{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,18]],"date-time":"2025-10-18T10:52:24Z","timestamp":1760784744033,"version":"build-2065373602"},"reference-count":26,"publisher":"Elsevier BV","issue":"24","license":[{"start":{"date-parts":[[2019,12,1]],"date-time":"2019-12-01T00:00:00Z","timestamp":1575158400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,12,1]],"date-time":"2019-12-01T00:00:00Z","timestamp":1575158400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bioorganic &amp; Medicinal Chemistry Letters"],"published-print":{"date-parts":[[2019,12]]},"DOI":"10.1016\/j.bmcl.2019.126741","type":"journal-article","created":{"date-parts":[[2019,10,16]],"date-time":"2019-10-16T01:54:57Z","timestamp":1571190897000},"page":"126741","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"title":["Identification of a new small molecule chemotype of Melanin Concentrating Hormone Receptor-1 antagonists using pharmacophore-based virtual screening"],"prefix":"10.1016","volume":"29","author":[{"given":"Mohamed A.","family":"Helal","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amar G.","family":"Chittiboyina","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mitchell A.","family":"Avery","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"4","key":"10.1016\/j.bmcl.2019.126741_b0005","doi-asserted-by":"crossref","first-page":"848","DOI":"10.3390\/nu11040848","article-title":"International study of childhood obesity, lifestyle and the environment (ISCOLE): contributions to understanding the global obesity epidemic","volume":"11","author":"Katzmarzyk","year":"2019","journal-title":"Nutrients"},{"key":"10.1016\/j.bmcl.2019.126741_b0010","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1016\/j.neuropharm.2018.07.004","article-title":"Melanin-concentrating hormone and orexin systems in rat nucleus incertus: dual innervation, bidirectional effects on neuron activity, and differential influences on arousal and feeding","volume":"139","author":"Sabetghadam","year":"2018","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.bmcl.2019.126741_b0015","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.ejphar.2016.12.018","article-title":"A novel and selective melanin-concentrating hormone receptor 1 antagonist ameliorates obesity and hepatic steatosis in diet-induced obese rodent models","volume":"796","author":"Kawata","year":"2017","journal-title":"Eur J Pharmacol"},{"issue":"29","key":"10.1016\/j.bmcl.2019.126741_b0020","doi-asserted-by":"crossref","first-page":"3424","DOI":"10.2174\/1381612824666180810162944","article-title":"The development of pharmacophore modeling: generation and recent applications in drug discovery","volume":"24","author":"Lu","year":"2018","journal-title":"Curr Pharm Des"},{"issue":"17","key":"10.1016\/j.bmcl.2019.126741_b0025","doi-asserted-by":"crossref","first-page":"1610","DOI":"10.1002\/cmdc.201900307","article-title":"Virtual pharmacophore screening identifies small-molecule inhibitors of the Rev1-CT\/RIR protein-protein interaction","volume":"14","author":"Dash","year":"2019","journal-title":"ChemMedChem"},{"issue":"18","key":"10.1016\/j.bmcl.2019.126741_b0030","doi-asserted-by":"crossref","first-page":"5684","DOI":"10.1021\/jm050103y","article-title":"6-Acylamino-2-aminoquinolines as potent melanin-concentrating hormone 1 receptor antagonists. Identification, structure-activity relationship, and investigation of binding mode","volume":"48","author":"Ulven","year":"2005","journal-title":"J Med Chem"},{"issue":"6","key":"10.1016\/j.bmcl.2019.126741_b0035","doi-asserted-by":"crossref","first-page":"2583","DOI":"10.1016\/j.ejmech.2009.01.031","article-title":"Homology modeling of MCH1 receptor and validation by docking\/scoring and protein-aligned CoMFA","volume":"44","author":"Abu-Hammad","year":"2009","journal-title":"Eur J Med Chem"},{"key":"10.1016\/j.bmcl.2019.126741_b0040","unstructured":"CATALYST 4.8 User Guide, A. I., San Diego, CA, USA; 2003."