{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,5]],"date-time":"2026-03-05T23:33:40Z","timestamp":1772753620306,"version":"3.50.1"},"reference-count":31,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2017,2,1]],"date-time":"2017-02-01T00:00:00Z","timestamp":1485907200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,2,1]],"date-time":"2017-02-01T00:00:00Z","timestamp":1485907200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"name":"National University of Singapore Faculty of Science","award":["R-148-000-169-133"],"award-info":[{"award-number":["R-148-000-169-133"]}]},{"name":"Drug Development Unit grant","award":["R-711-000-022-133"],"award-info":[{"award-number":["R-711-000-022-133"]}]},{"name":"Department of Pharmacy, NUS"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bioorganic &amp; Medicinal Chemistry Letters"],"published-print":{"date-parts":[[2017,2]]},"DOI":"10.1016\/j.bmcl.2016.12.079","type":"journal-article","created":{"date-parts":[[2017,1,4]],"date-time":"2017-01-04T11:15:23Z","timestamp":1483528523000},"page":"967-972","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":14,"title":["Discovery of medium ring thiophosphorus based heterocycles as antiproliferative agents"],"prefix":"10.1016","volume":"27","author":[{"given":"Wei","family":"Feng","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wisna","family":"Novera","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kaye","family":"Peh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Donavan","family":"Neo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pondy Murugappan","family":"Ramanujulu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philip K.","family":"Moore","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lih-Wen","family":"Deng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brian W.","family":"Dymock","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"13","key":"10.1016\/j.bmcl.2016.12.079_b0005","doi-asserted-by":"crossref","first-page":"1792","DOI":"10.1096\/fj.02-0211hyp","article-title":"Two's company, three's a crowd: can H2S be the third endogenous gaseous transmitter?","volume":"16","author":"Wang","year":"2002","journal-title":"Faseb J"},{"issue":"3","key":"10.1016\/j.bmcl.2016.12.079_b0010","doi-asserted-by":"crossref","first-page":"1066","DOI":"10.1523\/JNEUROSCI.16-03-01066.1996","article-title":"The possible role of hydrogen sulfide as an endogenous neuromodulator","volume":"16","author":"Abe","year":"1996","journal-title":"J Neurosci"},{"issue":"10","key":"10.1016\/j.bmcl.2016.12.079_b0015","doi-asserted-by":"crossref","first-page":"1879","DOI":"10.1097\/00004872-200310000-00015","article-title":"The role of hydrogen sulfide generation in the pathogenesis of hypertension in rats induced by inhibition of nitric oxide synthase","volume":"21","author":"Zhong","year":"2003","journal-title":"J Hypertens"},{"issue":"6","key":"10.1016\/j.bmcl.2016.12.079_b0020","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1586\/17512433.2013.842126","article-title":"Could hydrogen sulfide be the next blockbuster treatment for inflammatory disease?","volume":"6","author":"Li","year":"2013","journal-title":"Exp Rev Clin Pharmacol"},{"issue":"6","key":"10.1016\/j.bmcl.2016.12.079_b0025","doi-asserted-by":"crossref","first-page":"1196","DOI":"10.1096\/fj.04-3583fje","article-title":"Hydrogen sulfide is a novel mediator of lipopolysaccharide-induced inflammation in the mouse","volume":"19","author":"Li","year":"2005","journal-title":"Faseb J"},{"issue":"2","key":"10.1016\/j.bmcl.2016.12.079_b0030","doi-asserted-by":"crossref","first-page":"77","DOI":"10.2174\/187152811794776277","article-title":"Hydrogen sulfide: from physiology to pharmacology","volume":"10","author":"Fiorucci","year":"2011","journal-title":"Inflamm Allergy Drug Targets"},{"issue":"1\u20132","key":"10.1016\/j.bmcl.2016.12.079_b0035","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.pain.2007.01.026","article-title":"Hydrogen sulfide as a novel nociceptive messenger","volume":"132","author":"Kawabata","year":"2007","journal-title":"Pain"},{"issue":"6","key":"10.1016\/j.bmcl.2016.12.079_b0040","doi-asserted-by":"crossref","first-page":"e21077","DOI":"10.1371\/journal.pone.0021077","article-title":"The slow-releasing hydrogen sulfide donor, GYY4137, exhibits novel anti-cancer effects in vitro and in vivo","volume":"6","author":"Lee","year":"2011","journal-title":"Plos One"},{"issue":"5","key":"10.1016\/j.bmcl.2016.12.079_b0045","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1089\/ars.2013.5308","article-title":"Anti-cancer