{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T22:41:01Z","timestamp":1793918461556,"version":"4.8.0"},"reference-count":52,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bioorganic & Medicinal Chemistry Letters"],"published-print":{"date-parts":[[2021,6]]},"DOI":"10.1016\/j.bmcl.2021.128030","type":"journal-article","created":{"date-parts":[[2021,4,8]],"date-time":"2021-04-08T12:55:04Z","timestamp":1617886504000},"page":"128030","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":42,"special_numbering":"C","title":["Isatin-derived azoles as new potential antimicrobial agents: Design, synthesis and biological evaluation"],"prefix":"10.1016","volume":"41","author":[{"given":"Vijai Kumar Reddy","family":"Tangadanchu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan-Fei","family":"Sui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheng-He","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bmcl.2021.128030_h0005","doi-asserted-by":"crossref","first-page":"8720","DOI":"10.1021\/acsomega.8b02481","article-title":"Design, synthesis, antimicrobial evaluation, and molecular modeling studies of novel indolinedione\u2013coumarin molecular hybrids","volume":"4","author":"Bhagat","year":"2019","journal-title":"ACS Omega"},{"key":"10.1016\/j.bmcl.2021.128030_h0010","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1016\/j.ejmech.2018.07.025","article-title":"Design, synthesis and antimicrobial evaluation of propylene-tethered ciprofloxacin-isatin hybrids","volume":"156","author":"Wang","year":"2018","journal-title":"Eur J Med Chem"},{"key":"10.1016\/j.bmcl.2021.128030_h0015","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1016\/j.ejmech.2015.06.047","article-title":"Synthesis and evaluation of isatin-\u03b2-thiosemicarbazones as novel agents against antibiotic-resistant Gram-positive bacterial species","volume":"101","author":"Zhang","year":"2015","journal-title":"Eur J Med Chem"},{"key":"10.1016\/j.bmcl.2021.128030_h0020","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.ejmech.2018.10.008","article-title":"Novel indole-thiazolidinone conjugates: Design, synthesis and whole-cell phenotypic evaluation as a novel class of antimicrobial agents","volume":"160","author":"Abo-Ashour","year":"2018","journal-title":"Eur J Med Chem"},{"key":"10.1016\/j.bmcl.2021.128030_h0025","doi-asserted-by":"crossref","first-page":"1958","DOI":"10.3390\/molecules22111958","article-title":"Synthesis, spectroscopic characterization and antimicrobial potential of certain new isatin-indole molecular hybrids","volume":"22","author":"Al-Wabli","year":"2017","journal-title":"Molecules"},{"key":"10.1016\/j.bmcl.2021.128030_h0030","doi-asserted-by":"crossref","first-page":"2513","DOI":"10.1016\/j.bmcl.2016.03.093","article-title":"Efficient synthesis of new 2,3-dihydrooxazole-spirooxindoles hybrids as antimicrobial agents","volume":"26","author":"Tiwari","year":"2016","journal-title":"Bioorg Med Chem Lett"},{"key":"10.1016\/j.bmcl.2021.128030_h0035","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1021\/acsmedchemlett.8b00596","article-title":"Investigating the anticancer activity of isatin\/dihydropyrazole hybrids","volume":"10","author":"Meleddu","year":"2019","journal-title":"ACS Med Chem Lett"},{"key":"10.1016\/j.bmcl.2021.128030_h0040","doi-asserted-by":"crossref","first-page":"840","DOI":"10.1016\/j.ejmech.2018.12.026","article-title":"Design and development of isatin-triazole hydrazones as potential inhibitors of microtubule affinity-regulating kinase 4 for the therapeutic management of cell proliferation and metastasis","volume":"163","author":"Aneja","year":"2019","journal-title":"Eur J Med Chem"},{"key":"10.1016\/j.bmcl.2021.128030_h0045","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1016\/j.bioorg.2018.05.011","article-title":"Synthesis, SAR elucidations and molecular docking study of newly