{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T17:59:35Z","timestamp":1790272775355,"version":"4.1.0"},"reference-count":54,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bioorganic & Medicinal Chemistry Letters"],"published-print":{"date-parts":[[2021,6]]},"DOI":"10.1016\/j.bmcl.2021.127989","type":"journal-article","created":{"date-parts":[[2021,3,30]],"date-time":"2021-03-30T03:08:25Z","timestamp":1617073705000},"page":"127989","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":15,"special_numbering":"C","title":["Anti-fibrotic effects of brevilin A in hepatic fibrosis via inhibiting the STAT3 signaling pathway"],"prefix":"10.1016","volume":"41","author":[{"given":"Yong Joo","family":"Park","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mi Seon","family":"Jeon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seulah","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jung Kyu","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tae Su","family":"Jang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyu Hyuck","family":"Chung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ki Hyun","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bmcl.2021.127989_b0005","doi-asserted-by":"crossref","first-page":"786","DOI":"10.1038\/nrm3904","article-title":"Remodelling the extracellular matrix in development and disease","volume":"15","author":"Bonnans","year":"2014","journal-title":"Nat Rev Mol Cell Biol"},{"key":"10.1016\/j.bmcl.2021.127989_b0010","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1097\/MOG.0b013e3283279668","article-title":"Hepatic fibrosis","volume":"25","author":"Jiao","year":"2009","journal-title":"Curr Opin Gastroenterol"},{"key":"10.1016\/j.bmcl.2021.127989_b0015","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1038\/cmi.2011.53","article-title":"Liver fibrosis: mechanisms of immune-mediated liver injury","volume":"9","author":"Xu","year":"2012","journal-title":"Cell Mol Immunol"},{"key":"10.1016\/j.bmcl.2021.127989_b0020","doi-asserted-by":"crossref","unstructured":"Koyama Y, Brenner DA. Liver inflammation and fibrosis. J Clin Invest 2017;127(1): 55-64.","DOI":"10.1172\/JCI88881"},{"key":"10.1016\/j.bmcl.2021.127989_b0025","doi-asserted-by":"crossref","DOI":"10.1038\/ncomms3823","article-title":"Fate tracing reveals hepatic stellate cells as dominant contributors to liver fibrosis independent of its aetiology","volume":"4","author":"Mederacke","year":"2013","journal-title":"Nat Commun"},{"key":"10.1016\/j.bmcl.2021.127989_b0030","doi-asserted-by":"crossref","first-page":"948","DOI":"10.1016\/j.bbadis.2013.02.019","article-title":"Origins and functions of liver myofibroblasts","volume":"1832","author":"Lemoinne","year":"2013","journal-title":"Biochim Biophys Acta"},{"key":"10.1016\/j.bmcl.2021.127989_b0035","doi-asserted-by":"crossref","first-page":"E3297","DOI":"10.1073\/pnas.1400062111","article-title":"Origin of myofibroblasts in the fibrotic liver in mice","volume":"111","author":"Iwaisako","year":"2014","journal-title":"Proc Natl Acad Sci U S A."},{"key":"10.1016\/j.bmcl.2021.127989_b0040","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1055\/s-2001-17550","article-title":"History, heterogeneity, developmental biology, and functions of quiescent hepatic stellate cells","volume":"21","author":"Geerts","year":"2001","journal-title":"Semin Liver Dis"},{"key":"10.1016\/j.bmcl.2021.127989_b0045","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1016\/j.bbalip.2008.11.001","article-title":"Hepatic stellate cell lipid droplets: a specialized lipid droplet for retinoid storage","volume":"1791","author":"Blaner","year":"2009","journal-title":"Biochim Biophys