{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T10:58:02Z","timestamp":1770721082185,"version":"3.49.0"},"reference-count":58,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bioorganic &amp; Medicinal Chemistry Letters"],"published-print":{"date-parts":[[2023,1]]},"DOI":"10.1016\/j.bmcl.2022.129080","type":"journal-article","created":{"date-parts":[[2022,11,19]],"date-time":"2022-11-19T02:15:31Z","timestamp":1668824131000},"page":"129080","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":22,"special_numbering":"C","title":["Synthesis of esters and amides of 2-aryl-1-hydroxy-4-methyl-1H-imidazole-5-carboxylic acids and study of their antiviral activity against orthopoxviruses"],"prefix":"10.1016","volume":"79","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1542-5565","authenticated-orcid":false,"given":"P.A.","family":"Nikitina","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.I.","family":"Basanova","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.B.","family":"Nikolaenkova","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I.A.","family":"Os'kina","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"O.A.","family":"Serova","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N.I.","family":"Bormotov","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.N.","family":"Shishkina","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V.P.","family":"Perevalov","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.Ya.","family":"Tikhonov","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.bmcl.2022.129080_b0005","doi-asserted-by":"crossref","first-page":"2278","DOI":"10.1001\/jama.2022.9499","article-title":"What to know about monkeypox","volume":"327","author":"Harris","year":"2022","journal-title":"J Am Med Assoc"},{"key":"10.1016\/j.bmcl.2022.129080_b0010","doi-asserted-by":"crossref","first-page":"4068","DOI":"10.1128\/JCM.41.9.4068-4070.2003","article-title":"Smallpox: residual antibody after vacccination","volume":"41","author":"Gallwitz","year":"2003","journal-title":"J Clin Microbiol"},{"key":"10.1016\/j.bmcl.2022.129080_b0015","doi-asserted-by":"crossref","first-page":"D49","DOI":"10.1016\/j.vaccine.2011.05.037","article-title":"Emergence and reemergence of smallpox: The need for development of a new generation smallpox vaccine","volume":"29S","author":"Shchelkunov","year":"2011","journal-title":"Vaccine"},{"key":"10.1016\/j.bmcl.2022.129080_b0020","doi-asserted-by":"crossref","first-page":"138","DOI":"10.3390\/v12020138","article-title":"Smallpox in the Post-eradication era","volume":"12","author":"Meyer","year":"2020","journal-title":"Viruses"},{"key":"10.1016\/j.bmcl.2022.129080_b0025","unstructured":"World Health Organization. Multi-country outbreak of monkeypox. External Situation Report #6 \u2013 21 September 2022. Accessed 04 October 2022. https:\/\/www.who.int\/publications\/m\/item\/multi-country-outbreak-of-monkeypox--external-situation-report--6---21-september-2022."},{"key":"10.1016\/j.bmcl.2022.129080_b0030","doi-asserted-by":"crossref","unstructured":"Silva N.I.O., de Oliveira J.S., Kroon E.G., Trindade G.d.S., Drumond B.P. Here, There, and Everywhere: The Wide Host Range and Geographic Distribution of Zoonotic Orthopoxviruses. Viruses, 2021, 13, 43. DOI: 10.3390\/v13010043.","DOI":"10.3390\/v13010043"},{"key":"10.1016\/j.bmcl.2022.129080_b0035","doi-asserted-by":"crossref","unstructured":"Shchelkunov S.N., Shchelkunova G.A. We should be prepared to smallpox re-emergence. Voprosy Virusologii (Problems of Virology, Russian journal), 2019, 64(5), 206-214. (In Russ.) DOI: 10.36233\/0507-4088-2019-64-5-206-214.","DOI":"10.36233\/0507-4088-2019-64-5-206-214"},{"key":"10.1016\/j.bmcl.2022.129080_b0040","doi-asserted-by":"crossref","first-page":"2127","DOI":"10.1001\/jama.281.22.2127","article-title":"Smallpox as a biological weapon","volume":"281","author":"Henderson","year":"1999","journal-title":"J Am Med Assoc"},{"key":"10.1016\/j.bmcl.2022.129080_b0045","doi-asserted-by":"crossref","first-page":"817","DOI":"10.2174\/156652405774962326","article-title":"Countermeasures