{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T22:49:48Z","timestamp":1779317388487,"version":"3.51.4"},"reference-count":23,"publisher":"Elsevier BV","issue":"17","license":[{"start":{"date-parts":[[2016,9,1]],"date-time":"2016-09-01T00:00:00Z","timestamp":1472688000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2016,9,1]],"date-time":"2016-09-01T00:00:00Z","timestamp":1472688000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"name":"Innovative Medicines Joint Undertaking","award":["115583"],"award-info":[{"award-number":["115583"]}]},{"DOI":"10.13039\/501100000780","name":"European Union","doi-asserted-by":"crossref","award":["FP7\/2007-2013"],"award-info":[{"award-number":["FP7\/2007-2013"]}],"id":[{"id":"10.13039\/501100000780","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100013322","name":"EFPIA","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100013322","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bioorganic & Medicinal Chemistry Letters"],"published-print":{"date-parts":[[2016,9]]},"DOI":"10.1016\/j.bmcl.2016.07.061","type":"journal-article","created":{"date-parts":[[2016,7,29]],"date-time":"2016-07-29T07:32:40Z","timestamp":1469777560000},"page":"4179-4183","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":11,"title":["Discovery and structure\u2013activity relationships of a novel isothiazolone class of bacterial type II topoisomerase inhibitors"],"prefix":"10.1016","volume":"26","author":[{"given":"Ian R.","family":"Cooper","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew J.","family":"McCarroll","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"McGarry","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James","family":"Kirkham","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark","family":"Pichowicz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rolf","family":"Walker","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Catherine","family":"Warrilow","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anne-Marie","family":"Salisbury","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Victoria J.","family":"Savage","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emmanuel","family":"Moyo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Henry","family":"Forward","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonathan","family":"Cheung","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard","family":"Metzger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zoe","family":"Gault","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gary","family":"Nelson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Diarmaid","family":"Hughes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sha","family":"Cao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John","family":"Maclean","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C\u00e9dric","family":"Charrier","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark","family":"Craighead","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stuart","family":"Best","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Neil R.","family":"Stokes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew J.","family":"Ratcliffe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.bmcl.2016.07.061_b0005","series-title":"Tackling Drug-Resistant Infections Globally: Final Report and Recommendations","author":"O\u2019Neill","year":"2016"},{"key":"10.1016\/j.bmcl.2016.07.061_b0010","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.1086\/533452","volume":"197","author":"Rice","year":"2008","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.bmcl.2016.07.061_b0015","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1038\/nrd4572","volume":"14","author":"Tommasi","year":"2015","journal-title":"Nat. Rev. Drug Disc."},{"key":"10.1016\/j.bmcl.2016.07.061_b0020","doi-asserted-by":"crossref","first-page":"337","DOI":"10.3201\/eid0702.010239","volume":"7","author":"Hooper","year":"2001","journal-title":"Emerg. Infect. Dis."},{"key":"10.1016\/j.bmcl.2016.07.061_b0025","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1186\/s12879-015-1282-4","volume":"15","author":"Fasugba","year":"2015","journal-title":"BMC Infect. Dis."},{"key":"10.1016\/j.bmcl.2016.07.061_b0030","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1179\/1973947815Y.0000000054","volume":"27","author":"Bacci","year":"2015","journal-title":"J. Chemother."},{"key":"10.1016\/j.bmcl.2016.07.061_b0035","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1016\/j.ijantimicag.2015.03.001","volume":"45","author":"Potron","year":"2016","journal-title":"Int. J. Antimicrob. Agents"},{"key":"10.1016\/j.bmcl.2016.07.061_b0040","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1038\/nrmicro3380","volume":"13","author":"Blair","year":"2015","journal-title":"Nat. Rev. Microbiol."},{"key":"10.1016\/j.bmcl.2016.07.061_b0045","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1016\/j.tim.2014.04.007","volume":"22","author":"Redgrave","year":"2014","journal-title":"Trends Microbiol."},{"key":"10.1016\/j.bmcl.2016.07.061_b0050","doi-asserted-by":"crossref","first-page":"4055","DOI":"10.1039\/c0cc05111j","author":"Wright","year":"2011","journal-title":"Chem. Commun."},{"key":"10.1016\/j.bmcl.2016.07.061_b0055","doi-asserted-by":"crossref","first-page":"10144","DOI":"10.1021\/jm501552x","volume":"57","author":"Brown","year":"2014","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bmcl.2016.07.061_b0060","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1021\/acsinfecdis.5b00100","volume":"1","author":"Bush","year":"2015","journal-title":"ACS Infect. Dis."},{"key":"10.1016\/j.bmcl.2016.07.061_b0065","doi-asserted-by":"crossref","first-page":"2860","DOI":"10.1128\/AAC.01666-10","volume":"55","author":"Pucci","year":"2011","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.bmcl.2016.07.061_b0070","doi-asserted-by":"crossref","first-page":"1259","DOI":"10.1128\/AAC.01315-06","volume":"51","author":"Pucci","year":"2007","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.bmcl.2016.07.061_b0075","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1021\/jm051066d","volume":"49","author":"Wiles","year":"2006","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bmcl.2016.07.061_b0080","author":"Charrier","year":"2016","journal-title":"J. Antimicrob. Chemother."},{"key":"10.1016\/j.bmcl.2016.07.061_b0085","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/S0005-2736(03)00082-8","volume":"1612","author":"Jones","year":"2003","journal-title":"Biochim. Biophys. Acta\u2014Biomembr."},{"key":"10.1016\/j.bmcl.2016.07.061_b0090","doi-asserted-by":"crossref","first-page":"2532","DOI":"10.1021\/jm201275d","volume":"55","author":"Manchester","year":"2012","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bmcl.2016.07.061_b0095","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1128\/AAC.00665-08","volume":"53","author":"Morgan-Linnell","year":"2009","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.bmcl.2016.07.061_b0100","doi-asserted-by":"crossref","first-page":"e1000541","DOI":"10.1371\/journal.ppat.1000541","volume":"5","author":"Marcusson","year":"2009","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.bmcl.2016.07.061_b0105","doi-asserted-by":"crossref","first-page":"5392","DOI":"10.1016\/j.bmc.2014.07.040","volume":"22","author":"Reck","year":"2014","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.bmcl.2016.07.061_b0110","doi-asserted-by":"crossref","first-page":"6916","DOI":"10.1021\/jm300690s","volume":"55","author":"Reck","year":"2012","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bmcl.2016.07.061_b0115","doi-asserted-by":"crossref","first-page":"5029","DOI":"10.1021\/jm060379l","volume":"49","author":"Jamieson","year":"2006","journal-title":"J. Med. Chem."}],"container-title":["Bioorganic & Medicinal Chemistry Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0960894X16307892?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0960894X16307892?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,18]],"date-time":"2025-10-18T07:09:50Z","timestamp":1760771390000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0960894X16307892"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,9]]},"references-count":23,"journal-issue":{"issue":"17","published-print":{"date-parts":[[2016,9]]}},"alternative-id":["S0960894X16307892"],"URL":"https:\/\/doi.org\/10.1016\/j.bmcl.2016.07.061","relation":{},"ISSN":["0960-894X"],"issn-type":[{"value":"0960-894X","type":"print"}],"subject":[],"published":{"date-parts":[[2016,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Discovery and structure\u2013activity relationships of a novel isothiazolone class of bacterial type II topoisomerase inhibitors","name":"articletitle","label":"Article Title"},{"value":"Bioorganic & Medicinal Chemistry Letters","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bmcl.2016.07.061","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}