{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T12:10:26Z","timestamp":1774440626079,"version":"3.50.1"},"reference-count":28,"publisher":"Elsevier BV","issue":"13","license":[{"start":{"date-parts":[[2020,7,1]],"date-time":"2020-07-01T00:00:00Z","timestamp":1593561600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,7,1]],"date-time":"2020-07-01T00:00:00Z","timestamp":1593561600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002701","name":"Ministry of Education","doi-asserted-by":"publisher","award":["NRF-2018R1D1A1B07040998"],"award-info":[{"award-number":["NRF-2018R1D1A1B07040998"]}],"id":[{"id":"10.13039\/501100002701","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bioorganic &amp; Medicinal Chemistry Letters"],"published-print":{"date-parts":[[2020,7]]},"DOI":"10.1016\/j.bmcl.2020.127223","type":"journal-article","created":{"date-parts":[[2020,4,27]],"date-time":"2020-04-27T16:52:23Z","timestamp":1588006343000},"page":"127223","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"title":["Small molecule DTDQ exerts anti-metastatic effects in DU145 human castration-resistant prostate cancer cells via modulations of ERK, JNK, p38 and c-Myc signaling pathways"],"prefix":"10.1016","volume":"30","author":[{"given":"Juhyeon","family":"Son","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sang Yeol","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.bmcl.2020.127223_b0005","doi-asserted-by":"crossref","unstructured":"Macielag MJ. Chemical properties of antimicrobials and their uniqueness. Antibiotic Discovery and Development. Springer; 2012:793\u2013820.","DOI":"10.1007\/978-1-4614-1400-1_24"},{"key":"10.1016\/j.bmcl.2020.127223_b0010","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1038\/nrc2559","article-title":"Targeting cancer with small molecule kinase inhibitors","volume":"9","author":"Zhang","year":"2009","journal-title":"Nat Rev Cancer"},{"issue":"2","key":"10.1016\/j.bmcl.2020.127223_b0015","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.molonc.2012.02.004","article-title":"Discovery of small molecule cancer drugs: successes, challenges and opportunities","volume":"6","author":"Hoelder","year":"2012","journal-title":"Mol Oncol"},{"key":"10.1016\/j.bmcl.2020.127223_b0020","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1007\/s12013-017-0789-2","article-title":"IDH-inhibiting small molecule DTDQ inhibits migration and invasion of A549 human non-small-cell lung cancer cells via sequential inactivation of ERK and P38 signaling pathways","volume":"76","author":"Park","year":"2018","journal-title":"Cell Biochem Biophys"},{"key":"10.1016\/j.bmcl.2020.127223_b0025","first-page":"394","article-title":"Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"68","author":"Bray","year":"2018","journal-title":"CA Cancer J Clin"},{"key":"10.1016\/j.bmcl.2020.127223_b0030","doi-asserted-by":"crossref","first-page":"63","DOI":"10.14740\/wjon1191","article-title":"Epidemiology of prostate cancer","volume":"10","author":"Rawla","year":"2019","journal-title":"World J Oncol"},{"key":"10.1016\/j.bmcl.2020.127223_b0035","doi-asserted-by":"crossref","first-page":"2719","DOI":"10.1038\/emboj.2011.158","article-title":"The androgen receptor fuels prostate cancer by regulating central metabolism and biosynthesis","volume":"30","author":"Massie","year":"2011","journal-title":"EMBO J"},{"issue":"Suppl 1","key":"10.1016\/j.bmcl.2020.127223_b0040","first-page":"S3","article-title":"Androgen deprivation therapy in the treatment of advanced prostate cancer","volume":"9","author":"Perlmutter","year":"2007","journal-title":"Rev Urol"},{"key":"10.1016\/j.bmcl.2020.127223_b0045","first-page":"365","article-title":"Mechanisms of resistance in castration-resistant prostate cancer (CRPC)","volume":"4","author":"Chandrasekar","year":"2015","journal-title":"Transl Androl