{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T11:13:24Z","timestamp":1781867604798,"version":"3.54.5"},"reference-count":24,"publisher":"Elsevier BV","issue":"14","license":[{"start":{"date-parts":[[2020,7,1]],"date-time":"2020-07-01T00:00:00Z","timestamp":1593561600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,7,1]],"date-time":"2020-07-01T00:00:00Z","timestamp":1593561600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100004396","name":"Thailand Research Fund","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004396","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002842","name":"Chiang Mai University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002842","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bioorganic & Medicinal Chemistry Letters"],"published-print":{"date-parts":[[2020,7]]},"DOI":"10.1016\/j.bmcl.2020.127256","type":"journal-article","created":{"date-parts":[[2020,5,12]],"date-time":"2020-05-12T02:48:15Z","timestamp":1589251695000},"page":"127256","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":16,"title":["Isolation and biological activity of agrostophillinol from kaffir lime (Citrus hystrix) leaves"],"prefix":"10.1016","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7259-4694","authenticated-orcid":false,"given":"Songyot","family":"Anuchapreeda","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Riki","family":"Anzawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natsima","family":"Viriyaadhammaa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Waranya","family":"Neimkhum","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wantida","family":"Chaiyana","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6077-5017","authenticated-orcid":false,"given":"Siriporn","family":"Okonogi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0212-5371","authenticated-orcid":false,"given":"Toyonobu","family":"Usuki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bmcl.2020.127256_b0005","first-page":"1","article-title":"The medicinal and nutritional role of underutilized citrus fruit-Citrus hystrix (kaffir lime): a review","volume":"6","author":"Abirami","year":"2014","journal-title":"Drug Invent Today"},{"key":"10.1016\/j.bmcl.2020.127256_b0010","doi-asserted-by":"crossref","first-page":"1404","DOI":"10.1016\/S0031-9422(00)84357-5","article-title":"Podimuang V. Constituents of the leaf and peel oils of Citrus hystrix, D.C","volume":"10","author":"Lawrence","year":"1971","journal-title":"Phytochemistry"},{"key":"10.1016\/j.bmcl.2020.127256_b0015","first-page":"125","article-title":"Antimicrobial activities of essential oils and crude extracts from tropical Citrus spp. against food-related microorganisms","volume":"30","author":"Chanthaphon","year":"2008","journal-title":"Songklanakarin J Sci Technol"},{"key":"10.1016\/j.bmcl.2020.127256_b0020","series-title":"IEEE Student Conference on","first-page":"479","article-title":"MN Taib Essential oil composition of Kaffir lime: Comparative analysis between controlled steam distillation and hydrodistillation extraction process","author":"Kasuan","year":"2009"},{"key":"10.1016\/j.bmcl.2020.127256_b0025","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1002\/cbdv.200900196","article-title":"Chemical composition and antimicrobial activity of the essential oils from New Caledonian Citrus macroptera and Citrus hystrix","volume":"7","author":"Waikedre","year":"2010","journal-title":"Chem Biodivers"},{"key":"10.1016\/j.bmcl.2020.127256_b0030","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/S0305-1978(99)00036-8","article-title":"Chemical variability of peel and leaf essential oils of mandarins from Citrus reticulata Blanco","volume":"28","author":"Lota","year":"2000","journal-title":"Biochem System Ecol"},{"key":"10.1016\/j.bmcl.2020.127256_b0035","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1248\/cpb.41.714","article-title":"Studies on the differentiation inducers of myeloid leukemic cells from Citrus species","volume":"41","author":"Sugiyama","year":"1993","journal-title":"Chem Pharm Bull"},{"key":"10.1016\/j.bmcl.2020.127256_b0040","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1207\/s15327914nc5601_14","article-title":"Antiproliferative effects of citrus limonoids against human neuroblastoma and colonic adenocarcinoma cells","volume":"56","author":"Poulose","year":"2006","journal-title":"Nutr Cancer"},{"key":"10.1016\/j.bmcl.2020.127256_b0045","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1080\/13880200600685592","article-title":"Antioxidative and free radical scavenging activities of some plants used in Thai folk medicine","volume":"44","author":"Hutadilok-Towatana","year":"2006","journal-title":"Pharm Biol"},{"key":"10.1016\/j.bmcl.2020.127256_b0050","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1016\/j.foodchem.2006.07.034","article-title":"Study on antioxidant activity of certain plants in Thailand: mechanism of antioxidant action of guava leaf extract","volume":"103","author":"Tachakittirungrod","year":"2007","journal-title":"Food Chem"},{"key":"10.1016\/j.bmcl.2020.127256_b0055","first-page":"19","article-title":"The efficacy of ethyl acetate extract of Trichoderma culture broth on growth inhibition and aflatoxin production by Aspergillus flavus IMI 242684","volume":"10","author":"Jantarach","year":"2010","journal-title":"KMITL