Acta"},{"key":"10.1016\/j.bmcl.2021.127989_b0050","doi-asserted-by":"crossref","first-page":"10512","DOI":"10.3748\/wjg.v22.i48.10512","article-title":"Liver fibrosis and hepatic stellate cells: etiology, pathological hallmarks and therapeutic targets","volume":"22","author":"Zhang","year":"2016","journal-title":"World J Gastroenterol"},{"key":"10.1016\/j.bmcl.2021.127989_b0055","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1038\/nrgastro.2017.38","article-title":"Mechanisms of hepatic stellate cell activation","volume":"14","author":"Tsuchida","year":"2017","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"10.1016\/j.bmcl.2021.127989_b0060","doi-asserted-by":"crossref","first-page":"548","DOI":"10.3389\/fphar.2020.00548","article-title":"Targeting hepatic stellate cells for the treatment of liver fibrosis by natural products: is it the dawning of a new era?","volume":"11","author":"Chan","year":"2020","journal-title":"Front Pharmacol"},{"key":"10.1016\/j.bmcl.2021.127989_b0065","doi-asserted-by":"crossref","first-page":"2737","DOI":"10.1021\/acs.jnatprod.0c00673","volume":"83","author":"Lee","year":"2020","journal-title":"J Nat Prod"},{"key":"10.1016\/j.bmcl.2021.127989_b0070","doi-asserted-by":"crossref","first-page":"230","DOI":"10.20307\/nps.2020.26.3.230","volume":"26","author":"Lee","year":"2020","journal-title":"Nat Prod Sci"},{"key":"10.1016\/j.bmcl.2021.127989_b0075","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1007\/s12272-020-01213-6","volume":"43","author":"Lee","year":"2020","journal-title":"Arch Pharm Res"},{"key":"10.1016\/j.bmcl.2021.127989_b0080","doi-asserted-by":"crossref","first-page":"28","DOI":"10.20307\/nps.2019.25.1.28","volume":"25","author":"Trinh","year":"2019","journal-title":"Nat Prod Sci"},{"key":"10.1016\/j.bmcl.2021.127989_b0085","doi-asserted-by":"crossref","first-page":"118","DOI":"10.20307\/nps.2020.26.2.118","volume":"26","author":"Ha","year":"2020","journal-title":"Nat Prod Sci"},{"key":"10.1016\/j.bmcl.2021.127989_b0090","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1080\/10286020.2012.670222","article-title":"Two new sesquiterpene lactones from the supercritical fluid extract of Centipeda minima","volume":"14","author":"Wu","year":"2012","journal-title":"J Asian Nat Prod Res"},{"key":"10.1016\/j.bmcl.2021.127989_b0095","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.phytochem.2012.01.003","article-title":"Supercritical fluid extraction assisted isolation of sesquiterpene lactones with antiproliferative effects from Centipeda minima","volume":"76","author":"Wu","year":"2012","journal-title":"Phytochemistry"},{"key":"10.1016\/j.bmcl.2021.127989_b0100","first-page":"125","article-title":"New thymol derivate from Centipeda minima","volume":"25","author":"Pu","year":"2009","journal-title":"Chem Res Chinese Universities"},{"key":"10.1016\/j.bmcl.2021.127989_b0105","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1016\/j.biopha.2007.10.010","article-title":"6-O-Angeloylenolin induces apoptosis through a mitochondrial\/caspase and NF-\u03baB pathway in human leukemia HL60 cells","volume":"62","author":"ChangLong","year":"2008","journal-title":"Biomed Pharmacother"},{"key":"10.1016\/j.bmcl.2021.127989_b0110","doi-asserted-by":"crossref","first-page":"2135","DOI":"10.3390\/molecules14062135","article-title":"2\u03b2-(Isobutyryloxy)florilenalin, a sesquiterpene lactone isolated from the medicinal plant Centipeda minima, induces apoptosis in human nasopharyngeal carcinoma CNE cells","volume":"14","author":"Su","year":"2009","journal-title":"Molecules"},{"key":"10.1016\/j.bmcl.2021.127989_b0115","doi-asserted-by":"crossref","first-page":"4091","DOI":"10.1248\/cpb.33.4091","article-title":"Biologically active constituents of Centipeda minima: Isolation of a new plewolin ester and the