designed isatin based oxadiazole analogs as potent inhibitors of thymidine phosphorylase","volume":"79","author":"Javid","year":"2018","journal-title":"Bioorg Chem"},{"key":"10.1016\/j.bmcl.2021.128030_h0050","doi-asserted-by":"crossref","first-page":"6765","DOI":"10.1007\/s11164-017-3019-z","article-title":"New chalcones bearing isatin scaffold: synthesis, molecular modeling and biological evaluation as anticancer agents","volume":"43","author":"Ammar","year":"2017","journal-title":"Res Chem Intermed"},{"key":"10.1016\/j.bmcl.2021.128030_b0020","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1111\/cbdd.12668","article-title":"Practical synthesis, antidepressant, and anticonvulsant activity of 3-phenyliminoindolin-2-one derivatives","volume":"87","author":"Ma","year":"2016","journal-title":"Chem Biol Drug Des"},{"key":"10.1016\/j.bmcl.2021.128030_h0060","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1016\/j.ejmech.2015.02.032","article-title":"(3Z)-3-(2-[4-(aryl)-1,3-thiazol-2-yl]hydrazin-1-ylidene)-2,3-dihydro-1H-indol-2-one derivatives as dual inhibitors of HIV-1 reverse transcriptase","volume":"93","author":"Meleddu","year":"2015","journal-title":"Eur J Med Chem"},{"key":"10.1016\/j.bmcl.2021.128030_h0065","doi-asserted-by":"crossref","first-page":"20122","DOI":"10.1038\/srep20122","article-title":"Inhibition of chikungunya virus replication by 1-[(2-methylbenzimidazol-1-yl) methyl]-2-oxo-Indolin-3-ylidene] amino] thiourea(MBZM-N-IBT)","volume":"6","author":"Mishra","year":"2016","journal-title":"Sci Rep"},{"key":"10.1016\/j.bmcl.2021.128030_h0070","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1080\/14756366.2016.1238366","article-title":"Isatin thiazoline hybrids as dual inhibitors of HIV-1 reverse transcriptase","volume":"32","author":"Meleddu","year":"2017","journal-title":"J Enzyme Inhib Med Chem"},{"key":"10.1016\/j.bmcl.2021.128030_h0075","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1016\/j.bioorg.2017.01.006","article-title":"Dihydropyrimidinone-isatin hybrids as novel non-nucleoside HIV-1 reverse transcriptase inhibitors","volume":"70","author":"Devale","year":"2017","journal-title":"Bioorg Chem"},{"key":"10.1016\/j.bmcl.2021.128030_b0030","doi-asserted-by":"crossref","first-page":"380","DOI":"10.3389\/fcimb.2018.00380","article-title":"Highly potent 1H\u20131,2,3-triazole-tethered isatin-metronidazole conjugates against anaerobic foodborne, waterborne, and sexually-transmitted protozoal parasites","volume":"8","author":"Kumar","year":"2018","journal-title":"Front Cell Infect Microbiol"},{"key":"10.1016\/j.bmcl.2021.128030_b0035","doi-asserted-by":"crossref","first-page":"1224","DOI":"10.1007\/s11426-016-0026-7","article-title":"Indole methylation protects diketopiperazine configuration in the maremycin biosynthetic pathway","volume":"59","author":"Lan","year":"2016","journal-title":"Sci. China Chem"},{"key":"10.1016\/j.bmcl.2021.128030_b0040","doi-asserted-by":"crossref","first-page":"1900272","DOI":"10.1002\/ardp.201900272","article-title":"Isatin-azole hybrids and their anticancer activities","volume":"353","author":"Hou","year":"2020","journal-title":"Arch Pharm"},{"key":"10.1016\/j.bmcl.2021.128030_b0045","doi-asserted-by":"crossref","first-page":"6975","DOI":"10.1007\/s11164-014-1792-5","article-title":"Synthesis and evaluation of novel isatin and 5-isatinylidenerhodanine-based furan derivatives as antibacterial agents","volume":"41","author":"Baharfar","year":"2015","journal-title":"Res Chem Intermed"},{"key":"10.1016\/j.bmcl.2021.128030_h0100","doi-asserted-by":"crossref","DOI":"10.1016\/j.bioorg.2020.103710","article-title":"Hydrophobic substituents on isatin derivatives enhance their inhibition against bacterial peptidoglycan glycosyltransferase activity","volume":"97","author":"Wang","year":"2020","journal-title":"Bioorg