{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T22:44:23Z","timestamp":1789166663873,"version":"build-2803163510"},"reference-count":20,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T00:00:00Z","timestamp":1619827200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T00:00:00Z","timestamp":1619827200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T00:00:00Z","timestamp":1619827200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T00:00:00Z","timestamp":1619827200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T00:00:00Z","timestamp":1619827200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T00:00:00Z","timestamp":1619827200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T00:00:00Z","timestamp":1619827200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100004919","name":"KACST","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004919","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bioorganic &amp; Medicinal Chemistry Letters"],"published-print":{"date-parts":[[2021,5]]},"DOI":"10.1016\/j.bmcl.2021.127958","type":"journal-article","created":{"date-parts":[[2021,3,18]],"date-time":"2021-03-18T11:20:20Z","timestamp":1616066420000},"page":"127958","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":19,"special_numbering":"C","title":["Development of new disulfiram analogues as ALDH1a1-selective inhibitors"],"prefix":"10.1016","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4797-4035","authenticated-orcid":false,"given":"Ziad","family":"Omran","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bmcl.2021.127958_b0005","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1186\/1479-7364-5-4-283","article-title":"Update on the aldehyde dehydrogenase gene (ALDH) superfamily","volume":"5","author":"Jackson","year":"2011","journal-title":"Hum Genomics"},{"key":"10.1016\/j.bmcl.2021.127958_b0010","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.freeradbiomed.2012.11.010","article-title":"Aldehyde dehydrogenases in cellular responses to oxidative\/electrophilic stress","volume":"56","author":"Singh","year":"2013","journal-title":"Free Radic Biol Med"},{"key":"10.1016\/j.bmcl.2021.127958_b0015","doi-asserted-by":"crossref","first-page":"2552","DOI":"10.1002\/stem.186","article-title":"Dual SP\/ALDH functionalities refine the human hematopoietic Lin-CD34+CD38- stem\/progenitor cell compartment","volume":"27","author":"Pierre-Louis","year":"2009","journal-title":"Stem Cells"},{"key":"10.1016\/j.bmcl.2021.127958_b0020","doi-asserted-by":"crossref","first-page":"1527","DOI":"10.1016\/j.ejca.2011.01.011","article-title":"Primary breast cancer patients with high risk clinicopathologic features have high percentages of bone marrow epithelial cells with ALDH activity and CD44(+)CD24lo cancer stem cell phenotype","volume":"47","author":"Reuben","year":"2011","journal-title":"Eur J Cancer"},{"key":"10.1016\/j.bmcl.2021.127958_b0025","doi-asserted-by":"crossref","DOI":"10.3390\/cancers11040502","article-title":"A novel ALDH1A1 inhibitor targets cells with stem cell characteristics in ovarian cancer","volume":"11","author":"Nwani","year":"2019","journal-title":"Cancers (Basel)"},{"key":"10.1016\/j.bmcl.2021.127958_b0030","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1038\/nm1587","article-title":"Retinaldehyde represses adipogenesis and diet-induced obesity","volume":"13","author":"Ziouzenkova","year":"2007","journal-title":"Nat Med"},{"key":"10.1016\/j.bmcl.2021.127958_b0035","doi-asserted-by":"crossref","first-page":"1473","DOI":"10.2147\/DMSO.S254267","article-title":"Repurposing Disulfiram as an anti-obesity drug: treating and preventing obesity in high-fat-fed rats","volume":"13","author":"Omran","year":"2020","journal-title":"Diabetes Metab Syndr Obes"},{"key":"10.1016\/j.bmcl.2021.127958_b0040","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-019-50628-9","article-title":"Thermogenic crosstalk occurs between adipocytes from different species","volume":"9","author":"Gilor","year":"2019","journal-title":"Sci Rep"},{"key":"10.1016\/j.bmcl.2021.127958_b0045","doi-asserted-by":"crossref","first-page":"4637","DOI":"10.1128\/MCB.23.13.4637-4648.2003","article-title":"Targeted disruption of Aldh1a1 (Raldh1) provides evidence for a complex mechanism of retinoic acid synthesis in the