{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T03:20:20Z","timestamp":1778728820717,"version":"3.51.4"},"reference-count":38,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T00:00:00Z","timestamp":1617235200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T00:00:00Z","timestamp":1617235200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,11,11]],"date-time":"2021-11-11T00:00:00Z","timestamp":1636588800000},"content-version":"vor","delay-in-days":224,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100014440","name":"Espa\u00f1a Ministerio de Ciencia Innovaci\u00f3n y Universidades","doi-asserted-by":"publisher","award":["RTI2018-093940-BI00"],"award-info":[{"award-number":["RTI2018-093940-BI00"]}],"id":[{"id":"10.13039\/100014440","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002911","name":"Universidad Complutense de Madrid","doi-asserted-by":"publisher","award":["911120"],"award-info":[{"award-number":["911120"]}],"id":[{"id":"10.13039\/501100002911","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bioorganic & Medicinal Chemistry Letters"],"published-print":{"date-parts":[[2021,4]]},"DOI":"10.1016\/j.bmcl.2021.127843","type":"journal-article","created":{"date-parts":[[2021,2,5]],"date-time":"2021-02-05T21:45:01Z","timestamp":1612561501000},"page":"127843","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":8,"special_numbering":"C","title":["Promising hit compounds against resistant trichomoniasis: Synthesis and antiparasitic activity of 3-(\u03c9-aminoalkoxy)-1-benzyl-5-nitroindazoles"],"prefix":"10.1016","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8687-1100","authenticated-orcid":false,"given":"Alexandra","family":"Ib\u00e1\u00f1ez-Escribano","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Felipe","family":"Reviriego","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nerea","family":"Vela","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cristina","family":"Fonseca-Berzal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan Jos\u00e9","family":"Nogal-Ruiz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vicente J.","family":"Ar\u00e1n","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9 Antonio","family":"Escario","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alicia","family":"G\u00f3mez-Barrio","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.bmcl.2021.127843_b0005","doi-asserted-by":"crossref","first-page":"1720","DOI":"10.1377\/hlthaff.28.6.1720","volume":"28","author":"Hotez","year":"2009","journal-title":"Health Aff"},{"key":"10.1016\/j.bmcl.2021.127843_b0010","volume":"14","author":"Hotez","year":"2020","journal-title":"PLoS Negl. Trop. Dis."},{"key":"10.1016\/j.bmcl.2021.127843_b0015","unstructured":"WHO, Integrating neglected tropical diseases into global health and development: fourth WHO report on neglected tropical diseases, World Health Organization, Geneva, Switzerland, 2017."},{"key":"10.1016\/j.bmcl.2021.127843_b0020","unstructured":"WHO, Global incidence and prevalence of selected curable sexually transmitted infections-2008, World Health Organization, Geneva, Switzerland, 2012."},{"key":"10.1016\/j.bmcl.2021.127843_b0025","doi-asserted-by":"crossref","first-page":"548","DOI":"10.2471\/BLT.18.228486","volume":"97","author":"Rowley","year":"2019","journal-title":"Bull World Health Organ"},{"key":"10.1016\/j.bmcl.2021.127843_b0030","doi-asserted-by":"crossref","first-page":"698","DOI":"10.1086\/511278","volume":"195","author":"McClelland","year":"2007","journal-title":"J Infect Dis"},{"key":"10.1016\/j.bmcl.2021.127843_b0035","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1086\/526496","volume":"197","author":"Van Der Pol","year":"2008","journal-title":"J Infect Dis"},{"key":"10.1016\/j.bmcl.2021.127843_b0040","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/S0140-6736(05)78181-2","volume":"351","author":"Sorvillo","year":"1998","journal-title":"Lancet"},{"key":"10.1016\/j.bmcl.2021.127843_b0045","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1080\/028418600431003","volume":"39","author":"Viikki","year":"2000","journal-title":"Acta Oncol"},{"key":"10.1016\/j.bmcl.2021.127843_b0050","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1016\/j.ejogrb.2018.06.031","volume":"228","author":"Yang","year":"2018","journal-title":"Eur J Obstet Gynecol Reprod Biol"},{"key":"10.1016\/j.bmcl.2021.127843_b0055","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1002801","volume":"8","author":"Sutcliffe","year":"2012","journal-title":"PLoS Pathog"},{"key":"10.1016\/j.bmcl.2021.127843_b0060","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1186\/s12879-015-1055-0","volume":"15","author":"Kissinger","year":"2015","journal-title":"BMC Infect Dis"},{"key":"10.1016\/j.bmcl.2021.127843_b0065","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1086\/509934","volume":"44","author":"Van Der Pol","year":"2007","journal-title":"Clin Infect Dis"},{"issue":"suppl. 