Chem"},{"key":"10.1016\/j.bmcl.2021.128030_h0105","doi-asserted-by":"crossref","first-page":"2370","DOI":"10.3390\/molecules25102370","article-title":"Synthesis, redox properties and antibacterial activity of hindered phenols linked to heterocycles","volume":"25","author":"Koshelev","year":"2020","journal-title":"Molecules"},{"key":"10.1016\/j.bmcl.2021.128030_h0110","doi-asserted-by":"crossref","first-page":"8720","DOI":"10.1021\/acsomega.8b02481","article-title":"Design, synthesis, antimicrobial evaluation, and molecular modeling studies of novel indolinedione coumarin molecular hybrids","volume":"4","author":"Bhagat","year":"2019","journal-title":"ACS Omega"},{"key":"10.1016\/j.bmcl.2021.128030_h0115","doi-asserted-by":"crossref","first-page":"239","DOI":"10.2174\/092986712803414213","article-title":"Recent researches in triazole compounds as medicinal drugs","volume":"19","author":"Zhou","year":"2012","journal-title":"Curr Med Chem"},{"key":"10.1016\/j.bmcl.2021.128030_h0120","doi-asserted-by":"crossref","DOI":"10.1016\/j.bioorg.2019.103434","article-title":"Ethylenic conjugated coumarin thiazolidinediones as new efficient antimicrobial modulators against clinical methicillin-resistant Staphylococcus aureus","volume":"94","author":"Hu","year":"2020","journal-title":"Bioor Chem"},{"key":"10.1016\/j.bmcl.2021.128030_h0125","doi-asserted-by":"crossref","DOI":"10.1016\/j.bmcl.2020.126982","article-title":"Design and biological evaluation of a novel type of potential multi-targeting antimicrobial sulfanilamide hybrids in combination of pyrimidine and azoles","volume":"30","author":"Sui","year":"2020","journal-title":"Bioorg Med Chem Lett"},{"key":"10.1016\/j.bmcl.2021.128030_h0130","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1002\/med.21290","article-title":"Comprehensive review in current developments of imidazole-based medicinal chemistry","volume":"34","author":"Zhang","year":"2014","journal-title":"Med Res Rev"},{"key":"10.1016\/j.bmcl.2021.128030_h0135","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1016\/j.ejmech.2019.06.093","article-title":"Indole-nitroimidazole conjugates as efficient manipulators to decrease the genes expression of methicillin-resistant Staphylococcus aureus","volume":"179","author":"Li","year":"2019","journal-title":"Eur J Med Chem"},{"key":"10.1016\/j.bmcl.2021.128030_h0140","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1007\/s11426-017-9169-4","article-title":"Discovery of natural berberine derived nitroimidazoles as potentially multi-targeting agents against drug-resistant Escherichia coli","volume":"61","author":"Zhang","year":"2018","journal-title":"Sci. China Chem"},{"key":"10.1016\/j.bmcl.2021.128030_h0145","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1016\/j.ejmech.2018.06.022","article-title":"Novel carbazole-triazole conjugates as DNA-targeting membrane active potentiators against clinical isolated fungi","volume":"155","author":"Zhang","year":"2018","journal-title":"Eur J Med Chem"},{"key":"10.1016\/j.bmcl.2021.128030_h0150","doi-asserted-by":"crossref","first-page":"4964","DOI":"10.1016\/j.bmcl.2017.10.020","article-title":"Novel potentially antifungal hybrids of 5-flucytosine and fluconazole: Design, synthesis and bioactive evaluation","volume":"27","author":"Fang","year":"2017","journal-title":"Bioorg Med Chem Lett"},{"key":"10.1016\/j.bmcl.2021.128030_h0155","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1038\/nature17042","article-title":"Antibacterial drug discovery in the resistance era","volume":"529","author":"Brown","year":"2016","journal-title":"Nature"},{"key":"10.1016\/j.bmcl.2021.128030_h0160","doi-asserted-by":"crossref","first-page":"17028","DOI":"10.1038\/nmicrobiol.2017.28","article-title":"Pentamidine sensitizes Gram negative pathogens to antibiotics and overcomes acquired colistin resistance","volume":"2","author":"Stokes","year":"2017","journal-title":"Nat