{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T15:33:18Z","timestamp":1790609598159,"version":"4.1.0"},"reference-count":43,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001809","name":"NSFC","doi-asserted-by":"crossref","award":["U1204206"],"award-info":[{"award-number":["U1204206"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"NSFC","doi-asserted-by":"crossref","award":["81501782"],"award-info":[{"award-number":["81501782"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"NSFC","doi-asserted-by":"crossref","award":["21702190"],"award-info":[{"award-number":["21702190"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100012164","name":"863 Program","doi-asserted-by":"crossref","award":["2015AA020911"],"award-info":[{"award-number":["2015AA020911"]}],"id":[{"id":"10.13039\/501100012164","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Henan Province","award":["17A350004"],"award-info":[{"award-number":["17A350004"]}]},{"name":"Henan Province","award":["152300410034"],"award-info":[{"award-number":["152300410034"]}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bioorganic &amp; Medicinal Chemistry Letters"],"published-print":{"date-parts":[[2018,1]]},"DOI":"10.1016\/j.bmcl.2017.10.074","type":"journal-article","created":{"date-parts":[[2017,11,6]],"date-time":"2017-11-06T21:34:20Z","timestamp":1510004060000},"page":"214-221","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":42,"title":["NOTA analogue: A first dithiocarbamate inhibitor of metallo-\u03b2-lactamases"],"prefix":"10.1016","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4818-756X","authenticated-orcid":false,"given":"En","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming-Ming","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shu-Chao","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuai-Min","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"De-Yun","family":"Cui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan-Li","family":"Bo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng-Yan","family":"Bai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong-Gang","family":"Hua","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chun-Ling","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shangshang","family":"Qin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bmcl.2017.10.074_b0005","doi-asserted-by":"crossref","first-page":"742","DOI":"10.1016\/S1473-3099(14)70780-7","article-title":"Global antibiotic consumption 2000 to 2010: an analysis of national pharmaceutical sales data","volume":"14","author":"Van Boeckel","year":"2014","journal-title":"Lancet Infect Dis"},{"key":"10.1016\/j.bmcl.2017.10.074_b0010","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1038\/nature02759","article-title":"The challenge of emerging and re-emerging infectious diseases","volume":"430","author":"Van Boeckel","year":"2004","journal-title":"Nature"},{"key":"10.1016\/j.bmcl.2017.10.074_b0015","doi-asserted-by":"crossref","first-page":"1941","DOI":"10.1093\/jac\/dkr262","article-title":"Discovery research: the scientific challenge of finding new antibiotics","volume":"66","author":"Livermore","year":"2011","journal-title":"J Antimicrob Chemother"},{"key":"10.1016\/j.bmcl.2017.10.074_b0020","doi-asserted-by":"crossref","first-page":"4943","DOI":"10.1128\/AAC.00296-11","article-title":"Carbapenems: past, present, and future","volume":"55","author":"Papp-Wallace","year":"2011","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.bmcl.2017.10.074_b0025","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1021\/cr030102i","article-title":"Bacterial resistance to \u03b2-lactam antibiotics: compelling opportunism, compelling opportunity","volume":"105","author":"Fisher","year":"2005","journal-title":"Chem Rev"},{"key":"10.1016\/j.bmcl.2017.10.074_b0030","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/S1473-3099(08)70041-0","article-title":"Extended-spectrum \u03b2-lactamase-producing Enterobacteriaceae: an emerging public-health concern","volume":"8","author":"Pitout","year":"2008","journal-title":"Lancet Infect