{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T08:09:17Z","timestamp":1778573357812,"version":"3.51.4"},"reference-count":28,"publisher":"Elsevier BV","issue":"14","license":[{"start":{"date-parts":[[2020,7,1]],"date-time":"2020-07-01T00:00:00Z","timestamp":1593561600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,7,1]],"date-time":"2020-07-01T00:00:00Z","timestamp":1593561600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100003621","name":"Ministry of Science, ICT and Future Planning","doi-asserted-by":"publisher","award":["2015M3C1A3056410"],"award-info":[{"award-number":["2015M3C1A3056410"]}],"id":[{"id":"10.13039\/501100003621","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003621","name":"Ministry of Science, ICT and Future Planning","doi-asserted-by":"publisher","award":["2018R1A5A2024181"],"award-info":[{"award-number":["2018R1A5A2024181"]}],"id":[{"id":"10.13039\/501100003621","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002701","name":"Ministry of Education","doi-asserted-by":"publisher","award":["2018R1A6A3A01012344"],"award-info":[{"award-number":["2018R1A6A3A01012344"]}],"id":[{"id":"10.13039\/501100002701","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002701","name":"Ministry of Education","doi-asserted-by":"publisher","award":["2019M3E5D1A02067959"],"award-info":[{"award-number":["2019M3E5D1A02067959"]}],"id":[{"id":"10.13039\/501100002701","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002701","name":"Ministry of Education","doi-asserted-by":"publisher","award":["2017R1D1A1B03029055"],"award-info":[{"award-number":["2017R1D1A1B03029055"]}],"id":[{"id":"10.13039\/501100002701","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bioorganic &amp; Medicinal Chemistry Letters"],"published-print":{"date-parts":[[2020,7]]},"DOI":"10.1016\/j.bmcl.2020.127262","type":"journal-article","created":{"date-parts":[[2020,5,15]],"date-time":"2020-05-15T19:00:10Z","timestamp":1589569210000},"page":"127262","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"title":["Production of 64Cu-labeled monobody for imaging of human EphA2-expressing tumors"],"prefix":"10.1016","volume":"30","author":[{"given":"Ayoung","family":"Pyo","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sung-Hwan","family":"You","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hyeon","family":"Sik Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jung","family":"Young Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jung-Joon","family":"Min","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dong-Yeon","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yeongjin","family":"Hong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"3","key":"10.1016\/j.bmcl.2020.127262_b0005","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/j.cbpa.2009.04.627","article-title":"Engineered protein scaffolds as next-generation antibody therapeutics","volume":"13","author":"Gebauer","year":"2009","journal-title":"Curr Opin Chem Biol."},{"issue":"4","key":"10.1016\/j.bmcl.2020.127262_b0010","doi-asserted-by":"crossref","first-page":"445","DOI":"10.4161\/mabs.20776","article-title":"Molecular engineering of antibodies for therapeutic and diagnostic purposes","volume":"4","author":"Ducancel","year":"2012","journal-title":"mAbs."},{"key":"10.1016\/j.bmcl.2020.127262_b0015","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1146\/annurev-pharmtox-010818-021118","article-title":"Engineered protein scaffolds as next-generation therapeutics","volume":"60","author":"Gebauer","year":"2020","journal-title":"Annu Rev Pharmacol Toxicol."},{"issue":"1\u20132","key":"10.1016\/j.bmcl.2020.127262_b0020","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1093\/protein\/gzq097","article-title":"Adnectins: engineered target-binding protein therapeutics","volume":"24","author":"Lipovsek","year":"2011","journal-title":"Protein Eng Des Sel."},{"issue":"19\u201320","key":"10.1016\/j.bmcl.2020.127262_b0025","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1016\/j.drudis.2009.06.007","article-title":"FN3: a new protein scaffold reaches the clinic","volume":"14","author":"Bloom","year":"2009","journal-title":"Drug Discov Today."