{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T00:19:05Z","timestamp":1760833145547,"version":"build-2065373602"},"reference-count":19,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T00:00:00Z","timestamp":1617235200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T00:00:00Z","timestamp":1617235200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,2,18]],"date-time":"2022-02-18T00:00:00Z","timestamp":1645142400000},"content-version":"am","delay-in-days":323,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T00:00:00Z","timestamp":1617235200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T00:00:00Z","timestamp":1617235200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T00:00:00Z","timestamp":1617235200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T00:00:00Z","timestamp":1617235200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T00:00:00Z","timestamp":1617235200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bioorganic &amp; Medicinal Chemistry Letters"],"published-print":{"date-parts":[[2021,4]]},"DOI":"10.1016\/j.bmcl.2021.127858","type":"journal-article","created":{"date-parts":[[2021,2,19]],"date-time":"2021-02-19T08:11:13Z","timestamp":1613722273000},"page":"127858","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":9,"special_numbering":"C","title":["Novel bicyclic pyrazoles as potent ALK2 (R206H) inhibitors for the treatment of fibrodysplasia ossificans progressiva"],"prefix":"10.1016","volume":"38","author":[{"given":"Hirofumi","family":"Yamamoto","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naoki","family":"Sakai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5153-2176","authenticated-orcid":false,"given":"Satoshi","family":"Ohte","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomohiro","family":"Sato","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6310-6935","authenticated-orcid":false,"given":"Katsuhiko","family":"Sekimata","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takehisa","family":"Matsumoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kana","family":"Nakamura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hisami","family":"Watanabe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chiemi","family":"Mishima-Tsumagari","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akiko","family":"Tanaka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshinobu","family":"Hashizume","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Teruki","family":"Honma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9304-2098","authenticated-orcid":false,"given":"Takenobu","family":"Katagiri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kohei","family":"Miyazono","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroshi","family":"Tomoda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mikako","family":"Shirouzu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroo","family":"Koyama","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.bmcl.2021.127858_b0005","first-page":"437","volume":"10","author":"Pignolo","year":"2013","journal-title":"Pediatr Endocrinol Rev"},{"key":"10.1016\/j.bmcl.2021.127858_b0010","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1248\/cpb.c19-00882","volume":"68","author":"Sekimata","year":"2020","journal-title":"Chem Pharm Bull"},{"key":"10.1016\/j.bmcl.2021.127858_b0015","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1038\/ng.2925","volume":"46","author":"Taylor","year":"2014","journal-title":"Nat Genet"},{"key":"10.1016\/j.bmcl.2021.127858_b0020","doi-asserted-by":"crossref","first-page":"1363","DOI":"10.1038\/nm.1888","volume":"14","author":"Yu","year":"2008","journal-title":"Nat Med"},{"key":"10.1016\/j.bmcl.2021.127858_b0025","doi-asserted-by":"crossref","first-page":"1291","DOI":"10.1021\/cb300655w","volume":"8","author":"Mohedas","year":"2013","journal-title":"ACS Chem Biol"},{"key":"10.1016\/j.bmcl.2021.127858_b0030","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.1038\/s41467-019-08823-9","volume":"10","author":"Hoeman","year":"2019","journal-title":"Nat Commun"},{"key":"10.1016\/j.bmcl.2021.127858_b0035","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1038\/s42003-019-0420-8","volume":"2","author":"Carvalho","year":"2019","journal-title":"Commun Biol"},{"key":"10.1016\/j.bmcl.2021.127858_b0040","unstructured":"A Phase 1, randomized, double-blind, placebo-controlled, single and multiple ascending dose and food effect study to evaluate the safety, tolerability, and pharmacokinetics of BLU-782 when administered orally to healthy adult subjects. Available at: <https:\/\/clinicaltrials.gov\/ct2\/show\/NCT03858075?term=BLU-782&draw=2&rank=1> [Last accessed Jan 24, 2021]."},{"key":"10.1016\/j.bmcl.2021.127858_b0045","unstructured":"Saracatinib trial TO prevent FOP. Available at: <https:\/\/clinicaltrials.gov\/ct2\/show\/NCT04307953?term=AZD0530&draw=2&rank=2> [Last accessed Jan 24, 2021]."},{"key":"10.1016\/j.bmcl.2021.127858_b0050","unstructured":"Randomized, double-blind, placebo-controlled, single and multiple ascending dose study to evaluate the safety, tolerability and pharmacokinetics of KER-047 administered to healthy male volunteers and postmenopausal female volunteers. Available at: <https:\/\/www.anzctr.org.au\/Trial\/Registration\/TrialReview.aspx?id=376969> [Last accessed Jan 24, 2021]."},{"key":"10.1016\/j.bmcl.2021.127858_b0055","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1248\/cpb.c18-00598","volume":"67","author":"Sekimata","year":"2019","journal-title":"Chem Pharm Bull"},{"key":"10.1016\/j.bmcl.2021.127858_b0060","doi-asserted-by":"crossref","first-page":"11411","DOI":"10.1021\/acsomega.9b04245","volume":"5","author":"Sato","year":"2020","journal-title":"ASC Omega"},{"key":"10.1016\/j.bmcl.2021.127858_b0065","doi-asserted-by":"crossref","first-page":"1755","DOI":"10.1083\/jcb.127.6.1755","volume":"127","author":"Katagiri","year":"1994","journal-title":"J Cell Biol"},{"key":"10.1016\/j.bmcl.2021.127858_b0070","unstructured":"GLIDE. Schr\u00f6dinger Inc., New York, NY, USA, http:\/\/www.schrodinger.com\/."},{"key":"10.1016\/j.bmcl.2021.127858_b0075","doi-asserted-by":"crossref","first-page":"7149","DOI":"10.1074\/jbc.M801681200","volume":"284","author":"Fukuda","year":"2009","journal-title":"J Biol Chem"},{"key":"10.1016\/j.bmcl.2021.127858_b0080","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1038\/s41429-020-0316-3","volume":"73","author":"Ohte","year":"2020","journal-title":"J Antibiot"},{"key":"10.1016\/j.bmcl.2021.127858_b0085","unstructured":"Eickmeier C, Fuchs K, Peters S, et al. WO 2006\/103038; 2006."},{"key":"10.1016\/j.bmcl.2021.127858_b0090","unstructured":"Sawyer JS, Beight DW, Ciapetti P, et al. WO 2002\/094833; 2002."},{"key":"10.1016\/j.bmcl.2021.127858_b0095","doi-asserted-by":"crossref","first-page":"11763","DOI":"10.1016\/j.tet.2007.08.069","volume":"63","author":"Li","year":"2007","journal-title":"Tetrahedron"}],"container-title":["Bioorganic &amp; Medicinal Chemistry Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0960894X21000846?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0960894X21000846?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,18]],"date-time":"2025-10-18T07:38:46Z","timestamp":1760773126000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0960894X21000846"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,4]]},"references-count":19,"alternative-id":["S0960894X21000846"],"URL":"https:\/\/doi.org\/10.1016\/j.bmcl.2021.127858","relation":{},"ISSN":["0960-894X"],"issn-type":[{"type":"print","value":"0960-894X"}],"subject":[],"published":{"date-parts":[[2021,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Novel bicyclic pyrazoles as potent ALK2 (R206H) inhibitors for the treatment of fibrodysplasia ossificans progressiva","name":"articletitle","label":"Article Title"},{"value":"Bioorganic & Medicinal Chemistry Letters","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bmcl.2021.127858","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"127858"}}