{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,14]],"date-time":"2026-02-14T10:05:41Z","timestamp":1771063541127,"version":"3.50.1"},"reference-count":31,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["21771023"],"award-info":[{"award-number":["21771023"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["22076013"],"award-info":[{"award-number":["22076013"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009592","name":"Beijing Municipal Science and Technology Commission","doi-asserted-by":"publisher","award":["Z181100002218033"],"award-info":[{"award-number":["Z181100002218033"]}],"id":[{"id":"10.13039\/501100009592","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bioorganic &amp; Medicinal Chemistry Letters"],"published-print":{"date-parts":[[2022,10]]},"DOI":"10.1016\/j.bmcl.2022.128918","type":"journal-article","created":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T02:02:27Z","timestamp":1659319347000},"page":"128918","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Novel 99mTc labeled complexes with bisphosphonate isocyanide: Radiosynthesis and evaluation as potential bone-seeking agents"],"prefix":"10.1016","volume":"73","author":[{"given":"Di","family":"Xiao","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuhao","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junhong","family":"Feng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qing","family":"Ruan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qianna","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guangxing","family":"Yin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junbo","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.bmcl.2022.128918_b0005","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1002\/jbmr.3869","article-title":"A CTGF-UNX2-ANKL axis in breast and prostate cancer cells promotes tumor progression in bone","volume":"35","author":"Kim","year":"2020","journal-title":"J Bone Mineral Res"},{"key":"10.1016\/j.bmcl.2022.128918_b0010","doi-asserted-by":"crossref","first-page":"2099","DOI":"10.1002\/jbmr.3618","article-title":"Understanding the bone in cancer metastasis","volume":"33","author":"Fornetti","year":"2018","journal-title":"J Bone Miner Res"},{"key":"10.1016\/j.bmcl.2022.128918_b0015","doi-asserted-by":"crossref","first-page":"833","DOI":"10.2217\/nnm-2020-0024","article-title":"Bone-targeted PAMAM nanoparticle to treat bone metastases of lung cancer","volume":"15","author":"Bai","year":"2020","journal-title":"Nanomedicine."},{"key":"10.1016\/j.bmcl.2022.128918_b0020","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1007\/s10198-018-1011-1","article-title":"Denosumab versus bisphosphonates for the treatment of bone metastases from solid tumors: a systematic review","volume":"20","author":"Matuoka","year":"2019","journal-title":"Euro J Health Econo."},{"key":"10.1016\/j.bmcl.2022.128918_b0025","article-title":"Bone metastasis pattern of cancer patients with bone metastasis but no visceral metastasis","volume":"415","author":"Zhu","year":"2019","journal-title":"J Bone Oncol."},{"key":"10.1016\/j.bmcl.2022.128918_b0030","doi-asserted-by":"crossref","first-page":"1052","DOI":"10.1111\/bcp.13867","article-title":"Pharmacology of bisphosphonates","volume":"85","author":"Cremers","year":"2019","journal-title":"Br J Clin Pharmacol"},{"key":"10.1016\/j.bmcl.2022.128918_b0035","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.bone.2011.03.774","article-title":"The relationship between the chemistry and biological activity of the bisphosphonates","volume":"49","author":"Ebetino","year":"2011","journal-title":"Bone"},{"key":"10.1016\/j.bmcl.2022.128918_b0040","doi-asserted-by":"crossref","DOI":"10.1016\/j.bone.2020.115784","article-title":"Bisphosphonates for the treatment of fibrous dysplasia of bone","volume":"143","author":"Chapurlat","year":"2021","journal-title":"Bone"},{"key":"10.1016\/j.bmcl.2022.128918_b0045","doi-asserted-by":"crossref","first-page":"9381","DOI":"10.1021\/acs.jmedchem.6b00938","article-title":"A bone-seeking trans-cyclooctene for pretargeting and bioorthogonal chemistry: a proof of concept study using 99mTc- and 177Lu-labeled