{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T01:26:14Z","timestamp":1789694774555,"version":"4.0.1"},"reference-count":26,"publisher":"Elsevier BV","issue":"19","license":[{"start":{"date-parts":[[2019,10,1]],"date-time":"2019-10-01T00:00:00Z","timestamp":1569888000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,10,1]],"date-time":"2019-10-01T00:00:00Z","timestamp":1569888000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bioorganic &amp; Medicinal Chemistry Letters"],"published-print":{"date-parts":[[2019,10]]},"DOI":"10.1016\/j.bmcl.2019.08.022","type":"journal-article","created":{"date-parts":[[2019,8,12]],"date-time":"2019-08-12T11:15:12Z","timestamp":1565608512000},"page":"126618","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":35,"title":["New amide linked dimeric 1,2,3-triazoles bearing aryloxy scaffolds as a potent antiproliferative agents and EGFR tyrosine kinase phosphorylation inhibitors"],"prefix":"10.1016","volume":"29","author":[{"given":"Tejshri R.","family":"Deshmukh","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aniket P.","family":"Sarkate","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deepak K.","family":"Lokwani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shailee V.","family":"Tiwari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajaram","family":"Azad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bapurao B.","family":"Shingate","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bmcl.2019.08.022_b0005","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.bmcl.2018.11.021","article-title":"Targeting tyrosine kinase: development of acridone-pyrrole-oxindole hybrids against human breast cancer","volume":"29","author":"Kaur","year":"2019","journal-title":"Bioorg Med Chem Lett."},{"key":"10.1016\/j.bmcl.2019.08.022_b0010","first-page":"36","article-title":"Tyrosine kinase receptor inhibitors: a new target for antiproliferative drug development","volume":"1","author":"Bari","year":"2012","journal-title":"J PharmaSciTech"},{"key":"10.1016\/j.bmcl.2019.08.022_b0015","first-page":"3753","article-title":"Combination of the EGFR tyrosine kinase inhibitor AG1478 and 5-FU: no synergistic effect on EGFR phosphorylation, cell proliferation and apoptosis induction","volume":"33","author":"Yagublu","year":"2013","journal-title":"Antiproliferative Res"},{"key":"10.1016\/j.bmcl.2019.08.022_b0020","doi-asserted-by":"crossref","first-page":"807","DOI":"10.2174\/187152008785914743","article-title":"Dimeric approaches to anti-cancer chemotherapeutics","volume":"8","author":"Hadden","year":"2008","journal-title":"Antiproliferative Agents Med Chem"},{"key":"10.1016\/j.bmcl.2019.08.022_h0025","doi-asserted-by":"crossref","first-page":"46","DOI":"10.2174\/1871520616666161221112042","article-title":"Role of azoles incancer prevention and treatment: present and future perspectives","volume":"18","author":"Ahmad","year":"2018","journal-title":"Anti-Cancer Agents Med Chem"},{"key":"10.1016\/j.bmcl.2019.08.022_h0030","doi-asserted-by":"crossref","first-page":"6","DOI":"10.2174\/1871520616666160520112839","article-title":"The use of azoles containing natural products in cancer prevention and treatment: an overview","volume":"18","author":"Jabir","year":"2018","journal-title":"Anti-Cancer Agents Med Chem"},{"key":"10.1016\/j.bmcl.2019.08.022_h0035","doi-asserted-by":"crossref","first-page":"154","DOI":"10.20902\/IJCTR.2018.111116","article-title":"A review on azole derivatives as potent anticancer agents","volume":"11","author":"Bhardwaj","year":"2018","journal-title":"Int J Chemtech Res"},{"key":"10.1016\/j.bmcl.2019.08.022_h0040","doi-asserted-by":"crossref","first-page":"21","DOI":"10.2174\/1871520616666160811113531","article-title":"Recent advancements in 1,4-disubstituted-1H-1,2,3-triazoles as potential antiproliferative agents","volume":"18","author":"Lal","year":"2018","journal-title":"Antiproliferative Agents Med Chem"},{"key":"10.1016\/j.bmcl.2019.08.022_h0045","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1080\/15257770.2017.1342830","article-title":"Antibacterial, tyrosinase and DNA photocleavage studies of some triazolylnucleosides","volume":"36","author":"Kumar","year":"2017","journal-title":"Nucleos Nucleot Nucl."