{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,30]],"date-time":"2025-12-30T08:58:28Z","timestamp":1767085108890,"version":"build-2065373602"},"reference-count":16,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,7,15]],"date-time":"2022-07-15T00:00:00Z","timestamp":1657843200000},"content-version":"am","delay-in-days":317,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100000057","name":"NIGMS","doi-asserted-by":"publisher","award":["R01GM125939"],"award-info":[{"award-number":["R01GM125939"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bioorganic &amp; Medicinal Chemistry Letters"],"published-print":{"date-parts":[[2021,9]]},"DOI":"10.1016\/j.bmcl.2021.128260","type":"journal-article","created":{"date-parts":[[2021,7,13]],"date-time":"2021-07-13T01:55:34Z","timestamp":1626141334000},"page":"128260","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"special_numbering":"C","title":["Your mother was right, washing matters: An alkyne-analog of ibuprofen reveals unwanted reactivity of aromatic compounds with proteins during copper-catalyzed click chemistry"],"prefix":"10.1016","volume":"48","author":[{"given":"Giuliano","family":"Cutolo","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sahiti N.","family":"Shankar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthew R.","family":"Pratt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"3","key":"10.1016\/j.bmcl.2021.128260_b0005","doi-asserted-by":"crossref","first-page":"155","DOI":"10.5001\/omj.2010.49","article-title":"An overview of clinical pharmacology of ibuprofen","volume":"25","author":"Bushra","year":"2010","journal-title":"Oman Med J"},{"issue":"Suppl 1","key":"10.1016\/j.bmcl.2021.128260_b0010","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1007\/BF03342662","article-title":"Comparative Pharmacology of S(+)-Ibuprofen and (RS)-Ibuprofen","volume":"20","author":"Evans","year":"2001","journal-title":"Clin Rheumatol"},{"issue":"1","key":"10.1016\/j.bmcl.2021.128260_b0015","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/j.molcel.2014.03.027","article-title":"Nonenzymatic protein acylation as a carbon stress regulated by sirtuin deacylases","volume":"54","author":"Wagner","year":"2014","journal-title":"Mol. Cell"},{"issue":"2","key":"10.1016\/j.bmcl.2021.128260_b0020","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/j.chembiol.2017.01.002","article-title":"Discovering targets of non-enzymatic acylation by thioester reactivity profiling","volume":"24","author":"Kulkarni","year":"2017","journal-title":"Cell Chem Biol"},{"issue":"s178","key":"10.1016\/j.bmcl.2021.128260_b0025","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1111\/ijcp.12053","article-title":"Ibuprofen blood plasma levels and onset of analgesia","volume":"67","author":"Mehlisch","year":"2013","journal-title":"Int J Clin Pract"},{"issue":"1","key":"10.1016\/j.bmcl.2021.128260_b0030","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1177\/030006058501300110","article-title":"Ibuprofen: plasma concentrations in man","volume":"13","author":"Janssen","year":"1985","journal-title":"J Int Med Res"},{"issue":"4","key":"10.1016\/j.bmcl.2021.128260_b0035","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1016\/j.cell.2020.01.025","article-title":"Click chemistry in proteomic investigations","volume":"180","author":"Parker","year":"2020","journal-title":"Cell"},{"issue":"39","key":"10.1016\/j.bmcl.2021.128260_b0040","doi-asserted-by":"crossref","first-page":"14568","DOI":"10.1021\/ja408322b","article-title":"An alkyne-aspirin chemical reporter for the detection of aspirin-dependent protein modification in living cells","volume":"135","author":"Bateman","year":"2013","journal-title":"J Am Chem Soc"},{"issue":"1","key":"10.1016\/j.bmcl.2021.128260_b0045","article-title":"Mapping sites of aspirin-induced acetylations in live cells by quantitative acid-cleavable activity-based protein profiling (QA-ABPP)","volume":"5","author":"Wang","year":"2015","journal-title":"Sci Rep-UK"},{"issue":"5","key":"10.1016\/j.bmcl.2021.128260_b0050","doi-asserted-by":"crossref","first-page":"1141","DOI":"10.1021\/acschembio.9b01009","article-title":"Translation of microbiota short-chain fatty acid mechanisms affords anti-infective acyl-salicylic acid derivatives","volume":"15","author":"Yang","year":"2020","journal-title":"Acs Chem Biol"},{"issue":"2","key":"10.1016\/j.bmcl.2021.128260_b0055","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/S0022-328X(01)01149-4","article-title":"Heck arylation of allylic alcohols in molten salts","volume":"634","author":"Bouquillon","year":"2001","journal-title":"J Organomet Chem"},{"issue":"3","key":"10.1016\/j.bmcl.2021.128260_b0060","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1016\/0167-4838(91)90164-U","article-title":"Metabolic stereoisomeric inversion of ibuprofen in mammals","volume":"1078","author":"Chen","year":"1991","journal-title":"Biochim Biophys Acta Bba - Protein Struct Mol Enzym."},{"issue":"8","key":"10.1016\/j.bmcl.2021.128260_b0065","doi-asserted-by":"crossref","first-page":"2040","DOI":"10.1021\/acschembio.7b00346","article-title":"Quantitative chemical proteomic profiling of the in vivo targets of reactive drug metabolites","volume":"12","author":"Whitby","year":"2017","journal-title":"Acs Chem Biol"},{"issue":"5","key":"10.1016\/j.bmcl.2021.128260_b0070","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1038\/nmeth.4256","article-title":"MSFragger: ultrafast and comprehensive peptide identification in mass spectrometry\u2013based proteomics","volume":"14","author":"Kong","year":"2017","journal-title":"Nat Methods"},{"issue":"1","key":"10.1016\/j.bmcl.2021.128260_b0075","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-020-17921-y","article-title":"Identification of modified peptides using localization-aware open search","volume":"11","author":"Yu","year":"2020","journal-title":"Nat Commun"},{"key":"10.1016\/j.bmcl.2021.128260_b0080","doi-asserted-by":"crossref","unstructured":"Zanon PRA, Yu F, Musacchio P, et al. Profiling the Proteome-Wide Selectivity of Diverse Electrophiles. ChemRxiv. doi:10.26434\/chemrxiv.14186561.v1.","DOI":"10.26434\/chemrxiv.14186561.v1"}],"container-title":["Bioorganic &amp; Medicinal Chemistry Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0960894X2100487X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0960894X2100487X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,18]],"date-time":"2025-10-18T07:44:32Z","timestamp":1760773472000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0960894X2100487X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,9]]},"references-count":16,"alternative-id":["S0960894X2100487X"],"URL":"https:\/\/doi.org\/10.1016\/j.bmcl.2021.128260","relation":{},"ISSN":["0960-894X"],"issn-type":[{"type":"print","value":"0960-894X"}],"subject":[],"published":{"date-parts":[[2021,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Your mother was right, washing matters: An alkyne-analog of ibuprofen reveals unwanted reactivity of aromatic compounds with proteins during copper-catalyzed click chemistry","name":"articletitle","label":"Article Title"},{"value":"Bioorganic & Medicinal Chemistry Letters","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bmcl.2021.128260","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"128260"}}