{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,18]],"date-time":"2025-10-18T08:11:25Z","timestamp":1760775085755,"version":"build-2065373602"},"reference-count":25,"publisher":"Elsevier BV","issue":"23","license":[{"start":{"date-parts":[[2019,12,1]],"date-time":"2019-12-01T00:00:00Z","timestamp":1575158400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,12,1]],"date-time":"2019-12-01T00:00:00Z","timestamp":1575158400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100010002","name":"Ministry of Education","doi-asserted-by":"publisher","award":["CHM106-6-2"],"award-info":[{"award-number":["CHM106-6-2"]}],"id":[{"id":"10.13039\/100010002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004663","name":"Ministry of Science and Technology, Taiwan","doi-asserted-by":"publisher","award":["MOST105-2320-B-039-053-MY3","MOST107-2923-B-039-001-MY3"],"award-info":[{"award-number":["MOST105-2320-B-039-053-MY3","MOST107-2923-B-039-001-MY3"]}],"id":[{"id":"10.13039\/501100004663","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012544","name":"China Medical University, Taiwan","doi-asserted-by":"publisher","award":["CMU106-ASIA-06","CMU106-BC-1","CMU107-ASIA-12","CMU107-S-14"],"award-info":[{"award-number":["CMU106-ASIA-06","CMU106-BC-1","CMU107-ASIA-12","CMU107-S-14"]}],"id":[{"id":"10.13039\/501100012544","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bioorganic & Medicinal Chemistry Letters"],"published-print":{"date-parts":[[2019,12]]},"DOI":"10.1016\/j.bmcl.2019.126742","type":"journal-article","created":{"date-parts":[[2019,10,17]],"date-time":"2019-10-17T19:28:14Z","timestamp":1571340494000},"page":"126742","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"title":["Antiviral efficacy of bromo-anilino substituents of 4,5-dihydrofuran-3-carboxylate compound CW-33 against Japanese encephalitis virus"],"prefix":"10.1016","volume":"29","author":[{"given":"Jin-Cherng","family":"Lien","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chen-Sheng","family":"Lin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hsueh-Chou","family":"Lai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu-Chi","family":"Tsai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu-Fong","family":"Lin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"An-Cheng","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Su-Hua","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cheng-Wen","family":"Lin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.bmcl.2019.126742_b0005","doi-asserted-by":"crossref","first-page":"155","DOI":"10.2217\/fmb.12.139","article-title":"Factors shaping the adaptive landscape for arboviruses: implications for the emergence of disease","volume":"8","author":"Coffey","year":"2013","journal-title":"Fut Microbiol"},{"key":"10.1016\/j.bmcl.2019.126742_b0010","doi-asserted-by":"crossref","first-page":"4864","DOI":"10.1128\/JVI.00252-16","article-title":"Zika virus: new clinical syndromes and its emergence in the Western Hemisphere","volume":"90","author":"Lazear","year":"2016","journal-title":"J Virol"},{"key":"10.1016\/j.bmcl.2019.126742_b0015","doi-asserted-by":"crossref","first-page":"3091","DOI":"10.1128\/JVI.77.5.3091-3098.2003","article-title":"Origin and evolution of Japanese encephalitis virus in southeast Asia","volume":"77","author":"Solomon","year":"2003","journal-title":"J Virol"},{"year":"2019","series-title":"Japanese Encephalitis","author":"World Health Organization","key":"10.1016\/j.bmcl.2019.126742_b0020"},{"key":"10.1016\/j.bmcl.2019.126742_b0025","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0055165","article-title":"Molecular detection and genotyping of Japanese encephalitis virus in mosquitoes during a 2010 outbreak in the Republic of