antiallergy activity of sesquiterpene lactones","volume":"33","author":"Wu","year":"1985","journal-title":"Chem Pharm Bull"},{"key":"10.1016\/j.bmcl.2021.127989_b0120","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1016\/S0031-9422(97)00534-7","article-title":"Antibacterial constituents of the nepalese medicinal herb, Centipeda minima","volume":"47","author":"Taylor","year":"1998","journal-title":"Phytochemistry"},{"issue":"4","key":"10.1016\/j.bmcl.2021.127989_b0125","first-page":"479","article-title":"Antibacterial triterpenes from Centipeda minima (Compositae)","volume":"29","author":"Liang","year":"2007","journal-title":"Acta Bot Yunnan"},{"issue":"15","key":"10.1016\/j.bmcl.2021.127989_b0130","first-page":"1192","article-title":"Effects of the volatile oil of Centipeda minima on acute pleural effusion in rats induced by an intrapleural injection of car","volume":"30","author":"Qin","year":"2005","journal-title":"Zhongguo Zhongyao Zazhi"},{"issue":"12","key":"10.1016\/j.bmcl.2021.127989_b0135","doi-asserted-by":"crossref","first-page":"2810","DOI":"10.1002\/cbdv.200790230","article-title":"Two new antibacterial sesquiterpenoids from Centipeda minima","volume":"4","author":"Liang","year":"2007","journal-title":"Chem Biodivers"},{"issue":"5","key":"10.1016\/j.bmcl.2021.127989_b0140","doi-asserted-by":"crossref","first-page":"e63697","DOI":"10.1371\/journal.pone.0063697","article-title":"Brevilin A, a novel natural product, inhibits Janus Kinase activity and blocks STAT3 signaling in cancer cells","volume":"8","author":"Chen","year":"2013","journal-title":"PLoS ONE"},{"issue":"7","key":"10.1016\/j.bmcl.2021.127989_b0145","doi-asserted-by":"crossref","first-page":"2780","DOI":"10.1021\/jo01271a036","article-title":"Sesquiterpene lactones of Helenium alternifolium (Spreng.) Cabrera. Structures of brevilin A, linifolin A, and alternilin","volume":"33","author":"Herz","year":"1968","journal-title":"J Org Chem"},{"issue":"3","key":"10.1016\/j.bmcl.2021.127989_b0150","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1016\/0031-9422(77)80074-5","article-title":"Antitumor sesquiterpene lactones from Helenium microcephalum: isolation of mexicanin-E and structural characterization of microhelenin-B and -C","volume":"16","author":"Kuo-Hsiung","year":"1977","journal-title":"Phytochemistry"},{"key":"10.1016\/j.bmcl.2021.127989_b0155","doi-asserted-by":"crossref","first-page":"594","DOI":"10.3389\/fphar.2019.00594","article-title":"Brevilin A induces cell cycle arrest and apoptosis in nasopharyngeal carcinoma","volume":"10","author":"Liu","year":"2019","journal-title":"Front Pharmacol"},{"key":"10.1016\/j.bmcl.2021.127989_b0160","doi-asserted-by":"crossref","unstructured":"Su T, Wang YP, Wang XN, et al. The JAK2\/STAT3 pathway is involved in the anti-melanoma effects of brevilin A. Life Sci 241;2020: 117169.","DOI":"10.1016\/j.lfs.2019.117169"},{"key":"10.1016\/j.bmcl.2021.127989_b0165","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1016\/j.biopha.2017.12.057","article-title":"Brevilin A induces apoptosis and autophagy of colon adenocarcinoma cell CT26 via mitochondrial pathway and PI3K\/AKT\/mTOR inactivation","volume":"98","author":"You","year":"2018","journal-title":"Biomed Pharmacother"},{"key":"10.1016\/j.bmcl.2021.127989_b0170","doi-asserted-by":"crossref","first-page":"7031","DOI":"10.2147\/OTT.S179730","article-title":"Brevilin A promotes oxidative stress and induces mitochondrial apoptosis in U87 glioblastoma cells","volume":"11","author":"Wang","year":"2018","journal-title":"Onco Targets Ther"},{"issue":"9","key":"10.1016\/j.bmcl.2021.127989_b0175","doi-asserted-by":"crossref","first-page":"835","DOI":"10.3390\/v11090835","article-title":"a sesquiterpene lactone, inhibits the