{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T06:40:54Z","timestamp":1785220854165,"version":"3.55.0"},"reference-count":25,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2020,2,1]],"date-time":"2020-02-01T00:00:00Z","timestamp":1580515200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,2,1]],"date-time":"2020-02-01T00:00:00Z","timestamp":1580515200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003399","name":"Science and Technology Commission of Shanghai Municipality","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003399","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bioorganic &amp; Medicinal Chemistry Letters"],"published-print":{"date-parts":[[2020,2]]},"DOI":"10.1016\/j.bmcl.2020.126951","type":"journal-article","created":{"date-parts":[[2020,1,7]],"date-time":"2020-01-07T05:21:08Z","timestamp":1578374468000},"page":"126951","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":42,"title":["Design, synthesis, and structure-activity relationship studies of novel triazole agents with strong antifungal activity against Aspergillus fumigatus"],"prefix":"10.1016","volume":"30","author":[{"given":"Zichao","family":"Ding","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tingjunhong","family":"Ni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fei","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yumeng","family":"Hao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shichong","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyun","family":"Chai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongsheng","family":"Jin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ting","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanying","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dazhi","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"19","key":"10.1016\/j.bmcl.2020.126951_b0005","doi-asserted-by":"crossref","first-page":"5678","DOI":"10.1016\/j.bmc.2012.04.045","article-title":"The biology and chemistry of antifungal agents: A review","volume":"20","author":"Kathiravan","year":"2012","journal-title":"Bioorg Med Chem"},{"issue":"2","key":"10.1016\/j.bmcl.2020.126951_b0010","doi-asserted-by":"crossref","first-page":"179","DOI":"10.2217\/fmb.11.154","article-title":"New developments in invasive fungal disease","volume":"7","author":"Groll","year":"2012","journal-title":"Future Microbiol"},{"key":"10.1016\/j.bmcl.2020.126951_b0015","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1586\/eri.10.163","article-title":"Newer antifungal agents","volume":"9","author":"Turel","year":"2011","journal-title":"Expert Rev Anti-infect Ther"},{"key":"10.1016\/j.bmcl.2020.126951_b0020","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1358\/dof.2011.36.8.1686467","article-title":"Therapeutic target for candidiasis","volume":"36","author":"Sorbera","year":"2011","journal-title":"Drugs Future"},{"key":"10.1016\/j.bmcl.2020.126951_b0025","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1128\/CMR.12.2.310","article-title":"Aspergillus fumigatus and aspergillosis","volume":"12","author":"Latge","year":"1999","journal-title":"Clin Microbiol Rev"},{"issue":"3","key":"10.1016\/j.bmcl.2020.126951_b0030","first-page":"1661","article-title":"Yeast Cytochrome P-450 Catalyzing Lanosterol 14a-Demethylation","volume":"259","author":"Yuzo","year":"1984","journal-title":"J Biol Chem"},{"issue":"10","key":"10.1016\/j.bmcl.2020.126951_b0035","doi-asserted-by":"crossref","first-page":"2171","DOI":"10.1016\/j.bmcl.2017.03.062","article-title":"Design, synthesis, and in vitro evaluation of novel antifungal triazoles","volume":"27","author":"Xie","year":"2017","journal-title":"Bioorg Med Chem Lett"},{"key":"10.1016\/j.bmcl.2020.126951_b0040","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1007\/s11046-012-9526-y","article-title":"Invasive aspergillosis: resistance to antifungal drugs","volume":"12","author":"Hadrich","year":"2012","journal-title":"Mycopathologia"},{"key":"10.1016\/j.bmcl.2020.126951_b0045","doi-asserted-by":"crossref","first-page":"3669","DOI":"10.1016\/j.bmcl.2003.08.029","article-title":"Phosphonooxymethyl prodrugs of the broad spectrum antifungal azole, ravuconazole: synthesis and biological properties","volume":"13","author":"Ueda","year":"2003","journal-title":"Bioorg Med Chem Lett"},{"key":"10.1016\/j.bmcl.2020.126951_b0050","doi-asserted-by":"crossref","first-page":"1869","DOI":"10.1021\/jm9707277","article-title":"New azole antifungals: 3. Synthesis and antifungal activity of 3-substituted-4(3H)-quinazolinones","volume":"41","author":"Bartroli","year":"1998","journal-title":"J Med Chem"},{"key":"10.1016\/j.bmcl.2020.126951_b0055","first-page":"88","article-title":"Overview of albaconazole","volume":"5","author":"Bartroli","year":"2011","journal-title":"Eur Infect Dis"},{"issue":"2","key":"10.1016\/j.bmcl.2020.126951_b0060","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1021\/ml300429p","article-title":"Discovery of a Novel Broad-Spectrum Antifungal Agent Derived from Albaconazole","volume":"4","author":"Guillon","year":"2013","journal-title":"ACS Med Chem Lett"},{"key":"10.1016\/j.bmcl.2020.126951_b0065","doi-asserted-by":"crossref","first-page":"3687","DOI":"10.1021\/jm4016284","article-title":"Design, Synthesis, and