{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T00:54:32Z","timestamp":1790729672375,"version":"4.1.0"},"reference-count":38,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bioorganic & Medicinal Chemistry Letters"],"published-print":{"date-parts":[[2022,9]]},"DOI":"10.1016\/j.bmcl.2022.128877","type":"journal-article","created":{"date-parts":[[2022,7,1]],"date-time":"2022-07-01T03:20:38Z","timestamp":1656645638000},"page":"128877","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":38,"special_numbering":"C","title":["Synthesis and biological evaluation of new 2\u2011substituted\u20114\u2011amino-quinolines and -quinazoline as potential antifungal agents"],"prefix":"10.1016","volume":"72","author":[{"given":"Tian-Hong","family":"Qin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian-Chuan","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin-Yuan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin-Xiu","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0736-538X","authenticated-orcid":false,"given":"Yan-Ni","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"6390","key":"10.1016\/j.bmcl.2022.128877_b0005","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1126\/science.aap7999","article-title":"Worldwide emergence of resistance to antifungal drugs challenges human health and food security","volume":"360","author":"Fisher","year":"2018","journal-title":"Science"},{"issue":"165","key":"10.1016\/j.bmcl.2022.128877_b0010","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1126\/scitranslmed.3004404","article-title":"Hidden killers: Human fungal infections","volume":"4","author":"Brown","year":"2012","journal-title":"Sci Transl Med"},{"issue":"2","key":"10.1016\/j.bmcl.2022.128877_b0015","doi-asserted-by":"crossref","first-page":"1116","DOI":"10.1021\/acs.jmedchem.0c01763","article-title":"Novel carboline fungal histone deacetylase (HDAC) inhibitors for combinational treatment of azole-resistant candidiasis","volume":"64","author":"Li","year":"2021","journal-title":"J Med Chem"},{"key":"10.1016\/j.bmcl.2022.128877_b0020","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/j.ejmech.2017.05.043","article-title":"Design, synthesis and evaluation of aromatic heterocyclic derivatives as potent antifungal agents","volume":"137","author":"Zhao","year":"2017","journal-title":"Eur J Med Chem"},{"key":"10.1016\/j.bmcl.2022.128877_b0025","doi-asserted-by":"crossref","DOI":"10.1016\/j.bmcl.2020.127727","article-title":"Highly potent, broadly active antifungal agents for the treatment of invasive fungal infections","volume":"33","author":"Baugh","year":"2021","journal-title":"Bioorg Med Chem Lett"},{"issue":"1","key":"10.1016\/j.bmcl.2022.128877_b0030","doi-asserted-by":"crossref","first-page":"28","DOI":"10.3390\/jof6010028","article-title":"Aspiring antifungals: Review of current antifungal pipeline developments","volume":"6","author":"Gintjee","year":"2020","journal-title":"J Fungi"},{"issue":"17","key":"10.1016\/j.bmcl.2022.128877_b0035","doi-asserted-by":"crossref","first-page":"12903","DOI":"10.1021\/acs.jmedchem.1c01073","article-title":"Development of membrane-active honokiol\/magnolol amphiphiles as potent antibacterial agents against methicillin-resistant Staphylococcus aureus (MRSA)","volume":"64","author":"Guo","year":"2021","journal-title":"J Med Chem"},{"issue":"3","key":"10.1016\/j.bmcl.2022.128877_b0040","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1021\/acs.jnatprod.9b01285","article-title":"Natural products as sources of new drugs over the nearly four decades from 01\/1981 to 09\/2019","volume":"83","author":"Newman","year":"2020","journal-title":"J Nat