replication of influenza A virus in vitro and in vivo","volume":"11","author":"Zhang","year":"2019","journal-title":"Viruses"},{"issue":"1","key":"10.1016\/j.bmcl.2021.127989_b0180","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1136\/gut.2004.042127","article-title":"Human hepatic stellate cell lines, LX-1 and LX-2: new tools for analysis of hepatic fibrosis","volume":"54","author":"Xu","year":"2005","journal-title":"Gut"},{"issue":"11","key":"10.1016\/j.bmcl.2021.127989_b0185","doi-asserted-by":"crossref","DOI":"10.3390\/cells8111419","article-title":"TGF-beta in hepatic stellate cell activation and liver fibrogenesis-updated 2019","volume":"8","author":"Dewidar","year":"2019","journal-title":"Cells"},{"issue":"6","key":"10.1016\/j.bmcl.2021.127989_b0190","first-page":"386","article-title":"Immunomodulatory effects of transforming growth factor-beta in the liver","volume":"3","author":"Schon","year":"2014","journal-title":"Hepatobiliary Surg Nutr"},{"issue":"1","key":"10.1016\/j.bmcl.2021.127989_b0195","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1152\/physrev.00013.2007","article-title":"Hepatic stellate cells: protean, multifunctional, and enigmatic cells of the liver","volume":"88","author":"Friedman","year":"2008","journal-title":"Physiol Rev"},{"issue":"5","key":"10.1016\/j.bmcl.2021.127989_b0200","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1016\/j.dld.2004.11.009","article-title":"Alpha-SMA expression in hepatic stellate cells and quantitative analysis of hepatic fibrosis in cirrhosis and in recurrent chronic hepatitis after liver transplantation","volume":"37","author":"Carpino","year":"2005","journal-title":"Dig Liver Dis"},{"issue":"2","key":"10.1016\/j.bmcl.2021.127989_b0205","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1038\/nmeth736","article-title":"An extracellular matrix microarray for probing cellular differentiation","volume":"2","author":"Flaim","year":"2005","journal-title":"Nat Methods"},{"issue":"4","key":"10.1016\/j.bmcl.2021.127989_b0210","doi-asserted-by":"crossref","first-page":"1394","DOI":"10.1002\/hep.22193","article-title":"The role of matrix stiffness in regulating cell behavior","volume":"47","author":"Wells","year":"2008","journal-title":"Hepatology"},{"key":"10.1016\/j.bmcl.2021.127989_b0215","doi-asserted-by":"crossref","unstructured":"Lu P, Takai K, Weaver VM, Werb Z. Extracellular matrix degradation and remodeling in development and disease. Cold Spring Harb Perspect Biol. 2011;3(12).","DOI":"10.1101\/cshperspect.a005058"},{"issue":"7","key":"10.1016\/j.bmcl.2021.127989_b0220","doi-asserted-by":"crossref","first-page":"876","DOI":"10.1016\/j.bbadis.2012.11.002","article-title":"Extracellular matrix degradation in liver fibrosis: Biochemistry and regulation","volume":"1832","author":"Iredale","year":"2013","journal-title":"Biochim Biophys Acta"},{"issue":"6","key":"10.1016\/j.bmcl.2021.127989_b0225","doi-asserted-by":"crossref","first-page":"8101","DOI":"10.3892\/mmr.2015.4428","article-title":"Inhibition of procollagen I expression by oxymatrine in hepatic stellate cells is mediated via nuclear translocation of Ybox binding protein 1","volume":"12","author":"Du","year":"2015","journal-title":"Mol Med Rep"},{"issue":"9","key":"10.1016\/j.bmcl.2021.127989_b0230","doi-asserted-by":"crossref","first-page":"4168","DOI":"10.1210\/en.2010-0191","article-title":"Curcumin protects hepatic stellate cells against leptin-induced activation in vitro by accumulating intracellular lipids","volume":"151","author":"Tang","year":"2010","journal-title":"Endocrinology"},{"issue":"1","key":"10.1016\/j.bmcl.2021.127989_b0235","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1111\/j.1440-1746.2006.04361.x","article-title":"Antifibrotic