{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T14:06:25Z","timestamp":1784297185697,"version":"3.55.0"},"reference-count":30,"publisher":"Elsevier BV","issue":"19","license":[{"start":{"date-parts":[[2016,10,1]],"date-time":"2016-10-01T00:00:00Z","timestamp":1475280000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2016,10,1]],"date-time":"2016-10-01T00:00:00Z","timestamp":1475280000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["21372133"],"award-info":[{"award-number":["21372133"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Zhejiang Province National Natural Science Foundation of China","award":["LY16C140007"],"award-info":[{"award-number":["LY16C140007"]}]},{"DOI":"10.13039\/501100004543","name":"China Scholarship Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004543","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bioorganic &amp; Medicinal Chemistry Letters"],"published-print":{"date-parts":[[2016,10]]},"DOI":"10.1016\/j.bmcl.2016.08.059","type":"journal-article","created":{"date-parts":[[2016,8,24]],"date-time":"2016-08-24T03:17:45Z","timestamp":1472008665000},"page":"4661-4665","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":44,"title":["Synthesis and biological activities of novel 5-substituted-1,3,4-oxadiazole Mannich bases and bis-Mannich bases as ketol-acid reductoisomerase inhibitors"],"prefix":"10.1016","volume":"26","author":[{"given":"Yan","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xing-Hai","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi-Zhou","family":"Zhan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li-Yuan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zheng-Ming","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong-Hong","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bao-Lei","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bmcl.2016.08.059_b0005","doi-asserted-by":"crossref","first-page":"1231","DOI":"10.1351\/pac200173081231","volume":"73","author":"Thornton","year":"2001","journal-title":"Pure Appl. Chem."},{"key":"10.1016\/j.bmcl.2016.08.059_b0010","doi-asserted-by":"crossref","first-page":"6274","DOI":"10.1016\/j.bmcl.2007.09.012","volume":"17","author":"Lahm","year":"2007","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.bmcl.2016.08.059_b0015","doi-asserted-by":"crossref","first-page":"5515","DOI":"10.1021\/jf100300a","volume":"58","author":"Wang","year":"2010","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.bmcl.2016.08.059_b0020","doi-asserted-by":"crossref","first-page":"1443","DOI":"10.1126\/science.224.4656.1443","volume":"224","author":"Chaleff","year":"1984","journal-title":"Science"},{"key":"10.1016\/j.bmcl.2016.08.059_b0025","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1093\/jac\/42.4.475","volume":"4","author":"Grandoni","year":"1998","journal-title":"J. Antimicrob. Chemother."},{"key":"10.1016\/j.bmcl.2016.08.059_b0030","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1104\/pp.76.2.545","volume":"76","author":"Shaner","year":"1984","journal-title":"Plant Physiol."},{"key":"10.1016\/j.bmcl.2016.08.059_b0035","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1016\/0014-5793(88)80515-5","volume":"238","author":"Schulz","year":"1988","journal-title":"FEBS Lett."},{"key":"10.1016\/j.bmcl.2016.08.059_b0040","doi-asserted-by":"crossref","first-page":"2824","DOI":"10.1021\/bi00463a027","volume":"29","author":"Aulabaugh","year":"1990","journal-title":"Biochemistry"},{"key":"10.1016\/j.bmcl.2016.08.059_b0045","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.1016\/j.plantsci.2004.11.020","volume":"168","author":"Lee","year":"2005","journal-title":"Plant Sci."},{"key":"10.1016\/j.bmcl.2016.08.059_b0050","doi-asserted-by":"crossref","first-page":"4773","DOI":"10.1021\/bi9721389","volume":"37","author":"Halgand","year":"1998","journal-title":"Biochemistry"},{"key":"10.1016\/j.bmcl.2016.08.059_b0055","doi-asserted-by":"crossref","first-page":"2673","DOI":"10.1021\/jf902639x","volume":"58","author":"Liu","year":"2010","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.bmcl.2016.08.059_b0060","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1021\/op700281w","volume":"12","author":"Gonzalez","year":"2008","journal-title":"Org. Process Res. Dev."},{"key":"10.1016\/j.bmcl.2016.08.059_b0065","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1584\/jpestics.J14-04","volume":"39","author":"Takagaki","year":"2014","journal-title":"J. Pestic. Sci."},{"key":"10.1016\/j.bmcl.2016.08.059_b0070","first-page":"90","volume":"29","author":"Wang","year":"2008","journal-title":"Chem. J. Chin. Univ."