{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T09:06:22Z","timestamp":1785229582522,"version":"3.55.0"},"reference-count":12,"publisher":"Elsevier BV","issue":"23-24","license":[{"start":{"date-parts":[[2018,12,1]],"date-time":"2018-12-01T00:00:00Z","timestamp":1543622400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,12,1]],"date-time":"2018-12-01T00:00:00Z","timestamp":1543622400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100000002","name":"U.S. National Institutes of Health","doi-asserted-by":"publisher","award":["AI116723-01"],"award-info":[{"award-number":["AI116723-01"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000781","name":"European Research Council","doi-asserted-by":"publisher","award":["ERC-2013-CoG 614739-A HERO"],"award-info":[{"award-number":["ERC-2013-CoG 614739-A HERO"]}],"id":[{"id":"10.13039\/501100000781","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bioorganic & Medicinal Chemistry Letters"],"published-print":{"date-parts":[[2018,12]]},"DOI":"10.1016\/j.bmcl.2018.10.039","type":"journal-article","created":{"date-parts":[[2018,10,25]],"date-time":"2018-10-25T14:47:22Z","timestamp":1540478842000},"page":"3648-3651","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"title":["SAR of a new antischistosomal urea carboxylic acid"],"prefix":"10.1016","volume":"28","author":[{"given":"Jianbo","family":"Wu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunkai","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C\u00e9cile","family":"H\u00e4berli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen L.","family":"White","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David M.","family":"Shackleford","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gong","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuxiang","family":"Dong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan A.","family":"Charman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer","family":"Keiser","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan L.","family":"Vennerstrom","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bmcl.2018.10.039_b0005","unstructured":"Bernauer K, Link H, Stohler H. Antiandrogenic and schistosomicidal imidazolidine derivatives. US Patent 4,234,736; 1980."},{"key":"10.1016\/j.bmcl.2018.10.039_b0010","first-page":"261","article-title":"3-Arylhydantoine, eine substanzklasse mit schistosomizider wirkung","volume":"19","author":"Link","year":"1984","journal-title":"Eur J Med Chem \u2013 Chim Ther"},{"key":"10.1016\/j.bmcl.2018.10.039_b0015","doi-asserted-by":"crossref","first-page":"1788","DOI":"10.1093\/jac\/dkv016","article-title":"Aryl hydantoin Ro 13-3978, a broad spectrum antischistosomal","volume":"70","author":"Keiser","year":"2015","journal-title":"J Antimicrob Chemother"},{"key":"10.1016\/j.bmcl.2018.10.039_b0020","doi-asserted-by":"crossref","first-page":"10705","DOI":"10.1021\/acs.jmedchem.6b01410","article-title":"Revisiting the SAR of the antischistosomal aryl hydantoin (Ro 13-3978)","volume":"59","author":"Wang","year":"2016","journal-title":"J Med Chem"},{"key":"10.1016\/j.bmcl.2018.10.039_b0025","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1002\/jps.2600720426","article-title":"Determination of the dissociation constant of a weak acid using a dissolution rate method","volume":"72","author":"Hansen","year":"1983","journal-title":"J Pharm Sci"},{"key":"10.1016\/j.bmcl.2018.10.039_b0030","doi-asserted-by":"crossref","first-page":"4323","DOI":"10.1016\/j.bmc.2012.05.051","article-title":"Design, synthesis and antitumor activities of novel bis-aryl ureas derivatives as Raf kinase inhibitors","volume":"20","author":"Zhan","year":"2012","journal-title":"Bioorg Med Chem"},{"key":"10.1016\/j.bmcl.2018.10.039_b0035","article-title":"Azoloquinoxaline compounds as inhibitors of histamine receptors for the treatment of disease and their preparation","author":"Borchardt","year":"2011","journal-title":"US Pat Appl Publ"},{"key":"10.1016\/j.bmcl.2018.10.039_b0040","doi-asserted-by":"crossref","first-page":"5451","DOI":"10.1002\/ejoc.201200516","article-title":"SupraBox: Chiral supramolecular oxazoline ligands","author":"Durini","year":"2012","journal-title":"Eur J Org Chem"},{"key":"10.1016\/j.bmcl.2018.10.039_b0045","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1017\/S0031182009991739","article-title":"In vitro and in vivo trematode models for chemotherapeutic studies","volume":"137","author":"Keiser","year":"2010","journal-title":"Parasitology"},{"key":"10.1016\/j.bmcl.2018.10.039_b0050","doi-asserted-by":"crossref","first-page":"1791","DOI":"10.1093\/jac\/dkr178","article-title":"Interactions of mefloquine with praziquantel in the Schistosoma mansoni mouse model and in vitro","volume":"66","author":"Keiser","year":"2011","journal-title":"J Antimicrob Chemother"},{"key":"10.1016\/j.bmcl.2018.10.039_b0055","doi-asserted-by":"crossref","first-page":"4339","DOI":"10.1021\/jm040066v","article-title":"Discovering drugs through biological transformation: Role of pharmacologically active metabolites in drug discovery","volume":"47","author":"Fura","year":"2004","journal-title":"J Med Chem"},{"key":"10.1016\/j.bmcl.2018.10.039_b0060","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/S1359-6446(05)03681-0","article-title":"Role of pharmacologically active metabolites in drug discovery and development","volume":"11","author":"Fura","year":"2006","journal-title":"Drug Discov Today"}],"container-title":["Bioorganic & Medicinal Chemistry Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0960894X18308424?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0960894X18308424?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,18]],"date-time":"2025-10-18T07:26:49Z","timestamp":1760772409000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0960894X18308424"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,12]]},"references-count":12,"journal-issue":{"issue":"23-24","published-print":{"date-parts":[[2018,12]]}},"alternative-id":["S0960894X18308424"],"URL":"https:\/\/doi.org\/10.1016\/j.bmcl.2018.10.039","relation":{},"ISSN":["0960-894X"],"issn-type":[{"value":"0960-894X","type":"print"}],"subject":[],"published":{"date-parts":[[2018,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"SAR of a new antischistosomal urea carboxylic acid","name":"articletitle","label":"Article Title"},{"value":"Bioorganic & Medicinal Chemistry Letters","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bmcl.2018.10.039","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}