{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T18:58:56Z","timestamp":1773255536343,"version":"3.50.1"},"reference-count":18,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bioorganic & Medicinal Chemistry Letters"],"published-print":{"date-parts":[[2021,6]]},"DOI":"10.1016\/j.bmcl.2021.127974","type":"journal-article","created":{"date-parts":[[2021,3,24]],"date-time":"2021-03-24T02:56:25Z","timestamp":1616554585000},"page":"127974","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"special_numbering":"C","title":["Optimization of ether and aniline based inhibitors of lactate dehydrogenase"],"prefix":"10.1016","volume":"41","author":[{"given":"Plamen P.","family":"Christov","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kwangho","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Somnath","family":"Jana","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ian M.","family":"Romaine","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ganesha","family":"Rai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bryan T.","family":"Mott","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexander A.","family":"Allweil","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexander","family":"Lamers","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kyle R.","family":"Brimacombe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel J.","family":"Urban","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5331-2997","authenticated-orcid":false,"given":"Tobie D.","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xin","family":"Hu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christine M.","family":"Lukacs","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Douglas R.","family":"Davies","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7955-1451","authenticated-orcid":false,"given":"Ajit","family":"Jadhav","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthew D.","family":"Hall","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5851-5152","authenticated-orcid":false,"given":"Neal","family":"Green","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0929-2228","authenticated-orcid":false,"given":"William J.","family":"Moore","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9148-6100","authenticated-orcid":false,"given":"Gordon M.","family":"Stott","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew J.","family":"Flint","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David J.","family":"Maloney","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gary A.","family":"Sulikowski","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0153-5723","authenticated-orcid":false,"given":"Alex G.","family":"Waterson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.bmcl.2021.127974_b0005","first-page":"319","volume":"152","author":"Warburg","year":"1924","journal-title":"Biochem. Z."},{"key":"10.1016\/j.bmcl.2021.127974_b0010","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.1126\/science.1160809","volume":"324","author":"Vander Heiden","year":"2009","journal-title":"B. Science"},{"key":"10.1016\/j.bmcl.2021.127974_b0015","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1186\/1477-7819-12-78","volume":"12","author":"Yu","year":"2014","journal-title":"World J. Surg. Oncol."},{"key":"10.1016\/j.bmcl.2021.127974_b0020","doi-asserted-by":"crossref","first-page":"1523","DOI":"10.1007\/s13277-013-0679-1","volume":"34","author":"Rong","year":"2013","journal-title":"Tumour Biol."},{"key":"10.1016\/j.bmcl.2021.127974_b0025","first-page":"1","volume":"3","author":"Allison","year":"2014","journal-title":"Oncogensis"},{"key":"10.1016\/j.bmcl.2021.127974_b0030","doi-asserted-by":"crossref","first-page":"2037","DOI":"10.1073\/pnas.0914433107","volume":"107","author":"Le","year":"2010","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.bmcl.2021.127974_b0035","doi-asserted-by":"crossref","first-page":"3898","DOI":"10.1111\/j.1742-4658.2012.08748.x","volume":"279","author":"Sheng","year":"2012","journal-title":"FEBS J"},{"key":"10.1016\/j.bmcl.2021.127974_b0040","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1016\/j.ccr.2006.04.023","volume":"9","author":"Fantin","year":"2006","journal-title":"Canc. Cell"},{"key":"10.1016\/j.bmcl.2021.127974_b0045","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1016\/j.cmet.2014.03.003","volume":"19","author":"Xie","year":"2014","journal-title":"Cell Metab"},{"key":"10.1016\/j.bmcl.2021.127974_b0050","doi-asserted-by":"crossref","first-page":"1599","DOI":"10.1021\/jm101007q","volume":"24","author":"Granchi","year":"2011","journal-title":"J Med Chem"},{"key":"10.1016\/j.bmcl.2021.127974_b0055","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.1021\/jm3014844","volume":"56","author":"Kohlmann","year":"2013","journal-title":"J Med Chem"},{"key":"10.1016\/j.bmcl.2021.127974_b0060","doi-asserted-by":"crossref","first-page":"3285","DOI":"10.1021\/jm201734r","volume":"55","author":"Ward","year":"2012","journal-title":"J Med Chem"},{"key":"10.1016\/j.bmcl.2021.127974_b0065","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1186\/2049-3002-1-19","volume":"1","author":"Billiard","year":"2013","journal-title":"J Cancer Metab"},{"key":"10.1016\/j.bmcl.2021.127974_b0070","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1038\/nchembio.2143","volume":"12","author":"Boudreau","year":"2016","journal-title":"Nat Chem Biol"},{"key":"10.1016\/j.bmcl.2021.127974_b0075","doi-asserted-by":"crossref","first-page":"9184","DOI":"10.1021\/acs.jmedchem.7b00941","volume":"60","author":"Rai","year":"2017","journal-title":"J Med Chem"},{"issue":"19","key":"10.1016\/j.bmcl.2021.127974_b0080","doi-asserted-by":"crossref","first-page":"10984","DOI":"10.1021\/acs.jmedchem.0c00916","volume":"63","author":"Rai","year":"2020","journal-title":"J Med Chem"},{"issue":"9","key":"10.1016\/j.bmcl.2021.127974_b0085","doi-asserted-by":"crossref","first-page":"12564","DOI":"10.1021\/acs.chemrev.6b00512","volume":"116","author":"Ruiz-Castillo","year":"2016","journal-title":"Chem Rev"},{"key":"10.1016\/j.bmcl.2021.127974_b0090","doi-asserted-by":"crossref","first-page":"1653","DOI":"10.1124\/dmd.116.072017","volume":"44","author":"Shah","year":"2016","journal-title":"Drug Metab Dispos"}],"container-title":["Bioorganic & Medicinal Chemistry Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0960894X21002006?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0960894X21002006?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,18]],"date-time":"2025-10-18T07:41:00Z","timestamp":1760773260000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0960894X21002006"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,6]]},"references-count":18,"alternative-id":["S0960894X21002006"],"URL":"https:\/\/doi.org\/10.1016\/j.bmcl.2021.127974","relation":{},"ISSN":["0960-894X"],"issn-type":[{"value":"0960-894X","type":"print"}],"subject":[],"published":{"date-parts":[[2021,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Optimization of ether and aniline based inhibitors of lactate dehydrogenase","name":"articletitle","label":"Article Title"},{"value":"Bioorganic & Medicinal Chemistry Letters","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bmcl.2021.127974","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"127974"}}