{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T20:12:38Z","timestamp":1777493558169,"version":"3.51.4"},"reference-count":10,"publisher":"Elsevier BV","issue":"17","license":[{"start":{"date-parts":[[2017,9,1]],"date-time":"2017-09-01T00:00:00Z","timestamp":1504224000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,9,1]],"date-time":"2017-09-01T00:00:00Z","timestamp":1504224000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bioorganic &amp; Medicinal Chemistry Letters"],"published-print":{"date-parts":[[2017,9]]},"DOI":"10.1016\/j.bmcl.2017.07.037","type":"journal-article","created":{"date-parts":[[2017,7,13]],"date-time":"2017-07-13T15:03:14Z","timestamp":1499958194000},"page":"4118-4121","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"title":["N-alkyl-[1,1\u2032-biphenyl]-2-sulfonamide derivatives as novel broad spectrum anti-epileptic drugs with efficacy equivalent to that of sodium valproate"],"prefix":"10.1016","volume":"27","author":[{"given":"Tomoyuki","family":"Tanaka","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nana","family":"Yajima","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomoko","family":"Kiyoshi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshiki","family":"Miura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seiji","family":"Iwama","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.bmcl.2017.07.037_b0005","unstructured":"FDA fact sheet: <http:\/\/www.who.int\/mediacentre\/factsheets\/fs999\/en\/>."},{"key":"10.1016\/j.bmcl.2017.07.037_b0010","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1586\/14737175.6.3.397","volume":"6","author":"Kwan","year":"2006","journal-title":"Exper Rev Neurother"},{"key":"10.1016\/j.bmcl.2017.07.037_b0015","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1016\/S1474-4422(07)70215-6","volume":"6","author":"Perucca","year":"2007","journal-title":"Lancet Neurol"},{"key":"10.1016\/j.bmcl.2017.07.037_b0020","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1016\/j.seizure.2011.01.003","volume":"20","author":"Loscher","year":"2011","journal-title":"Sezures"},{"key":"10.1016\/j.bmcl.2017.07.037_b0025","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/S0920-1211(02)00070-0","volume":"50","author":"Schmidt","year":"2002","journal-title":"Epilepsy Res"},{"key":"10.1016\/j.bmcl.2017.07.037_b0030","unstructured":"NIH once recommended these \u201cin vivo screening\u201d approach, see; Stables JP, et al. \u201cThe NIH Anticonvulsant Drug Development(ADD) Program: preclinical anticonvulsants creening project\u201d <http:\/\/www.ninds.nih.gov\/research\/asp\/addadd_review.pdf>."},{"key":"10.1016\/j.bmcl.2017.07.037_b0035","doi-asserted-by":"crossref","first-page":"1138","DOI":"10.1021\/jm970682+","volume":"41","author":"Ucar","year":"1998","journal-title":"J Med Chem"},{"key":"10.1016\/j.bmcl.2017.07.037_b0040","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/j.bmcl.2016.11.035","volume":"27","author":"Tanaka","year":"2017","journal-title":"Bioorg Med Chem Lett"},{"key":"10.1016\/j.bmcl.2017.07.037_b0050","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1016\/0013-4694(90)90099-6","volume":"76","author":"Sato","year":"1990","journal-title":"Electroenceph Clin Neurophysiol"},{"key":"10.1016\/j.bmcl.2017.07.037_b0055","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/S0920-1211(01)00302-3","volume":"47","author":"Barton","year":"2001","journal-title":"Epilepsy Res"}],"container-title":["Bioorganic &amp; Medicinal Chemistry Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0960894X17307333?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0960894X17307333?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,18]],"date-time":"2025-10-18T07:19:46Z","timestamp":1760771986000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0960894X17307333"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,9]]},"references-count":10,"journal-issue":{"issue":"17","published-print":{"date-parts":[[2017,9]]}},"alternative-id":["S0960894X17307333"],"URL":"https:\/\/doi.org\/10.1016\/j.bmcl.2017.07.037","relation":{},"ISSN":["0960-894X"],"issn-type":[{"value":"0960-894X","type":"print"}],"subject":[],"published":{"date-parts":[[2017,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"N-alkyl-[1,1\u2032-biphenyl]-2-sulfonamide derivatives as novel broad spectrum anti-epileptic drugs with efficacy equivalent to that of sodium valproate","name":"articletitle","label":"Article Title"},{"value":"Bioorganic & Medicinal Chemistry Letters","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bmcl.2017.07.037","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}