{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T22:27:22Z","timestamp":1773008842169,"version":"3.50.1"},"reference-count":23,"publisher":"Elsevier BV","issue":"10","license":[{"start":{"date-parts":[[2018,6,1]],"date-time":"2018-06-01T00:00:00Z","timestamp":1527811200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,6,1]],"date-time":"2018-06-01T00:00:00Z","timestamp":1527811200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100003345","name":"CAMS","doi-asserted-by":"publisher","award":["No. 2016-I2M-1-014"],"award-info":[{"award-number":["No. 2016-I2M-1-014"]}],"id":[{"id":"10.13039\/501100003345","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bioorganic & Medicinal Chemistry Letters"],"published-print":{"date-parts":[[2018,6]]},"DOI":"10.1016\/j.bmcl.2018.04.049","type":"journal-article","created":{"date-parts":[[2018,4,20]],"date-time":"2018-04-20T12:34:21Z","timestamp":1524227661000},"page":"1699-1703","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":13,"title":["Design, synthesis and biological evaluation of substituted (+)-SG-1 derivatives as novel anti-HIV agents"],"prefix":"10.1016","volume":"28","author":[{"given":"Xiaoyu","family":"Liu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Panpan","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoyu","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mingyu","family":"Ba","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaozhen","family":"Jiao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ying","family":"Guo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ping","family":"Xie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.bmcl.2018.04.049_b0005","unstructured":"http:\/\/www.who.int\/mediacentre\/factsheets\/fs360\/en\/ (accessed 18.01.8.)."},{"key":"10.1016\/j.bmcl.2018.04.049_b0010","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1177\/095632020401500302","volume":"15","author":"Zhang","year":"2004","journal-title":"Antivir Chem Chemother"},{"key":"10.1016\/j.bmcl.2018.04.049_b0015","unstructured":"https:\/\/hivdb.stanford.edu\/pages\/phenoSummary\/Pheno.NNRTI.Full.html\/; (accessed 18.01.18)."},{"key":"10.1016\/j.bmcl.2018.04.049_b0020","doi-asserted-by":"crossref","first-page":"263","DOI":"10.3390\/v8100263","volume":"8","author":"Lai","year":"2016","journal-title":"Viruses"},{"key":"10.1016\/j.bmcl.2018.04.049_b0025","doi-asserted-by":"crossref","first-page":"1","DOI":"10.7448\/IAS.16.1.18567","volume":"16","author":"Usach","year":"2013","journal-title":"J Int AIDS Soc"},{"key":"10.1016\/j.bmcl.2018.04.049_b0030","doi-asserted-by":"crossref","first-page":"11309","DOI":"10.1128\/JVI.05578-11","volume":"85","author":"Hu","year":"2011","journal-title":"J Virol"},{"key":"10.1016\/j.bmcl.2018.04.049_b0035","doi-asserted-by":"crossref","first-page":"1323","DOI":"10.1055\/s-2008-1081314","volume":"74","author":"Cos","year":"2008","journal-title":"Planta Med"},{"key":"10.1016\/j.bmcl.2018.04.049_b0040","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1016\/j.antiviral.2009.11.002","volume":"85","author":"Lee","year":"2010","journal-title":"Antiviral Res"},{"key":"10.1016\/j.bmcl.2018.04.049_b0045","author":"Guo","year":"2018","journal-title":"J Asian Nat Prod Res"},{"key":"10.1016\/j.bmcl.2018.04.049_b0050","doi-asserted-by":"crossref","first-page":"6324","DOI":"10.1016\/j.tetlet.2014.09.090","volume":"55","author":"Li","year":"2014","journal-title":"Tetrahed Lett"},{"key":"10.1016\/j.bmcl.2018.04.049_b0055","doi-asserted-by":"crossref","first-page":"8129","DOI":"10.1021\/jm101024j","volume":"53","author":"Goff","year":"2010","journal-title":"J Med Chem"},{"key":"10.1016\/j.bmcl.2018.04.049_h0060","first-page":"34","volume":"15","author":"Jiao","year":"2007","journal-title":"Chin J Synth Chem"},{"key":"10.1016\/j.bmcl.2018.04.049_h0065","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1016\/S0040-4020(01)90001-8","volume":"43","author":"Chattopadhyay","year":"1987","journal-title":"Tetrahedron"},{"key":"10.1016\/j.bmcl.2018.04.049_h0070","doi-asserted-by":"crossref","first-page":"1906","DOI":"10.1039\/B202493D","volume":"1","author":"Eklund","year":"2002","journal-title":"J Chem Soc Perkin Trans"},{"key":"10.1016\/j.bmcl.2018.04.049_b0065","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1016\/S0960-894X(02)00990-3","volume":"13","author":"Hunt","year":"2003","journal-title":"Bioorg Med Chem Lett"},{"key":"10.1016\/j.bmcl.2018.04.049_b0070","first-page":"3475","volume":"21","author":"Kyasa","year":"2011","journal-title":"Synthesis"},{"key":"10.1016\/j.bmcl.2018.04.049_b0075","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.1055\/s-0033-1338414","volume":"24","author":"Aigret","year":"2013","journal-title":"Synlett"},{"key":"10.1016\/j.bmcl.2018.04.049_b0080","doi-asserted-by":"crossref","first-page":"2298","DOI":"10.1021\/np400683h","volume":"76","author":"Ma","year":"2013","journal-title":"J Nat Prod"},{"key":"10.1016\/j.bmcl.2018.04.049_b0085","unstructured":"Chen Q, Tang K, Zhang X, et al. Acta Pharm Sin B. 2017; Ahead of Print. 2017, doi: 10.1016\/j.apsb. 2017.08.003."},{"key":"10.1016\/j.bmcl.2018.04.049_b0090","unstructured":"WHO, http:\/\/www.who.int\/drugresistance\/hivaids\/en\/."},{"key":"10.1016\/j.bmcl.2018.04.049_b0095","unstructured":"HIV resistance database, Stanford University https:\/\/hivdb.stanford.edu\/pages\/phenoSummary\/Pheno.NNRTI.Simple.html."},{"key":"10.1016\/j.bmcl.2018.04.049_b0100","unstructured":"HIV database, https:\/\/hivdb.stanford.edu\/dr-summary\/resistance-notes\/NNRTI\/."},{"key":"10.1016\/j.bmcl.2018.04.049_b0105","doi-asserted-by":"crossref","first-page":"11300","DOI":"10.1128\/JVI.05584-11","volume":"85","author":"Xu","year":"2011","journal-title":"J Virol"}],"container-title":["Bioorganic & Medicinal Chemistry Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0960894X18303615?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0960894X18303615?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,18]],"date-time":"2025-10-18T07:24:20Z","timestamp":1760772260000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0960894X18303615"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,6]]},"references-count":23,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2018,6]]}},"alternative-id":["S0960894X18303615"],"URL":"https:\/\/doi.org\/10.1016\/j.bmcl.2018.04.049","relation":{},"ISSN":["0960-894X"],"issn-type":[{"value":"0960-894X","type":"print"}],"subject":[],"published":{"date-parts":[[2018,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Design, synthesis and biological evaluation of substituted (+)-SG-1 derivatives as novel anti-HIV agents","name":"articletitle","label":"Article Title"},{"value":"Bioorganic & Medicinal Chemistry Letters","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bmcl.2018.04.049","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}