{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T21:08:00Z","timestamp":1778792880373,"version":"3.51.4"},"reference-count":24,"publisher":"Elsevier BV","issue":"15","license":[{"start":{"date-parts":[[2018,8,1]],"date-time":"2018-08-01T00:00:00Z","timestamp":1533081600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,8,1]],"date-time":"2018-08-01T00:00:00Z","timestamp":1533081600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2019,8,2]],"date-time":"2019-08-02T00:00:00Z","timestamp":1564704000000},"content-version":"am","delay-in-days":366,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,8,1]],"date-time":"2018-08-01T00:00:00Z","timestamp":1533081600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2018,8,1]],"date-time":"2018-08-01T00:00:00Z","timestamp":1533081600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2018,8,1]],"date-time":"2018-08-01T00:00:00Z","timestamp":1533081600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2018,8,1]],"date-time":"2018-08-01T00:00:00Z","timestamp":1533081600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2018,8,1]],"date-time":"2018-08-01T00:00:00Z","timestamp":1533081600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100006132","name":"Office of Science","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006132","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["AG 18933"],"award-info":[{"award-number":["AG 18933"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P30CA023168"],"award-info":[{"award-number":["P30CA023168"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000015","name":"U.S. Department of Energy","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000015","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100011592","name":"Office of the Executive Vice President for Research and Partnerships, Purdue University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100011592","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006224","name":"Argonne National Laboratory","doi-asserted-by":"publisher","award":["DE-AC02-06CH11357"],"award-info":[{"award-number":["DE-AC02-06CH11357"]}],"id":[{"id":"10.13039\/100006224","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bioorganic & Medicinal Chemistry Letters"],"published-print":{"date-parts":[[2018,8]]},"DOI":"10.1016\/j.bmcl.2018.06.045","type":"journal-article","created":{"date-parts":[[2018,6,26]],"date-time":"2018-06-26T18:02:20Z","timestamp":1530036140000},"page":"2605-2610","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"title":["Design, synthesis, X-ray studies, and biological evaluation of novel BACE1 inhibitors with bicyclic isoxazoline carboxamides as the P3 ligand"],"prefix":"10.1016","volume":"28","author":[{"given":"Arun K.","family":"Ghosh","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Koena","family":"Ghosh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Margherita","family":"Brindisi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emma K.","family":"Lendy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu-Chen","family":"Yen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nagaswamy","family":"Kumaragurubaran","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiangping","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jordan","family":"Tang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew D.","family":"Mesecar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.bmcl.2018.06.045_b0005","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1186\/1750-1326-8-33","volume":"8","author":"Rutten","year":"2013","journal-title":"Mol Neurodegener"},{"key":"10.1016\/j.bmcl.2018.06.045_b0010","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/biohorizons\/hzu002","volume":"7","author":"Lansdall","year":"2014","journal-title":"Biosci Horiz"},{"key":"10.1016\/j.bmcl.2018.06.045_b0015","unstructured":"Alzheimers.net. 2016 Alzheimer\u2019s statistics. http:\/\/www.alzheimers.net\/resources\/alzheimers-statistics\/; 2016 Accessed 15.05.18."},{"key":"10.1016\/j.bmcl.2018.06.045_b0020","unstructured":"Alzheimer\u2019s Association. Alzheimers Dement; 2012:131\u2013168; vol. 8."