. Parasitol."},{"key":"10.1016\/j.bmcl.2016.07.058_b0175","doi-asserted-by":"crossref","first-page":"2553","DOI":"10.1110\/ps.8.12.2553","volume":"8","author":"Arnon","year":"1999","journal-title":"Protein Sci."},{"key":"10.1016\/j.bmcl.2016.07.058_b0180","doi-asserted-by":"crossref","first-page":"1509","DOI":"10.1016\/j.bcp.2005.03.005","volume":"69","author":"Pess\u00f4a","year":"2005","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.bmcl.2016.07.058_b0185","doi-asserted-by":"crossref","first-page":"83","DOI":"10.4269\/ajtmh.1983.32.83","volume":"32","author":"Mellin","year":"1983","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"10.1016\/j.bmcl.2016.07.058_b0190","doi-asserted-by":"crossref","first-page":"4184","DOI":"10.1016\/j.bmc.2005.04.030","volume":"13","author":"Viegas","year":"2005","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.bmcl.2016.07.058_b0195","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1017\/S0031182002002536","volume":"125","author":"Sato","year":"2002","journal-title":"Parasitology"},{"key":"10.1016\/j.bmcl.2016.07.058_b0200","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/S0169-409X(02)00169-2","volume":"55","author":"Schinkel","year":"2003","journal-title":"Adv. Drug Delivery Rev."},{"key":"10.1016\/j.bmcl.2016.07.058_b0205","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1016\/j.ijpara.2015.03.004","volume":"45","author":"Sotillo","year":"2015","journal-title":"Int. J. Parasitol. Aust. Soc. Parasitol."},{"key":"10.1016\/j.bmcl.2016.07.058_b0210","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1038\/nri843","volume":"2","author":"Pearce","year":"2002","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.bmcl.2016.07.058_b0215","doi-asserted-by":"crossref","first-page":"1791","DOI":"10.1017\/S003118201000065X","volume":"137","author":"Couto","year":"2010","journal-title":"Parasitology"},{"key":"10.1016\/j.bmcl.2016.07.058_b0220","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1590\/S0074-02762008000800007","volume":"103","author":"Araujo","year":"2008","journal-title":"Mem. Inst. Oswaldo Cruz."},{"key":"10.1016\/j.bmcl.2016.07.058_b0225","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.actatropica.2007.04.002","volume":"102","author":"Mattos","year":"2007","journal-title":"Acta Trop."},{"key":"10.1016\/j.bmcl.2016.07.058_b0230","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1093\/jac\/45.6.819","volume":"45","author":"Ara\u00fajo","year":"2000","journal-title":"J. Antimicrob. Chemother."},{"key":"10.1016\/j.bmcl.2016.07.058_b0235","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1111\/j.1600-079X.2009.00708.x","volume":"47","author":"Kuehn","year":"2009","journal-title":"J. Pineal. Res."},{"key":"10.1016\/j.bmcl.2016.07.058_b0240","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.parint.2010.10.003","volume":"60","author":"Hausen","year":"2011","journal-title":"Parasitol. Int."},{"key":"10.1016\/j.bmcl.2016.07.058_b0245","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1017\/S0022149X0999054X","volume":"84","author":"Liang","year":"2010","journal-title":"J. Helminthol."},{"key":"10.1016\/j.bmcl.2016.07.058_b0250","doi-asserted-by":"crossref","first-page":"1077","DOI":"10.1007\/s00436-013-3743-2","volume":"113","author":"Santos","year":"2014","journal-title":"Parasitol. Res."},{"key":"10.1016\/j.bmcl.2016.07.058_b0255","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1620\/tjem.202.63","volume":"202","author":"Chisty","year":"2004","journal-title":"Tohoku J. Exp. Med."},{"key":"10.1016\/j.bmcl.2016.07.058_b0260","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.biortech.2005.11.020","volume":"98","author":"Aldenir","year":"2007","journal-title":"Bioresour. Technol."},{"key":"10.1016\/j.bmcl.2016.07.058_b0265","doi-asserted-by":"crossref","first-page":"2713","DOI":"10.1016\/j.bmc.2012.02.023","volume":"20","author":"Dias","year":"2012","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.bmcl.2016.07.058_b0270","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1007\/s00436-010-1910-2","volume":"107","author":"Mengome","year":"2010","journal-title":"Parasitol. Res."},{"key":"10.1016\/j.bmcl.2016.07.058_b0275","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1111\/cbdd.12017","volume":"80","author":"Machado","year":"2012","journal-title":"Chem. Biol. Drug Des."}],"container-title":["Bioorganic & Medicinal Chemistry Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0960894X16307867?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0960894X16307867?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,18]],"date-time":"2025-10-18T07:11:15Z","timestamp":1760771475000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0960894X16307867"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,9]]},"references-count":55,"journal-issue":{"issue":"17","published-print":{"date-parts":[[2016,9]]}},"alternative-id":["S0960894X16307867"],"URL":"https:\/\/doi.org\/10.1016\/j.bmcl.2016.07.058","relation":{},"ISSN":["0960-894X"],"issn-type":[{"value":"0960-894X","type":"print"}],"subject":[],"published":{"date-parts":[[2016,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"In vitro evaluation of the schistosomicidal effect of the extracts, fractions and major 3-hydroxy-2,6-dialkyl-substituted piperidine alkaloids from the flowers of Senna spectabilis (Fabaceae)","name":"articletitle","label":"Article Title"},{"value":"Bioorganic & Medicinal Chemistry Letters","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bmcl.2016.07.058","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}