{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T07:55:02Z","timestamp":1776239702560,"version":"3.50.1"},"reference-count":22,"publisher":"Elsevier BV","issue":"21","license":[{"start":{"date-parts":[[2020,11,1]],"date-time":"2020-11-01T00:00:00Z","timestamp":1604188800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,11,1]],"date-time":"2020-11-01T00:00:00Z","timestamp":1604188800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,12,3]],"date-time":"2020-12-03T00:00:00Z","timestamp":1606953600000},"content-version":"vor","delay-in-days":32,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004828","name":"Grand Challenges Canada","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004828","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008507","name":"California Polytechnic State University, San Luis Obispo","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008507","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bioorganic & Medicinal Chemistry Letters"],"published-print":{"date-parts":[[2020,11]]},"DOI":"10.1016\/j.bmcl.2020.127502","type":"journal-article","created":{"date-parts":[[2020,8,18]],"date-time":"2020-08-18T13:03:46Z","timestamp":1597755826000},"page":"127502","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":18,"title":["Antimalarial activity of tetrahydro-\u03b2-carbolines targeting the ATP binding pocket of the Plasmodium falciparum heat shock 90 protein"],"prefix":"10.1016","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9714-4139","authenticated-orcid":false,"given":"Scott","family":"Eagon","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9463-0526","authenticated-orcid":false,"given":"Jared T.","family":"Hammill","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jordan","family":"Bach","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nikalet","family":"Everson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tyler A.","family":"Sisley","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael J.","family":"Walls","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sierra","family":"Durham","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dylan R.","family":"Pillai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mofolusho O.","family":"Falade","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amy L.","family":"Rice","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joshua J.","family":"Kimball","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Horacio","family":"Lazaro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Celine","family":"DiBernardo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Kiplin Guy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.bmcl.2020.127502_b0005","unstructured":"World Malaria Report 2019. World Health Organization; Geneva, Switzerland. 2019. https:\/\/www.who.int\/publications-detail\/world-malaria-report-2019."},{"key":"10.1016\/j.bmcl.2020.127502_b0010","doi-asserted-by":"crossref","first-page":"62901","DOI":"10.1371\/journal.pone.0062906","article-title":"The open access malaria box: a drug discovery catalyst for neglected diseases","volume":"8","author":"Spangenberg","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.bmcl.2020.127502_b0015","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1111\/joim.12223","article-title":"The path of malaria vaccine development: challenges and perspectives","volume":"275","author":"Arama","year":"2014","journal-title":"J Intern Med"},{"key":"10.1016\/j.bmcl.2020.127502_h0020","doi-asserted-by":"crossref","first-page":"17050","DOI":"10.1038\/nrdp.2017.50","volume":"3","author":"Phillips","year":"2017","journal-title":"Malaria Nat Rev Dis Prim"},{"key":"10.1016\/j.bmcl.2020.127502_h0025","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1017\/S0031182013000826","article-title":"Antimalarial Drug Discovery \u2013 the Path towards Eradication","volume":"141","author":"Durrows","year":"2014","journal-title":"Parasitology"},{"key":"10.1016\/j.bmcl.2020.127502_h0030","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1038\/nrmicro3138","article-title":"Antimalarial Drug Discovery: Approaches and Progress toward New Medicines","volume":"11","author":"Flannery","year":"2013","journal-title":"Nat Rev Microbiol"},{"key":"10.1016\/j.bmcl.2020.127502_h0035","doi-asserted-by":"crossref","first-page":"1126","DOI":"10.1021\/ml4004414","article-title":"Antimalarial drug discovery: from quinine to the dream of eradication","volume":"4","author":"Renslo","year":"2013","journal-title":"ACS Med Chem Lett"},{"key":"10.1016\/j.bmcl.2020.127502_h0040","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1056\/NEJMoa0808859","article-title":"Artemisinin resistance in plasmodium falciparum malaria","volume":"361","author":"Dondorp","year":"2009","journal-title":"N Engl J Med"},{"key":"10.1016\/j.bmcl.2020.127502_h0045","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1038\/nrmicro.2017.161","article-title":"Drug resistance in plasmodium","volume":"16","author":"Haldar","year":"2018","journal-title":"Nat Rev Micro"},{"key":"10.1016\/j.bmcl.2020.127502_b0030","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.ddtec.2014.03.002","article-title":"Antimalarial