activity of new designer hydrogen sulfide-donating hybrids","volume":"20","author":"Kashfi","year":"2014","journal-title":"Antioxid Redox Sign"},{"issue":"16","key":"10.1016\/j.bmcl.2016.12.079_b0050","doi-asserted-by":"crossref","first-page":"6456","DOI":"10.1021\/acs.jmedchem.5b00848","article-title":"Discovery of new H2S releasing phosphordithioates and 2,3-dihydro-2-phenyl-2-sulfanylenebenzo[d][1,3,2]oxazaphospholes with improved antiproliferative activity","volume":"58","author":"Feng","year":"2015","journal-title":"J Med Chem"},{"issue":"6","key":"10.1016\/j.bmcl.2016.12.079_b0055","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1016\/j.bcp.2011.12.020","article-title":"Hydrogen sulfide-releasing aspirin modulates xenobiotic metabolizing enzymes in vitro and in vivo","volume":"83","author":"Chattopadhyay","year":"2012","journal-title":"Biochem Pharmacol"},{"issue":"6","key":"10.1016\/j.bmcl.2016.12.079_b0060","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1016\/j.bcp.2011.12.018","article-title":"Hydrogen sulfide-releasing NSAIDs inhibit the growth of human cancer cells: a general property and evidence of a tissue type-independent effect","volume":"83","author":"Chattopadhyay","year":"2012","journal-title":"Biochem Pharmacol"},{"issue":"5","key":"10.1016\/j.bmcl.2016.12.079_b0065","doi-asserted-by":"crossref","first-page":"706","DOI":"10.1016\/j.freeradbiomed.2006.12.011","article-title":"Anti-inflammatory and gastrointestinal effects of a novel diclofenac derivative","volume":"42","author":"Li","year":"2007","journal-title":"Free Rad Biol Med"},{"issue":"1","key":"10.1016\/j.bmcl.2016.12.079_b0070","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.freeradbiomed.2009.04.014","article-title":"GYY4137, a novel hydrogen sulfide-releasing molecule, protects against endotoxic shock in the rat","volume":"47","author":"Li","year":"2009","journal-title":"Free Rad Biol Med"},{"issue":"10","key":"10.1016\/j.bmcl.2016.12.079_b0075","doi-asserted-by":"crossref","first-page":"1147","DOI":"10.1089\/ars.2009.2899","article-title":"The Effect of Hydrogen Sulfide Donors on Lipopolysaccharide-Induced Formation of Inflammatory Mediators in Macrophages","volume":"12","author":"Whiteman","year":"2010","journal-title":"Antioxid Redox Sign"},{"issue":"5","key":"10.1016\/j.bmcl.2016.12.079_b0080","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1016\/j.bcp.2012.10.019","article-title":"Biology and therapeutic potential of hydrogen sulfide and hydrogen sulfide-releasing chimeras","volume":"85","author":"Kashfi","year":"2013","journal-title":"Biochem Pharmacol"},{"issue":"3","key":"10.1016\/j.bmcl.2016.12.079_b0085","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1016\/j.bbrc.2012.02.051","article-title":"NOSH-aspirin (NBS-1120), a novel nitric oxide- and hydrogen sulfide-releasing hybrid is a potent inhibitor of colon cancer cell growth in vitro and in a xenograft mouse model","volume":"419","author":"Chattopadhyay","year":"2012","journal-title":"Biochem Biophys Res Commun"},{"issue":"80","key":"10.1016\/j.bmcl.2016.12.079_b0090","doi-asserted-by":"crossref","first-page":"11788","DOI":"10.1039\/C4CC00968A","article-title":"Hydrogen sulfide (H2S) releasing agents: chemistry and biological applications","volume":"50","author":"Zhao","year":"2014","journal-title":"Chem Commun"},{"issue":"5","key":"10.1016\/j.bmcl.2016.12.079_b0095","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1039\/C3MD00362K","article-title":"Hydrogen sulfide donors in research and drug development","volume":"5","author":"Song","year":"2014","journal-title":"Med Chem Commun"},{"issue":"18","key":"10.1016\/j.bmcl.2016.12.079_b0100","doi-asserted-by":"crossref","first-page":"7501","DOI":"10.1021\/acs.jmedchem.5b01033","article-title":"Design, synthesis, and cardioprotective effects of N-mercapto-based hydrogen sulfide donors","volume":"58","author":"Zhao","year":"2015","journal-title":"J Med Chem"},{"issue":"6","key":"10.1016\/j.bmcl.2016.12.079_b0105","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1039\/C3MD00323J","article-title":"The synthesis and functional evaluation of a mitochondria-targeted hydrogen sulfide donor, (10-oxo-10-(4-(3-thioxo-3H-1,2-dithiol-5-yl)phenoxy)decyl)triphenylphosphonium bromide (AP39)","volume":"5","author":"Le Trionnaire","year":"2014","journal-title":"Med Chem Commun"},{"issue":"10","key":"10.1016\/j.bmcl.2016.12.079_b0110","doi-asserted-by":"crossref","first-page":"904","DOI":"10.1021\/ml400239a","article-title":"Arylthioamides as H2S donors: l-cysteine-activated releasing