},{"issue":"4","key":"10.1016\/j.bmcl.2020.127262_b0030","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.1016\/0022-2836(94)90013-2","article-title":"Crystal structure of the tenth type III cell adhesion module of human fibronectin","volume":"236","author":"Dickinson","year":"1994","journal-title":"J Mol Biol."},{"issue":"4","key":"10.1016\/j.bmcl.2020.127262_b0035","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1016\/0092-8674(92)90600-H","article-title":"The three-dimensional structure of the tenth type III module of fibronectin: an insight into RGD-mediated interactions","volume":"71","author":"Main","year":"1992","journal-title":"Cell"},{"issue":"9","key":"10.1016\/j.bmcl.2020.127262_b0040","doi-asserted-by":"crossref","first-page":"2003","DOI":"10.1002\/ijc.25147","article-title":"The role of Eph receptors and ephrin ligands in colorectal cancer","volume":"126","author":"Herath","year":"2010","journal-title":"Int J Cancer."},{"issue":"24","key":"10.1016\/j.bmcl.2020.127262_b0045","doi-asserted-by":"crossref","first-page":"18575","DOI":"10.1074\/jbc.M109.075085","article-title":"EphA2 mutation in lung squamous cell carcinoma promotes increased cell survival, cell invasion, focal adhesions, and mammalian target of rapamycin activation","volume":"285","author":"Faoro","year":"2010","journal-title":"J Biol Chem."},{"issue":"4","key":"10.1016\/j.bmcl.2020.127262_b0050","doi-asserted-by":"crossref","first-page":"1492","DOI":"10.2353\/ajpath.2009.080473","article-title":"Kinase-dependent and -independent roles of EphA2 in the regulation of prostate cancer invasion and metastasis","volume":"174","author":"Taddei","year":"2009","journal-title":"Am J Pathol."},{"issue":"5","key":"10.1016\/j.bmcl.2020.127262_b0055","doi-asserted-by":"crossref","first-page":"2072","DOI":"10.1158\/0008-5472.CAN-08-1845","article-title":"EphA2 reexpression prompts invasion of melanoma cells shifting from mesenchymal to amoeboid-like motility style","volume":"69","author":"Parri","year":"2009","journal-title":"Cancer Res."},{"issue":"3","key":"10.1016\/j.bmcl.2020.127262_b0060","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1373\/clinchem.2003.026849","article-title":"Differential gene expression of Eph receptors and ephrins in benign human tissues and cancers","volume":"50","author":"Hafner","year":"2004","journal-title":"Clin Chem."},{"key":"10.1016\/j.bmcl.2020.127262_b0065","doi-asserted-by":"crossref","first-page":"7390104","DOI":"10.1155\/2018\/7390104","article-title":"Differential expression patterns of Eph receptors and ephrin ligands in human cancers","volume":"2018","author":"Kou","year":"2018","journal-title":"Biomed Res Int."},{"issue":"3","key":"10.1016\/j.bmcl.2020.127262_b0070","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1038\/nrc2806","article-title":"Eph receptors and ephrins in cancer: bidirectional signalling and beyond","volume":"10","author":"Pasquale","year":"2010","journal-title":"Nat Rev Cancer."},{"issue":"12","key":"10.1016\/j.bmcl.2020.127262_b0075","doi-asserted-by":"crossref","first-page":"1795","DOI":"10.1158\/1541-7786.MCR-08-0244","article-title":"The EphA2 receptor and ephrinA1 ligand in solid tumors: function and therapeutic targeting","volume":"6","author":"Wykosky","year":"2008","journal-title":"Mol Cancer Res."},{"issue":"52","key":"10.1016\/j.bmcl.2020.127262_b0080","doi-asserted-by":"crossref","first-page":"6043","DOI":"10.1038\/sj.onc.1204004","article-title":"The ephrin-A1 ligand and its receptor, EphA2, are expressed during tumor neovascularization","volume":"19","author":"Ogawa","year":"2000","journal-title":"Oncogene."},{"issue":"1","key":"10.1016\/j.bmcl.2020.127262_b0085","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1023\/A:1022546620495","article-title":"Overexpression and functional alterations of the EphA2 tyrosine kinase in cancer","volume":"20","author":"Kinch","year":"2003","journal-title":"Clin Exp Metastas."},{"issue":"9","key":"10.1016\/j.bmcl.2020.127262_b0090","doi-asserted-by":"crossref","first-page":"2562","DOI":"10.1158\/1078-0432.CCR-10-0017","article-title":"EphA2 targeted chemotherapy using an antibody drug conjugate in endometrial carcinoma","volume":"16","author":"Lee","year":"2010","journal-title":"Clin Cancer Res."