{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T03:09:41Z","timestamp":1767841781563,"version":"3.49.0"},"reference-count":31,"publisher":"Elsevier BV","issue":"23","license":[{"start":{"date-parts":[[2017,12,1]],"date-time":"2017-12-01T00:00:00Z","timestamp":1512086400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,12,1]],"date-time":"2017-12-01T00:00:00Z","timestamp":1512086400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 GM106218"],"award-info":[{"award-number":["R01 GM106218"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 AI111464"],"award-info":[{"award-number":["R01 AI111464"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 GM066170"],"award-info":[{"award-number":["R01 GM066170"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R35 GM122536"],"award-info":[{"award-number":["R35 GM122536"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bioorganic &amp; Medicinal Chemistry Letters"],"published-print":{"date-parts":[[2017,12]]},"DOI":"10.1016\/j.bmcl.2017.10.056","type":"journal-article","created":{"date-parts":[[2017,10,25]],"date-time":"2017-10-25T01:32:05Z","timestamp":1508895125000},"page":"5163-5166","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":12,"title":["Structure-activity relationships of 2-substituted phenyl-N-phenyl-2-oxoacetohydrazonoyl cyanides as novel antagonists of exchange proteins directly activated by cAMP (EPACs)"],"prefix":"10.1016","volume":"27","author":[{"given":"Zhiqing","family":"Liu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yingmin","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haiying","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pingyuan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fang C.","family":"Mei","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Na","family":"Ye","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3479-1694","authenticated-orcid":false,"given":"Xiaodong","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2811-1090","authenticated-orcid":false,"given":"Jia","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.bmcl.2017.10.056_b0005","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1111\/j.1745-7270.2008.00438.x","volume":"40","author":"Cheng","year":"2008","journal-title":"Acta Biochim Biophys Sin (Shanghai)"},{"key":"10.1016\/j.bmcl.2017.10.056_b0010","doi-asserted-by":"crossref","first-page":"2275","DOI":"10.1126\/science.282.5397.2275","volume":"282","author":"Kawasaki","year":"1998","journal-title":"Science"},{"key":"10.1016\/j.bmcl.2017.10.056_b0015","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1038\/24884","volume":"396","author":"de Rooij","year":"1998","journal-title":"Nature"},{"key":"10.1016\/j.bmcl.2017.10.056_b0020","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1146\/annurev.pharmtox.010909.105714","volume":"50","author":"Gloerich","year":"2010","journal-title":"Annu Rev Pharmacol Toxicol"},{"key":"10.1016\/j.bmcl.2017.10.056_b0025","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1073\/pnas.0408579102","volume":"102","author":"Berman","year":"2005","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.bmcl.2017.10.056_b0030","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1038\/nsb878","volume":"10","author":"Rehmann","year":"2003","journal-title":"Nat Struct Biol"},{"key":"10.1016\/j.bmcl.2017.10.056_b0035","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1038\/nrm1197","volume":"4","author":"Bos","year":"2003","journal-title":"Nat Rev Mol Cell Biol"},{"key":"10.1016\/j.bmcl.2017.10.056_b0040","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1093\/abbs\/gmv115","volume":"48","author":"Almahariq","year":"2016","journal-title":"Acta Biochim Biophys Sin (Shanghai)"},{"key":"10.1016\/j.bmcl.2017.10.056_b0045","doi-asserted-by":"crossref","first-page":"3036","DOI":"10.1073\/pnas.1516036113","volume":"113","author":"Singhmar","year":"2016","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.bmcl.2017.10.056_b0050","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1042\/BST20110642","volume":"40","author":"Laurent","year":"2012","journal-title":"Biochem Soc Trans"},{"key":"10.1016\/j.bmcl.2017.10.056_b0055","doi-asserted-by":"crossref","first-page":"14144","DOI":"10.1073\/pnas.0812536106","volume":"106","author":"Cazorla","year":"2009","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.bmcl.2017.10.056_b0060","doi-asserted-by":"crossref","first-page":"4122","DOI":"10.1096\/fj.13-230433","volume":"27","author":"Kai","year":"2013","journal-title":"FASEB J"},{"key":"10.1016\/j.bmcl.2017.10.056_b0065","doi-asserted-by":"crossref","first-page":"1633","DOI":"10.1016\/j.bmcl.2017.02.065","volume":"27","author":"Wang","year":"2017","journal-title":"Bioorg Med Chem