properties and vascular effects in vitro and in vivo","volume":"4","author":"Martelli","year":"2013","journal-title":"ACS Med Chem Lett"},{"issue":"6","key":"10.1016\/j.bmcl.2016.12.079_b0115","doi-asserted-by":"crossref","first-page":"1558","DOI":"10.1021\/ol500385a","article-title":"S-aroylthiooximes: a facile route to hydrogen sulfide releasing compounds with structure-dependent release kinetics","volume":"16","author":"Foster","year":"2014","journal-title":"Org Lett"},{"issue":"23","key":"10.1016\/j.bmcl.2016.12.079_b0120","doi-asserted-by":"crossref","first-page":"7256","DOI":"10.1021\/jacs.6b03780","article-title":"Self-immolative thiocarbamates provide access to triggered H2S donors and analyte replacement fluorescent probes","volume":"138","author":"Steiger","year":"2016","journal-title":"J Am Chem Soc"},{"issue":"7","key":"10.1016\/j.bmcl.2016.12.079_b0125","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1021\/jm970530e","article-title":"Physicochemical high throughput screening: parallel artificial membrane permeation assay in the description of passive absorption processes","volume":"41","author":"Kansy","year":"1998","journal-title":"J Med Chem"},{"issue":"1-4","key":"10.1016\/j.bmcl.2016.12.079_b0130","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1080\/10426509508042046","article-title":"Studies on organophosphorus compounds .17. The reaction of Lawesson's reagent with 1,2-phenylenediamine derivatives, 2-aminophenol and 2-amino-2-methyl-1-propanol, a new route to 1,3,2-diazaphosphole-2-sulfide","volume":"105","author":"Shabana","year":"1995","journal-title":"Phosphorus Sulfur Silicon Relat Elem"},{"issue":"23","key":"10.1016\/j.bmcl.2016.12.079_b0135","doi-asserted-by":"crossref","first-page":"6975","DOI":"10.1016\/S0040-4020(01)81350-8","article-title":"Organophosphorus compounds XV. The reaction of 2,4-bis(4-methoxyphenyl)-1,3,2,4-dithiadiphosphetane-2,4-disulfide (Lawesson's Reagent) with aromatic dihydroxy compounds. Simple new route to 1,3,2-dioxaphospholane-2-sulfide","volume":"50","author":"Shabana","year":"1994","journal-title":"Tetrahedron"},{"issue":"10","key":"10.1016\/j.bmcl.2016.12.079_b0140","doi-asserted-by":"crossref","first-page":"1697","DOI":"10.1080\/00397910701265697","article-title":"Syntheses and antimicrobial activity of some novel 6-substituted dibenzo[d, f][1,3,2]dioxaphophepin-6-oxides, sulfides, and selenides","volume":"37","author":"Haranath","year":"2007","journal-title":"Synth Commun"},{"issue":"10","key":"10.1016\/j.bmcl.2016.12.079_b0145","doi-asserted-by":"crossref","first-page":"2812","DOI":"10.1021\/jo00036a011","article-title":"Synthesis and conformational analysis of torsionally constrained 1,3,2-dioxaphosphepanes","volume":"57","author":"Setzer","year":"1992","journal-title":"J Org Chem"},{"issue":"9","key":"10.1016\/j.bmcl.2016.12.079_b0150","doi-asserted-by":"crossref","first-page":"1649","DOI":"10.1039\/C5MD00170F","article-title":"Investigating the generation of hydrogen sulfide from the phosphonamidodithioate slow-release donor GYY4137","volume":"6","author":"Alexander","year":"2015","journal-title":"Med Chem Commun"},{"issue":"18","key":"10.1016\/j.bmcl.2016.12.079_b0155","doi-asserted-by":"crossref","first-page":"4322","DOI":"10.1111\/bph.12773","article-title":"Utilizing hydrogen sulfide as a novel anti-cancer agent by targeting cancer glycolysis and pH imbalance","volume":"171","author":"Lee","year":"2014","journal-title":"Br J Pharmacol"}],"container-title":["Bioorganic &amp; Medicinal Chemistry Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0960894X16313580?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0960894X16313580?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,18]],"date-time":"2025-10-18T07:18:14Z","timestamp":1760771894000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0960894X16313580"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,2]]},"references-count":31,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2017,2]]}},"alternative-id":["S0960894X16313580"],"URL":"https:\/\/doi.org\/10.1016\/j.bmcl.2016.12.079","relation":{},"ISSN":["0960-894X"],"issn-type":[{"value":"0960-894X","type":"print"}],"subject":[],"published":{"date-parts":[[2017,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Discovery of medium ring thiophosphorus based heterocycles as antiproliferative agents","name":"articletitle","label":"Article Title"},{"value":"Bioorganic & Medicinal Chemistry Letters","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bmcl.2016.12.079","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}