{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T00:18:41Z","timestamp":1760833121546,"version":"build-2065373602"},"reference-count":30,"publisher":"Elsevier BV","issue":"10","license":[{"start":{"date-parts":[[2018,6,1]],"date-time":"2018-06-01T00:00:00Z","timestamp":1527811200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,6,1]],"date-time":"2018-06-01T00:00:00Z","timestamp":1527811200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100009841","name":"University of the Pacific","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009841","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Faculty Research Committee"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bioorganic & Medicinal Chemistry Letters"],"published-print":{"date-parts":[[2018,6]]},"DOI":"10.1016\/j.bmcl.2018.04.030","type":"journal-article","created":{"date-parts":[[2018,4,12]],"date-time":"2018-04-12T02:30:49Z","timestamp":1523500249000},"page":"1781-1784","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"title":["Preliminary in vitro and in vivo investigation of a potent platelet derived growth factor receptor (PDGFR) family kinase inhibitor"],"prefix":"10.1016","volume":"28","author":[{"given":"Elizabeth A.","family":"Wilson","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wade A.","family":"Russu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hassan M.","family":"Shallal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.bmcl.2018.04.030_b0005","doi-asserted-by":"crossref","first-page":"3435","DOI":"10.1073\/pnas.85.10.3435","volume":"85","author":"Gronwald","year":"1988","journal-title":"Proc Nat Acad Sci"},{"key":"10.1016\/j.bmcl.2018.04.030_b0010","doi-asserted-by":"crossref","first-page":"9287","DOI":"10.1016\/S0021-9258(18)98348-1","volume":"268","author":"Heidaran","year":"1993","journal-title":"J Biol Chem"},{"key":"10.1016\/j.bmcl.2018.04.030_b0015","doi-asserted-by":"crossref","first-page":"1564","DOI":"10.1126\/science.2538922","volume":"243","author":"Williams","year":"1989","journal-title":"Science"},{"key":"10.1016\/j.bmcl.2018.04.030_b0020","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1016\/S0092-8674(00)81270-2","volume":"85","author":"Bostrom","year":"1996","journal-title":"Cell"},{"key":"10.1016\/j.bmcl.2018.04.030_b0025","doi-asserted-by":"crossref","first-page":"3457","DOI":"10.1242\/dev.127.16.3457","volume":"127","author":"Karlsson","year":"2000","journal-title":"Development"},{"key":"10.1016\/j.bmcl.2018.04.030_b0030","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1242\/dev.117.2.525","volume":"117","author":"Pringle","year":"1993","journal-title":"Development"},{"key":"10.1016\/j.bmcl.2018.04.030_b0035","doi-asserted-by":"crossref","first-page":"2611","DOI":"10.1242\/dev.126.12.2611","volume":"126","author":"Karlsson","year":"1999","journal-title":"Development"},{"key":"10.1016\/j.bmcl.2018.04.030_b0040","doi-asserted-by":"crossref","first-page":"1207","DOI":"10.1073\/pnas.71.4.1207","volume":"71","author":"Ross","year":"1974","journal-title":"Proc Natl Acad Sci"},{"key":"10.1016\/j.bmcl.2018.04.030_b0045","doi-asserted-by":"crossref","first-page":"3313","DOI":"10.1242\/dev.125.17.3313","volume":"125","author":"Lindahl","year":"1998","journal-title":"Development"},{"key":"10.1016\/j.bmcl.2018.04.030_b0050","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1038\/323226a0","volume":"323","author":"Yarden","year":"1986","journal-title":"Nature"},{"key":"10.1016\/j.bmcl.2018.04.030_b0055","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1038\/ng0197-95","volume":"15","author":"Simon","year":"1997","journal-title":"Nat Genet"},{"key":"10.1016\/j.bmcl.2018.04.030_b0060","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/0092-8674(94)90322-0","volume":"77","author":"Golub","year":"1994","journal-title":"Cell"},{"key":"10.1016\/j.bmcl.2018.04.030_b0065","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1126\/science.1079666","volume":"299","author":"Heinrich","year":"2003","journal-title":"Science"},{"key":"10.1016\/j.bmcl.2018.04.030_b0070","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1002\/gcc.10035","volume":"34","author":"Zhao","year":"2002","journal-title":"Genes