tetrazines","volume":"59","author":"Yazdani","year":"2016","journal-title":"J Med Chem"},{"key":"10.1016\/j.bmcl.2022.128918_b0050","doi-asserted-by":"crossref","first-page":"1260","DOI":"10.1021\/acs.jmedchem.0c01292","article-title":"Bisphosphonates, old friends of bones and new trends in clinics","volume":"64","author":"Barbosa","year":"2021","journal-title":"J Med Chem"},{"key":"10.1016\/j.bmcl.2022.128918_b0055","doi-asserted-by":"crossref","first-page":"45","DOI":"10.3390\/ph10020045","article-title":"Novel radiolabeled bisphosphonates for PET diagnosis and endoradiotherapy of bone metastases","volume":"10","author":"Pfannkuchen","year":"2017","journal-title":"Pharmaceuticals."},{"key":"10.1016\/j.bmcl.2022.128918_b0060","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.nucmedbio.2020.04.002","article-title":"Biodistribution, dosimetry, and temporal signal-to-noise ratio analyses of normal and cancer uptake of [68Ga]Ga-P15-041, a gallium-68 labeled bisphosphonate, from first-in-human studies","volume":"86","author":"Doot","year":"2020","journal-title":"Nucl Med Biol"},{"key":"10.1016\/j.bmcl.2022.128918_b0065","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1007\/s12149-019-01348-7","article-title":"Preliminary results of biodistribution and dosimetric analysis of [68Ga]Ga-DOTAZOL: a new zoledronate-based bisphosphonate for PET\/CT diagnosis of bone diseases","volume":"33","author":"Khawar","year":"2019","journal-title":"Ann Nucl Med"},{"key":"10.1016\/j.bmcl.2022.128918_b0070","doi-asserted-by":"crossref","first-page":"1126","DOI":"10.2967\/jnumed.120.255851","article-title":"Evaluation of safety and dosimetry of 177Lu-DOTA-ZOL for therapy of bone metastases","volume":"62","author":"Fernandez","year":"2021","journal-title":"J Nucl Med"},{"issue":"5","key":"10.1016\/j.bmcl.2022.128918_b0075","doi-asserted-by":"crossref","first-page":"2958","DOI":"10.1021\/acs.inorgchem.6b03058","article-title":"Technetium(I) complexes of bathophenanthrolinedisulfonic acid","volume":"56","author":"Yazdani","year":"2017","journal-title":"Inorg Chem."},{"key":"10.1016\/j.bmcl.2022.128918_b0080","doi-asserted-by":"crossref","first-page":"1284","DOI":"10.2967\/jnumed.119.236943","article-title":"SPECT\/CT: standing on the shoulders of giants, it is time to reach for the sky!","volume":"61","author":"Wyngaert","year":"2020","journal-title":"J Nucl Med"},{"key":"10.1016\/j.bmcl.2022.128918_b0085","doi-asserted-by":"crossref","first-page":"496","DOI":"10.3390\/molecules23020496","article-title":"In silico-based repositioning of phosphinothricin as a novel Technetium-99m imaging probe with potential anti-cancer activity","volume":"23","author":"Sakr","year":"2018","journal-title":"Molecules"},{"key":"10.1016\/j.bmcl.2022.128918_b0090","doi-asserted-by":"crossref","first-page":"11537220","DOI":"10.1016\/j.bone.2020.115372","article-title":"Imaging with radiolabelled bisphosphonates","volume":"137","author":"Cook","year":"2020","journal-title":"Bone"},{"key":"10.1016\/j.bmcl.2022.128918_b0095","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1039\/B512310K","article-title":"'Magic bullets' for bone diseases: progress in rational design of bone-seeking medicinal agents","volume":"36","author":"Zhang","year":"2007","journal-title":"Chem Soc Rev"},{"key":"10.1016\/j.bmcl.2022.128918_b0100","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1155\/2011\/537687","article-title":"Advances in drug design of radiometal-based imaging agents for bone disorders","volume":"2011","author":"Ogawa","year":"2011","journal-title":"Int J Mol Imaging."},{"key":"10.1016\/j.bmcl.2022.128918_b0105","doi-asserted-by":"crossref","first-page":"2301","DOI":"10.1021\/acs.molpharmaceut.6b00081","article-title":"Development and pharmacological evaluation of new bone-targeted 99mTc radiolabeled bisphosphonates","volume":"13","author":"Makris","year":"2016","journal-title":"Mol Pharm"},{"key":"10.1016\/j.bmcl.2022.128918_b0110","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1148\/rg.232025103","article-title":"Pharmaceutical and clinical development of phosphonate-based radiopharmaceuticals for the targeted treatment of bone metastases","volume":"23","author":"Love","year":"2003","journal-title":"Radiographics."