Urol"},{"key":"10.1016\/j.bmcl.2020.127223_b0050","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/j.jsbmb.2013.06.002","article-title":"Novel therapeutic approaches for the treatment of castration-resistant prostate cancer","volume":"138","author":"Heidegger","year":"2013","journal-title":"J Steroid Biochem Mol Biol"},{"key":"10.1016\/j.bmcl.2020.127223_b0055","article-title":"MAP kinases and prostate cancer","volume":"2012","author":"Rodriguez-Berriguete","year":"2012","journal-title":"J Signal Transduct"},{"key":"10.1016\/j.bmcl.2020.127223_b0060","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.nutres.2018.07.003","article-title":"Maclurin exerts anti-cancer effects on PC3 human prostate cancer cells via activation of p38 and inhibitions of JNK, FAK, AKT, and c-Myc signaling pathways","volume":"58","author":"Lee","year":"2018","journal-title":"Nutr Res"},{"key":"10.1016\/j.bmcl.2020.127223_b0065","unstructured":"DTDQ was purchased from AKos consulting and solutions (Germany). Antibodies against phospho-ERK (sc-7383), ERK (sc-94), JNK (sc-571), phospho-JNK (sc-6254), phospho-p38 (sc-17852-R), p38 (sc-7972), Actin (sc-1615), c-Myc (sc-40), \u03b2-catenin (sc-7199), NF-\u03baB (sc-372) and ETS-1 (sc-350) were purchased from Santa Cruz Biotechnology (Santa Cruz, CA, USA). Anti-rabbit IgG-HRP, anti-mouse IgG-HRP and anti-goat IgG-HRP were purchased from Bethyl laboratories (Montgomery, TX, USA). RPMI 1640, penicillin\u2013streptomycin and fetal bovine serum (FBS) were purchased from Hyclone (Manassas, VA, USA). Dulbecco\u2019s phosphate buffered saline (PBS) was obtained from Sigma-Aldrich (ST. Louis, MO, USA)."},{"key":"10.1016\/j.bmcl.2020.127223_b0070","article-title":"Tomentosin displays anti-carcinogenic effect in human osteosarcoma MG-63 cells via the induction of intracellular reactive oxygen species","volume":"20","author":"Lee","year":"2019","journal-title":"Int J Mol Sci."},{"key":"10.1016\/j.bmcl.2020.127223_b0075","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/j.juro.2010.03.034","article-title":"Skeletal related events, bone metastasis and survival of prostate cancer: a population based cohort study in Denmark (1999 to 2007)","volume":"184","author":"Norgaard","year":"2010","journal-title":"J Urol"},{"key":"10.1016\/j.bmcl.2020.127223_b0080","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/j.ceb.2011.12.004","article-title":"Directed cell invasion and migration during metastasis","volume":"24","author":"Bravo-Cordero","year":"2012","journal-title":"Curr Opin Cell Biol"},{"issue":"3","key":"10.1016\/j.bmcl.2020.127223_b0085","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1016\/j.jgr.2018.11.002","article-title":"Synergistic anticancer effects of timosaponin AIII and ginsenosides in MG63 human osteosarcoma cells","volume":"43","author":"Jung","year":"2019","journal-title":"J Ginseng Res"},{"key":"10.1016\/j.bmcl.2020.127223_b0090","doi-asserted-by":"crossref","first-page":"2223","DOI":"10.1016\/j.bmc.2007.01.011","article-title":"Matrix metalloproteinases (MMPs): chemical-biological functions and (Q)SARs","volume":"15","author":"Verma","year":"2007","journal-title":"Bioorg Med Chem"},{"key":"10.1016\/j.bmcl.2020.127223_b0095","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1111\/j.1742-4658.2010.07919.x","article-title":"Roles of matrix metalloproteinases in cancer progression and their pharmacological targeting","volume":"278","author":"Gialeli","year":"2011","journal-title":"FEBS J"},{"key":"10.1016\/j.bmcl.2020.127223_b0100","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1007\/s00240-004-0440-8","article-title":"Matrix metalloproteinases as diagnostic (MMP-13) and prognostic (MMP-2, MMP-9) markers of prostate cancer","volume":"33","author":"Morgia","year":"2005","journal-title":"Urol Res"},{"key":"10.1016\/j.bmcl.2020.127223_b0105","doi-asserted-by":"crossref","DOI":"10.1016\/j.cbi.2019.108910","article-title":"Ursonic