},{"key":"10.1016\/j.bmcl.2019.08.022_h0050","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1039\/C8MD00620B","article-title":"Synthesis and discovery of asiatic acid based 1,2,3-triazole derivatives as antitumor agents blocking NF-kB activation and cell migration","volume":"10","author":"Huang","year":"2019","journal-title":"Med Chem Commun"},{"key":"10.1016\/j.bmcl.2019.08.022_h0055","doi-asserted-by":"crossref","first-page":"2051","DOI":"10.1007\/s00044-018-2213-x","article-title":"Novel triazoles of 3-acetylbetulin and betulone as anticancer agents","volume":"27","author":"Bebenek","year":"2018","journal-title":"Med Chem Res"},{"key":"10.1016\/j.bmcl.2019.08.022_h0060","doi-asserted-by":"crossref","first-page":"1128","DOI":"10.1016\/S1359-6446(03)02933-7","article-title":"The growing impact of click chemistry on drug discovery","volume":"8","author":"Kolb","year":"2003","journal-title":"Drug Discov Today"},{"key":"10.1016\/j.bmcl.2019.08.022_h0065","doi-asserted-by":"crossref","first-page":"3057","DOI":"10.1021\/jo011148j","article-title":"Peptidotriazoles on solid phase: [1,2,3]-triazoles by regiospecific copper(I)-catalyzed 1,3-dipolar cycloadditions of terminal alkynes to azides","volume":"67","author":"Tornoe","year":"2002","journal-title":"J Org Chem"},{"key":"10.1016\/j.bmcl.2019.08.022_h0070","doi-asserted-by":"crossref","first-page":"2596","DOI":"10.1002\/1521-3773(20020715)41:14<2596::AID-ANIE2596>3.0.CO;2-4","article-title":"A stepwise Huisgen cycloaddition process: copper(I)-catalyzed regioselective ligation of azides and terminal alkynes","volume":"41","author":"Rostovtsev","year":"2002","journal-title":"Angew Chem Int Ed"},{"key":"10.1016\/j.bmcl.2019.08.022_h0075","doi-asserted-by":"crossref","first-page":"2004","DOI":"10.1002\/1521-3773(20010601)40:11<2004::AID-ANIE2004>3.0.CO;2-5","article-title":"Click chemistry: diverse chemical function from a few good reactions","volume":"40","author":"Kolb","year":"2001","journal-title":"Angew Chem Int Ed"},{"key":"10.1016\/j.bmcl.2019.08.022_b0040","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.bioorg.2017.01.010","article-title":"Medicinal attributes of 1,2,3-triazoles: current developments","volume":"71","author":"Dheer","year":"2017","journal-title":"Bioorg Chem"},{"key":"10.1016\/j.bmcl.2019.08.022_b0045","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1186\/s40064-015-1352-5","article-title":"Discovery of novel 1,2,3-triazole derivatives as antiproliferative agents using QSAR and in silico structural modification","volume":"4","author":"Prachayasittikul","year":"2015","journal-title":"SpringerPlus"},{"key":"10.1016\/j.bmcl.2019.08.022_b0050","doi-asserted-by":"crossref","first-page":"6157","DOI":"10.1016\/j.bmc.2015.07.069","article-title":"Synthesis of 1,2-benzisoxazole tethered 1,2,3-triazoles that exhibit antiproliferative activity in acute myeloid leukemia cell lines by inhibiting histone deacetylases, and inducing p21 and tubulin acetylation","volume":"23","author":"Ashwini","year":"2015","journal-title":"Bioorg Med Chem"},{"key":"10.1016\/j.bmcl.2019.08.022_b0055","doi-asserted-by":"crossref","first-page":"663","DOI":"10.3797\/scipharm.1302-04","article-title":"Synthesis of 1,2,3-triazole derivatives