Lett"},{"key":"10.1016\/j.bmcl.2017.10.056_b0070","doi-asserted-by":"crossref","first-page":"36552","DOI":"10.1038\/srep36552","volume":"6","author":"Wang","year":"2016","journal-title":"Sci Rep"},{"key":"10.1016\/j.bmcl.2017.10.056_b0075","doi-asserted-by":"crossref","first-page":"3651","DOI":"10.1021\/jm401425e","volume":"57","author":"Chen","year":"2014","journal-title":"J Med Chem"},{"key":"10.1016\/j.bmcl.2017.10.056_b0080","doi-asserted-by":"crossref","first-page":"2052","DOI":"10.1002\/cbic.200800216","volume":"9","author":"Vliem","year":"2008","journal-title":"ChemBioChem"},{"key":"10.1016\/j.bmcl.2017.10.056_b0085","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1038\/s41598-017-00455-7","volume":"7","author":"Parnell","year":"2017","journal-title":"Sci Rep"},{"key":"10.1016\/j.bmcl.2017.10.056_b0090","doi-asserted-by":"crossref","first-page":"e30441","DOI":"10.1371\/journal.pone.0030441","volume":"7","author":"Tsalkova","year":"2012","journal-title":"PLoS ONE"},{"key":"10.1016\/j.bmcl.2017.10.056_b0095","doi-asserted-by":"crossref","first-page":"18613","DOI":"10.1073\/pnas.1210209109","volume":"109","author":"Tsalkova","year":"2012","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.bmcl.2017.10.056_b0100","doi-asserted-by":"crossref","first-page":"4038","DOI":"10.1016\/j.bmcl.2012.04.082","volume":"22","author":"Chen","year":"2012","journal-title":"Bioorg Med Chem Lett"},{"key":"10.1016\/j.bmcl.2017.10.056_b0105","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1021\/acsmedchemlett.5b00477","volume":"7","author":"Wild","year":"2016","journal-title":"ACS Med Chem Lett"},{"key":"10.1016\/j.bmcl.2017.10.056_b0110","doi-asserted-by":"crossref","first-page":"952","DOI":"10.1021\/jm3014162","volume":"56","author":"Chen","year":"2013","journal-title":"J Med Chem"},{"key":"10.1016\/j.bmcl.2017.10.056_b0115","doi-asserted-by":"crossref","first-page":"44192","DOI":"10.1074\/jbc.M112.422956","volume":"287","author":"Courilleau","year":"2012","journal-title":"J Biol Chem"},{"key":"10.1016\/j.bmcl.2017.10.056_b0120","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1016\/j.bbrc.2013.09.107","volume":"440","author":"Courilleau","year":"2013","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.bmcl.2017.10.056_b0125","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1124\/mol.112.080689","volume":"83","author":"Almahariq","year":"2013","journal-title":"Mol Pharmacol"},{"key":"10.1016\/j.bmcl.2017.10.056_b0130","doi-asserted-by":"crossref","first-page":"9344","DOI":"10.1038\/srep09344","volume":"5","author":"Zhu","year":"2015","journal-title":"Sci Rep"},{"key":"10.1016\/j.bmcl.2017.10.056_b0135","doi-asserted-by":"crossref","first-page":"19615","DOI":"10.1073\/pnas.1314400110","volume":"110","author":"Gong","year":"2013","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.bmcl.2017.10.056_b0140","doi-asserted-by":"crossref","first-page":"6033","DOI":"10.1021\/acs.jmedchem.5b00635","volume":"58","author":"Ye","year":"2015","journal-title":"J Med Chem"},{"key":"10.1016\/j.bmcl.2017.10.056_b0145","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1016\/j.ejmech.2014.09.003","volume":"86","author":"Liu","year":"2014","journal-title":"Eur J Med Chem"},{"key":"10.1016\/j.bmcl.2017.10.056_b0150","doi-asserted-by":"crossref","first-page":"1546","DOI":"10.1016\/j.tetlet.2013.01.024","volume":"54","author":"Chen","year":"2013","journal-title":"Tetrahedron Lett"},{"key":"10.1016\/j.bmcl.2017.10.056_b0160","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.ejmech.2017.04.001","volume":"134","author":"Ye","year":"2017","journal-title":"Eur J Med Chem"}],"container-title":["Bioorganic &amp; Medicinal Chemistry Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0960894X17310545?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0960894X17310545?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,18]],"date-time":"2025-10-18T07:19:23Z","timestamp":1760771963000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0960894X17310545"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,12]]},"references-count":31,"journal-issue":{"issue":"23","published-print":{"date-parts":[[2017,12]]}},"alternative-id":["S0960894X17310545"],"URL":"https:\/\/doi.org\/10.1016\/j.bmcl.2017.10.056","relation":{},"ISSN":["0960-894X"],"issn-type":[{"value":"0960-894X","type":"print"}],"subject":[],"published":{"date-parts":[[2017,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Structure-activity relationships of 2-substituted phenyl-N-phenyl-2-oxoacetohydrazonoyl cyanides as novel antagonists of exchange proteins directly activated by cAMP (EPACs)","name":"articletitle","label":"Article Title"},{"value":"Bioorganic & Medicinal Chemistry Letters","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bmcl.2017.10.056","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}