{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T22:52:35Z","timestamp":1787093555318,"version":"build-2736575974"},"reference-count":21,"publisher":"Elsevier BV","issue":"19","license":[{"start":{"date-parts":[[2016,10,1]],"date-time":"2016-10-01T00:00:00Z","timestamp":1475280000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2016,10,1]],"date-time":"2016-10-01T00:00:00Z","timestamp":1475280000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100000925","name":"NHMRC","doi-asserted-by":"publisher","award":["1093062"],"award-info":[{"award-number":["1093062"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000925","name":"NHMRC","doi-asserted-by":"publisher","award":["545943"],"award-info":[{"award-number":["545943"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Australian Postgraduate Award"},{"name":"Cooperative Research Centre for Cancer Therapeutics"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bioorganic &amp; Medicinal Chemistry Letters"],"published-print":{"date-parts":[[2016,10]]},"DOI":"10.1016\/j.bmcl.2016.08.028","type":"journal-article","created":{"date-parts":[[2016,8,12]],"date-time":"2016-08-12T03:49:04Z","timestamp":1470973744000},"page":"4790-4794","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":10,"title":["Development of single and mixed isoform selectivity PI3K\u03b4 inhibitors by targeting Asn836 of PI3K\u03b4"],"prefix":"10.1016","volume":"26","author":[{"given":"Michelle S.","family":"Miller","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon J.","family":"Mountford","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jo-Anne","family":"Pinson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhaohua","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"K\u00fcnzli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vanit","family":"Patel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon J.","family":"Hogg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jake","family":"Shortt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ian G.","family":"Jennings","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip E.","family":"Thompson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bmcl.2016.08.028_b0005","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/j.coph.2015.05.016","volume":"23","author":"Yap","year":"2015","journal-title":"Curr. Opin. Pharmacol."},{"key":"10.1016\/j.bmcl.2016.08.028_b0010","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1111\/j.1600-065X.2010.00934.x","volume":"237","author":"Werner","year":"2010","journal-title":"Immunol. Rev."},{"key":"10.1016\/j.bmcl.2016.08.028_b0015","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1038\/nature11378","volume":"490","author":"Schmitz","year":"2012","journal-title":"Nature"},{"key":"10.1016\/j.bmcl.2016.08.028_b0020","doi-asserted-by":"crossref","first-page":"1525","DOI":"10.1158\/1078-0432.CCR-14-2522","volume":"21","author":"Miller","year":"2015","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.bmcl.2016.08.028_b0025","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1177\/1078155215572933","volume":"22","author":"Hewett","year":"2016","journal-title":"J. Oncol. Pharm. Pract."},{"key":"10.1016\/j.bmcl.2016.08.028_b0030","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1182\/blood-2010-03-275305","volume":"117","author":"Lannutti","year":"2011","journal-title":"Blood"},{"key":"10.1016\/j.bmcl.2016.08.028_b0035","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1186\/1479-5876-12-10","volume":"12","author":"Cui","year":"2014","journal-title":"J. Transl. Med."},{"key":"10.1016\/j.bmcl.2016.08.028_b0040","doi-asserted-by":"crossref","first-page":"1196","DOI":"10.1038\/leu.2013.369","volume":"28","author":"Lonetti","year":"2014","journal-title":"Leukemia"},{"key":"10.1016\/j.bmcl.2016.08.028_b0045","doi-asserted-by":"crossref","first-page":"2076","DOI":"10.1016\/j.ejca.2015.07.018","volume":"51","author":"Pereira","year":"2015","journal-title":"Eur. J. Cancer"},{"key":"10.1016\/j.bmcl.2016.08.028_b0050","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1021\/cb300666s","volume":"8","author":"Zheng","year":"2013","journal-title":"ACS Chem. Biol."},{"key":"10.1016\/j.bmcl.2016.08.028_b0055","doi-asserted-by":"crossref","first-page":"4296","DOI":"10.1016\/j.bmcl.2012.05.027","volume":"22","author":"Sutherlin","year":"2012","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.bmcl.2016.08.028_b0060","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1124\/mol.111.072546","volume":"80","author":"Zheng","year":"2011","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.bmcl.2016.08.028_b0065","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1042\/BJ20120499","volume":"444","author":"Zheng","year":"2012","journal-title":"Biochem. J."},{"key":"10.1016\/j.bmcl.2016.08.028_b0070","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1042\/BJ20080512","volume":"414","author":"Frazzetto","year":"2008","journal-title":"Biochem. J."},{"key":"10.1016\/j.bmcl.2016.08.028_b0075","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1042\/BJ20110502","volume":"438","author":"Jamieson","year":"2011","journal-title":"Biochem. J."},{"key":"10.1016\/j.bmcl.2016.08.028_b0080","doi-asserted-by":"crossref","first-page":"4723","DOI":"10.1016\/j.bmcl.2013.06.020","volume":"23","author":"Furet","year":"2013","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.bmcl.2016.08.028_b0085","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1038\/nchembio0410-306a","volume":"6","author":"Berndt","year":"2010","journal-title":"Nat. Chem. Biol."},{"key":"10.1016\/j.bmcl.2016.08.028_b0090","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1021\/ml300336j","volume":"4","author":"Pinson","year":"2013","journal-title":"ACS Med. Chem. Lett."},{"key":"10.1016\/j.bmcl.2016.08.028_b0095","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1016\/j.ejmech.2016.06.010","volume":"122","author":"Zheng","year":"2016","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.bmcl.2016.08.028_b0100","doi-asserted-by":"crossref","first-page":"7105","DOI":"10.1021\/jm200688y","volume":"54","author":"Rewcastle","year":"2011","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bmcl.2016.08.028_b0105","doi-asserted-by":"crossref","first-page":"802","DOI":"10.1016\/j.bmcl.2012.11.076","volume":"23","author":"Miller","year":"2013","journal-title":"Bioorg. Med. Chem. Lett."}],"container-title":["Bioorganic &amp; Medicinal Chemistry Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0960894X16308496?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0960894X16308496?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,18]],"date-time":"2025-10-18T07:12:30Z","timestamp":1760771550000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0960894X16308496"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,10]]},"references-count":21,"journal-issue":{"issue":"19","published-print":{"date-parts":[[2016,10]]}},"alternative-id":["S0960894X16308496"],"URL":"https:\/\/doi.org\/10.1016\/j.bmcl.2016.08.028","relation":{},"ISSN":["0960-894X"],"issn-type":[{"value":"0960-894X","type":"print"}],"subject":[],"published":{"date-parts":[[2016,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Development of single and mixed isoform selectivity PI3K\u03b4 inhibitors by targeting Asn836 of PI3K\u03b4","name":"articletitle","label":"Article Title"},{"value":"Bioorganic & Medicinal Chemistry Letters","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bmcl.2016.08.028","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}