},{"key":"10.1016\/j.bmcl.2022.128918_b0115","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1007\/s00775-007-0215-0","article-title":"A new bisphosphonate-containing 99mTc(I) tricarbonyl complex potentially useful as bone-seeking agent: synthesis and biological evaluation","volume":"12","author":"Palma","year":"2007","journal-title":"J Biol Inorg Chem"},{"key":"10.1016\/j.bmcl.2022.128918_b0120","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1080\/10717544.2017.1422295","article-title":"Bone-targeted methotrexate\u2013alendronate conjugate inhibits osteoclastogenesis in vitro and prevents bone loss and inflammation of collageninduced arthritis in vivo","volume":"25","author":"Xie","year":"2018","journal-title":"Drug Delivery"},{"key":"10.1016\/j.bmcl.2022.128918_b0125","doi-asserted-by":"crossref","first-page":"345","DOI":"10.59566\/IJBS.2009.5345","article-title":"Pamidronate alters the growth plate in the oim mouse model for osteogenesis imperfecta","volume":"5","author":"Evans","year":"2009","journal-title":"Int J Bioc Sci."},{"key":"10.1016\/j.bmcl.2022.128918_b0130","doi-asserted-by":"crossref","first-page":"1255","DOI":"10.1007\/s10967-013-2833-z","article-title":"In vitro incorporation studies of 99mTc-alendronate sodium at different bone cell lines","volume":"299","author":"Gundogdu","year":"2014","journal-title":"J Radioanal Nucl Chem"},{"key":"10.1016\/j.bmcl.2022.128918_b0135","doi-asserted-by":"crossref","first-page":"2787","DOI":"10.1039\/c0dt01396j","article-title":"99mTc(CO)3-labeled pamidronate and alendronate for bone imaging","volume":"40","author":"Palma","year":"2011","journal-title":"Dalton Trans"},{"key":"10.1016\/j.bmcl.2022.128918_b0140","doi-asserted-by":"crossref","first-page":"3417","DOI":"10.1021\/acs.molpharmaceut.8b00415","article-title":"Novel 99mTc-labeled glucose derivative for single photon emission computed tomography: a promising tumor imaging agent","volume":"15","author":"Zhang","year":"2018","journal-title":"Mol Pharm"},{"key":"10.1016\/j.bmcl.2022.128918_b0145","doi-asserted-by":"crossref","first-page":"3331","DOI":"10.1021\/acs.jmedchem.6b00024","article-title":"Purification-free method for preparing technetium-99m-labeled multivalent probes for enhanced in vivo imaging of saturable systems","volume":"59","author":"Mizuno","year":"2016","journal-title":"J Med Chem"},{"key":"10.1016\/j.bmcl.2022.128918_b0150","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1111\/cbdd.13117","article-title":"Synthesis and evaluation of a novel 99mTc nitrido radiopharmaceutical with alendronate dithiocarbamate as a potential bone-imaging agent","volume":"91","author":"Song","year":"2018","journal-title":"Chem Biol Drug Des"},{"key":"10.1016\/j.bmcl.2022.128918_b0155","first-page":"2042","article-title":"Development of a novel 99mTc-chelate-conjugated bisphosphonate with high affinity for bone as a bone scintigraphic agent","volume":"47","author":"Ogawa","year":"2006","journal-title":"J Nucl Med"}],"container-title":["Bioorganic &amp; Medicinal Chemistry Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0960894X22003948?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0960894X22003948?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,18]],"date-time":"2025-10-18T07:47:06Z","timestamp":1760773626000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0960894X22003948"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,10]]},"references-count":31,"alternative-id":["S0960894X22003948"],"URL":"https:\/\/doi.org\/10.1016\/j.bmcl.2022.128918","relation":{},"ISSN":["0960-894X"],"issn-type":[{"value":"0960-894X","type":"print"}],"subject":[],"published":{"date-parts":[[2022,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Novel 99mTc labeled complexes with bisphosphonate isocyanide: Radiosynthesis and evaluation as potential bone-seeking agents","name":"articletitle","label":"Article Title"},{"value":"Bioorganic & Medicinal Chemistry Letters","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bmcl.2022.128918","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"128918"}}