{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T10:38:20Z","timestamp":1790678300185,"version":"4.1.0"},"reference-count":14,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,2,1]],"date-time":"2021-02-01T00:00:00Z","timestamp":1612137600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,2,1]],"date-time":"2021-02-01T00:00:00Z","timestamp":1612137600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bioorganic & Medicinal Chemistry Letters"],"published-print":{"date-parts":[[2021,2]]},"DOI":"10.1016\/j.bmcl.2020.127753","type":"journal-article","created":{"date-parts":[[2020,12,28]],"date-time":"2020-12-28T13:11:14Z","timestamp":1609161074000},"page":"127753","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":16,"special_numbering":"C","title":["N-(6-phenylpyridazin-3-yl)benzenesulfonamides as highly potent, brain-permeable, and orally active kynurenine monooxygenase inhibitors"],"prefix":"10.1016","volume":"33","author":[{"given":"Hidenori","family":"Kimura","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hitoshi","family":"Suda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Momoe","family":"Kassai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mika","family":"Endo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoko","family":"Deai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masahiro","family":"Yahata","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5514-3434","authenticated-orcid":false,"given":"Mari","family":"Miyajima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshiaki","family":"Isobe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bmcl.2020.127753_b0005","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/j.semcdb.2015.03.002","volume":"40","author":"Maddison","year":"2015","journal-title":"Seminars in Cell & Development Biology."},{"key":"10.1016\/j.bmcl.2020.127753_b0010","first-page":"1","volume":"2","author":"Chen","year":"2009","journal-title":"Int J Trp Res."},{"key":"10.1016\/j.bmcl.2020.127753_b0015","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1007\/s00406-012-0384-x","volume":"263","author":"Schwarz","year":"2013","journal-title":"Eur Arch Psychiatry Clin Neurosci."},{"key":"10.1016\/j.bmcl.2020.127753_b0020","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1038\/s42003-019-0520-5","volume":"2","author":"Zhang","year":"2019","journal-title":"Communications Biology."},{"key":"10.1016\/j.bmcl.2020.127753_b0025","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fmolb.2019.00003","volume":"6","author":"Phillips","year":"2019","journal-title":"Frontiers in Molecular Biosciences."},{"key":"10.1016\/j.bmcl.2020.127753_b0030","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1016\/j.cell.2011.05.020","volume":"145","author":"Zwilling","year":"2011","journal-title":"Cell"},{"key":"10.1016\/j.bmcl.2020.127753_b0035","doi-asserted-by":"crossref","first-page":"2297","DOI":"10.1124\/dmd.112.046532","volume":"40","author":"Beconi","year":"2012","journal-title":"Drug Metab Dispos"},{"key":"10.1016\/j.bmcl.2020.127753_b0040","doi-asserted-by":"crossref","first-page":"4378","DOI":"10.1021\/jm970467t","volume":"40","author":"Rover","year":"1997","journal-title":"J Med Chem."},{"key":"10.1016\/j.bmcl.2020.127753_b0045","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.expneurol.2016.05.005","volume":"282","author":"Beaumont","year":"2016","journal-title":"Exp Neurol"},{"key":"10.1016\/j.bmcl.2020.127753_b0050","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1016\/S0092-8674(00)81369-0","volume":"87","author":"Mangiarini","year":"1996","journal-title":"Cell"},{"key":"10.1016\/j.bmcl.2020.127753_b0055","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1002\/cne.20680","volume":"490","author":"Stack","year":"2005","journal-title":"J Comp Neurol."},{"key":"10.1016\/j.bmcl.2020.127753_b0060","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1016\/j.nbd.2006.02.011","volume":"23","author":"Guidetti","year":"2006","journal-title":"Neurobiol Dis."},{"key":"10.1016\/j.bmcl.2020.127753_b0065","doi-asserted-by":"crossref","first-page":"1416","DOI":"10.1111\/j.1471-4159.2010.06675.x","volume":"113","author":"Sathyasaikumar","year":"2010","journal-title":"J. Neurochem."},{"key":"10.1016\/j.bmcl.2020.127753_b0070","doi-asserted-by":"crossref","first-page":"36554","DOI":"10.1074\/jbc.M113.503813","volume":"288","author":"Giorgini","year":"2013","journal-title":"J Biol Chem."}],"container-title":["Bioorganic & Medicinal Chemistry Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0960894X20308647?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0960894X20308647?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,18]],"date-time":"2025-10-18T07:38:20Z","timestamp":1760773100000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0960894X20308647"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,2]]},"references-count":14,"alternative-id":["S0960894X20308647"],"URL":"https:\/\/doi.org\/10.1016\/j.bmcl.2020.127753","relation":{},"ISSN":["0960-894X"],"issn-type":[{"value":"0960-894X","type":"print"}],"subject":[],"published":{"date-parts":[[2021,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"N-(6-phenylpyridazin-3-yl)benzenesulfonamides as highly potent, brain-permeable, and orally active kynurenine monooxygenase inhibitors","name":"articletitle","label":"Article Title"},{"value":"Bioorganic & Medicinal Chemistry Letters","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bmcl.2020.127753","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"127753"}}