and evaluation of their antiproliferative activity","volume":"81","author":"Pokhodylo","year":"2013","journal-title":"Sci Pharm"},{"key":"10.1016\/j.bmcl.2019.08.022_b0060","doi-asserted-by":"crossref","first-page":"3389","DOI":"10.1021\/jm1000979","article-title":"N-((1-Benzyl-1H-1,2,3-triazol-4-yl)methyl) arylamide as a new scaffold that provides rapid access to antimicrotubule agents: synthesis and evaluation of antiproliferative activity against select cancer cell lines","volume":"53","author":"Stefely","year":"2010","journal-title":"J Med Chem"},{"key":"10.1016\/j.bmcl.2019.08.022_b0065","doi-asserted-by":"crossref","first-page":"1213","DOI":"10.1016\/j.bmc.2011.12.047","article-title":"Inhibition of Dengue virus and West Nile virus proteases by click chemistry-derived benz[d]isothiazol-3(2H)-one derivatives","volume":"20","author":"Tiew","year":"2012","journal-title":"Bioorg Med Chem"},{"key":"10.1016\/j.bmcl.2019.08.022_h0110","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1016\/j.ejmech.2015.10.019","article-title":"A click chemistry approach for the synthesis of mono and bis aryloxy linked coumarinyl triazoles as anti-tubercular agents","volume":"105","author":"Anand","year":"2015","journal-title":"Eur J Med Chem"},{"key":"10.1016\/j.bmcl.2019.08.022_h0115","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.ejmech.2016.02.041","article-title":"Synthesis of newer 1,2,3-triazole linked chalcone and flavone hybrid compounds and evaluation of their antimicrobial and cytotoxic activities","volume":"113","author":"Kant","year":"2016","journal-title":"Eur J Med Chem"},{"key":"10.1016\/j.bmcl.2019.08.022_b0080","doi-asserted-by":"crossref","first-page":"7331","DOI":"10.1007\/s11164-017-3078-1","article-title":"Novel quinoline-based oxadiazole derivatives induce G2\/M arrest and apoptosis in human breast cancer MCF-7 cell line","volume":"43","author":"Dofe","year":"2017","journal-title":"Res Chem Intermed"},{"key":"10.1016\/j.bmcl.2019.08.022_b0085","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1007\/BF03401931","article-title":"Activator protein-1 mediates induced but not basal epidermal growth factor receptor gene expression","volume":"6","author":"Johnson","year":"2000","journal-title":"Mol Med"},{"key":"10.1016\/j.bmcl.2019.08.022_b0090","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1021\/jm050540c","article-title":"Novel procedure for modelling ligand\/receptor induced fit effects","volume":"49","author":"Scherman","year":"2006","journal-title":"J Med Chem"}],"container-title":["Bioorganic &amp; Medicinal Chemistry Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0960894X19305463?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0960894X19305463?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,18]],"date-time":"2025-10-18T07:31:10Z","timestamp":1760772670000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0960894X19305463"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,10]]},"references-count":26,"journal-issue":{"issue":"19","published-print":{"date-parts":[[2019,10]]}},"alternative-id":["S0960894X19305463"],"URL":"https:\/\/doi.org\/10.1016\/j.bmcl.2019.08.022","relation":{},"ISSN":["0960-894X"],"issn-type":[{"value":"0960-894X","type":"print"}],"subject":[],"published":{"date-parts":[[2019,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"New amide linked dimeric 1,2,3-triazoles bearing aryloxy scaffolds as a potent antiproliferative agents and EGFR tyrosine kinase phosphorylation inhibitors","name":"articletitle","label":"Article Title"},{"value":"Bioorganic & Medicinal Chemistry Letters","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bmcl.2019.08.022","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"126618"}}