Dis"},{"key":"10.1016\/j.bmcl.2017.10.074_b0035","doi-asserted-by":"crossref","first-page":"1791","DOI":"10.3201\/eid1710.110655","article-title":"Global spread of carbapenemase-producing Enterobacteriaceae","volume":"17","author":"Nordmann","year":"2011","journal-title":"Emerg Infect Dis"},{"key":"10.1016\/j.bmcl.2017.10.074_b0040","first-page":"147","article-title":"New Delhi Metallo-lactamase (NDM-1) in enterobacteriaceae: treatment options with carbapenems compromised","volume":"58","author":"Deshpande","year":"2010","journal-title":"J Assoc Physicians India"},{"key":"10.1016\/j.bmcl.2017.10.074_b0045","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.2165\/00003495-200767070-00006","article-title":"Comparative review of the carbapenems","volume":"67","author":"Zhanel","year":"2007","journal-title":"Drugs"},{"key":"10.1016\/j.bmcl.2017.10.074_b0050","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1128\/AAC.40.2.349","article-title":"Multifocal outbreaks of metallo-beta-lactamase-producing Pseudomonas aeruginosa resistant to broad-spectrum beta-lactams, including carbapenems","volume":"40","author":"Senda","year":"1996","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.bmcl.2017.10.074_b0055","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1128\/CMR.00037-09","article-title":"Three decades of beta-lactamase inhibitors","volume":"23","author":"Drawz","year":"2010","journal-title":"Clin Microbiol Rev"},{"key":"10.1016\/j.bmcl.2017.10.074_b0060","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1093\/jac\/dkg067","article-title":"On functional and structural heterogeneity of VIM-type metallo-beta-lactamases","volume":"51","author":"Docquier","year":"2003","journal-title":"J Antimicrob Chemother"},{"key":"10.1016\/j.bmcl.2017.10.074_b0065","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1128\/AAC.01009-09","article-title":"Updated functional classification of beta-lactamases","volume":"54","author":"Bush","year":"2010","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.bmcl.2017.10.074_b0070","doi-asserted-by":"crossref","first-page":"2282","DOI":"10.1039\/b802311e","article-title":"Structural basis for the broad-spectrum inhibition of metallo-beta-lactamases by thiols","volume":"6","author":"Lienard","year":"2008","journal-title":"Org Biomol Chem"},{"key":"10.1016\/j.bmcl.2017.10.074_b0075","doi-asserted-by":"crossref","first-page":"1648","DOI":"10.1016\/j.bbapap.2013.04.024","article-title":"Metallo-beta-lactamase: inhibitors and reporter substrates","volume":"1834","author":"Fast","year":"2013","journal-title":"Biochim Biophys Acta"},{"key":"10.1016\/j.bmcl.2017.10.074_b0080","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1111\/nyas.12023","article-title":"Proliferation and significance of clinically relevant beta-lactamases","volume":"1277","author":"Bush","year":"2013","journal-title":"Ann NY Acad Sci"},{"key":"10.1016\/j.bmcl.2017.10.074_b0085","doi-asserted-by":"crossref","first-page":"23868","DOI":"10.1074\/jbc.M301062200","article-title":"The 1.5-a structure of Chryseobacterium meningosepticum zinc beta-lactamase in complex with the inhibitor, d-captopril","volume":"278","author":"Garcia-Saez","year":"2003","journal-title":"J Biol Chem"},{"key":"10.1016\/j.bmcl.2017.10.074_b0090","doi-asserted-by":"crossref","first-page":"1589","DOI":"10.1016\/j.bmcl.2016.02.007","article-title":"Captopril analogues as metallo-beta-lactamase inhibitors","volume":"26","author":"Yusof","year":"2016","journal-title":"Bioorg Med Chem Lett"},{"key":"10.1016\/j.bmcl.2017.10.074_b0095","doi-asserted-by":"crossref","first-page":"31913","DOI":"10.1074\/jbc.M104742200","article-title":"Succinic acids as potent inhibitors of plasmid-borne IMP-1 metallo-\u03b2-lactamase","volume":"276","author":"Toney","year":"2001","journal-title":"J Biol Chem"},{"key":"10.1016\/j.bmcl.2017.10.074_b0100","doi-asserted-by":"crossref","first-page":"3625","DOI":"10.1128\/AAC.01397-09","article-title":"In vitro potentiation of carbapenems with ME1071, a novel metallo-\u03b2-lactamase inhibitor, against metallo-\u03b2-lactamase-producing Pseudomonas aeruginosa clinical isolates","volume":"54","author":"Ishii","year":"2010","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.bmcl.2017.10.074_b0105","doi-asserted-by":"crossref","first-page":"6945","DOI":"10.1021\/jm400769b","article-title":"Assay