Chromosomes Cancer"},{"key":"10.1016\/j.bmcl.2018.04.030_b0075","first-page":"495","volume":"59","author":"Smith","year":"2000","journal-title":"Exp Neurol"},{"key":"10.1016\/j.bmcl.2018.04.030_b0080","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1053\/hupa.2002.124124","volume":"33","author":"Heinrich","year":"2002","journal-title":"Hum Pathol"},{"key":"10.1016\/j.bmcl.2018.04.030_b0085","doi-asserted-by":"crossref","first-page":"2460","DOI":"10.1182\/blood-2013-04-496448","volume":"122","author":"Schwaab","year":"2013","journal-title":"Blood"},{"key":"10.1016\/j.bmcl.2018.04.030_b0090","doi-asserted-by":"crossref","first-page":"851","DOI":"10.3324\/haematol.12171","volume":"93","author":"Montero","year":"2008","journal-title":"Haematologica"},{"key":"10.1016\/j.bmcl.2018.04.030_b0095","first-page":"1911","volume":"10","author":"Nakao","year":"1996","journal-title":"Leukemia"},{"unstructured":"For commentary see: Sawyers, CL. Nature Med. 2009;15:xxiv\u2013xxvii.","key":"10.1016\/j.bmcl.2018.04.030_b0100"},{"key":"10.1016\/j.bmcl.2018.04.030_b0105","doi-asserted-by":"crossref","first-page":"2043","DOI":"10.1016\/j.ejmech.2011.02.057","volume":"46","author":"Shallal","year":"2011","journal-title":"Eur J Med Chem"},{"unstructured":"Wilson EA, Russu WA. Discovery of Mutant Selective Platelet Derived Growth Factor Receptor (PDGFR) Family Kinases. In: Presented at Frontiers in Medicinal Chemistry, San Francisco, July 23\u201325, 2013.","key":"10.1016\/j.bmcl.2018.04.030_b0110"},{"unstructured":"Russu WA, Shallal HM. Piperazinylpyrimidine analogues as protein kinase inhibitors. US 8,609,672 B2, Issued Dec. 17, 2013.","key":"10.1016\/j.bmcl.2018.04.030_b0115"},{"unstructured":"DiPietro LV, Hodus BL, Kim JL, Miduturu CV, Wenglosky SM, Wilson D, Zhang Y. US 9,499,522 B2, Issued Nov. 22, 2016.","key":"10.1016\/j.bmcl.2018.04.030_b0120"},{"key":"10.1016\/j.bmcl.2018.04.030_b0125","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1016\/j.exphem.2005.11.015","volume":"34","author":"Demehri","year":"2006","journal-title":"Exp Hematol"},{"key":"10.1016\/j.bmcl.2018.04.030_b0130","doi-asserted-by":"crossref","first-page":"3754","DOI":"10.1182\/blood-2004-06-2189","volume":"104","author":"Corbin","year":"2004","journal-title":"Blood"},{"key":"10.1016\/j.bmcl.2018.04.030_b0135","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1158\/0008-5472.CAN-05-2050","volume":"66","author":"Schittenhelm","year":"2006","journal-title":"Cancer Res"},{"key":"10.1016\/j.bmcl.2018.04.030_b0140","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1042\/bj3490135","volume":"349","author":"Meergans","year":"2000","journal-title":"Biochem J"},{"key":"10.1016\/j.bmcl.2018.04.030_b0145","first-page":"11","volume":"2","author":"Gonzalez","year":"2017","journal-title":"Regenerative Med"},{"key":"10.1016\/j.bmcl.2018.04.030_b0150","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1124\/jpet.103.052530","volume":"307","author":"Moss","year":"2003","journal-title":"Pharm Exp Ther"}],"container-title":["Bioorganic & Medicinal Chemistry Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0960894X18303421?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0960894X18303421?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,18]],"date-time":"2025-10-18T07:22:57Z","timestamp":1760772177000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0960894X18303421"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,6]]},"references-count":30,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2018,6]]}},"alternative-id":["S0960894X18303421"],"URL":"https:\/\/doi.org\/10.1016\/j.bmcl.2018.04.030","relation":{},"ISSN":["0960-894X"],"issn-type":[{"type":"print","value":"0960-894X"}],"subject":[],"published":{"date-parts":[[2018,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Preliminary in vitro and in vivo investigation of a potent platelet derived growth factor receptor (PDGFR) family kinase inhibitor","name":"articletitle","label":"Article Title"},{"value":"Bioorganic & Medicinal Chemistry Letters","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bmcl.2018.04.030","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}