{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T00:17:38Z","timestamp":1760833058042,"version":"build-2065373602"},"reference-count":21,"publisher":"Elsevier BV","issue":"23","license":[{"start":{"date-parts":[[2016,12,1]],"date-time":"2016-12-01T00:00:00Z","timestamp":1480550400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2016,12,1]],"date-time":"2016-12-01T00:00:00Z","timestamp":1480550400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bioorganic &amp; Medicinal Chemistry Letters"],"published-print":{"date-parts":[[2016,12]]},"DOI":"10.1016\/j.bmcl.2016.10.049","type":"journal-article","created":{"date-parts":[[2016,10,19]],"date-time":"2016-10-19T11:06:31Z","timestamp":1476875191000},"page":"5757-5764","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":14,"title":["Discovery, characterization and biological evaluation of a novel (R)-4,4-difluoropiperidine scaffold as dopamine receptor 4 (D4R) antagonists"],"prefix":"10.1016","volume":"26","author":[{"given":"Daniel E.","family":"Jeffries","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonathan O.","family":"Witt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea L.","family":"McCollum","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kayla J.","family":"Temple","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miguel A.","family":"Hurtado","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9116-5606","authenticated-orcid":false,"given":"Joel M.","family":"Harp","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna L.","family":"Blobaum","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Craig W.","family":"Lindsley","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Corey R.","family":"Hopkins","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.bmcl.2016.10.049_b0005","doi-asserted-by":"crossref","first-page":"1503","DOI":"10.1016\/S0028-3908(96)00100-1","volume":"35","author":"Jaber","year":"1996","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.bmcl.2016.10.049_b0010","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1021\/cr300113a","volume":"113","author":"Ye","year":"2013","journal-title":"Chem. Rev."},{"key":"10.1016\/j.bmcl.2016.10.049_b0015","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1001\/archneur.61.5.641","volume":"61","author":"Girault","year":"2004","journal-title":"Arch. Neurol."},{"key":"10.1016\/j.bmcl.2016.10.049_b0020","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1038\/358149a0","volume":"358","author":"Van Tol","year":"1992","journal-title":"Nature"},{"key":"10.1016\/j.bmcl.2016.10.049_b0025","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1016\/j.neubiorev.2009.06.005","volume":"34","author":"Tost","year":"2010","journal-title":"Neurosci. Biobehav. Rev."},{"key":"10.1016\/j.bmcl.2016.10.049_b0030","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1016\/S0022-3565(24)37092-2","volume":"283","author":"Patel","year":"1997","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.bmcl.2016.10.049_b0035","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1016\/S0165-6147(97)01066-3","volume":"18","author":"Bristow","year":"1997","journal-title":"Trends Pharm. Sci."},{"key":"10.1016\/j.bmcl.2016.10.049_b0040","doi-asserted-by":"crossref","first-page":"1256","DOI":"10.1016\/S0022-3565(24)37123-X","volume":"283","author":"Bristow","year":"1997","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.bmcl.2016.10.049_b0045","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1124\/pr.111.005678","volume":"65","author":"Huot","year":"2013","journal-title":"Pharmacol. Rev."},{"key":"10.1016\/j.bmcl.2016.10.049_b0050","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/B978-0-12-420118-7.00008-1","volume":"69","author":"Di Ciano","year":"2014","journal-title":"Adv. Pharmacol."},{"key":"10.1016\/j.bmcl.2016.10.049_b0055","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1097\/FBP.0000000000000096","volume":"26","author":"Huot","year":"2015","journal-title":"Behav. Pharmacol."},{"key":"10.1016\/j.bmcl.2016.10.049_b0060","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1124\/jpet.112.195693","volume":"342","author":"Huot","year":"2012","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.bmcl.2016.10.049_b0065","doi-asserted-by":"crossref","first-page":"1060","DOI":"10.1021\/ml500267c","volume":"5","author":"Berry","year":"2014","journal-title":"ACS Med. Chem. Lett."},{"key":"10.1016\/j.bmcl.2016.10.049_b0070","doi-asserted-by":"crossref","first-page":"2481","DOI":"10.1016\/j.bmcl.2016.03.102","volume":"26","author":"Witt","year":"2016","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.bmcl.2016.10.049_b0075","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/j.nbd.2016.09.001","volume":"96","author":"Sebastianutto","year":"2016","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.bmcl.2016.10.049_b0080","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1021\/jo00395a032","volume":"43","author":"Krapcho","year":"1978","journal-title":"J. Org. Chem."},{"key":"10.1016\/j.bmcl.2016.10.049_b0085","first-page":"2561","volume":"17","author":"Singh","year":"2002","journal-title":"Synthesis"},{"key":"10.1016\/j.bmcl.2016.10.049_b0090","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1016\/j.bmcl.2009.11.034","volume":"20","author":"Stanton","year":"2010","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.bmcl.2016.10.049_b0105","doi-asserted-by":"crossref","first-page":"1350","DOI":"10.1016\/S0090-9556(24)14938-0","volume":"27","author":"Orbach","year":"1999","journal-title":"Drug Metab. Disp."},{"key":"10.1016\/j.bmcl.2016.10.049_b0110","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1158\/1535-7163.MCT-06-0324","volume":"6","author":"Smith","year":"2007","journal-title":"Mol. Cancer Ther."},{"key":"10.1016\/j.bmcl.2016.10.049_b0115","doi-asserted-by":"crossref","first-page":"e00077","DOI":"10.1002\/prp2.77","volume":"2","author":"Bridges","year":"2014","journal-title":"Pharmacol. Res. Perspect."}],"container-title":["Bioorganic &amp; Medicinal Chemistry Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0960894X16310873?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0960894X16310873?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,18]],"date-time":"2025-10-18T07:13:26Z","timestamp":1760771606000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0960894X16310873"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,12]]},"references-count":21,"journal-issue":{"issue":"23","published-print":{"date-parts":[[2016,12]]}},"alternative-id":["S0960894X16310873"],"URL":"https:\/\/doi.org\/10.1016\/j.bmcl.2016.10.049","relation":{},"ISSN":["0960-894X"],"issn-type":[{"type":"print","value":"0960-894X"}],"subject":[],"published":{"date-parts":[[2016,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Discovery, characterization and biological evaluation of a novel (R)-4,4-difluoropiperidine scaffold as dopamine receptor 4 (D4R) antagonists","name":"articletitle","label":"Article Title"},{"value":"Bioorganic & Medicinal Chemistry Letters","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bmcl.2016.10.049","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}