Microbiol"},{"key":"10.1016\/j.bmcl.2021.128030_h0165","doi-asserted-by":"crossref","first-page":"1694","DOI":"10.2174\/1568026619666190619115735","article-title":"Molecular hybridization as a tool for designing multitarget drug candidates for complex diseases","volume":"19","author":"Ivasiv","year":"2019","journal-title":"Curr Top Med Chem"},{"key":"10.1016\/j.bmcl.2021.128030_h0170","doi-asserted-by":"crossref","first-page":"1709","DOI":"10.4155\/fmc-2019-0303","article-title":"An unexpected discovery toward novel membrane active sulfonyl thiazoles as potential MRSA DNA intercalators","volume":"12","author":"Hu","year":"2020","journal-title":"Future Med Chem"},{"issue":"59","key":"10.1016\/j.bmcl.2021.128030_h0175","doi-asserted-by":"crossref","first-page":"4488","DOI":"10.1021\/acs.jmedchem.5b01678","article-title":"Novel 3-aminothiazolquinolones: Design, synthesis, bioactive evaluation, SARs, and preliminary antibacterial mechanism","volume":"59","author":"Cui","year":"2016","journal-title":"J Med Chem"},{"key":"10.1016\/j.bmcl.2021.128030_h0180","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1016\/j.ejmech.2019.06.046","article-title":"A new exploration towards aminothiazolquinolone oximes as potentially multi-targeting antibacterial agents: design, synthesis and evaluation acting on microbes, DNA, HSA and topoisomerase IV","volume":"179","author":"Wang","year":"2019","journal-title":"Eur J Med Chem"},{"key":"10.1016\/j.bmcl.2021.128030_h0185","doi-asserted-by":"crossref","first-page":"3884","DOI":"10.2174\/1381612811319210013","article-title":"Current developments of coumarin compounds in medicinal chemistry","volume":"19","author":"Peng","year":"2013","journal-title":"Curr Pharm Des"},{"key":"10.1016\/j.bmcl.2021.128030_h0190","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1039\/C8QO01180J","article-title":"Novel potential artificial MRSA DNA intercalators: Synthesis and biological evaluation of berberine-derived thiazolidinediones","volume":"6","author":"Sun","year":"2019","journal-title":"Org Chem Front"},{"key":"10.1016\/j.bmcl.2021.128030_h0195","doi-asserted-by":"crossref","first-page":"1036","DOI":"10.1021\/acs.molpharmaceut.8b01021","article-title":"Sulfonamide-derived four-component molecular hybrids as novel DNA-targeting membrane active potentiators against clinical Escherichia coli","volume":"16","author":"Hu","year":"2019","journal-title":"Mol Pharm"},{"key":"10.1016\/j.bmcl.2021.128030_h0200","doi-asserted-by":"crossref","first-page":"10160","DOI":"10.1021\/jm3012728","article-title":"A bactericidal guanidinomethyl biaryl that alters the dynamics of bacterial FtsZ polymerization","volume":"55","author":"Kaul","year":"2012","journal-title":"J Med Chem"},{"key":"10.1016\/j.bmcl.2021.128030_h0205","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1016\/j.ejmech.2014.02.027","article-title":"Bifunctional ethyl 2-amino-4-methylthiazole-5-carboxylate derivatives: Synthesis and in vitro biological evaluation as antimicrobial and anticancer agents","volume":"76","author":"Rostom","year":"2014","journal-title":"Eur J Med Chem"},{"key":"10.1016\/j.bmcl.2021.128030_h0210","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.ejmech.2019.01.072","article-title":"Design and synthesis of aminothiazolyl norfloxacin analogues as potential antimicrobial agents and their biological evaluation","volume":"167","author":"Wang","year":"2019","journal-title":"Eur J Med Chem"},{"key":"10.1016\/j.bmcl.2021.128030_h0215","doi-asserted-by":"crossref","first-page":"6511","DOI":"10.1016\/j.bmc.2017.10.028","article-title":"Discovery of novel nitroimidazole enols as Pseudomonas aeruginosa DNA cleavage agents","volume":"25","author":"Li","year":"2017","journal-title":"Bioorg Med Chem"},{"key":"10.1016\/j.bmcl.2021.128030_h0220","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2021.113340","article-title":"Membrane