},{"key":"10.1016\/j.bmcl.2016.08.059_b0075","doi-asserted-by":"crossref","first-page":"5796","DOI":"10.1016\/j.bmcl.2009.07.139","volume":"19","author":"Milinkevich","year":"2009","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.bmcl.2016.08.059_b0080","doi-asserted-by":"crossref","first-page":"2278","DOI":"10.1016\/j.bmcl.2006.01.026","volume":"16","author":"Li","year":"2006","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.bmcl.2016.08.059_b0085","doi-asserted-by":"crossref","first-page":"1236","DOI":"10.1016\/j.bmc.2006.08.033","volume":"14","author":"Ahmed","year":"2006","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.bmcl.2016.08.059_b0090","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.1016\/j.ejmech.2008.06.019","volume":"44","author":"Bayrak","year":"2009","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.bmcl.2016.08.059_b0095","doi-asserted-by":"crossref","first-page":"1246","DOI":"10.3724\/SP.J.1095.2012.00537","volume":"29","author":"Chen","year":"2012","journal-title":"Chin. J. Appl. Chem."},{"key":"10.1016\/j.bmcl.2016.08.059_b0100","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1159\/000048533","volume":"47","author":"Pandeya","year":"2001","journal-title":"Chemotherapy"},{"key":"10.1016\/j.bmcl.2016.08.059_b0105","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1111\/j.1747-0285.2011.01132.x","volume":"78","author":"Wang","year":"2011","journal-title":"Chem. Biol. Drug Des."},{"key":"10.1016\/j.bmcl.2016.08.059_b0110","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.jfluchem.2016.02.004","volume":"184","author":"Wang","year":"2016","journal-title":"J. Fluorine Chem."},{"key":"10.1016\/j.bmcl.2016.08.059_b0115","doi-asserted-by":"crossref","first-page":"4963","DOI":"10.1016\/j.ejmech.2010.08.003","volume":"45","author":"Keshari","year":"2010","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.bmcl.2016.08.059_b0120","doi-asserted-by":"crossref","first-page":"2003","DOI":"10.3390\/12082003","volume":"12","author":"Wu","year":"2007","journal-title":"Molecules"},{"key":"10.1016\/j.bmcl.2016.08.059_b0125","doi-asserted-by":"crossref","first-page":"1785","DOI":"10.1039\/c2ob06730g","volume":"10","author":"Manishkumar","year":"2012","journal-title":"Org. Biomol. Chem."},{"key":"10.1016\/j.bmcl.2016.08.059_b0130","doi-asserted-by":"crossref","first-page":"17718","DOI":"10.1021\/ja803434z","volume":"130","author":"Chekmeneva","year":"2008","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.bmcl.2016.08.059_b0135","doi-asserted-by":"crossref","first-page":"1154","DOI":"10.1002\/jctb.500","volume":"76","author":"Liu","year":"2001","journal-title":"J. Chem. Technol. Biotechnol."},{"key":"10.1016\/j.bmcl.2016.08.059_b0140","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1002\/ps.972","volume":"61","author":"Wang","year":"2005","journal-title":"Pest. Manag. Sci."},{"key":"10.1016\/j.bmcl.2016.08.059_b0145","doi-asserted-by":"crossref","first-page":"12725","DOI":"10.3390\/molecules181012725","volume":"18","author":"Sun","year":"2013","journal-title":"Molecules"},{"key":"10.1016\/j.bmcl.2016.08.059_b0150","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.pestbp.2011.08.006","volume":"101","author":"Liu","year":"2011","journal-title":"Pest. Biochem. Physiol."}],"container-title":["Bioorganic &amp; Medicinal Chemistry Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0960894X16308927?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0960894X16308927?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,18]],"date-time":"2025-10-18T07:10:14Z","timestamp":1760771414000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0960894X16308927"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,10]]},"references-count":30,"journal-issue":{"issue":"19","published-print":{"date-parts":[[2016,10]]}},"alternative-id":["S0960894X16308927"],"URL":"https:\/\/doi.org\/10.1016\/j.bmcl.2016.08.059","relation":{},"ISSN":["0960-894X"],"issn-type":[{"value":"0960-894X","type":"print"}],"subject":[],"published":{"date-parts":[[2016,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Synthesis and biological activities of novel 5-substituted-1,3,4-oxadiazole Mannich bases and bis-Mannich bases as ketol-acid reductoisomerase inhibitors","name":"articletitle","label":"Article Title"},{"value":"Bioorganic & Medicinal Chemistry Letters","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bmcl.2016.08.059","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}