{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,9]],"date-time":"2025-11-09T07:45:43Z","timestamp":1762674343473,"version":"build-2065373602"},"reference-count":14,"publisher":"Elsevier BV","issue":"18","license":[{"start":{"date-parts":[[2019,9,1]],"date-time":"2019-09-01T00:00:00Z","timestamp":1567296000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,9,1]],"date-time":"2019-09-01T00:00:00Z","timestamp":1567296000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100008078","name":"University of Strathclyde","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008078","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Friends of Paul O'Gorman Leukaemia Research Centre"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bioorganic & Medicinal Chemistry Letters"],"published-print":{"date-parts":[[2019,9]]},"DOI":"10.1016\/j.bmcl.2019.07.049","type":"journal-article","created":{"date-parts":[[2019,7,27]],"date-time":"2019-07-27T01:44:02Z","timestamp":1564191842000},"page":"2622-2625","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"title":["An investigation of targeted inhibition of transcription factor activity with pyrrole imidazole polyamide (PA) in chronic myeloid leukemia (CML) blast crisis cells"],"prefix":"10.1016","volume":"29","author":[{"given":"K.","family":"Hayatigolkhatmi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Padroni","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W.","family":"Su","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Fang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"G\u00f3mez-Casta\u00f1eda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y.C.","family":"Hsieh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Jackson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.","family":"Pellicano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.A.","family":"Burley","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.G.","family":"J\u00f8rgensen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.bmcl.2019.07.049_b0005","first-page":"2","article-title":"Pharmacological manipulation of transcription factor protein-protein interactions: opportunities and obstacles","volume":"4","author":"Fontaine","year":"2015","journal-title":"Cell Regeneration (London)"},{"key":"10.1016\/j.bmcl.2019.07.049_b0010","doi-asserted-by":"crossref","first-page":"1863","DOI":"10.1073\/pnas.1222035110","article-title":"Antitumor activity of a pyrrole-imidazole polyamide","volume":"110","author":"Yang","year":"2013","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.bmcl.2019.07.049_b0015","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/B978-0-12-409547-2.12561-2","article-title":"DNA minor groove binders as therapeutic agents","author":"Withers","year":"2017","journal-title":"Compr Supramolecular Chemi II"},{"key":"10.1016\/j.bmcl.2019.07.049_b0020","doi-asserted-by":"crossref","first-page":"1393","DOI":"10.1016\/j.bmc.2018.01.026","article-title":"Sequence-specific DNA binding pyrrole\u2013imidazole polyamides and their applications","volume":"26","author":"Kawamoto","year":"2018","journal-title":"Bioorganic Med Chem"},{"key":"10.1016\/j.bmcl.2019.07.049_b0025","doi-asserted-by":"crossref","first-page":"14521","DOI":"10.1021\/ja105068b","article-title":"Structural basis for cyclic Py-Im polyamide allosteric inhibition of nuclear receptor binding","volume":"132","author":"Chenoweth","year":"2010","journal-title":"J Am Chem Soc"},{"key":"10.1016\/j.bmcl.2019.07.049_b0030","doi-asserted-by":"crossref","first-page":"1532","DOI":"10.1182\/blood-2017-05-783845","article-title":"hsa-mir183\/EGR1\u2013mediated regulation of E2F1 is required for CML stem\/progenitor cell survival","volume":"131","author":"Pellicano","year":"2018","journal-title":"Blood"},{"key":"10.1016\/j.bmcl.2019.07.049_b0035","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1016\/j.beha.2016.10.005","article-title":"Management of CML-blast crisis","volume":"29","author":"Hehlmann","year":"2016","journal-title":"Best Pract Res Clin Haematol"},{"key":"10.1016\/j.bmcl.2019.07.049_b0040","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.bcmd.2017.11.002","article-title":"Investigation of a minor groove-binding polyamide targeted to E2F1 transcription factor in chronic myeloid leukaemia (CML) cells","volume":"69","author":"Hayatigolkhatmi","year":"2018","journal-title":"Blood Cells Mol Dis"},{"key":"10.1016\/j.bmcl.2019.07.049_b0045","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1016\/S0959-440X(03)00081-2","article-title":"Recognition of the DNA minor groove by pyrrole-imidazole polyamides","volume":"13","author":"Dervan","year":"2003","journal-title":"Curr Opin Struct Biol"},{"key":"10.1016\/j.bmcl.2019.07.049_b0050","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1021\/ol503388a","article-title":"Fully automated synthesis of DNA-binding Py-Im polyamides using a triphosgene coupling strategy","volume":"17","author":"Fang","year":"2015","journal-title":"Org Lett"},{"key":"10.1016\/j.bmcl.2019.07.049_b0055","doi-asserted-by":"crossref","first-page":"8.10.1","DOI":"10.1002\/0471142700.nc0810s63","article-title":"Pyrrole-imidazole polyamides: manual solid-phase synthesis","volume":"63","author":"Pauff","year":"2015","journal-title":"Curr Protoc Nucleic Acid Chem"},{"key":"10.1016\/j.bmcl.2019.07.049_b0060","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1093\/nar\/gkx1211","article-title":"Structural basis of DNA duplex distortion induced by thiazole-containing hairpin polyamides","volume":"46","author":"Padroni","year":"2018","journal-title":"Nucl Acids Res"},{"key":"10.1016\/j.bmcl.2019.07.049_b0065","doi-asserted-by":"crossref","first-page":"2757","DOI":"10.1002\/chem.201805932","article-title":"A phosphorus analogue of p-quinodimethane with a planar P4 ring: a metal-free diphosphorus source","volume":"25","author":"Rottsch\u00e4fer","year":"2019","journal-title":"Chem Eur J"},{"key":"10.1016\/j.bmcl.2019.07.049_b0070","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/j.scr.2012.12.003","article-title":"Stemformatics: visualisation and sharing of stem cell gene expression","volume":"10","author":"Wells","year":"2013","journal-title":"Stem Cell Res"}],"container-title":["Bioorganic & Medicinal Chemistry Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0960894X19305189?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0960894X19305189?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,18]],"date-time":"2025-10-18T07:30:19Z","timestamp":1760772619000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0960894X19305189"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,9]]},"references-count":14,"journal-issue":{"issue":"18","published-print":{"date-parts":[[2019,9]]}},"alternative-id":["S0960894X19305189"],"URL":"https:\/\/doi.org\/10.1016\/j.bmcl.2019.07.049","relation":{},"ISSN":["0960-894X"],"issn-type":[{"type":"print","value":"0960-894X"}],"subject":[],"published":{"date-parts":[[2019,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"An investigation of targeted inhibition of transcription factor activity with pyrrole imidazole polyamide (PA) in chronic myeloid leukemia (CML) blast crisis cells","name":"articletitle","label":"Article Title"},{"value":"Bioorganic & Medicinal Chemistry Letters","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bmcl.2019.07.049","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}