developing retina","volume":"23","author":"Fan","year":"2003","journal-title":"Mol Cell Biol"},{"key":"10.1016\/j.bmcl.2021.127958_b0050","first-page":"26","article-title":"How to conjugate the stemness marker ALDH1A1 with tumor angiogenesis, progression, and drug resistance","volume":"3","author":"Ciccone","year":"2020","journal-title":"Cancer Drug Resistance"},{"key":"10.1016\/j.bmcl.2021.127958_b0055","doi-asserted-by":"crossref","first-page":"51","DOI":"10.2174\/1389557516666160617100328","article-title":"Obesity: current treatment and future horizons","volume":"17","author":"Omran","year":"2016","journal-title":"Mini Rev Med Chem"},{"key":"10.1016\/j.bmcl.2021.127958_b0060","first-page":"286","article-title":"Preliminary report on clinical trials of antabuse","volume":"60","author":"Bell","year":"1949","journal-title":"Can Med Assoc J"},{"key":"10.1016\/j.bmcl.2021.127958_b0065","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1124\/pr.111.005538","article-title":"Aldehyde dehydrogenase inhibitors: a comprehensive review of the pharmacology, mechanism of action, substrate specificity, and clinical application","volume":"64","author":"Koppaka","year":"2012","journal-title":"Pharmacol Rev"},{"key":"10.1016\/j.bmcl.2021.127958_b0070","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/S0009-2797(00)00225-8","article-title":"In vivo inhibition of aldehyde dehydrogenase by disulfiram","volume":"130\u2013132","author":"Lipsky","year":"2001","journal-title":"Chem Biol Interact"},{"key":"10.1016\/j.bmcl.2021.127958_b0075","doi-asserted-by":"crossref","first-page":"3248","DOI":"10.2174\/1381612825666190816233755","article-title":"An updated review of disulfiram: molecular targets and strategies for cancer treatment","volume":"25","author":"Yang","year":"2019","journal-title":"Curr Pharm Des"},{"key":"10.1016\/j.bmcl.2021.127958_b0080","doi-asserted-by":"crossref","first-page":"1541","DOI":"10.1016\/S0969-2126(98)00152-X","article-title":"Sheep liver cytosolic aldehyde dehydrogenase: the structure reveals the basis for the retinal specificity of class 1 aldehyde dehydrogenases","volume":"6","author":"Moore","year":"1998","journal-title":"Structure"},{"key":"10.1016\/j.bmcl.2021.127958_b0085","unstructured":"Mario, S., Hosler, John F. N,N'-dicarboxymethyl thiuram disulfides. U.S. Patent 2,784,223, issued March 5, 1957."},{"key":"10.1016\/j.bmcl.2021.127958_b0090","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1016\/j.bcp.2014.12.014","article-title":"Disulfiram-induced cytotoxicity and endo-lysosomal sequestration of zinc in breast cancer cells","volume":"93","author":"Wiggins","year":"2015","journal-title":"Biochem Pharmacol"},{"key":"10.1016\/j.bmcl.2021.127958_b0095","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1602\/neurorx.2.4.541","article-title":"Medicinal chemical properties of successful central nervous system drugs","volume":"2","author":"Pajouhesh","year":"2005","journal-title":"NeuroRx"},{"key":"10.1016\/j.bmcl.2021.127958_b0100","doi-asserted-by":"crossref","first-page":"739","DOI":"10.15288\/jsa.1983.44.739","article-title":"Disulfiram-induced de novo seizures in the absence of ethanol challenge","volume":"44","author":"McConchie","year":"1983","journal-title":"J Stud Alcohol"}],"container-title":["Bioorganic &amp; Medicinal Chemistry Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0960894X21001840?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0960894X21001840?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,18]],"date-time":"2025-10-18T07:42:16Z","timestamp":1760773336000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0960894X21001840"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,5]]},"references-count":20,"alternative-id":["S0960894X21001840"],"URL":"https:\/\/doi.org\/10.1016\/j.bmcl.2021.127958","relation":{},"ISSN":["0960-894X"],"issn-type":[{"value":"0960-894X","type":"print"}],"subject":[],"published":{"date-parts":[[2021,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Development of new disulfiram analogues as ALDH1a1-selective inhibitors","name":"articletitle","label":"Article Title"},{"value":"Bioorganic & Medicinal Chemistry Letters","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bmcl.2021.127958","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"127958"}}