platform for clinically relevant metallo-beta-lactamases","volume":"56","author":"van Berkel","year":"2013","journal-title":"J Med Chem"},{"key":"10.1016\/j.bmcl.2017.10.074_b0110","doi-asserted-by":"crossref","first-page":"1469","DOI":"10.1517\/13543776.2013.831071","article-title":"\u03b2-Lactamase inhibitors: a review of the patent literature (2010\u20132013)","volume":"23","author":"Buynak","year":"2013","journal-title":"Expert Opin Ther Pat"},{"key":"10.1016\/j.bmcl.2017.10.074_b0115","doi-asserted-by":"crossref","first-page":"3282","DOI":"10.1016\/j.bmcl.2011.04.027","article-title":"The identification of new metallo-beta-lactamase inhibitor leads from fragment-based screening","volume":"21","author":"Vella","year":"2011","journal-title":"Bioorg Med Chem Lett"},{"key":"10.1016\/j.bmcl.2017.10.074_b0120","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1038\/nature13445","article-title":"Aspergillomarasmine A overcomes metallo-beta-lactamase antibiotic resistance","volume":"510","author":"King","year":"2014","journal-title":"Nature"},{"key":"10.1016\/j.bmcl.2017.10.074_b0125","doi-asserted-by":"crossref","first-page":"e28005","DOI":"10.1371\/journal.pone.0028005","article-title":"Positron emission tomography imaging of CD105 expression with a 64 Cu-labeled monoclonal antibody: NOTA is superior to DOTA","volume":"6","author":"Zhang","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.bmcl.2017.10.074_b0130","doi-asserted-by":"crossref","first-page":"15726","DOI":"10.1021\/ja106399h","article-title":"Acyclic chelate with ideal properties for 68Ga PET imaging agent elaboration","volume":"132","author":"Boros","year":"2010","journal-title":"J Am Chem Soc"},{"key":"10.1016\/j.bmcl.2017.10.074_b0135","doi-asserted-by":"crossref","first-page":"308","DOI":"10.2967\/jnumed.113.128397","article-title":"Preclinical evaluation of 68Ga-labeled 1,4,7-triazacyclononane-1,4,7-triacetic acid-ubiquicidin as a radioligand for PET infection imaging","volume":"55","author":"Ebenhan","year":"2014","journal-title":"J Nucl Med"},{"key":"10.1016\/j.bmcl.2017.10.074_b0140","doi-asserted-by":"crossref","first-page":"1594","DOI":"10.1093\/jac\/dku538","article-title":"NOTA: a potent metallo-beta-lactamase inhibitor","volume":"70","author":"Somboro","year":"2015","journal-title":"J Antimicrob Chemother"},{"key":"10.1016\/j.bmcl.2017.10.074_b0145","doi-asserted-by":"crossref","first-page":"3626","DOI":"10.1021\/jm501844d","article-title":"Approved drugs containing thiols as inhibitors of metallo-beta-lactamases: strategy to combat multidrug-resistant bacteria","volume":"58","author":"Klingler","year":"2015","journal-title":"J Med Chem"},{"key":"10.1016\/j.bmcl.2017.10.074_b0150","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1021\/acsinfecdis.5b00033","article-title":"Zinc chelation by a small-molecule adjuvant potentiates meropenem activity in vivo against NDM-1-producing Klebsiella pneumoniae","volume":"1","author":"Falconer","year":"2015","journal-title":"ACS Infect Dis"},{"key":"10.1016\/j.bmcl.2017.10.074_b0155","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.cbpa.2012.12.021","article-title":"Clawing back: broadening the notion of metal chelators in medicine","volume":"17","author":"Franz","year":"2013","journal-title":"Curr Opin Chem Biol"},{"key":"10.1016\/j.bmcl.2017.10.074_b0160","doi-asserted-by":"crossref","first-page":"14901","DOI":"10.1073\/pnas.0604979103","article-title":"A class of iron chelators with a wide spectrum of potent antitumor activity that overcomes resistance to chemotherapeutics","volume":"103","author":"Whitnall","year":"2006","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.bmcl.2017.10.074_b0165","doi-asserted-by":"crossref","first-page":"2177","DOI":"10.1039\/B919237A","article-title":"Minding metals: tailoring multifunctional chelating agents for neurodegenerative disease","volume":"39","author":"Perez","year":"2010","journal-title":"Dalton Trans"},{"key":"10.1016\/j.bmcl.2017.10.074_b0170","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.ejmech.2012.12.046","article-title":"Design