drug resistance: new treatment options for Plasmodium","volume":"11","author":"Gamo","year":"2014","journal-title":"Drug Dis Today: Technol"},{"key":"10.1016\/j.bmcl.2020.127502_b0035","doi-asserted-by":"crossref","first-page":"2753","DOI":"10.2174\/1568026616666160413141911","article-title":"Heat Shock Protein (HSP) Drug Discovery and Development: Targeting Heat Shock Proteins in Disease","volume":"16","author":"Shrestha","year":"2016","journal-title":"Curr Top Med Chem"},{"key":"10.1016\/j.bmcl.2020.127502_b0040","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/0378-1119(94)90661-0","article-title":"Sequence, Transcript Characterization and Polymorphisms of a Plasmodium falciparum Gene Belonging to the Heat-Shock Protein (Hsp) 90 Family","volume":"151","author":"Su","year":"1994","journal-title":"Gene"},{"key":"10.1016\/j.bmcl.2020.127502_b0045","doi-asserted-by":"crossref","first-page":"3552","DOI":"10.1021\/jm901796s","article-title":"A Repurposing Strategy Identifies Novel Synergistic inhibitors of Plasmodium falciparum Heat Shock Protein 90","volume":"53","author":"Shahinas","year":"2010","journal-title":"J Med Chem"},{"key":"10.1016\/j.bmcl.2020.127502_b0050","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1016\/j.coph.2008.06.015","article-title":"Targeting Hsp90: Small-Molecule Inhibitors and their Clinical Development","volume":"8","author":"Taldone","year":"2008","journal-title":"Curr Opin Phamacol"},{"key":"10.1016\/j.bmcl.2020.127502_b0055","doi-asserted-by":"crossref","first-page":"4207","DOI":"10.1128\/AAC.00328-12","article-title":"Harmine is a Potent Antimalarial Targeting Hsp90 and Synergizes with Chloroquine and Artemisinin","volume":"56","author":"Shahinas","year":"2012","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.bmcl.2020.127502_b0060","doi-asserted-by":"crossref","first-page":"1653","DOI":"10.1002\/ejoc.201301580","article-title":"Microwave-Assisted Synthesis of Tetrahydro-\u03b2-carbolines and \u03b2-Carbolines","volume":"8","author":"Eagon","year":"2014","journal-title":"Eur J Org Chem"},{"key":"10.1016\/j.bmcl.2020.127502_b0065","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1186\/s12936-016-1625-7","article-title":"In Vitro and in Vivo Anti-malarial Activity of Novel Harmine-Analog Heat Shock Protein 90 Inhibitors: A Possible Partner for Artemisinin","volume":"15","author":"Bayih","year":"2016","journal-title":"Malar J"},{"key":"10.1016\/j.bmcl.2020.127502_b0070","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1002\/jcc.21334","article-title":"AutoDock Vina: Improving the Speed and Accuracy of Docking with a New Scoring Function, Efficient Optimization, and Multithreading","volume":"31","author":"Trott","year":"2010","journal-title":"J Comput Chem"},{"key":"10.1016\/j.bmcl.2020.127502_b0075","first-page":"115","article-title":"iDock: A Multithreaded Virtual Screening Tool for Flexible Ligand Docking","volume":"34","author":"Li","year":"2015","journal-title":"CIBCB"},{"key":"10.1016\/j.bmcl.2020.127502_b0080","doi-asserted-by":"crossref","DOI":"10.1016\/j.jmgm.2020.107532","article-title":"Evaulation of Consensus Scoring Methods for AutoDock Vina, Smina and iDock","volume":"96","author":"Masters","year":"2020","journal-title":"J Mol Graph Model"},{"key":"10.1016\/j.bmcl.2020.127502_h0105","doi-asserted-by":"crossref","first-page":"2747","DOI":"10.1016\/j.tetlet.2017.05.098","article-title":"Synthesis of \u03b2-Carbolines via a Silver-Mediated Oxidation of Tetrahydro-\u03b2-carbolines","volume":"58","author":"Durham","year":"2017","journal-title":"Tetrahedron Lett"},{"key":"10.1016\/j.bmcl.2020.127502_h0110","doi-asserted-by":"crossref","first-page":"3428","DOI":"10.1039\/c3ob40661j","article-title":"Tandem Iodine-Mediated Oxidations of Tetrahydro-\u03b2-carbolines: Total Synthesis of Eudistomins Y1\u2013Y7","volume":"11","author":"Panarese","year":"2013","journal-title":"Org Biomol Chem"}],"container-title":["Bioorganic & Medicinal Chemistry Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0960894X20306132?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0960894X20306132?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,18]],"date-time":"2025-10-18T07:35:43Z","timestamp":1760772943000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0960894X20306132"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,11]]},"references-count":22,"journal-issue":{"issue":"21","published-print":{"date-parts":[[2020,11]]}},"alternative-id":["S0960894X20306132"],"URL":"https:\/\/doi.org\/10.1016\/j.bmcl.2020.127502","relation":{},"ISSN":["0960-894X"],"issn-type":[{"value":"0960-894X","type":"print"}],"subject":[],"published":{"date-parts":[[2020,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Antimalarial activity of tetrahydro-\u03b2-carbolines targeting the ATP binding pocket of the Plasmodium falciparum heat shock 90 protein","name":"articletitle","label":"Article Title"},{"value":"Bioorganic & Medicinal Chemistry Letters","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bmcl.2020.127502","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 The Authors. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"127502"}}