{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T11:05:35Z","timestamp":1775041535017,"version":"3.50.1"},"reference-count":30,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,10,5]],"date-time":"2023-10-05T00:00:00Z","timestamp":1696464000000},"content-version":"am","delay-in-days":703,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["21wm0325002h"],"award-info":[{"award-number":["21wm0325002h"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["20H03497"],"award-info":[{"award-number":["20H03497"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["20H05773"],"award-info":[{"award-number":["20H05773"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008965","name":"Takahashi Industrial and Economic Research Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008965","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bioorganic &amp; Medicinal Chemistry Letters"],"published-print":{"date-parts":[[2021,11]]},"DOI":"10.1016\/j.bmcl.2021.128389","type":"journal-article","created":{"date-parts":[[2021,9,30]],"date-time":"2021-09-30T03:58:15Z","timestamp":1632974295000},"page":"128389","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":12,"special_numbering":"C","title":["Preparation of glycopolymers having sialyl \u03b12\u00a0\u2192\u00a03 lactose moieties as the potent inhibitors for mumps virus"],"prefix":"10.1016","volume":"52","author":[{"given":"Koji","family":"Matsuoka","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takayuki","family":"Kaneshima","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryota","family":"Adachi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiei","family":"Sasaki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takao","family":"Hashiguchi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tetsuo","family":"Koyama","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takahiko","family":"Matsushita","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ken","family":"Hatano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"4","key":"10.1016\/j.bmcl.2021.128389_b0005","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1002\/jmv.25683","article-title":"Global health concerns stirred by emerging viral infections","volume":"92","author":"Luo","year":"2020","journal-title":"J Med Virol"},{"issue":"3","key":"10.1016\/j.bmcl.2021.128389_b0010","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pbio.3001006","article-title":"SARS-CoV-2 variants reveal features critical for replication in primary human cells","volume":"19","author":"Pohl","year":"2021","journal-title":"PLoS Biol"},{"issue":"9616","key":"10.1016\/j.bmcl.2021.128389_b0015","doi-asserted-by":"crossref","first-page":"932","DOI":"10.1016\/S0140-6736(08)60419-5","article-title":"Mumps","volume":"371","author":"Hviid","year":"2008","journal-title":"Lancet"},{"issue":"5","key":"10.1016\/j.bmcl.2021.128389_b0020","doi-asserted-by":"crossref","first-page":"1686","DOI":"10.3390\/ijerph17051686","article-title":"Current status of mumps virus infection: epidemiology, pathogenesis, and vaccine","volume":"17","author":"Su","year":"2020","journal-title":"Int J Environ Res Public Health"},{"issue":"5","key":"10.1016\/j.bmcl.2021.128389_b0025","doi-asserted-by":"crossref","first-page":"e1004791","DOI":"10.1371\/journal.ppat.1004791","article-title":"Remembering mumps","volume":"11","author":"Latner","year":"2015","journal-title":"Plos Pathogens"},{"issue":"2","key":"10.1016\/j.bmcl.2021.128389_b0030","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1002\/rmv.1819","article-title":"Genomic diversity of mumps virus and global distribution of the 12 genotypes","volume":"25","author":"Jin","year":"2015","journal-title":"Rev Med Virol"},{"issue":"41","key":"10.1016\/j.bmcl.2021.128389_b0035","doi-asserted-by":"crossref","first-page":"11579","DOI":"10.1073\/pnas.1608383113","article-title":"Trisaccharide containing alpha 2,3-linked sialic acid is a receptor for mumps virus","volume":"113","author":"Kubota","year":"2016","journal-title":"PNAS"},{"key":"10.1016\/j.bmcl.2021.128389_b0040","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1146\/annurev.bi.56.070187.002053","article-title":"The structure and function of the hemagglutinin membrane glycoprotein of influenza-virus","volume":"56","author":"Wiley","year":"1987","journal-title":"Annu