},{"issue":"9","key":"10.1016\/j.bmcl.2019.126741_b0045","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.2174\/0929867013372481","article-title":"Pharmacophore modeling and three-dimensional database searching for drug design using catalyst","volume":"8","author":"Kurogi","year":"2001","journal-title":"Curr Med Chem"},{"issue":"16","key":"10.1016\/j.bmcl.2019.126741_b0050","doi-asserted-by":"crossref","first-page":"3691","DOI":"10.1016\/j.bmcl.2005.05.039","article-title":"Discovery and SAR of 4-amino-2-biarylbutylurea MCH 1 receptor antagonists through solid-phase parallel synthesis","volume":"15","author":"Guo","year":"2005","journal-title":"Bioorg Med Chem Lett"},{"issue":"5","key":"10.1016\/j.bmcl.2019.126741_b0055","doi-asserted-by":"crossref","first-page":"1829","DOI":"10.1016\/j.bmc.2004.11.046","article-title":"Discovery of melanin-concentrating hormone receptor R1 antagonists using high-throughput synthesis","volume":"13","author":"Su","year":"2005","journal-title":"Bioorg Med Chem"},{"issue":"16","key":"10.1016\/j.bmcl.2019.126741_b0060","doi-asserted-by":"crossref","first-page":"3696","DOI":"10.1016\/j.bmcl.2005.05.085","article-title":"Discovery and SAR of biaryl piperidine MCH1 receptor antagonists through solid-phase encoded combinatorial synthesis","volume":"15","author":"Guo","year":"2005","journal-title":"Bioorg Med Chem Lett"},{"issue":"14","key":"10.1016\/j.bmcl.2019.126741_b0065","doi-asserted-by":"crossref","first-page":"3674","DOI":"10.1016\/j.bmcl.2006.04.062","article-title":"Design and synthesis of orally efficacious benzimidazoles as melanin-concentrating hormone receptor 1 antagonists","volume":"16","author":"Wu","year":"2006","journal-title":"Bioorg Med Chem Lett"},{"issue":"20","key":"10.1016\/j.bmcl.2019.126741_b0070","doi-asserted-by":"crossref","first-page":"5427","DOI":"10.1016\/j.bmcl.2006.07.058","article-title":"Novel aminobenzimidazoles as selective MCH-R1 antagonists for the treatment of metabolic diseases","volume":"16","author":"Sasikumar","year":"2006","journal-title":"Bioorg Med Chem Lett"},{"issue":"3","key":"10.1016\/j.bmcl.2019.126741_b0075","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1016\/j.bmcl.2006.10.096","article-title":"Novel pyrazolopiperazinone- and pyrrolopiperazinone-based MCH-R1 antagonists","volume":"17","author":"Meyers","year":"2007","journal-title":"Bioorg Med Chem Lett"},{"issue":"3","key":"10.1016\/j.bmcl.2019.126741_b0080","doi-asserted-by":"crossref","first-page":"814","DOI":"10.1016\/j.bmcl.2006.10.053","article-title":"Aminomethyl tetrahydronaphthalene biphenyl carboxamide MCH-R1 antagonists\u2013Increasing selectivity over hERG","volume":"17","author":"Meyers","year":"2007","journal-title":"Bioorg Med Chem Lett"},{"issue":"5","key":"10.1016\/j.bmcl.2019.126741_b0085","doi-asserted-by":"crossref","first-page":"2353","DOI":"10.1021\/jm201596h","article-title":"Melanin-concentrating hormone receptor 1 antagonists. Synthesis and structure-activity relationships of novel 3-(aminomethyl)quinolines","volume":"55","author":"Kamata","year":"2012","journal-title":"J Med Chem"},{"issue":"16","key":"10.1016\/j.bmcl.2019.126741_b0090","doi-asserted-by":"crossref","first-page":"3275","DOI":"10.1016\/j.bmcl.2015.05.065","article-title":"Design, synthesis and evaluation of MCH receptor 1 antagonists\u2013Part III: discovery of pre-clinical development candidate BI 186908","volume":"25","author":"Oost","year":"2015","journal-title":"Bioorg Med Chem Lett"},{"year":"2000","series-title":"Pharmacophore Perception, Development, and Use in Drug