Structure\u2212Activity Relationship Studies of Novel Fused Heterocycles-Linked Triazoles with Good Activity and Water Solubility","volume":"57","author":"Cao","year":"2014","journal-title":"J Med Chem"},{"key":"10.1016\/j.bmcl.2020.126951_b0070","doi-asserted-by":"crossref","first-page":"5222","DOI":"10.1016\/j.bmcl.2007.06.076","article-title":"Synthesis and SAR studies of novel antifungal 1,2,3-triazines","volume":"17","author":"Hunt","year":"2007","journal-title":"Bioorg Med Chem Lett"},{"key":"10.1016\/j.bmcl.2020.126951_b0075","doi-asserted-by":"crossref","first-page":"4776","DOI":"10.1021\/jo001499i","article-title":"Synthesis and Unusual Chemical Reactivity of Certain Novel 4,5-Disubstituted 7-Benzylpyrrolo[2,3-d][1,2,3]triazines","volume":"66","author":"Migawa","year":"2001","journal-title":"J Org Chem"},{"key":"10.1016\/j.bmcl.2020.126951_b0080","doi-asserted-by":"crossref","first-page":"3840","DOI":"10.1021\/jm0402014","volume":"48","author":"Migawa","year":"2005","journal-title":"J Med Chem"},{"key":"10.1016\/j.bmcl.2020.126951_b0085","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1021\/jo01061a618","article-title":"Notes. Some Halogenated 1,2,3-Benzotriazin-4(3H)ones","volume":"26","author":"Gadekar","year":"1961","journal-title":"J Org Chem"},{"key":"10.1016\/j.bmcl.2020.126951_b0090","doi-asserted-by":"crossref","first-page":"1383","DOI":"10.1021\/jo01051a062","article-title":"1,2,3-Benzotriazine Sulfonamides. A New Class of Oral Diuretic Agents","volume":"27","author":"Gadekar","year":"1962","journal-title":"J Org Chem"},{"key":"10.1016\/j.bmcl.2020.126951_b0095","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1016\/S0223-5234(99)00126-9","article-title":"Preparation and local anaesthetic activity of benzotriazinone and benzoyltriazole derivatives","volume":"34","author":"Caliendo","year":"1999","journal-title":"Eur J Med Chem"},{"key":"10.1016\/j.bmcl.2020.126951_b0100","doi-asserted-by":"crossref","first-page":"1146","DOI":"10.1016\/j.bmcl.2011.11.096","article-title":"Cu-mediated N-arylation of 1,2,3-triazin-4-ones: Synthesis of fused triazinone derivatives as potential inhibitors of chorismate mutase","volume":"22","author":"Kumar","year":"2012","journal-title":"Bioorg Med Chem Lett"},{"key":"10.1016\/j.bmcl.2020.126951_b0105","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1021\/op900065c","article-title":"The Process Development of Ravuconazole: An Efficient Multikilogram Scale Preparation of an Antifungal Agent","volume":"13","author":"Jaan","year":"2009","journal-title":"Org Process Res Dev"},{"key":"10.1016\/j.bmcl.2020.126951_b0110","unstructured":"Clinical and Laboratory Standards Institute\/National Committee for Clinical Laboratory Standards, Reference Method for Broth Dilution Antifungal Susceptibility Testing of Yeast, third ed., Clinical and Laboratory Standards Institute, Wayne, PA, 2009. Approved Standard, Document M27ea3."},{"key":"10.1016\/j.bmcl.2020.126951_b0115","unstructured":"Clinical and Laboratory Standards Institute\/National Committee for Clinical Laboratory Standards, Reference Method for Broth Dilution Antifungal Susceptibility Testing of Yeast, third ed., Clinical and Laboratory Standards Institute, Wayne, PA, 2008. Approved Standard, Document M38eA2."},{"key":"10.1016\/j.bmcl.2020.126951_b0120","doi-asserted-by":"crossref","first-page":"6728","DOI":"10.1074\/jbc.M117.778308","article-title":"Structural analyses of Candida albicans sterol 14 alpha-demethylase complexed with azole drugs address the molecular basis of azole-mediated inhibition of fungal sterol biosynthesis","volume":"292","author":"Hargrove","year":"2017","journal-title":"J Biol Chem"},{"key":"10.1016\/j.bmcl.2020.126951_b0125","doi-asserted-by":"crossref","first-page":"23916","DOI":"10.1074\/jbc.M115.677310","article-title":"Structure-Functional Characterization of Cytochrome P450 Sterol Alpha-Demethylase (Cyp51B) from Aspergillus Fumigatus and Molecular Basis for the Development of Antifungal Drugs","volume":"290","author":"Hargrove","year":"2015","journal-title":"J Biol Chem"}],"container-title":["Bioorganic &amp; Medicinal Chemistry Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0960894X20300044?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0960894X20300044?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,18]],"date-time":"2025-10-18T07:31:37Z","timestamp":1760772697000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0960894X20300044"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,2]]},"references-count":25,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2020,2]]}},"alternative-id":["S0960894X20300044"],"URL":"https:\/\/doi.org\/10.1016\/j.bmcl.2020.126951","relation":{},"ISSN":["0960-894X"],"issn-type":[{"value":"0960-894X","type":"print"}],"subject":[],"published":{"date-parts":[[2020,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Design, synthesis, and structure-activity relationship studies of novel triazole agents with strong antifungal activity against Aspergillus fumigatus","name":"articletitle","label":"Article Title"},{"value":"Bioorganic & Medicinal Chemistry Letters","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bmcl.2020.126951","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"126951"}}