},{"key":"10.1016\/j.bmcl.2018.06.045_b0025","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1152\/physrev.2001.81.2.741","volume":"81","author":"Selkoe","year":"2001","journal-title":"Physiol Rev"},{"key":"10.1016\/j.bmcl.2018.06.045_b0030","doi-asserted-by":"crossref","first-page":"A23","DOI":"10.1038\/399a023","volume":"399","author":"Selkoe","year":"1999","journal-title":"Nature"},{"key":"10.1016\/j.bmcl.2018.06.045_b0035","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1038\/nrd2896","volume":"9","author":"Citron","year":"2010","journal-title":"Nat Rev Drug Discovery"},{"key":"10.1016\/j.bmcl.2018.06.045_b0040","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1186\/s13195-014-0089-7","volume":"6","author":"Vassar","year":"2014","journal-title":"Alzheimer\u2019s Res Ther"},{"key":"10.1016\/j.bmcl.2018.06.045_b0045","doi-asserted-by":"crossref","unstructured":"Sinha S. BACE a (almost) perfect target for staving off Alzheimer\u2019s disease. In Ghosh AK, ed. Aspartic acid proteases as therapeutic targets, Methods and principles in medicinal chemistry. Weinheim: Wiley-VCH; 2010:393\u2013412. vol 45.","DOI":"10.1002\/9783527630943.ch14"},{"key":"10.1016\/j.bmcl.2018.06.045_b0050","first-page":"1","article-title":"The design, development, and evaluation of Bace1 inhibitors for the treatment of Alzheimer\u2019s disease","author":"Ghosh","year":"2016","journal-title":"Top Med Chem"},{"key":"10.1016\/j.bmcl.2018.06.045_b0055","doi-asserted-by":"crossref","first-page":"6765","DOI":"10.1039\/C3CS60460H","volume":"43","author":"Ghosh","year":"2014","journal-title":"Chem Soc Rev"},{"key":"10.1016\/j.bmcl.2018.06.045_b0060","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1111\/joim.12191","volume":"275","author":"Schneider","year":"2014","journal-title":"J Int Med"},{"key":"10.1016\/j.bmcl.2018.06.045_b0065","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1186\/alzrt269","volume":"6","author":"Cummings","year":"2014","journal-title":"Alzheimers Res Ther"},{"key":"10.1016\/j.bmcl.2018.06.045_b0070","doi-asserted-by":"crossref","first-page":"3522","DOI":"10.1021\/ja000300g","volume":"122","author":"Ghosh","year":"2000","journal-title":"J Am Chem Soc"},{"key":"10.1016\/j.bmcl.2018.06.045_b0075","doi-asserted-by":"crossref","first-page":"2865","DOI":"10.1021\/jm0101803","volume":"44","author":"Ghosh","year":"2001","journal-title":"J Med Chem"},{"key":"10.1016\/j.bmcl.2018.06.045_b0080","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1126\/science.290.5489.150","volume":"290","author":"Hong","year":"2000","journal-title":"Science"},{"key":"10.1016\/j.bmcl.2018.06.045_b0085","doi-asserted-by":"crossref","first-page":"5310","DOI":"10.1021\/ja058636j","volume":"128","author":"Ghosh","year":"2006","journal-title":"J Am Chem Soc"},{"key":"10.1016\/j.bmcl.2018.06.045_b0090","doi-asserted-by":"crossref","first-page":"9195","DOI":"10.1021\/jm3008823","volume":"55","author":"Ghosh","year":"2012","journal-title":"J Med Chem"},{"key":"10.1016\/j.bmcl.2018.06.045_b0095","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1021\/jo00151a017","volume":"48","author":"Kozikowski","year":"1983","journal-title":"J Org Chem"},{"key":"10.1016\/j.bmcl.2018.06.045_b0100","unstructured":"Single-crystal X-ray analysis was performed in-house Dr. Phil Fanwick, X-ray Crystallography Laboratory, Department of Chemistry, Purdue University: West Lafayette. IN 47907."},{"key":"10.1016\/j.bmcl.2018.06.045_b0110","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1016\/j.bmcl.2014.11.087","volume":"25","author":"Ghosh","year":"2015","journal-title":"Bioorg Med Chem Lett"},{"key":"10.1016\/j.bmcl.2018.06.045_b0115","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1016\/j.bmcl.2007.12.028","volume":"18","author":"Ghosh","year":"2008","journal-title":"Bioorg Med Chem Lett"},{"key":"10.1016\/j.bmcl.2018.06.045_b0120","doi-asserted-by":"crossref","first-page":"12450","DOI":"10.1021\/bi001494f","volume":"39","author":"Ermolieff","year":"2000","journal-title":"Biochem"},{"key":"10.1016\/j.bmcl.2018.06.045_b0130","doi-asserted-by":"crossref","first-page":"2399","DOI":"10.1021\/jm061338s","volume":"50","author":"Ghosh","year":"2007","journal-title":"J Med Chem"}],"container-title":["Bioorganic & Medicinal Chemistry Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0960894X18305468?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0960894X18305468?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T20:12:57Z","timestamp":1778789577000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0960894X18305468"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,8]]},"references-count":24,"journal-issue":{"issue":"15","published-print":{"date-parts":[[2018,8]]}},"alternative-id":["S0960894X18305468"],"URL":"https:\/\/doi.org\/10.1016\/j.bmcl.2018.06.045","relation":{},"ISSN":["0960-894X"],"issn-type":[{"value":"0960-894X","type":"print"}],"subject":[],"published":{"date-parts":[[2018,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Design, synthesis, X-ray studies, and biological evaluation of novel BACE1 inhibitors with bicyclic isoxazoline carboxamides as the P3 ligand","name":"articletitle","label":"Article Title"},{"value":"Bioorganic & Medicinal Chemistry Letters","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bmcl.2018.06.045","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}