Design","author":"Guner","key":"10.1016\/j.bmcl.2019.126741_b0095"},{"issue":"9","key":"10.1016\/j.bmcl.2019.126741_b0100","doi-asserted-by":"crossref","first-page":"2535","DOI":"10.1016\/j.bmcl.2007.02.012","article-title":"Thienopyrimidinone bis-aminopyrrolidine ureas as potent melanin-concentrating hormone receptor-1 (MCH-R1) antagonists","volume":"17","author":"Zhang","year":"2007","journal-title":"Bioorg Med Chem Lett"},{"issue":"8","key":"10.1016\/j.bmcl.2019.126741_b0105","doi-asserted-by":"crossref","first-page":"2365","DOI":"10.1016\/j.bmcl.2006.11.068","article-title":"Identification of diamino chromone-2-carboxamides as MCHr1 antagonists with minimal hERG channel activity","volume":"17","author":"Judd","year":"2007","journal-title":"Bioorg Med Chem Lett"},{"issue":"18","key":"10.1016\/j.bmcl.2019.126741_b0110","doi-asserted-by":"crossref","first-page":"4922","DOI":"10.1016\/j.bmcl.2006.06.049","article-title":"Synthesis and structure-activity relationships of retro bis-aminopyrrolidine urea (rAPU) derived small-molecule antagonists of the melanin-concentrating hormone receptor-1 (MCH-R1). Part 2","volume":"16","author":"Hudson","year":"2006","journal-title":"Bioorg Med Chem Lett"},{"issue":"16","key":"10.1016\/j.bmcl.2019.126741_b0115","doi-asserted-by":"crossref","first-page":"5369","DOI":"10.1016\/j.bmc.2007.05.068","article-title":"study of bicyclo[4.1.0]heptanes as melanin-concentrating hormone receptor R1 antagonists: taming hERG","volume":"15","author":"Su","year":"2007","journal-title":"Bioorg Med Chem"},{"issue":"19","key":"10.1016\/j.bmcl.2019.126741_b0120","doi-asserted-by":"crossref","first-page":"4559","DOI":"10.1016\/j.bmcl.2016.08.072","article-title":"Evolution of physicochemical properties of melanin concentrating hormone receptor 1 (MCHr1) antagonists","volume":"26","author":"Johansson","year":"2016","journal-title":"Bioorg Med Chem Lett"},{"key":"10.1016\/j.bmcl.2019.126741_b0125","doi-asserted-by":"crossref","first-page":"42717","DOI":"10.1038\/srep42717","article-title":"SwissADME: a free web tool to evaluate pharmacokinetics, drug-likeness and medicinal chemistry friendliness of small molecules","volume":"7","author":"Daina","year":"2017","journal-title":"Sci Rep"},{"issue":"3","key":"10.1016\/j.bmcl.2019.126741_b0130","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1021\/ci100355c","article-title":"New insights into the binding mode of melanin concentrating hormone receptor-1 antagonists: homology modeling and explicit membrane molecular dynamics simulation study","volume":"51","author":"Helal","year":"2011","journal-title":"J Chem Inf Model"}],"container-title":["Bioorganic &amp; Medicinal Chemistry Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0960894X19307048?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0960894X19307048?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,18]],"date-time":"2025-10-18T07:30:52Z","timestamp":1760772652000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0960894X19307048"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,12]]},"references-count":26,"journal-issue":{"issue":"24","published-print":{"date-parts":[[2019,12]]}},"alternative-id":["S0960894X19307048"],"URL":"https:\/\/doi.org\/10.1016\/j.bmcl.2019.126741","relation":{},"ISSN":["0960-894X"],"issn-type":[{"type":"print","value":"0960-894X"}],"subject":[],"published":{"date-parts":[[2019,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Identification of a new small molecule chemotype of Melanin Concentrating Hormone Receptor-1 antagonists using pharmacophore-based virtual screening","name":"articletitle","label":"Article Title"},{"value":"Bioorganic & Medicinal Chemistry Letters","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bmcl.2019.126741","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"126741"}}