active 7-thiazoxime quinolones as novel DNA binding agents to decrease the genes expression and exert potent anti-methicillin-resistant Staphylococcus aureus activity","volume":"217","author":"Chen","year":"2021","journal-title":"Eur J Med Chem"},{"key":"10.1016\/j.bmcl.2021.128030_h9000","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1038\/s41586-020-2605-1","article-title":"DNA targeting and interference by a bacterial Argonaute nuclease","volume":"587","author":"Kuzmenko","year":"2020","journal-title":"Nature"},{"key":"10.1016\/j.bmcl.2021.128030_h0230","doi-asserted-by":"crossref","first-page":"1621","DOI":"10.1016\/j.bmcl.2018.03.046","article-title":"Novel purine benzimidazoles as antimicrobial agents by regulating ROS generation and targeting clinically resistant Staphylococcus aureus DNA groove","volume":"28","author":"Wang","year":"2018","journal-title":"Bioorg Med Chem Lett"},{"key":"10.1016\/j.bmcl.2021.128030_h0235","doi-asserted-by":"crossref","first-page":"14330","DOI":"10.1039\/C6CC07674B","article-title":"Neutral red as a specific light-up fluorescent probe for i-motif DNA","volume":"52","author":"Xu","year":"2016","journal-title":"Chem Commun"},{"key":"10.1016\/j.bmcl.2021.128030_h0240","doi-asserted-by":"crossref","first-page":"1529","DOI":"10.1039\/C8MD00301G","article-title":"Novel organophosphorus aminopyrimidines as unique structural DNA-targeting membrane active inhibitors towards drug-resistant methicillin-resistant Staphylococcus aureus","volume":"9","author":"Li","year":"2018","journal-title":"Med Chem Commun"},{"key":"10.1016\/j.bmcl.2021.128030_h9005","article-title":"Synthesis and biological evaluation of quinazolonethiazoles as new potential conquerors towards Pseudomonas aeruginosa","volume":"39","author":"Wang","year":"2020","journal-title":"Chin J Chem"},{"key":"10.1016\/j.bmcl.2021.128030_h9010","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1021\/acsmedchemlett.7b00514","article-title":"Potential antimicrobial isopropanol-conjugated carbazole azoles as dual targeting inhibitors of Enterococcus faecalis","volume":"9","author":"Zhang","year":"2018","journal-title":"ACS Med Chem Lett"},{"key":"10.1016\/j.bmcl.2021.128030_h9015","article-title":"Unique para-aminobenzenesulfonyl oxadiazoles as novel structural potential membrane active antibacterial agents towards drug-resistant methicillin resistant Staphylococcus aureus","author":"Wang","year":"2021","journal-title":"Bioorg Med Chem Lett"},{"key":"10.1016\/j.bmcl.2021.128030_h9020","doi-asserted-by":"crossref","DOI":"10.1002\/asia.202100146","article-title":"Pyrimidinetrione-imidazoles as a unique structural type of potential agents towards Candida albicans: Design, synthesis and biological evaluation","author":"Sui","year":"2021","journal-title":"Chem Asian J"}],"container-title":["Bioorganic & Medicinal Chemistry Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0960894X21002560?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0960894X21002560?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,18]],"date-time":"2025-10-18T07:43:52Z","timestamp":1760773432000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0960894X21002560"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,6]]},"references-count":52,"alternative-id":["S0960894X21002560"],"URL":"https:\/\/doi.org\/10.1016\/j.bmcl.2021.128030","relation":{},"ISSN":["0960-894X"],"issn-type":[{"value":"0960-894X","type":"print"}],"subject":[],"published":{"date-parts":[[2021,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Isatin-derived azoles as new potential antimicrobial agents: Design, synthesis and biological evaluation","name":"articletitle","label":"Article Title"},{"value":"Bioorganic & Medicinal Chemistry Letters","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bmcl.2021.128030","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"128030"}}