Rev Biochem"},{"issue":"1","key":"10.1016\/j.bmcl.2021.128389_b0045","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1128\/mr.56.1.152-179.1992","article-title":"Evolution and ecology of influenza-A viruses","volume":"56","author":"Webster","year":"1992","journal-title":"Microbiol Rev"},{"issue":"6172","key":"10.1016\/j.bmcl.2021.128389_b0050","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1038\/333426a0","article-title":"Structure of the influenza-virus hemagglutinin complexed with its receptor, sialic-acid","volume":"333","author":"Weis","year":"1988","journal-title":"Nature"},{"issue":"4","key":"10.1016\/j.bmcl.2021.128389_b0055","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1016\/0163-7827(94)90026-4","article-title":"Gangliosides as influenza-virus receptors \u2013 variation of influenza-viruses and their recognition of the receptor sialo-sugar chainS","volume":"33","author":"Suzuki","year":"1994","journal-title":"Prog Lipid Res"},{"issue":"1","key":"10.1016\/j.bmcl.2021.128389_b0060","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-020-58559-6","article-title":"Structural basis for Glycan-receptor binding by mumps virus hemagglutinin-neuraminidase","volume":"10","author":"Forgione","year":"2020","journal-title":"Sci Rep"},{"issue":"19","key":"10.1016\/j.bmcl.2021.128389_b0065","doi-asserted-by":"crossref","first-page":"3327","DOI":"10.1016\/S0040-4039(01)00422-1","article-title":"An alternative route for the construction of carbosilane dendrimers uniformly functionalized with lactose or sialyllactose moieties","volume":"42","author":"Matsuoka","year":"2001","journal-title":"Tetrahedron Lett"},{"issue":"15","key":"10.1016\/j.bmcl.2021.128389_b0070","doi-asserted-by":"crossref","first-page":"4405","DOI":"10.1016\/j.bmcl.2008.06.101","article-title":"Sialyl alpha(2 -> 3) lactose clusters using carbosilane dendrimer core scaffolds as influenza hemagglutinin blockers","volume":"18","author":"Oka","year":"2008","journal-title":"Bioorg Med Chem Lett"},{"issue":"15","key":"10.1016\/j.bmcl.2021.128389_b0075","doi-asserted-by":"crossref","first-page":"5465","DOI":"10.1016\/j.bmc.2009.06.035","article-title":"Syntheses and biological evaluations of carbosilane dendrimers uniformly functionalized with sialyl alpha(2 -> 3) lactose moieties as inhibitors for human influenza viruses","volume":"17","author":"Oka","year":"2009","journal-title":"Bioorg Med Chem"},{"issue":"3","key":"10.1016\/j.bmcl.2021.128389_b0080","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1016\/j.bmcl.2006.10.085","article-title":"Thiosialoside clusters using carbosilane dendrimer core scaffolds as a new class of influenza neuraminidase inhibitors","volume":"17","author":"Sakamoto","year":"2007","journal-title":"Bioorg Med Chem Lett"},{"issue":"1","key":"10.1016\/j.bmcl.2021.128389_b0085","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/S0021-9258(18)33240-X","article-title":"Binding of synthetic oligosaccharides to the hepatic Gal\/GalNAc lectin \u2013 dependence on fine structural features","volume":"258","author":"Lee","year":"1983","journal-title":"J Biol Chem"},{"issue":"7\u20139","key":"10.1016\/j.bmcl.2021.128389_b0090","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1023\/A:1011070425430","article-title":"Affinity enhancement by multivalent lectin-carbohydrate interaction","volume":"17","author":"Lee","year":"2000","journal-title":"Glycoconj J"},{"issue":"2","key":"10.1016\/j.bmcl.2021.128389_b0095","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1021\/cr000418f","article-title":"The cluster glycoside effect","volume":"102","author":"Lundquist","year":"2002","journal-title":"Chem Rev"},{"issue":"1","key":"10.1016\/j.bmcl.2021.128389_b0100","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1016\/j.bmc.2011.10.064","article-title":"Synthesis and biological evaluation of sialic acid derivatives containing a long hydrophobic chain at the anomeric position and their C-5 linked polymers as potent influenza virus inhibitors","volume":"20","author":"Suzuki","year":"2012","journal-title":"Bioorg Med Chem"},{"issue":"21","key":"10.1016\/j.bmcl.2021.128389_b0105","doi-asserted-by":"crossref","first-page":"2593","DOI":"10.1016\/j.tetlet.2009.03.099","article-title":"Synthetic construction of a Le(x) determinant via gabriel amine synthesis and