Korea","volume":"8","author":"Seo","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.bmcl.2019.126742_b0030","doi-asserted-by":"crossref","first-page":"2354","DOI":"10.3201\/eid1712.110914","article-title":"Japanese encephalitis virus genotype replacement, Taiwan, 2009\u20132010","volume":"17","author":"Chen","year":"2011","journal-title":"Emerg Infect Dis"},{"key":"10.1016\/j.bmcl.2019.126742_b0035","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1186\/1743-422X-7-127","article-title":"Molecular epidemiology of Japanese encephalitis virus circulating in South Korea, 1983\u20132005","volume":"7","author":"Yun","year":"2010","journal-title":"Virol J"},{"key":"10.1016\/j.bmcl.2019.126742_b0040","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pntd.0001834","article-title":"Partially neutralizing potency against emerging genotype I virus among children received formalin-inactivated Japanese encephalitis virus vaccine","volume":"6","author":"Fan","year":"2012","journal-title":"PLoS Negl Trop Dis"},{"key":"10.1016\/j.bmcl.2019.126742_b0045","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pntd.0002153","article-title":"Circulation of Japanese encephalitis virus in pigs and mosquito vectors within Can Tho city, Vietnam","volume":"7","author":"Lindahl","year":"2013","journal-title":"PLoS Negl Trop Dis"},{"key":"10.1016\/j.bmcl.2019.126742_b0050","doi-asserted-by":"crossref","first-page":"3155","DOI":"10.3390\/v7062764","article-title":"Antiviral potential of a novel compound CW-33 against enterovirus A71 via inhibition of viral 2A protease","volume":"7","author":"Wang","year":"2015","journal-title":"Viruses"},{"key":"10.1016\/j.bmcl.2019.126742_b0055","doi-asserted-by":"crossref","first-page":"E1386","DOI":"10.3390\/ijms17091386","article-title":"Antiviral activity of a novel compound CW-33 against Japanese encephalitis virus through inhibiting intracellular calcium overload","volume":"17","author":"Huang","year":"2016","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.bmcl.2019.126742_b0060","doi-asserted-by":"crossref","first-page":"2024","DOI":"10.3892\/ijmm.2019.4113","article-title":"Molecular interaction of the antiviral compound CW\u201333 and its analogues with the NS2B\u2013NS3 protease of the Japanese encephalitis virus","volume":"43","author":"Chen","year":"2019","journal-title":"Int J Mol Med"},{"key":"10.1016\/j.bmcl.2019.126742_b0065","doi-asserted-by":"crossref","first-page":"16595","DOI":"10.1038\/s41598-018-34932-4","article-title":"Structure analysis and antiviral activity of CW-33 analogues against Japanese encephalitis virus","volume":"8","author":"Lien","year":"2018","journal-title":"Sci Rep"},{"key":"10.1016\/j.bmcl.2019.126742_b0070","doi-asserted-by":"crossref","first-page":"E76","DOI":"10.3390\/v9040076","article-title":"Single-round infectious particle antiviral screening assays for the japanese encephalitis virus","volume":"9","author":"Lu","year":"2017","journal-title":"Viruses"},{"key":"10.1016\/j.bmcl.2019.126742_b0075","doi-asserted-by":"crossref","first-page":"E954","DOI":"10.3390\/ijms18050954","article-title":"Tubacin, an HDAC6 selective inhibitor, reduces the replication of the japanese encephalitis virus via the decrease of viral RNA synthesis","volume":"18","author":"Lu","year":"2017","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.bmcl.2019.126742_b0080","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/0378-4274(88)90031-8","article-title":"Modeling the tissue solubilities and metabolic rate constant (Vmax) of halogenated methanes, ethanes, and ethylenes","volume":"43","author":"Gargas","year":"1988","journal-title":"Toxicol Lett"},{"issue":"3","key":"10.1016\/j.bmcl.2019.126742_b0085","doi-asserted-by":"crossref","first-page":"E68","DOI":"10.3390\/pathogens7030068","article-title":"Early events in japanese encephalitis virus infection: viral