Prod"},{"key":"10.1016\/j.bmcl.2022.128877_b0045","doi-asserted-by":"crossref","DOI":"10.1016\/j.bioorg.2021.104639","article-title":"Quinolines, a perpetual, multipurpose scaffold in medicinal chemistry","volume":"109","author":"Yadav","year":"2021","journal-title":"Bioorg Chem"},{"issue":"16","key":"10.1016\/j.bmcl.2022.128877_b0050","doi-asserted-by":"crossref","first-page":"2209","DOI":"10.2174\/1389557521666210210155908","article-title":"Quinoline: An attractive scaffold in drug design","volume":"21","author":"Moor","year":"2021","journal-title":"Mini-Rev Med Chem"},{"key":"10.1016\/j.bmcl.2022.128877_b0055","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.ejmech.2018.11.026","article-title":"Green recipes to quinoline: A review","volume":"164","author":"Nainwal","year":"2019","journal-title":"Eur J Med Chem"},{"issue":"8","key":"10.1016\/j.bmcl.2022.128877_b0060","doi-asserted-by":"crossref","first-page":"617","DOI":"10.2174\/1568026620666200127141550","article-title":"Quinoline containing side-chain antimalarial analogs: Recent advances and therapeutic application","volume":"20","author":"Joshi","year":"2020","journal-title":"Curr Trends Med Chem"},{"issue":"21","key":"10.1016\/j.bmcl.2022.128877_b0065","doi-asserted-by":"crossref","first-page":"9672","DOI":"10.1021\/acs.jmedchem.6b00723","article-title":"Discovery of a quinoline-4-carboxamide derivative with a novel mechanism of action, multistage antimalarial activity, and potent in vivo efficacy","volume":"59","author":"Baragana","year":"2016","journal-title":"J Med Chem"},{"issue":"28","key":"10.1016\/j.bmcl.2022.128877_b0070","doi-asserted-by":"crossref","first-page":"2599","DOI":"10.2174\/1568026620999200917154225","article-title":"An overview of privileged scaffold: Quinolines and isoquinolines in medicinal chemistry as anticancer agents","volume":"20","author":"Mao","year":"2020","journal-title":"Curr Trends Med Chem"},{"issue":"3","key":"10.1016\/j.bmcl.2022.128877_b0075","doi-asserted-by":"crossref","first-page":"e2000232","DOI":"10.1002\/ardp.202000232","article-title":"Recent update on antibacterial and antifungal activity of quinoline scaffolds","volume":"354","author":"Dorababu","year":"2021","journal-title":"Arch Pharm (Weinheim)"},{"key":"10.1016\/j.bmcl.2022.128877_b0080","doi-asserted-by":"crossref","DOI":"10.1016\/j.bioorg.2021.104803","article-title":"Novel structural hybrids of quinoline and thiazole moieties: Synthesis and evaluation of antibacterial and antifungal activities with molecular modeling studies","volume":"110","author":"Eissa","year":"2021","journal-title":"Bioorg Chem"},{"issue":"41","key":"10.1016\/j.bmcl.2022.128877_b0085","doi-asserted-by":"crossref","first-page":"11340","DOI":"10.1021\/acs.jafc.9b04224","article-title":"Design, synthesis, and antifungal evaluation of novel quinoline derivatives inspired from natural quinine alkaloids","volume":"67","author":"Yang","year":"2019","journal-title":"J Agric Food Chem"},{"issue":"8","key":"10.1016\/j.bmcl.2022.128877_b0090","doi-asserted-by":"crossref","first-page":"2263","DOI":"10.1093\/jac\/dkx117","article-title":"The quinoline bromoquinol exhibits broad-spectrum antifungal activity and induces oxidative stress and apoptosis in Aspergillus fumigatus","volume":"72","author":"Yaakov","year":"2017","journal-title":"J Antimicrob Chemother"},{"issue":"9","key":"10.1016\/j.bmcl.2022.128877_b0095","doi-asserted-by":"crossref","first-page":"1185","DOI":"10.2174\/1381612826666201211121721","article-title":"Chloroquine analogs: An overview of natural and synthetic quinolines as broad spectrum antiviral agents","volume":"27","author":"Pallaval","year":"2021","journal-title":"Curr Pharm Des"},{"key":"10.1016\/j.bmcl.2022.128877_b0100","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2021.113220","article-title":"Synthetic