the glycopolymer involving highly clustered Le(x) residues","volume":"50","author":"Matsuoka","year":"2009","journal-title":"Tetrahedron Lett"},{"issue":"22","key":"10.1016\/j.bmcl.2021.128389_b0110","doi-asserted-by":"crossref","first-page":"5792","DOI":"10.1016\/j.bmc.2018.10.023","article-title":"Synthetic construction of sugar-amino acid hybrid polymers involving globotriaose or lactose and evaluation of their biological activities against Shiga toxins produced by Escherichia coli O157:H7","volume":"26","author":"Matsuoka","year":"2018","journal-title":"Bioorg Med Chem"},{"key":"10.1016\/j.bmcl.2021.128389_b0115","doi-asserted-by":"crossref","first-page":"128404","DOI":"10.1016\/j.molstruc.2020.128404","article-title":"Verification of suitable ratio of carbohydrate residues in a glycopolymer having GlcNAc moieties for determining the affinity for wheat germ agglutinin","volume":"1217","author":"Matsuoka","year":"2020","journal-title":"J Mol Struct"},{"issue":"15","key":"10.1016\/j.bmcl.2021.128389_b0120","doi-asserted-by":"crossref","DOI":"10.1128\/JVI.00344-19","article-title":"Molecular Mechanism of the Flexible Glycan Receptor Recognition by Mumps Virus","volume":"93","author":"Kubota","year":"2019","journal-title":"J Virol"},{"issue":"50","key":"10.1016\/j.bmcl.2021.128389_b0125","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/S0065-2318(08)60150-X","article-title":"Anomeric-oxygen activation for glycoside synthesis \u2013 the trichloroacetimidate method","volume":"50","author":"Schmidt","year":"1994","journal-title":"Adv Carbohydr Chem Biochem"},{"issue":"6","key":"10.1016\/j.bmcl.2021.128389_b0130","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1080\/07328309208020087","article-title":"Synthetic studies on sialoglycoconjugates. 41. A facile total synthesis of ganglioside GM2","volume":"11","author":"Hasegawa","year":"1992","journal-title":"J Carbohydr Chem"},{"issue":"9","key":"10.1016\/j.bmcl.2021.128389_b0135","doi-asserted-by":"crossref","first-page":"1895","DOI":"10.1002\/(SICI)1099-0690(199809)1998:9<1895::AID-EJOC1895>3.0.CO;2-S","article-title":"Synthesis of specifically labelled ganglioside 1c-C-13 -GM(3)","volume":"1998","author":"Tietze","year":"1998","journal-title":"Eur J Org Chem"},{"issue":"2","key":"10.1016\/j.bmcl.2021.128389_b0140","first-page":"1613","article-title":"The saponification acetyl sugar and relative substances","volume":"62","author":"Zemplen","year":"1929","journal-title":"Ber Dtsch Chem Ges"},{"key":"10.1016\/j.bmcl.2021.128389_b0145","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/j.bioorg.2016.08.002","article-title":"Synthetic assembly of novel avidin-biotin-GlcNAc (ABG) complex as an attractive bio-probe and its interaction with wheat germ agglutinin (WGA)","volume":"68","author":"Kumari","year":"2016","journal-title":"Bioorg Chem"},{"issue":"18","key":"10.1016\/j.bmcl.2021.128389_b0150","doi-asserted-by":"crossref","first-page":"4182","DOI":"10.1021\/ma00220a024","article-title":"Synthetic glycoconjugates \u2013 simple and potential glycoprotein models containing pendant N-acetyl-D-glucosamine and N,N'-diacetylchitobiose","volume":"23","author":"Nishimura","year":"1990","journal-title":"Macromolecules"}],"container-title":["Bioorganic &amp; Medicinal Chemistry Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0960894X21006168?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0960894X21006168?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,18]],"date-time":"2025-10-18T07:43:27Z","timestamp":1760773407000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0960894X21006168"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,11]]},"references-count":30,"alternative-id":["S0960894X21006168"],"URL":"https:\/\/doi.org\/10.1016\/j.bmcl.2021.128389","relation":{},"ISSN":["0960-894X"],"issn-type":[{"value":"0960-894X","type":"print"}],"subject":[],"published":{"date-parts":[[2021,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Preparation of glycopolymers having sialyl \u03b12\u00a0\u2192\u00a03 lactose moieties as the potent inhibitors for mumps virus","name":"articletitle","label":"Article Title"},{"value":"Bioorganic & Medicinal Chemistry Letters","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bmcl.2021.128389","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"128389"}}