},{"issue":"22","key":"10.1016\/j.bmcl.2020.127262_b0095","doi-asserted-by":"crossref","first-page":"9367","DOI":"10.1158\/0008-5472.CAN-08-1933","article-title":"A human antibody-drug conjugate targeting EphA2 inhibits tumor growth in vivo","volume":"68","author":"Jackson","year":"2008","journal-title":"Cancer Res."},{"issue":"12","key":"10.1016\/j.bmcl.2020.127262_b0100","doi-asserted-by":"crossref","first-page":"2024","DOI":"10.1007\/s00259-007-0503-5","article-title":"Quantitative radioimmunoPET imaging of EphA2 in tumor-bearing mice","volume":"34","author":"Cai","year":"2007","journal-title":"Eur J Nucl Med Mol I."},{"issue":"7","key":"10.1016\/j.bmcl.2020.127262_b0105","doi-asserted-by":"crossref","first-page":"e0180786","DOI":"10.1371\/journal.pone.0180786","article-title":"Engineering of monobody conjugates for human EphA2-specific optical imaging","volume":"12","author":"Kim","year":"2017","journal-title":"PLoS ONE"},{"issue":"7","key":"10.1016\/j.bmcl.2020.127262_b0110","doi-asserted-by":"crossref","first-page":"e0132976","DOI":"10.1371\/journal.pone.0132976","article-title":"Isolation and characterization of a monobody with a fibronectin domain III scaffold that specifically binds EphA2","volume":"10","author":"Park","year":"2015","journal-title":"PLoS ONE"},{"issue":"7","key":"10.1016\/j.bmcl.2020.127262_b0115","doi-asserted-by":"crossref","first-page":"1168","DOI":"10.2967\/jnumed.108.061739","article-title":"Small-animal PET of tumors with (64)Cu-labeled RGD-bombesin heterodimer","volume":"50","author":"Liu","year":"2009","journal-title":"J Nucl Med."},{"issue":"11","key":"10.1016\/j.bmcl.2020.127262_b0120","doi-asserted-by":"crossref","first-page":"1838","DOI":"10.2967\/jnumed.117.192245","article-title":"PET-guided evaluation and optimization of internalized antibody-drug conjugates targeting erythropoietin-producing hepatoma A2 receptor","volume":"58","author":"Jacobson","year":"2017","journal-title":"J Nucl Med."},{"issue":"6","key":"10.1016\/j.bmcl.2020.127262_b0125","doi-asserted-by":"crossref","first-page":"974","DOI":"10.2967\/jnumed.115.169839","article-title":"Molecular imaging and quantitation of EphA2 expression in xenograft models with 89Zr-DS-8895a","volume":"57","author":"Burvenich","year":"2016","journal-title":"J Nucl Med."},{"key":"10.1016\/j.bmcl.2020.127262_b0130","doi-asserted-by":"crossref","first-page":"385","DOI":"10.2310\/7290.2015.00008","article-title":"EphA2 as a diagnostic imaging target in glioblastoma: a positron emission tomography\/magnetic resonance imaging study","volume":"14","author":"Puttick","year":"2015","journal-title":"Mol Imaging."},{"issue":"11","key":"10.1016\/j.bmcl.2020.127262_b0135","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1002\/jlcr.3237","article-title":"Radiofluorination and first radiopharmacological characterization of a SWLAY peptide-based ligand targeting EphA2","volume":"57","author":"Pretze","year":"2014","journal-title":"J Labelled Comp Radiopharm."},{"issue":"4","key":"10.1016\/j.bmcl.2020.127262_b0140","doi-asserted-by":"crossref","first-page":"1325","DOI":"10.3892\/ijo.2016.3369","article-title":"PET imaging of epidermal growth factor receptor expression in tumours using 89Zr-labelled ZEGFR:2377 affibody molecules","volume":"48","author":"Garousi","year":"2016","journal-title":"Int J Oncol."}],"container-title":["Bioorganic &amp; Medicinal Chemistry Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0960894X2030367X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0960894X2030367X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T07:21:01Z","timestamp":1778570461000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0960894X2030367X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,7]]},"references-count":28,"journal-issue":{"issue":"14","published-print":{"date-parts":[[2020,7]]}},"alternative-id":["S0960894X2030367X"],"URL":"https:\/\/doi.org\/10.1016\/j.bmcl.2020.127262","relation":{},"ISSN":["0960-894X"],"issn-type":[{"value":"0960-894X","type":"print"}],"subject":[],"published":{"date-parts":[[2020,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Production of 64Cu-labeled monobody for imaging of human EphA2-expressing tumors","name":"articletitle","label":"Article Title"},{"value":"Bioorganic & Medicinal Chemistry Letters","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bmcl.2020.127262","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"127262"}}