and medicinal perspective of quinolines as antiviral agents","volume":"215","author":"Kaur","year":"2021","journal-title":"Eur J Med Chem"},{"issue":"31","key":"10.1016\/j.bmcl.2022.128877_b0105","doi-asserted-by":"crossref","first-page":"9878","DOI":"10.1002\/slct.202002345","article-title":"Quinoline glycoconjugates as potentially anticancer and anti-inflammatory agents: An investigation involving synthesis, biological screening, and docking","volume":"5","author":"Pallavi","year":"2020","journal-title":"Chemistryselect"},{"issue":"16","key":"10.1016\/j.bmcl.2022.128877_b0110","doi-asserted-by":"crossref","first-page":"2285","DOI":"10.2174\/1389557521666210111145011","article-title":"Antioxidant, anti-inflammatory, antibacterial, and analgesic activities and mechanisms of quinolines, indoles and related derivatives","volume":"21","author":"Zhang","year":"2021","journal-title":"Mini-Rev Med Chem"},{"key":"10.1016\/j.bmcl.2022.128877_b0115","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1016\/j.jphotobiol.2017.05.043","article-title":"Synthesis, structural elucidation, antioxidant, CT-DNA binding and molecular docking studies of novel chloroquinoline derivatives: promising antioxidant and anti-diabetic agents","volume":"173","author":"Murugavel","year":"2017","journal-title":"J Photochem Photobiol B"},{"issue":"80","key":"10.1016\/j.bmcl.2022.128877_b0120","doi-asserted-by":"crossref","first-page":"65496","DOI":"10.1039\/C5RA08778C","article-title":"Antihypertensive activity of a quinoline appended chalcone derivative and its site specific binding interaction with a relevant target carrier protein","volume":"5","author":"Kumar","year":"2015","journal-title":"RSC Adv"},{"key":"10.1016\/j.bmcl.2022.128877_b0125","doi-asserted-by":"crossref","first-page":"1463","DOI":"10.1016\/j.ejmech.2017.10.046","article-title":"Quinoline derivatives bearing pyrazole moiety: synthesis and biological evaluation as possible antibacterial and antifungal agents","volume":"143","author":"El Shehry","year":"2018","journal-title":"Eur J Med Chem"},{"issue":"5","key":"10.1016\/j.bmcl.2022.128877_b0130","doi-asserted-by":"crossref","first-page":"e2100106","DOI":"10.1002\/cbdv.202100106","article-title":"4-Aminoquinolines bearing a 1,3-benzodioxole moiety: synthesis and biological evaluation as potential antifungal agents","volume":"18","author":"Yang","year":"2021","journal-title":"Chem Biodiversity"},{"issue":"4","key":"10.1016\/j.bmcl.2022.128877_b0135","doi-asserted-by":"crossref","first-page":"1065","DOI":"10.1007\/s11030-019-10012-1","article-title":"Synthesis and biological evaluation of 2-phenyl-4-aminoquinolines as potential antifungal agents","volume":"24","author":"Yang","year":"2020","journal-title":"Mol Diversity"},{"issue":"8","key":"10.1016\/j.bmcl.2022.128877_b0140","doi-asserted-by":"crossref","first-page":"2143","DOI":"10.6023\/cjoc201801024","article-title":"Synthesis and antifungal activities of 4-thioquinoline compounds","volume":"38","author":"Yang","year":"2018","journal-title":"Chin J Org Chem"},{"key":"10.1016\/j.bmcl.2022.128877_b0145","unstructured":"Yang R, Qin TH, Li ZL, Xie JL, He RX. Preparation of 4-aminoquinoline compound as agricultural antibacterial agent: China, CN110372588A [P]. 2019-10-25."