{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T12:21:24Z","timestamp":1790770884003,"version":"4.1.0"},"reference-count":26,"publisher":"Elsevier BV","issue":"16","license":[{"start":{"date-parts":[[2020,8,1]],"date-time":"2020-08-01T00:00:00Z","timestamp":1596240000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,8,1]],"date-time":"2020-08-01T00:00:00Z","timestamp":1596240000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100007325","name":"Kobayashi International Scholarship Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007325","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bioorganic & Medicinal Chemistry Letters"],"published-print":{"date-parts":[[2020,8]]},"DOI":"10.1016\/j.bmcl.2020.127352","type":"journal-article","created":{"date-parts":[[2020,6,18]],"date-time":"2020-06-18T02:40:14Z","timestamp":1592448014000},"page":"127352","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":28,"title":["Chemical constituents of Callistemon citrinus from Egypt and their antiausterity activity against PANC-1 human pancreatic cancer cell line"],"prefix":"10.1016","volume":"30","author":[{"given":"Ahmed M.","family":"Tawila","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sijia","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min Jo","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashraf M.","family":"Omar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dya Fita","family":"Dibwe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun-ya","family":"Ueda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9568-1528","authenticated-orcid":false,"given":"Naoki","family":"Toyooka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5299-193X","authenticated-orcid":false,"given":"Suresh","family":"Awale","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bmcl.2020.127352_b0005","first-page":"394","article-title":"Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"68","author":"Bray","year":"2018","journal-title":"CA: Cancer J Clin"},{"key":"10.1016\/j.bmcl.2020.127352_b0010","first-page":"6201","article-title":"Remarkable tolerance of tumor cells to nutrient deprivation: possible new biochemical target for cancer therapy","volume":"60","author":"Izuishi","year":"2000","journal-title":"Cancer Res"},{"key":"10.1016\/j.bmcl.2020.127352_b0015","doi-asserted-by":"crossref","first-page":"58649","DOI":"10.18632\/oncotarget.10765","article-title":"Angiogenesis in pancreatic ductal adenocarcinoma: A controversial issue","volume":"7","author":"Longo","year":"2016","journal-title":"Oncotarget."},{"key":"10.1016\/j.bmcl.2020.127352_b0020","doi-asserted-by":"crossref","first-page":"1877","DOI":"10.1021\/acs.jnatprod.8b00405","article-title":"Chemical constituents of Thai Citrus hystrix and their antiausterity activity against the PANC-1 human pancreatic cancer cell line","volume":"81","author":"Sun","year":"2018","journal-title":"J Nat Prod."},{"key":"10.1016\/j.bmcl.2020.127352_b0025","doi-asserted-by":"crossref","first-page":"2282","DOI":"10.1021\/acs.jnatprod.8b00733","article-title":"Ancistrolikokine E3, a 5, 8\u2032-coupled naphthylisoquinoline alkaloid, eliminates the tolerance of cancer cells to nutrition starvation by inhibition of the Akt\/mTOR\/autophagy signaling pathway","volume":"81","author":"Awale","year":"2018","journal-title":"J Nat Prod"},{"key":"10.1016\/j.bmcl.2020.127352_b0030","doi-asserted-by":"crossref","first-page":"3133","DOI":"10.1021\/acs.jnatprod.9b00735","article-title":"Chemical constituents of Anneslea fragrans and their antiausterity activity against the PANC-1 human pancreatic cancer cell line","volume":"82","author":"Omar","year":"2019","journal-title":"J Nat Prod"},{"key":"10.1016\/j.bmcl.2020.127352_b0035","first-page":"39","article-title":"(+)-Grandifloracin, an antiausterity agent, induces autophagic PANC-1 pancreatic cancer cell death","volume":"8","author":"Ueda","year":"2013","journal-title":"Drug Des Dev Ther"},{"issue":"3","key":"10.1016\/j.bmcl.2020.127352_b0040","doi-asserted-by":"crossref","first-page":"1751","DOI":"10.1158\/0008-5472.CAN-05-3143","article-title":"Identification of arctigenin as an antitumor agent having the ability to eliminate the tolerance of cancer cells to nutrient starvation","volume":"66","author":"Awale","year":"2006","journal-title":"Cancer Res"},{"key":"10.1016\/j.bmcl.2020.127352_b0045","doi-asserted-by":"crossref","first-page":"597","DOI":"10.2217\/bmm.12.69","article-title":"Early diagnosis of pancreatic cancer: challenges and new developments","volume":"6","author":"Kaur","year":"2012","journal-title":"Biomark Med"},{"key":"10.1016\/j.bmcl.2020.127352_b0050","first-page":"E48","article-title":"Pulmonary metastases in pancreatic cancer, is there a survival influence?","volume":"6","author":"Deeb","year":"2015","journal-title":"J Gastrointest Oncol"},{"key":"10.1016\/j.bmcl.2020.127352_b0055","doi-asserted-by":"crossref","first-page":"1818","DOI":"10.1111\/cas.13086","article-title":"Phase I trial of GBS-01 for advanced pancreatic cancer refractory to gemcitabine","volume":"107","author":"Ikeda","year":"2016","journal-title":"Cancer Sci"},{"key":"10.1016\/j.bmcl.2020.127352_b0060","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.fitote.2015.10.013","article-title":"Alkylphloroglucinol derivatives and triterpenoids with soluble epoxide hydrolase inhibitory activity from Callistemon