{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T14:19:46Z","timestamp":1790518786364,"version":"4.1.0"},"reference-count":12,"publisher":"Elsevier BV","issue":"16","license":[{"start":{"date-parts":[[2020,8,1]],"date-time":"2020-08-01T00:00:00Z","timestamp":1596240000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,8,1]],"date-time":"2020-08-01T00:00:00Z","timestamp":1596240000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"name":"CAMS Innovation Fund for Medical Sciences","award":["CAMS-2017-I2M-1-011"],"award-info":[{"award-number":["CAMS-2017-I2M-1-011"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["81903432"],"award-info":[{"award-number":["81903432"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bioorganic & Medicinal Chemistry Letters"],"published-print":{"date-parts":[[2020,8]]},"DOI":"10.1016\/j.bmcl.2020.127209","type":"journal-article","created":{"date-parts":[[2020,4,27]],"date-time":"2020-04-27T05:07:11Z","timestamp":1587964031000},"page":"127209","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"title":["A novel method for preparing Eligulstat through chiral resolution"],"prefix":"10.1016","volume":"30","author":[{"given":"Jianxun","family":"Du","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weiming","family":"Chu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengmeng","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunying","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenhua","family":"Feng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bmcl.2020.127209_b0005","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1615\/CritRevOncog.2013006060","article-title":"Gaucher disease: a comprehensive review","volume":"18","author":"Rosenbloom","year":"2013","journal-title":"Crit Rev Oncog."},{"key":"10.1016\/j.bmcl.2020.127209_b0010","article-title":"Synthesis of UDP-glucose: N-acylsphingosine glucosyltransferase inhibitors","author":"Hirth","year":"2003","journal-title":"PCT Int Appl."},{"key":"10.1016\/j.bmcl.2020.127209_b0015","doi-asserted-by":"crossref","first-page":"8621","DOI":"10.1016\/S0040-4039(02)02096-8","article-title":"syn-Selective additions to Garner aldehyde: synthesis of a potent glucosylceramide synthase inhibitor","volume":"43","author":"Husain","year":"2002","journal-title":"Tetrahedron Lett."},{"key":"10.1016\/j.bmcl.2020.127209_b0020","doi-asserted-by":"crossref","first-page":"2042","DOI":"10.1002\/cmdc.201500407","article-title":"Synthesis and evaluation of hybrid structures composed of two glucosylceramide synthase inhibitors","volume":"10","author":"van den Berg","year":"2015","journal-title":"ChemMedChem."},{"key":"10.1016\/j.bmcl.2020.127209_b0025","unstructured":"Xu, X. N., CN 104557851 A, 2015."},{"key":"10.1016\/j.bmcl.2020.127209_b0030","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1080\/00397911.2017.1416636","article-title":"Concise and efficient synthesis of eliglustat","volume":"48","author":"Liu","year":"2018","journal-title":"Synth Commun."},{"issue":"6","key":"10.1016\/j.bmcl.2020.127209_b0035","doi-asserted-by":"crossref","first-page":"1204","DOI":"10.1021\/acs.oprd.9b00138","article-title":"Development of an efficient and scalable asymmetric synthesis of Eliglustat via Ruthenium(II)-catalyzed asymmetric transfer hydrogenation","volume":"23","author":"Sun","year":"2019","journal-title":"Org Process Res Dev."},{"key":"10.1016\/j.bmcl.2020.127209_b0040","article-title":"Process for preparing (alpha S, beta R)-6-bromo-alpha-[2-(dimethylamino) ethyl]-2-methoxy-alpha-1-naphthalenyl-beta-phenyl-3-quinolineethanol","author":"Porstmann","year":"2006","journal-title":"PCT Int Appl."},{"key":"10.1016\/j.bmcl.2020.127209_b0045","doi-asserted-by":"crossref","first-page":"1663","DOI":"10.1016\/S0957-4166(01)00293-2","article-title":"Highly efficient resolution of (\u00b1)-Tramadol with di-p-toluoyl-tartaric acid (DTTA)","volume":"12","author":"Evans","year":"2001","journal-title":"Tetrahedron Asymm."},{"key":"10.1016\/j.bmcl.2020.127209_b0050","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1021\/op000281v","article-title":"A practical procedure for the resolution of (+)-and (\u2212)-Tramadol","volume":"4","author":"Itov","year":"2000","journal-title":"Org Process Res Dev."},{"key":"10.1016\/j.bmcl.2020.127209_b0055","first-page":"89","article-title":"Novel methods of resolving racemic diols and amino alcohols","volume":"35","author":"Periasamy","year":"2002","journal-title":"Aldrichim Acta."},{"key":"10.1016\/j.bmcl.2020.127209_b0060","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1021\/jm00368a011","article-title":"Design synthesis and X-ray data of novel potential antipsychotic agents. Substituted 7-phenylquinolizidines: stereospecific, neuroleptic, and antinociceptive properties","volume":"27","author":"Imhof","year":"1984","journal-title":"J Med Chem."}],"container-title":["Bioorganic & Medicinal Chemistry Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0960894X20303097?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0960894X20303097?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,18]],"date-time":"2025-10-18T07:39:06Z","timestamp":1760773146000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0960894X20303097"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,8]]},"references-count":12,"journal-issue":{"issue":"16","published-print":{"date-parts":[[2020,8]]}},"alternative-id":["S0960894X20303097"],"URL":"https:\/\/doi.org\/10.1016\/j.bmcl.2020.127209","relation":{},"ISSN":["0960-894X"],"issn-type":[{"value":"0960-894X","type":"print"}],"subject":[],"published":{"date-parts":[[2020,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A novel method for preparing Eligulstat through chiral resolution","name":"articletitle","label":"Article Title"},{"value":"Bioorganic & Medicinal Chemistry Letters","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bmcl.2020.127209","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"127209"}}