and synthesis of novel 1,2,3-triazole-dithiocarbamate hybrids as potential anticancer agents","volume":"62","author":"Duan","year":"2013","journal-title":"Eur J Med Chem"},{"key":"10.1016\/j.bmcl.2017.10.074_b0175","doi-asserted-by":"crossref","first-page":"3011","DOI":"10.1007\/s00044-016-1721-9","article-title":"Design, synthesis, and preliminary evaluation of the biological activity of dithiocarbamate-3-epi-jaspine B hybrids","volume":"25","author":"Zhang","year":"2016","journal-title":"Med Chem Res"},{"key":"10.1016\/j.bmcl.2017.10.074_b0180","doi-asserted-by":"crossref","first-page":"4691","DOI":"10.1021\/jm400414j","article-title":"Xanthates and trithiocarbonates strongly inhibit carbonic anhydrases and show antiglaucoma effects in vivo","volume":"56","author":"Carta","year":"2013","journal-title":"J Med Chem"},{"key":"10.1016\/j.bmcl.2017.10.074_b0185","doi-asserted-by":"crossref","first-page":"4393","DOI":"10.1002\/chem.200501423","article-title":"Structure and total synthesis of aspernigerin: a novel cytotoxic endophyte metabolite","volume":"12","author":"Shen","year":"2006","journal-title":"Chem Eur J"},{"key":"10.1016\/j.bmcl.2017.10.074_b0190","doi-asserted-by":"crossref","first-page":"1516","DOI":"10.1016\/j.bmc.2012.08.046","article-title":"Characterization, bioinformatic analysis and dithiocarbamate inhibition studies of two new \u03b1-carbonic anhydrases, CAH1 and CAH2, from the fruit fly Drosophila melanogaster","volume":"21","author":"Syrj\u00e4nen","year":"2013","journal-title":"Bioorg Med Chem"},{"key":"10.1016\/j.bmcl.2017.10.074_b0195","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1080\/00397919908085736","article-title":"Convenient synthesis of 1,4-di-(alkyldithioate) piperazines","volume":"29","author":"Li","year":"1999","journal-title":"Synth Commun"},{"key":"10.1016\/j.bmcl.2017.10.074_b0205","doi-asserted-by":"crossref","first-page":"3877","DOI":"10.1128\/JCM.02117-12","article-title":"Laboratory detection of Enterobacteriaceae that produce carbapenemases","volume":"50","author":"Doyle","year":"2012","journal-title":"J Clin Microbiol"},{"key":"10.1016\/j.bmcl.2017.10.074_b0210","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1038\/nature14098","article-title":"A new antibiotic kills pathogens without detectable resistance","volume":"517","author":"Ling","year":"2015","journal-title":"Nature"},{"key":"10.1016\/j.bmcl.2017.10.074_b0215","doi-asserted-by":"crossref","first-page":"5486","DOI":"10.1021\/acs.jmedchem.5b00443","article-title":"Membrane active small molecules show selective broad spectrum antibacterial activity with no detectable resistance and eradicate biofilms","volume":"58","author":"Hoque","year":"2015","journal-title":"J Med Chem"},{"key":"10.1016\/j.bmcl.2017.10.074_b0220","doi-asserted-by":"crossref","first-page":"13670","DOI":"10.1039\/C5CC05159B","article-title":"Selective and broad spectrum amphiphilic small molecules to combat bacterial resistance and eradicate biofilms","volume":"51","author":"Hoque","year":"2015","journal-title":"Chem Commun"}],"container-title":["Bioorganic &amp; Medicinal Chemistry Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0960894X17310569?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0960894X17310569?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,18]],"date-time":"2025-10-18T07:22:01Z","timestamp":1760772121000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0960894X17310569"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,1]]},"references-count":43,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2018,1]]}},"alternative-id":["S0960894X17310569"],"URL":"https:\/\/doi.org\/10.1016\/j.bmcl.2017.10.074","relation":{},"ISSN":["0960-894X"],"issn-type":[{"value":"0960-894X","type":"print"}],"subject":[],"published":{"date-parts":[[2018,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"NOTA analogue: A first dithiocarbamate inhibitor of metallo-\u03b2-lactamases","name":"articletitle","label":"Article Title"},{"value":"Bioorganic & Medicinal Chemistry Letters","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bmcl.2017.10.074","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}