citrinus","volume":"109","author":"Khanh","year":"2016","journal-title":"Fitoterapia"},{"key":"10.1016\/j.bmcl.2020.127352_b0065","doi-asserted-by":"crossref","first-page":"552","DOI":"10.25135\/rnp.70.17.03.049","article-title":"Chemical and biological investigation of Ochrosia elliptica Labill. cultivated in Egypt","volume":"11","author":"El-shiekh","year":"2017","journal-title":"Rec Nat Prod"},{"key":"10.1016\/j.bmcl.2020.127352_b0070","doi-asserted-by":"crossref","first-page":"259","DOI":"10.4314\/tjpr.v11i2.12","article-title":"Ayo R G Isolation and characterization of lup-20 (29)-ene-3, 28-diol (betulin) from the stem-bark of Adenium obesum (Apocynaceae)","volume":"11","author":"Tijjani","year":"2012","journal-title":"Trop J Pharm Res"},{"key":"10.1016\/j.bmcl.2020.127352_b0075","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1007\/s10600-011-0048-5","article-title":"Synthesis of 3\u03b2-hydroxy-20-oxo-30-norlupan-28-oic (platanic) acid and its glycosides","volume":"47","author":"Denisenko","year":"2011","journal-title":"Chem Nat Compd"},{"key":"10.1016\/j.bmcl.2020.127352_b0080","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1515\/znc-2013-9-1004","article-title":"Chemical constituents and cytotoxic effect of the main compounds of Lythrum salicaria L","volume":"68","author":"Manayi","year":"2013","journal-title":"Z Naturforsch C"},{"key":"10.1016\/j.bmcl.2020.127352_b0085","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1002\/mrc.1214","article-title":"Complete assignments of 1H and 13C NMR resonances of oleanolic acid, 18\u03b1-oleanolic acid, ursolic acid and their 11-oxo derivatives","volume":"41","author":"Seebacher","year":"2003","journal-title":"Magn Reson Chem."},{"key":"10.1016\/j.bmcl.2020.127352_b0090","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1021\/acs.orglett.5b03360","article-title":"Callistrilones A and B, triketone\u2013phloroglucinol\u2013monoterpene hybrids with a new skeleton from Callistemon rigidus","volume":"18","author":"Cao","year":"2016","journal-title":"Org Lett"},{"key":"10.1016\/j.bmcl.2020.127352_b0095","doi-asserted-by":"crossref","DOI":"10.1002\/cbdv.201800172","article-title":"Antiviral triketone-phloroglucinol-monoterpene adducts from Callistemon rigidus","volume":"15","author":"Cao","year":"2018","journal-title":"Chem Biodivers"},{"key":"10.1016\/j.bmcl.2020.127352_b0100","doi-asserted-by":"crossref","first-page":"1506","DOI":"10.1039\/C8QO00130H","article-title":"Asymmetric total syntheses of callistrilones B, G and J","volume":"5","author":"Hu","year":"2018","journal-title":"Org Chem Front"},{"key":"10.1016\/j.bmcl.2020.127352_b0105","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1021\/acs.orglett.7b03815","article-title":"Biomimetic total syntheses of callistrilones A, B, and D","volume":"20","author":"Dethe","year":"2018","journal-title":"Org Lett"},{"key":"10.1016\/j.bmcl.2020.127352_b0110","doi-asserted-by":"crossref","first-page":"2509","DOI":"10.1021\/acs.orglett.8b00238","article-title":"Biomimetic syntheses of callistrilones A-E via an oxidative [3+2] cycloaddition","volume":"20","author":"Guo","year":"2018","journal-title":"Org Lett"},{"key":"10.1016\/j.bmcl.2020.127352_b0115","doi-asserted-by":"crossref","first-page":"1488","DOI":"10.1039\/C7SC04672C","article-title":"Catalytic asymmetric total syntheses of myrtucommuacetalone, myrtucommuacetalone B, and callistrilones A, C, D and E","volume":"9","author":"Cheng","year":"2018","journal-title":"Chem Sci"},{"key":"10.1016\/j.bmcl.2020.127352_b0120","unstructured":"Ye W, Wang L, Cao J, Wang Y. A class of heteroterpene compounds and their application in the preparation of antibacterial drugs. 2017;China Patent No. CN106800546A. Guangzhou Huaxue Intellectual Property Agency Co.,Ltd."},{"key":"10.1016\/j.bmcl.2020.127352_b0125","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1038\/nmeth.2019","article-title":"Fiji: an open-source platform for biological-image analysis","volume":"9","author":"Schindelin","year":"2012","journal-title":"Nat Methods"},{"key":"10.1016\/j.bmcl.2020.127352_b0130","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0092444","article-title":"Colony area: An ImageJ Plugin to automatically quantify colony formation in clonogenic assays","volume":"9","author":"Guzm\u00e1n","year":"2014","journal-title":"PLoS ONE"}],"container-title":["Bioorganic & Medicinal Chemistry Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0960894X20304637?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0960894X20304637?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,18]],"date-time":"2025-10-18T07:38:54Z","timestamp":1760773134000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0960894X20304637"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,8]]},"references-count":26,"journal-issue":{"issue":"16","published-print":{"date-parts":[[2020,8]]}},"alternative-id":["S0960894X20304637"],"URL":"https:\/\/doi.org\/10.1016\/j.bmcl.2020.127352","relation":{},"ISSN":["0960-894X"],"issn-type":[{"value":"0960-894X","type":"print"}],"subject":[],"published":{"date-parts":[[2020,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Chemical constituents of Callistemon citrinus from Egypt and their antiausterity activity against PANC-1 human pancreatic cancer cell line","name":"articletitle","label":"Article Title"},{"value":"Bioorganic & Medicinal Chemistry Letters","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bmcl.2020.127352","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"127352"}}