entry","volume":"7","author":"Yun","year":"2018","journal-title":"Pathogens"},{"issue":"11","key":"10.1016\/j.bmcl.2019.126742_b0090","doi-asserted-by":"crossref","first-page":"E630","DOI":"10.3390\/v10110630","article-title":"TIM-1 promotes japanese encephalitis virus entry and infection","volume":"10","author":"Niu","year":"2018","journal-title":"Viruses"},{"issue":"6","key":"10.1016\/j.bmcl.2019.126742_b0095","doi-asserted-by":"crossref","first-page":"e02274","DOI":"10.1128\/JVI.02274-16","article-title":"GRP78 is an important host factor for japanese encephalitis virus entry and replication in mammalian cells","volume":"91","author":"Nain","year":"2017","journal-title":"J Virol"},{"issue":"Pt 12","key":"10.1016\/j.bmcl.2019.126742_b0100","doi-asserted-by":"crossref","first-page":"2803","DOI":"10.1099\/vir.0.033993-0","article-title":"Identification of heat-shock protein 90 beta in Japanese encephalitis virus-induced secretion proteins","volume":"92","author":"Hung","year":"2011","journal-title":"J Gen Virol"},{"issue":"9","key":"10.1016\/j.bmcl.2019.126742_b0105","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1021\/acsinfecdis.5b00066","article-title":"Flavivirus entry inhibitors","volume":"1","author":"Wang","year":"2015","journal-title":"ACS Infect Dis"},{"issue":"8","key":"10.1016\/j.bmcl.2019.126742_b0110","doi-asserted-by":"crossref","first-page":"1006","DOI":"10.1016\/j.chembiol.2018.05.011","article-title":"Inhibition of flaviviruses by targeting a conserved pocket on the viral envelope protein","volume":"25","author":"de Wispelaere","year":"2018","journal-title":"Cell Chem Biol"},{"key":"10.1016\/j.bmcl.2019.126742_b0115","doi-asserted-by":"crossref","first-page":"398","DOI":"10.3389\/fcimb.2018.00398","article-title":"Cellular targets for the treatment of flavivirus infections","volume":"8","author":"Zakaria","year":"2018","journal-title":"Front Cell Infect Microbiol"},{"key":"10.1016\/j.bmcl.2019.126742_b0120","doi-asserted-by":"crossref","first-page":"1884","DOI":"10.1093\/jac\/dks147","article-title":"Ivermectin is a potent inhibitor of flavivirus replication specifically targeting NS3 helicase activity: new prospects for an old drug","volume":"67","author":"Mastrangelo","year":"2012","journal-title":"J Antimicrob. Chemother"},{"key":"10.1016\/j.bmcl.2019.126742_b0125","doi-asserted-by":"crossref","first-page":"3226","DOI":"10.1128\/AAC.00189-09","article-title":"Cyclosporine inhibits flavivirus replication through blocking the interaction between host cyclophilins and viral NS5 protein","volume":"53","author":"Qing","year":"2009","journal-title":"Antimicrob Agents Chemother"}],"container-title":["Bioorganic & Medicinal Chemistry Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0960894X1930705X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0960894X1930705X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,18]],"date-time":"2025-10-18T07:31:47Z","timestamp":1760772707000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0960894X1930705X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,12]]},"references-count":25,"journal-issue":{"issue":"23","published-print":{"date-parts":[[2019,12]]}},"alternative-id":["S0960894X1930705X"],"URL":"https:\/\/doi.org\/10.1016\/j.bmcl.2019.126742","relation":{},"ISSN":["0960-894X"],"issn-type":[{"type":"print","value":"0960-894X"}],"subject":[],"published":{"date-parts":[[2019,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Antiviral efficacy of bromo-anilino substituents of 4,5-dihydrofuran-3-carboxylate compound CW-33 against Japanese encephalitis virus","name":"articletitle","label":"Article Title"},{"value":"Bioorganic & Medicinal Chemistry Letters","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bmcl.2019.126742","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"126742"}}