Sci Tech J"},{"key":"10.1016\/j.bmcl.2020.127256_b0060","doi-asserted-by":"crossref","first-page":"1351","DOI":"10.1016\/j.foodchem.2008.11.033","article-title":"Apoptosis-mediated proliferation inhibition of human colon cancer cells by volatile principles of Citrus aurantifolia","volume":"114","author":"Patil","year":"2009","journal-title":"Food Chem"},{"key":"10.1016\/j.bmcl.2020.127256_b0065","doi-asserted-by":"crossref","first-page":"2779","DOI":"10.1021\/jf00058a043","article-title":"Glyceroglycolipids from Citrus hystrix, a traditional herb in Thailand, potently inhibit the tumor-promoting activity of 12-O-tetradecanoylphorbol 13-acetate in mouse skin","volume":"43","author":"Murakami","year":"1995","journal-title":"J Agric Food Chem"},{"key":"10.1016\/j.bmcl.2020.127256_b0070","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/j.canlet.2005.04.021","article-title":"Anti-proliferative activity of essential oil extracted from Thai medicinal plants on KB and P388 cell lines","volume":"235","author":"Manosroi","year":"2006","journal-title":"Cancer Lett"},{"key":"10.1016\/j.bmcl.2020.127256_b0075","doi-asserted-by":"crossref","first-page":"19710","DOI":"10.1074\/jbc.271.33.19710","article-title":"Post-translational modifications of Ras and Ral are important for the action of Ral GDP dissociation stimulator","volume":"271","author":"Hinoi","year":"1996","journal-title":"J Biol Chem"},{"key":"10.1016\/j.bmcl.2020.127256_b0080","first-page":"3097","article-title":"Cytotoxic effects of crude kaffir lime (Citrus hystrix, DC.) leaf fractional extracts on leukemic cell lines","volume":"5","author":"Chueahongthong","year":"2011","journal-title":"J Med Plants Res"},{"key":"10.1016\/j.bmcl.2020.127256_b0085","doi-asserted-by":"crossref","first-page":"1300","DOI":"10.3390\/molecules25061300","article-title":"Antileukemic Cell Proliferation of Active Compounds from Kaffir Lime (Citrus hystrix) Leaves","volume":"25","author":"Anuchapreeda","year":"2020","journal-title":"Molecules"},{"key":"10.1016\/j.bmcl.2020.127256_b0090","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1016\/S0031-9422(02)00487-9","article-title":"Triterpenoids from the orchids Agrostophyllum brevipes and Agrostophyllum callosum","volume":"62","author":"Majumder","year":"2003","journal-title":"Phytochemistry"},{"key":"10.1016\/j.bmcl.2020.127256_b0095","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1007\/BF02532428","article-title":"24-Methylenelanost-9(11)-en-3beta-ol, new triterpene alcohol from shea butter","volume":"10","author":"Itoh","year":"1975","journal-title":"Lipids"},{"key":"10.1016\/j.bmcl.2020.127256_b0100","first-page":"013","article-title":"Cytotoxicity of extracts from fruit plants against leukemic cell lines","volume":"4","author":"Ampasavate","year":"2010","journal-title":"Afr J Pharm Pharmacol"},{"key":"10.1016\/j.bmcl.2020.127256_b0105","unstructured":"Agrostophillinol: a white solid; [\u03b1]25D +60.6 (c 0.45, CHCl3) [ref. 18. [\u03b1]D +46 CHCl3)]. 1H-NMR (500 MHz, CDCl3) \u03b4 5.22 (1H, m, H11), 4.71 (1H, brs, H31b), 4.66 (1H, brs, H31a), 3.22 (1H, dd, J = 4.4, 11.2 Hz, H3), 1.05 (3H, s), 1.02 (6H, dd, J = 7.0, 3.0 Hz, H26,27), 0.99 (3H, s), 0.91 (3H, d, J = 6.7 Hz, H21), 0.83 (3H, s) 0.75 (3H, s), 0.65 (3H, s); EI-HRMS (m\/z) calcd for C31H52O [M]+ 440.4018, found 440.4018."},{"key":"10.1016\/j.bmcl.2020.127256_b0110","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1097\/BOR.0000000000000255","article-title":"The biology behind interleukin-6 targeted interventions","volume":"28","author":"Liu","year":"2016","journal-title":"Curr Opin Rheumatol"},{"key":"10.1016\/j.bmcl.2020.127256_b0115","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.cytogfr.2017.03.003","article-title":"IL-6 signaling in diabetic nephropathy: From pathophysiology to therapeutic perspectives","volume":"37","author":"Feigerlova","year":"2017","journal-title":"Cytokine Growth Factor Rev"},{"key":"10.1016\/j.bmcl.2020.127256_b0120","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1080\/1744666X.2017.1295850","article-title":"The role and therapeutic targeting of IL-6 in rheumatoid arthritis","volume":"13","author":"Narazaki","year":"2017","journal-title":"Expert Rev. Clin. Immunol."}],"container-title":["Bioorganic & Medicinal Chemistry Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0960894X20303619?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0960894X20303619?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,18]],"date-time":"2025-10-18T07:34:38Z","timestamp":1760772878000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0960894X20303619"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,7]]},"references-count":24,"journal-issue":{"issue":"14","published-print":{"date-parts":[[2020,7]]}},"alternative-id":["S0960894X20303619"],"URL":"https:\/\/doi.org\/10.1016\/j.bmcl.2020.127256","relation":{},"ISSN":["0960-894X"],"issn-type":[{"value":"0960-894X","type":"print"}],"subject":[],"published":{"date-parts":[[2020,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Isolation and biological activity of agrostophillinol from kaffir lime (Citrus hystrix) leaves","name":"articletitle","label":"Article Title"},{"value":"Bioorganic & Medicinal Chemistry Letters","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bmcl.2020.127256","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"127256"}}