},{"key":"10.1016\/j.bmcl.2022.128877_b0150","doi-asserted-by":"crossref","DOI":"10.1016\/j.bmcl.2021.128013","article-title":"Inhibitory effects and mechanism of antifungal action of the natural cyclic depsipeptide, aureobasidin A against Cryptococcus neoformans","volume":"41","author":"Teymuri","year":"2021","journal-title":"Bioorg Med Chem Lett"},{"issue":"22","key":"10.1016\/j.bmcl.2022.128877_b0155","doi-asserted-by":"crossref","first-page":"4964","DOI":"10.1016\/j.bmcl.2017.10.020","article-title":"Novel potentially antifungal hybrids of 5-flucytosine and fluconazole: Design, synthesis and bioactive evaluation","volume":"27","author":"Fang","year":"2017","journal-title":"Bioorg Med Chem Lett"},{"issue":"12","key":"10.1016\/j.bmcl.2022.128877_b0160","doi-asserted-by":"crossref","first-page":"2427","DOI":"10.1016\/j.bmc.2019.02.009","article-title":"Design, synthesis and biological evaluation of amide-pyridine derivatives as novel dual-target (SE, CYP51) antifungal inhibitors","volume":"27","author":"Sun","year":"2019","journal-title":"Bioorg Med Chem"},{"key":"10.1016\/j.bmcl.2022.128877_b0165","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2021.113557","article-title":"Discovery of novel purinylthiazolylethanone derivatives as anti-Candida albicans agents through possible multifaceted mechanisms","volume":"221","author":"Sui","year":"2021","journal-title":"Eur J Med Chem"},{"key":"10.1016\/j.bmcl.2022.128877_b0170","doi-asserted-by":"crossref","DOI":"10.1016\/j.bmc.2021.116184","article-title":"Synthesis of osthol-based botanical fungicides and their antifungal application in crop protection","volume":"40","author":"Guo","year":"2021","journal-title":"Bioorg Med Chem"},{"key":"10.1016\/j.bmcl.2022.128877_b0175","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/j.biochi.2016.05.013","article-title":"Antifungal peptides: To be or not to be membrane active","volume":"130","author":"Rautenbach","year":"2016","journal-title":"Biochimie"},{"key":"10.1016\/j.bmcl.2022.128877_b0180","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1016\/j.ejmech.2017.02.055","article-title":"Synthesis and formulation studies of griseofulvin analogues with improved solubility and metabolic stability","volume":"130","author":"Petersen","year":"2017","journal-title":"Eur J Med Chem"},{"key":"10.1016\/j.bmcl.2022.128877_b0185","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/j.ejmech.2018.12.042","article-title":"N, N'-diaryl-bishydrazones in a biphenyl platform: Broad spectrum antifungal agents","volume":"164","author":"Thamban Chandrika","year":"2019","journal-title":"Eur J Med Chem"},{"issue":"9","key":"10.1016\/j.bmcl.2022.128877_b0190","doi-asserted-by":"crossref","first-page":"2478","DOI":"10.1021\/acsinfecdis.0c00377","article-title":"Discovery, synthesis, and biological evaluation of dunnianol-based mannich bases against methicillin-resistant Staphylococcus aureus (MRSA)","volume":"6","author":"Guo","year":"2020","journal-title":"Acs Infect Dis"}],"container-title":["Bioorganic & Medicinal Chemistry Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0960894X22003535?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0960894X22003535?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,18]],"date-time":"2025-10-18T07:46:35Z","timestamp":1760773595000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0960894X22003535"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,9]]},"references-count":38,"alternative-id":["S0960894X22003535"],"URL":"https:\/\/doi.org\/10.1016\/j.bmcl.2022.128877","relation":{},"ISSN":["0960-894X"],"issn-type":[{"value":"0960-894X","type":"print"}],"subject":[],"published":{"date-parts":[[2022,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Synthesis and biological evaluation of new 2\u2011substituted\u20114\u2011amino-quinolines and -quinazoline as potential antifungal agents","name":"articletitle","label":"Article Title"},{"value":"Bioorganic & Medicinal Chemistry Letters","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bmcl.2022.128877","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"128877"}}