8","key":"10.1016\/j.bmcl.2021.127843_b0070","doi-asserted-by":"crossref","first-page":"S837","DOI":"10.1093\/cid\/civ738","volume":"61","author":"Meites","year":"2015","journal-title":"Clin Infect Dis"},{"issue":"370","key":"10.1016\/j.bmcl.2021.127843_b0075","first-page":"e1","volume":"198","author":"Helms","year":"2008","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.bmcl.2021.127843_b0080","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1177\/0956462414525947","volume":"25","author":"Sherrard","year":"2014","journal-title":"Int J STD AIDS"},{"key":"10.1016\/j.bmcl.2021.127843_b0085","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1016\/j.ejmech.2017.11.029","volume":"143","author":"Bala","year":"2018","journal-title":"Eur J Med Chem"},{"key":"10.1016\/j.bmcl.2021.127843_b0090","first-page":"3197","volume":"13","author":"Ar\u00e1n","year":"2005","journal-title":"Med Chem"},{"key":"10.1016\/j.bmcl.2021.127843_b0095","doi-asserted-by":"crossref","first-page":"245","DOI":"10.2174\/157016305775202955","volume":"2","author":"Marrero-Ponce","year":"2005","journal-title":"Curr Drug Discov Technol"},{"key":"10.1016\/j.bmcl.2021.127843_b0100","doi-asserted-by":"crossref","first-page":"6502","DOI":"10.1016\/j.bmc.2006.06.016","volume":"14","author":"Marrero-Ponce","year":"2006","journal-title":"J. Bioorg. Med. Chem."},{"key":"10.1016\/j.bmcl.2021.127843_b0105","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1017\/S0031182015001419","volume":"143","author":"Ib\u00e1\u00f1ez-Escribano","year":"2016","journal-title":"Parasitology"},{"key":"10.1016\/j.bmcl.2021.127843_b0110","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1016\/j.ejmech.2016.03.036","volume":"115","author":"Fonseca-Berzal","year":"2016","journal-title":"Eur J Med Chem"},{"key":"10.1016\/j.bmcl.2021.127843_b0115","doi-asserted-by":"crossref","first-page":"1246","DOI":"10.1002\/cmdc.201800084","volume":"13","author":"Fonseca-Berzal","year":"2018","journal-title":"ChemMedChem"},{"key":"10.1016\/j.bmcl.2021.127843_b0120","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1021\/jm00319a009","volume":"9","author":"Palazzo","year":"1966","journal-title":"J Med Chem"},{"key":"10.1016\/j.bmcl.2021.127843_b0125","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1002\/jlac.199619960507","author":"Ar\u00e1n","year":"1996","journal-title":"Liebigs Ann"},{"key":"10.1016\/j.bmcl.2021.127843_b0130","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1055\/s-1978-24840","volume":"9","author":"Baiocchi","year":"1978","journal-title":"Synthesis"},{"key":"10.1016\/j.bmcl.2021.127843_b0135","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1016\/j.ejmech.2012.10.009","volume":"58","author":"Vega","year":"2012","journal-title":"Eur J Med Chem"},{"key":"10.1016\/j.bmcl.2021.127843_b0140","doi-asserted-by":"crossref","first-page":"3572","DOI":"10.1139\/v70-598","volume":"48","author":"Wolfe","year":"1970","journal-title":"Can J Chem"},{"key":"10.1016\/j.bmcl.2021.127843_b0145","unstructured":"Price, B. J.; Clitherow, J. W.; Bradshaw, J.; Martin-Smith, M. (Allen & Hanburys Ltd., London, England), German Pat. DE 2821410 A1, 1978."},{"key":"10.1016\/j.bmcl.2021.127843_b0150","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1590\/S0074-02762012000500010","volume":"107","author":"Ib\u00e1\u00f1ez Escribano","year":"2012","journal-title":"Mem Inst Oswaldo Cruz"},{"key":"10.1016\/j.bmcl.2021.127843_b0155","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/j.mimet.2014.07.031","volume":"105","author":"Ib\u00e1\u00f1ez-Escribano","year":"2014","journal-title":"J Microbiol Methods"},{"key":"10.1016\/j.bmcl.2021.127843_b0160","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/S0169-409X(96)00423-1","volume":"23","author":"Lipinski","year":"1997","journal-title":"Adv Drug Deliv Rev"},{"key":"10.1016\/j.bmcl.2021.127843_b0165","doi-asserted-by":"crossref","first-page":"2615","DOI":"10.1021\/jm020017n","volume":"45","author":"Veber","year":"2002","journal-title":"J Med Chem"},{"key":"10.1016\/j.bmcl.2021.127843_b0170","doi-asserted-by":"crossref","first-page":"S7","DOI":"10.1186\/1471-2202-9-S3-S7","volume":"9","author":"Hefti","year":"2008","journal-title":"BMC Neurosci."},{"key":"10.1016\/j.bmcl.2021.127843_b0175","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1038\/nrd1824","volume":"4","author":"Pink","year":"2005","journal-title":"Nat Rev Drug Discov"},{"key":"10.1016\/j.bmcl.2021.127843_b0180","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1128\/iai.53.2.285-293.1986","volume":"53","author":"Alderete","year":"1986","journal-title":"Infect Immun"},{"key":"10.1016\/j.bmcl.2021.127843_b0185","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1590\/S0074-02762002000600026","volume":"97","author":"G\u00f3mez-Barrio","year":"2002","journal-title":"Mem Inst Oswaldo Cruz"},{"key":"10.1016\/j.bmcl.2021.127843_b0190","doi-asserted-by":"crossref","DOI":"10.1016\/j.meegid.2020.104318","volume":"82","author":"Squire","year":"2020","journal-title":"Infect Genet Evol"}],"container-title":["Bioorganic & Medicinal Chemistry Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0960894X2100069X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0960894X2100069X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T16:20:44Z","timestamp":1778084444000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0960894X2100069X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,4]]},"references-count":38,"alternative-id":["S0960894X2100069X"],"URL":"https:\/\/doi.org\/10.1016\/j.bmcl.2021.127843","relation":{},"ISSN":["0960-894X"],"issn-type":[{"value":"0960-894X","type":"print"}],"subject":[],"published":{"date-parts":[[2021,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Promising hit compounds against resistant trichomoniasis: Synthesis and antiparasitic activity of 3-(\u03c9-aminoalkoxy)-1-benzyl-5-nitroindazoles","name":"articletitle","label":"Article Title"},{"value":"Bioorganic & Medicinal Chemistry Letters","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bmcl.2021.127843","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 The Authors. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"127843"}}