{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T07:34:04Z","timestamp":1769153644528,"version":"3.49.0"},"reference-count":7,"publisher":"Elsevier BV","issue":"17","license":[{"start":{"date-parts":[[2018,9,1]],"date-time":"2018-09-01T00:00:00Z","timestamp":1535760000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,9,1]],"date-time":"2018-09-01T00:00:00Z","timestamp":1535760000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31570032"],"award-info":[{"award-number":["31570032"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31711530219"],"award-info":[{"award-number":["31711530219"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31171201"],"award-info":[{"award-number":["31171201"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"NSFC-Shandong Joint Foundation","award":["U1706206"],"award-info":[{"award-number":["U1706206"]}]},{"name":"NSFC-Shandong Joint Foundation","award":["U1406403"],"award-info":[{"award-number":["U1406403"]}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bioorganic & Medicinal Chemistry Letters"],"published-print":{"date-parts":[[2018,9]]},"DOI":"10.1016\/j.bmcl.2018.07.029","type":"journal-article","created":{"date-parts":[[2018,7,19]],"date-time":"2018-07-19T23:48:46Z","timestamp":1532044126000},"page":"2865-2868","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":16,"title":["Generation of methylated violapyrones with improved anti-influenza A virus activity by heterologous expression of a type III PKS gene in a marine Streptomyces strain"],"prefix":"10.1016","volume":"28","author":[{"given":"Lukuan","family":"Hou","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuyao","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huiming","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huayue","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1598-3217","authenticated-orcid":false,"given":"Wenli","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.bmcl.2018.07.029_b0005","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1007\/s10295-013-1348-5","article-title":"Heterologous expression of natural product biosynthetic gene clusters in Streptomyces coelicolor: from genome mining to manipulation of biosynthetic pathways","volume":"41","author":"Gomez-Escribano","year":"2014","journal-title":"J Ind Microbiol Biotechnol"},{"key":"10.1016\/j.bmcl.2018.07.029_b0010","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1039\/C6NP00017G","article-title":"Engineering microbial hosts for production of bacterial natural products","volume":"33","author":"Zhang","year":"2016","journal-title":"Nat Prod Rep"},{"key":"10.1016\/j.bmcl.2018.07.029_b0015","doi-asserted-by":"crossref","first-page":"2126","DOI":"10.1021\/np4003417","article-title":"Violapyrones A-G, alpha-pyrone derivatives from Streptomyces violascens isolated from Hylobates hoolock feces","volume":"76","author":"Zhang","year":"2013","journal-title":"J Nat Prod"},{"key":"10.1016\/j.bmcl.2018.07.029_b0020","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1186\/s12934-016-0515-6","article-title":"Activation of a plasmid-situated type III PKS gene cluster by deletion of a wbl gene in deepsea-derived Streptomyces somaliensis SCSIO ZH66","volume":"15","author":"Huang","year":"2016","journal-title":"Microb Cell Fact"},{"key":"10.1016\/j.bmcl.2018.07.029_b0025","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1186\/s12934-018-0908-9","article-title":"Overexpression of a type III PKS gene affording novel violapyrones with enhanced anti-influenza A virus activity","volume":"17","author":"Hou","year":"2018","journal-title":"Microb Cell Fact"},{"key":"10.1016\/j.bmcl.2018.07.029_b0030","first-page":"53","article-title":"Development of the genetic system of mangrove derived Streptomyces sp. OUC6819. Chin","volume":"35","author":"Liu","year":"2016","journal-title":"J Mar Drugs"},{"key":"10.1016\/j.bmcl.2018.07.029_b0035","doi-asserted-by":"crossref","first-page":"3283","DOI":"10.3390\/md12063283","article-title":"Violapyrones H and I, new cytotoxic compounds isolated from Streptomyces sp. associated with the marine starfish Acanthaster planci","volume":"12","author":"Shin","year":"2014","journal-title":"Mar Drugs"}],"container-title":["Bioorganic & Medicinal Chemistry Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0960894X18306103?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0960894X18306103?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,18]],"date-time":"2025-10-18T07:26:21Z","timestamp":1760772381000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0960894X18306103"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,9]]},"references-count":7,"journal-issue":{"issue":"17","published-print":{"date-parts":[[2018,9]]}},"alternative-id":["S0960894X18306103"],"URL":"https:\/\/doi.org\/10.1016\/j.bmcl.2018.07.029","relation":{},"ISSN":["0960-894X"],"issn-type":[{"value":"0960-894X","type":"print"}],"subject":[],"published":{"date-parts":[[2018,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Generation of methylated violapyrones with improved anti-influenza A virus activity by heterologous expression of a type III PKS gene in a marine Streptomyces strain","name":"articletitle","label":"Article Title"},{"value":"Bioorganic & Medicinal Chemistry Letters","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bmcl.2018.07.029","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}