effects of tetrandrine on hepatic stellate cells and rats with liver fibrosis","volume":"22","author":"Hsu","year":"2007","journal-title":"J Gastroenterol Hepatol"},{"issue":"1","key":"10.1016\/j.bmcl.2021.127989_b0240","doi-asserted-by":"crossref","first-page":"9289","DOI":"10.1038\/s41598-017-09673-5","article-title":"Quercetin prevents hepatic fibrosis by inhibiting hepatic stellate cell activation and reducing autophagy via the TGF-beta1\/Smads and PI3K\/Akt pathways","volume":"7","author":"Wu","year":"2017","journal-title":"Sci Rep"},{"key":"10.1016\/j.bmcl.2021.127989_b0245","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.cbi.2014.07.007","article-title":"Resveratrol mitigate structural changes and hepatic stellate cell activation in N'-nitrosodimethylamine-induced liver fibrosis via restraining oxidative damage","volume":"221","author":"Ahmad","year":"2014","journal-title":"Chem Biol Interact"},{"issue":"1","key":"10.1016\/j.bmcl.2021.127989_b0250","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1093\/abbs\/gmx118","article-title":"Smad3-STAT3 crosstalk in pathophysiological contexts","volume":"50","author":"Itoh","year":"2018","journal-title":"Acta Biochim Biophys Sin (Shanghai)"},{"issue":"1","key":"10.1016\/j.bmcl.2021.127989_b0255","doi-asserted-by":"crossref","first-page":"30","DOI":"10.3390\/cells9010030","article-title":"(-)-Catechin-7-O-\u03b2-D-apiofuranoside inhibits hepatic stellate cell activation by suppressing the STAT3 signaling pathway","volume":"9","author":"Park","year":"2020","journal-title":"Cells"},{"key":"10.1016\/j.bmcl.2021.127989_b0260","doi-asserted-by":"crossref","first-page":"9044","DOI":"10.3390\/ijms21239044","article-title":"Hepatoprotective potency of chrysophanol 8-O-glucoside from Rheum palmatum L. against hepatic fibrosis via regulation of the STAT3 signaling pathway","volume":"21","author":"Park","year":"2020","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.bmcl.2021.127989_b0265","doi-asserted-by":"crossref","first-page":"4302","DOI":"10.1074\/jbc.M116.773085","article-title":"Transforming growth factor-beta (TGF-beta) directly activates the JAK1-STAT3 axis to induce hepatic fibrosis in coordination with the SMAD pathway","volume":"292","author":"Tang","year":"2017","journal-title":"J Biol Chem"},{"key":"10.1016\/j.bmcl.2021.127989_b0270","doi-asserted-by":"crossref","first-page":"30708","DOI":"10.1074\/jbc.M113.478685","article-title":"Transforming growth factor-beta (TGF-beta)-mediated connective tissue growth factor (CTGF) expression in hepatic stellate cells requires Stat3 signaling activation","volume":"288","author":"Liu","year":"2013","journal-title":"J Biol Chem"}],"container-title":["Bioorganic & Medicinal Chemistry Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0960894X21002158?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0960894X21002158?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,18]],"date-time":"2025-10-18T07:41:46Z","timestamp":1760773306000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0960894X21002158"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,6]]},"references-count":54,"alternative-id":["S0960894X21002158"],"URL":"https:\/\/doi.org\/10.1016\/j.bmcl.2021.127989","relation":{},"ISSN":["0960-894X"],"issn-type":[{"value":"0960-894X","type":"print"}],"subject":[],"published":{"date-parts":[[2021,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Anti-fibrotic effects of brevilin A in hepatic fibrosis via inhibiting the STAT3 signaling pathway","name":"articletitle","label":"Article Title"},{"value":"Bioorganic & Medicinal Chemistry Letters","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bmcl.2021.127989","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"127989"}}