{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T07:12:28Z","timestamp":1777360348797,"version":"3.51.4"},"reference-count":14,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bioorganic &amp; Medicinal Chemistry Letters"],"published-print":{"date-parts":[[2021,1]]},"DOI":"10.1016\/j.bmcl.2020.127669","type":"journal-article","created":{"date-parts":[[2020,11,7]],"date-time":"2020-11-07T11:11:21Z","timestamp":1604747481000},"page":"127669","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"special_numbering":"C","title":["Discovery and SAR studies of 2-alkyl-3-phenyl-2,4,5,6,7,8-hexahydropyrazolo[3,4-d]azepines as 5-HT7\/2 inhibitors leading to the identification of a clinical candidate"],"prefix":"10.1016","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2567-9841","authenticated-orcid":false,"given":"Curt A.","family":"Dvorak","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dale A.","family":"Rudolph","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Diane","family":"Nepomuceno","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lisa","family":"Dvorak","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brian","family":"Lord","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ian","family":"Fraser","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pascal","family":"Bonaventure","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Timothy","family":"Lovenberg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicholas I.","family":"Carruthers","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.bmcl.2020.127669_b0005","doi-asserted-by":"crossref","unstructured":"(a) Hoyer, D. and Martin, G. R., Classification and nomenclature of 5-HT receptors: a comment on current issues. Behav Brain Res. 73, 263-268. (b) Hoyer, D., Hannon, J. P. and Martin, G. R., 2002. Molecular, pharmacological and functional diversity of 5-HT receptors. Pharmacol Biochem Behav. 1996. 71, 533-554.","DOI":"10.1016\/S0091-3057(01)00746-8"},{"issue":"1","key":"10.1016\/j.bmcl.2020.127669_b0010","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1016\/S0165-6147(97)01143-7","article-title":"The structure and signalling properties of 5-HT receptors: an endless diversity?","volume":"19","author":"Martin","year":"1998","journal-title":"Trends Pharmacol Sci"},{"key":"#cr-split#-10.1016\/j.bmcl.2020.127669_b0015.1","doi-asserted-by":"crossref","unstructured":"(a) Stahl SM, The serotonin-7 receptor as a novel therapeutic target. J Clin Psychiatry 2010, 71, 1414-1415","DOI":"10.4088\/JCP.10bs06601gry"},{"key":"#cr-split#-10.1016\/j.bmcl.2020.127669_b0015.2","doi-asserted-by":"crossref","unstructured":"(b) Leopoldo M, Lacivita E, Berardi F, Perrone R, Hedlund PB. Serotonin 5-HT7 receptor agents: Structure-activity relationships and potential therapeutic applications in central nervous system disorders. Pharmacol Ther. 2011, 129, 120-148","DOI":"10.1016\/j.pharmthera.2010.08.013"},{"key":"#cr-split#-10.1016\/j.bmcl.2020.127669_b0015.3","doi-asserted-by":"crossref","unstructured":"(c) Matthys A, Haegeman G, Van Craenenbroeck K, Vanhoenacker P. Role of the 5-HT7 receptor in the central nervous system: from current status to future perspectives. Mol Neurobiol. 2011, 43, 228-253.","DOI":"10.1007\/s12035-011-8175-3"},{"key":"10.1016\/j.bmcl.2020.127669_b0020","doi-asserted-by":"crossref","unstructured":"Lovell, Peter J.; Bromidge, Steven M.; Dabbs, Steven; Duckworth, D. Malcolm; Forbes, Ian T.; Jennings, Andrew J.; King, Frank D.; Middlemiss, Derek N.; Rahman, Shirley K.; Saunders, Damian V.; Collin, Lissa L.; Hagan, Jim J.; Riley, Graham J.; Thomas, David R. J. Med. Chem. 2000, 43, 342-345.","DOI":"10.1021\/jm991151j"},{"issue":"2","key":"10.1016\/j.bmcl.2020.127669_b0025","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1124\/jpet.112.193995","volume":"342","author":"Bonaventure","year":"2012","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1016\/j.bmcl.2020.127669_b0030","doi-asserted-by":"crossref","first-page":"4188","DOI":"10.1021\/jo0477897","article-title":"Palladium-catalyzed coupling of pyrazole triflates with arylboronic acids","volume":"70","author":"Dvorak","year":"2005","journal-title":"J Org Chem"},{"key":"10.1016\/j.bmcl.2020.127669_b0035","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/S0163-7258(98)00019-9","article-title":"5-Hydroxytryptamine 2-family receptors (5-hydroxytryptamine2A, 5-hydroxytryptamine2B, 5-hydroxytryptamine2C): where structure meets function","volume":"79","author":"Roth","year":"1998","journal-title":"Pharmacol Ther"},{"key":"10.1016\/j.bmcl.2020.127669_h0040","doi-asserted-by":"crossref","first-page":"1375","DOI":"10.1073\/pnas.0337340100","volume":"100","author":"Hedlund","year":"2003","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.bmcl.2020.127669_h0045","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1016\/S0028-3908(03)00117-5","volume":"44","author":"Guscott","year":"2003","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.bmcl.2020.127669_b0045","doi-asserted-by":"crossref","first-page":"8836","DOI":"10.1523\/JNEUROSCI.23-26-08836.2003","volume":"23","author":"Gonzalez-Maeso","year":"2003","journal-title":"J Neurosci"},{"key":"10.1016\/j.bmcl.2020.127669_b0050","doi-asserted-by":"crossref","first-page":"876","DOI":"10.1021\/op2001194","volume":"15","author":"Liang","year":"2011","journal-title":"Org Process Res Dev"},{"key":"10.1016\/j.bmcl.2020.127669_b0055","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1007\/BF02245606","article-title":"Risperidone compared with new and reference antipsychotic drugs: in vitro and in vivo receptor binding","volume":"124","author":"Schotte","year":"1996","journal-title":"Psychopharmacology"}],"container-title":["Bioorganic &amp; Medicinal Chemistry Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0960894X20307800?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0960894X20307800?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,18]],"date-time":"2025-10-18T07:38:56Z","timestamp":1760773136000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0960894X20307800"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1]]},"references-count":14,"alternative-id":["S0960894X20307800"],"URL":"https:\/\/doi.org\/10.1016\/j.bmcl.2020.127669","relation":{},"ISSN":["0960-894X"],"issn-type":[{"value":"0960-894X","type":"print"}],"subject":[],"published":{"date-parts":[[2021,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Discovery and SAR studies of 2-alkyl-3-phenyl-2,4,5,6,7,8-hexahydropyrazolo[3,4-d]azepines as 5-HT7\/2 inhibitors leading to the identification of a clinical candidate","name":"articletitle","label":"Article Title"},{"value":"Bioorganic & Medicinal Chemistry Letters","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bmcl.2020.127669","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"127669"}}