acid exerts inhibitory effects on matrix metalloproteinases via ERK signaling pathway","volume":"315","author":"Son","year":"2020","journal-title":"Chem Biol Interact"},{"key":"10.1016\/j.bmcl.2020.127223_b0110","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1096\/fasebj.13.8.781","article-title":"Regulation of matrix metalloproteinase expression in tumor invasion","volume":"13","author":"Westermarck","year":"1999","journal-title":"FASEB J"},{"key":"10.1016\/j.bmcl.2020.127223_b0115","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1007\/s11010-015-2331-4","article-title":"Maclurin suppresses migration and invasion of human non-small-cell lung cancer cells via anti-oxidative activity and inhibition of the Src\/FAK-ERK-beta-catenin pathway","volume":"402","author":"Ku","year":"2015","journal-title":"Mol Cell Biochem"},{"key":"10.1016\/j.bmcl.2020.127223_b0120","doi-asserted-by":"crossref","unstructured":"Lee YS, Lan Tran HT, Van Ta Q. Regulation of expression of matrix metalloproteinase-9 by JNK in Raw 264.7 cells: presence of inhibitory factor(s) suppressing MMP-9 induction in serum and conditioned media. Exp Mol Med. 2009;41(4): 259\u2013268.","DOI":"10.3858\/emm.2009.41.4.029"},{"key":"10.1016\/j.bmcl.2020.127223_b0125","doi-asserted-by":"crossref","first-page":"2777","DOI":"10.3892\/or.2014.3520","article-title":"Berberine hydrochloride IL-8 dependently inhibits invasion and IL-8-independently promotes cell apoptosis in MDA-MB-231 cells","volume":"32","author":"Li","year":"2014","journal-title":"Oncol Rep"},{"key":"10.1016\/j.bmcl.2020.127223_b0130","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.cbi.2015.08.014","article-title":"Emetine inhibits migration and invasion of human non-small-cell lung cancer cells via regulation of ERK and p38 signaling pathways","volume":"242","author":"Kim","year":"2015","journal-title":"Chem Biol Interact"},{"key":"10.1016\/j.bmcl.2020.127223_b0135","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1159\/000481645","article-title":"Licochalcone A inhibits MMPs and ADAMTSs via the NF-kappaB and Wnt\/beta-catenin signaling pathways in rat chondrocytes","volume":"43","author":"Chen","year":"2017","journal-title":"Cell Physiol Biochem."},{"key":"10.1016\/j.bmcl.2020.127223_b0140","doi-asserted-by":"crossref","first-page":"836","DOI":"10.1111\/j.1365-2559.2006.02432.x","article-title":"Ets-1 is up-regulated together with its target gene products matrix metalloproteinase-2 and matrix metalloproteinase-9 in atypical and anaplastic meningiomas","volume":"48","author":"Okuducu","year":"2006","journal-title":"Histopathology"}],"container-title":["Bioorganic &amp; Medicinal Chemistry Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0960894X20303231?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0960894X20303231?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,18]],"date-time":"2025-10-18T07:35:12Z","timestamp":1760772912000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0960894X20303231"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,7]]},"references-count":28,"journal-issue":{"issue":"13","published-print":{"date-parts":[[2020,7]]}},"alternative-id":["S0960894X20303231"],"URL":"https:\/\/doi.org\/10.1016\/j.bmcl.2020.127223","relation":{},"ISSN":["0960-894X"],"issn-type":[{"value":"0960-894X","type":"print"}],"subject":[],"published":{"date-parts":[[2020,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Small molecule DTDQ exerts anti-metastatic effects in DU145 human castration-resistant prostate cancer cells via modulations of ERK, JNK, p38 and c-Myc signaling pathways","name":"articletitle","label":"Article Title"},{"value":"Bioorganic & Medicinal Chemistry Letters","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bmcl.2020.127223","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"127223"}}