{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T21:10:30Z","timestamp":1789765830225,"version":"4.0.1"},"reference-count":27,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100005205","name":"Janssen Research and Development LLC","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005205","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bioorganic & Medicinal Chemistry Letters"],"published-print":{"date-parts":[[2021,11]]},"DOI":"10.1016\/j.bmcl.2021.128353","type":"journal-article","created":{"date-parts":[[2021,9,4]],"date-time":"2021-09-04T18:57:04Z","timestamp":1630781824000},"page":"128353","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":10,"special_numbering":"C","title":["Oxadiazepinone HBV capsid assembly modulators"],"prefix":"10.1016","volume":"52","author":[{"given":"Scott D.","family":"Kuduk","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bart","family":"Stoops","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela M.","family":"Lam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine","family":"Espiritu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Vogel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincent","family":"Lau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Klaus","family":"Klumpp","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Osvaldo A.","family":"Flores","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George D.","family":"Hartman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bmcl.2021.128353_b0005","doi-asserted-by":"crossref","first-page":"953","DOI":"10.3851\/IMP2654","volume":"18","author":"Cowie","year":"2013","journal-title":"Antivir Ther"},{"key":"10.1016\/j.bmcl.2021.128353_b0010","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.coviro.2016.06.004","volume":"18","author":"Zoulim","year":"2016","journal-title":"Curr Opin Virol"},{"key":"10.1016\/j.bmcl.2021.128353_b0015","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/S1473-3099(15)00436-3","volume":"16","author":"Brahmania","year":"2016","journal-title":"Lancet Infect Dis"},{"key":"10.1016\/j.bmcl.2021.128353_b0020","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.antiviral.2015.06.020","volume":"121","author":"Zlotnick","year":"2015","journal-title":"Antiviral Res"},{"key":"10.1016\/j.bmcl.2021.128353_b0025","doi-asserted-by":"crossref","first-page":"1221","DOI":"10.1126\/science.1243462","volume":"343","author":"Lucifora","year":"2014","journal-title":"Science"},{"key":"10.1016\/j.bmcl.2021.128353_b0030","doi-asserted-by":"crossref","first-page":"720","DOI":"10.4161\/epi.6.6.15815","volume":"6","author":"Guo","year":"2011","journal-title":"Epigenetics"},{"key":"10.1016\/j.bmcl.2021.128353_b0035","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1126\/science.1077215","volume":"299","author":"Deres","year":"2003","journal-title":"Science"},{"key":"10.1016\/j.bmcl.2021.128353_b0040","doi-asserted-by":"crossref","first-page":"793","DOI":"10.3851\/IMP2152","volume":"17","author":"Wang","year":"2012","journal-title":"Antivir Ther"},{"key":"10.1016\/j.bmcl.2021.128353_b0045","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/S0166-3542(01)00216-9","volume":"54","author":"Weber","year":"2002","journal-title":"Antiviral Res"},{"key":"10.1016\/j.bmcl.2021.128353_b0050","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0025096","volume":"6","author":"Brezillon","year":"2011","journal-title":"PLoS ONE"},{"key":"10.1016\/j.bmcl.2021.128353_b0055","series-title":"The Liver Meeting 2015 (AASLD), San Francisco, CA","author":"Lam","year":"2015"},{"key":"10.1016\/j.bmcl.2021.128353_b0060","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1016\/j.jhep.2016.05.029","volume":"65","author":"Wang","year":"2016","journal-title":"J Hepatol"},{"issue":"8","key":"10.1016\/j.bmcl.2021.128353_b0065","doi-asserted-by":"crossref","first-page":"e00560","DOI":"10.1128\/AAC.00560-17","volume":"61","author":"Berke","year":"2017","journal-title":"Antimicrob Agents Chemother"},{"issue":"1","key":"10.1016\/j.bmcl.2021.128353_b0070","doi-asserted-by":"crossref","first-page":"e01440","DOI":"10.1128\/AAC.01440-19","volume":"64","author":"Ko","year":"2019","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.bmcl.2021.128353_b0075","first-page":"1","volume":"63","author":"Lam","year":"2018","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.bmcl.2021.128353_b0080","doi-asserted-by":"crossref","first-page":"2405","DOI":"10.1016\/j.bmcl.2019.05.029","volume":"29","author":"Kuduk","year":"2019","journal-title":"Bioorg Med Chem Lett"},{"key":"10.1016\/j.bmcl.2021.128353_b0085","doi-asserted-by":"crossref","DOI":"10.1016\/j.bmcl.2021.127848","volume":"39","author":"Kuduk","year":"2021","journal-title":"Bioorg Med Chem Lett"},{"key":"10.1016\/j.bmcl.2021.128353_b0090","unstructured":"Hartman GD, Kuduk SD. WO 2018005881, April 1, 2018."},{"key":"10.1016\/j.bmcl.2021.128353_b0100","unstructured":"See reference 15 for a detailed description of the assay."},{"key":"10.1016\/j.bmcl.2021.128353_b0105","unstructured":"Simple groups such as CO2H, CONH2, CH2OH are not shown, but all gave HBV DNA EC50s > 10 \u03bcM."},{"key":"10.1016\/j.bmcl.2021.128353_b0110","doi-asserted-by":"crossref","unstructured":"Methodology inspired by this reaction has been described: DeRatt, L.G.; Lawson, E.C.; Wang, C.Y.; Kuduk, S.D. Org. Lett. 2019, 21, 9642-9645.","DOI":"10.1021\/acs.orglett.9b03810"},{"key":"10.1016\/j.bmcl.2021.128353_b0120","unstructured":"The corresponding (R,S) diastereomers showed similar PK properties compared to (R,R) in Table 4."},{"key":"10.1016\/j.bmcl.2021.128353_b0125","doi-asserted-by":"crossref","first-page":"1527","DOI":"10.1124\/dmd.112.044628","volume":"40","author":"Varma","year":"2012","journal-title":". Drug Metab Disp"},{"key":"10.1016\/j.bmcl.2021.128353_b0130","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1517\/17425255.2010.482930","volume":"6","author":"Feng","year":"2010","journal-title":"Drug Metab Toxicol"},{"key":"10.1016\/j.bmcl.2021.128353_b0135","unstructured":"All compounds are single enantiomers with R,R configuration."},{"key":"10.1016\/j.bmcl.2021.128353_b0140","unstructured":"No cytotoxicity was seen as the CC50 in HepG2.2.15 cells was > 100 \u03bcM for compounds described herein."},{"key":"10.1016\/j.bmcl.2021.128353_b0145","unstructured":"http:\/\/www.oecd.org\/dataoecd\/18\/34\/1948442.pdf."}],"container-title":["Bioorganic & Medicinal Chemistry Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0960894X21005801?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0960894X21005801?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,18]],"date-time":"2025-10-18T07:43:10Z","timestamp":1760773390000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0960894X21005801"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,11]]},"references-count":27,"alternative-id":["S0960894X21005801"],"URL":"https:\/\/doi.org\/10.1016\/j.bmcl.2021.128353","relation":{},"ISSN":["0960-894X"],"issn-type":[{"value":"0960-894X","type":"print"}],"subject":[],"published":{"date-parts":[[2021,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Oxadiazepinone HBV capsid assembly modulators","name":"articletitle","label":"Article Title"},{"value":"Bioorganic & Medicinal Chemistry Letters","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bmcl.2021.128353","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"128353"}}