{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T12:04:10Z","timestamp":1769169850898,"version":"3.49.0"},"reference-count":16,"publisher":"Elsevier BV","issue":"8","license":[{"start":{"date-parts":[[2020,4,1]],"date-time":"2020-04-01T00:00:00Z","timestamp":1585699200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,4,1]],"date-time":"2020-04-01T00:00:00Z","timestamp":1585699200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81573298"],"award-info":[{"award-number":["81573298"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81621064"],"award-info":[{"award-number":["81621064"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"CAMS Innovation Fund for Medical Sciences","award":["2017-I2M-1-012"],"award-info":[{"award-number":["2017-I2M-1-012"]}]},{"name":"Drug Innovation Major Project of China","award":["2018ZX09711001-007-002"],"award-info":[{"award-number":["2018ZX09711001-007-002"]}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bioorganic &amp; Medicinal Chemistry Letters"],"published-print":{"date-parts":[[2020,4]]},"DOI":"10.1016\/j.bmcl.2019.126887","type":"journal-article","created":{"date-parts":[[2019,12,13]],"date-time":"2019-12-13T03:21:35Z","timestamp":1576207295000},"page":"126887","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"title":["Synthesis and in vitro activity of asymmetric indole-based bisamidine compounds against Gram-positive and Gram-negative pathogens"],"prefix":"10.1016","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4643-2143","authenticated-orcid":false,"given":"Xiaofang","family":"Chen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yonghua","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chong","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xinxin","family":"Hu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yanbin","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yongzhong","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cong","family":"Bian","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xuefu","family":"You","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laixing","family":"Hu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.bmcl.2019.126887_b0005","doi-asserted-by":"crossref","first-page":"1281","DOI":"10.1021\/cb300063v","volume":"7","author":"Czihal","year":"2012","journal-title":"ACS Chem Biol"},{"key":"10.1016\/j.bmcl.2019.126887_b0010","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1038\/nrd.2017.23","volume":"16","author":"Dickey","year":"2017","journal-title":"Nat Rev Drug Discovery"},{"key":"10.1016\/j.bmcl.2019.126887_b0015","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1038\/ja.2017.30","volume":"70","author":"Martens","year":"2017","journal-title":"J Antibiot (Tokyo)"},{"key":"10.1016\/j.bmcl.2019.126887_b0020","doi-asserted-by":"crossref","first-page":"16162","DOI":"10.1038\/nmicrobiol.2016.162","volume":"1","author":"Lam","year":"2016","journal-title":"Nat Microbiol"},{"key":"10.1016\/j.bmcl.2019.126887_b0025","doi-asserted-by":"crossref","first-page":"3366","DOI":"10.1016\/j.bmcl.2014.05.094","volume":"24","author":"Nguyen","year":"2014","journal-title":"Bioorg Med Chem Lett"},{"key":"10.1016\/j.bmcl.2019.126887_b0030","doi-asserted-by":"crossref","first-page":"1292","DOI":"10.1016\/j.bmcl.2009.01.075","volume":"19","author":"Hu","year":"2009","journal-title":"Bioorg Med Chem Lett"},{"key":"10.1016\/j.bmcl.2019.126887_b0035","doi-asserted-by":"crossref","first-page":"3374","DOI":"10.1016\/j.bmcl.2009.05.061","volume":"19","author":"Hu","year":"2009","journal-title":"Bioorg Med Chem Lett"},{"key":"10.1016\/j.bmcl.2019.126887_b0040","doi-asserted-by":"crossref","first-page":"4626","DOI":"10.1016\/j.bmcl.2009.06.077","volume":"19","author":"Hu","year":"2009","journal-title":"Bioorg Med Chem Lett"},{"key":"10.1016\/j.bmcl.2019.126887_b0045","doi-asserted-by":"crossref","first-page":"5789","DOI":"10.1016\/j.bmc.2015.07.006","volume":"23","author":"Nguyen","year":"2015","journal-title":"Bioorg Med Chem Lett"},{"key":"10.1016\/j.bmcl.2019.126887_b0050","doi-asserted-by":"crossref","first-page":"1590","DOI":"10.1016\/j.ejmech.2017.10.056","volume":"143","author":"Farahat","year":"2018","journal-title":"Eur J Med Chem"},{"key":"10.1016\/j.bmcl.2019.126887_b0055","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1080\/15476910701680087","volume":"4","author":"Plaza","year":"2007","journal-title":"J Immunotoxicol"},{"key":"10.1016\/j.bmcl.2019.126887_b0060","doi-asserted-by":"crossref","first-page":"17028","DOI":"10.1038\/nmicrobiol.2017.28","volume":"2","author":"Stokes","year":"2017","journal-title":"Nat Microbiol"},{"key":"10.1016\/j.bmcl.2019.126887_b0065","doi-asserted-by":"crossref","first-page":"7790","DOI":"10.1016\/j.bmc.2013.10.014","volume":"21","author":"Williams","year":"2013","journal-title":"Bioorg Med Chem"},{"key":"10.1016\/j.bmcl.2019.126887_b0070","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1016\/j.bmcl.2017.01.019","volume":"27","author":"Chen","year":"2017","journal-title":"Bioorg Med Chem Lett"},{"key":"10.1016\/j.bmcl.2019.126887_b0075","doi-asserted-by":"crossref","first-page":"5643","DOI":"10.1016\/j.bmc.2006.04.036","volume":"14","author":"Lazo","year":"2006","journal-title":"Bioorg Med Chem"},{"key":"10.1016\/j.bmcl.2019.126887_b0080","unstructured":"CLSI. In Methods for dilution antimicrobial susceptibility tests for bacteria that grow aerobically; approved standard-ninth edition. CLSI document M07-A9; Wayne, P. A., Ed.; Clinical and Laboratory Standards Institute, 2012."}],"container-title":["Bioorganic &amp; Medicinal Chemistry Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0960894X19308650?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0960894X19308650?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,18]],"date-time":"2025-10-18T07:34:02Z","timestamp":1760772842000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0960894X19308650"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,4]]},"references-count":16,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2020,4]]}},"alternative-id":["S0960894X19308650"],"URL":"https:\/\/doi.org\/10.1016\/j.bmcl.2019.126887","relation":{},"ISSN":["0960-894X"],"issn-type":[{"value":"0960-894X","type":"print"}],"subject":[],"published":{"date-parts":[[2020,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Synthesis and in vitro activity of asymmetric indole-based bisamidine compounds against Gram-positive and Gram-negative pathogens","name":"articletitle","label":"Article Title"},{"value":"Bioorganic & Medicinal Chemistry Letters","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bmcl.2019.126887","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"126887"}}