to the bioterrorist threat of smallpox","volume":"5","author":"Jahrling","year":"2005","journal-title":"Curr Mol Med"},{"key":"10.1016\/j.bmcl.2022.129080_b0050","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1177\/0897190012456366","article-title":"Bioterrorism: pathogens as weapons","volume":"25","author":"Anderson","year":"2012","journal-title":"J Pharm Pract"},{"key":"10.1016\/j.bmcl.2022.129080_b0055","doi-asserted-by":"crossref","first-page":"5","DOI":"10.2217\/fmb.14.108","article-title":"The need for a decision: the future of biological science and humanity","volume":"10","author":"Shapiro","year":"2015","journal-title":"Future Microbiol"},{"key":"10.1016\/j.bmcl.2022.129080_b0060","doi-asserted-by":"crossref","first-page":"2057","DOI":"10.1056\/NEJMc1208124","article-title":"Variola virus in a 300-year-old siberian mummy","volume":"367","author":"Biagini","year":"2012","journal-title":"N Engl J Med"},{"key":"10.1016\/j.bmcl.2022.129080_b0065","doi-asserted-by":"crossref","first-page":"177","DOI":"10.3201\/eid2002.131098","article-title":"Poxvirus viability and signatures in historical relics","volume":"20","author":"McCollum","year":"2014","journal-title":"Emerg Infect Dis"},{"key":"10.1016\/j.bmcl.2022.129080_b0070","doi-asserted-by":"crossref","first-page":"2803","DOI":"10.3390\/v2122803","article-title":"Cidofovir activity against poxvirus infections","volume":"2","author":"Andrei","year":"2010","journal-title":"Viruses"},{"key":"10.1016\/j.bmcl.2022.129080_b0075","doi-asserted-by":"crossref","first-page":"2409","DOI":"10.3390\/v2112409","article-title":"Development of ST-246 \u00ae for treatment of poxvirus infections","volume":"2","author":"Jordan","year":"2010","journal-title":"Viruses"},{"key":"10.1016\/j.bmcl.2022.129080_b0080","doi-asserted-by":"crossref","DOI":"10.1016\/j.antiviral.2021.105182","article-title":"Benefit-risk assessment for brincidofovir for the treatment of smallpox: U.S. Food and drug administration\u2019s evaluation","volume":"195","author":"Chan-Tack","year":"2021","journal-title":"Antiv Res"},{"key":"10.1016\/j.bmcl.2022.129080_b0085","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1080\/14787210.2020.1819791","article-title":"An overview of tecovirimat for smallpox treatment and expanded anti-orthopoxvirus applications","volume":"19","author":"Russo","year":"2021","journal-title":"Expert Rev Anti-Infect Ther"},{"key":"10.1016\/j.bmcl.2022.129080_b0090","doi-asserted-by":"crossref","first-page":"1229","DOI":"10.1099\/jgv.0.000422","article-title":"New effective chemically synthesized anti-smallpox compound NIOCH-14","volume":"97","author":"Mazurkov","year":"2016","journal-title":"J General Virol"},{"key":"10.1016\/j.bmcl.2022.129080_b0095","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1007\/s10517-020-05034-x","article-title":"Estimation of absolute bioavailability of the chemical substance of the anti-smallpox preparation NIOCH-14 in mice","volume":"170","author":"Mazurkov","year":"2020","journal-title":"Bull Exp Biol Med"},{"key":"10.1016\/j.bmcl.2022.129080_b0100","doi-asserted-by":"crossref","unstructured":"Moiseev I.K., Kon\u2019kov S.A., Ovchinnikov K.A., Kilyaeva N.M., Bormasheva K.M., Nechaeva O.N., Leonova M.V., Klimochkin Yu.N., Balakhnin S.M., Bormotov N.I., Serova O.A., Belanov E.F. Synthesis and antiviral activity of new adamantane dervatives. Pharm. Chem. J., 2012, 45(10), 588-592. DOI: 10.1007\/s11094-012-0686-3.","DOI":"10.1007\/s11094-012-0686-3"},{"key":"10.1016\/j.bmcl.2022.129080_b0105","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2021.113485","article-title":"Adamantane derivatives as potential inhibitors of p37 major envelope protein and poxvirus reproduction. Design, synthesis and antiviral activity","volume":"221","author":"Shiryaev","year":"2021","journal-title":"Eur J Med Chem"},{"key":"10.1016\/j.bmcl.2022.129080_b0110","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1007\/s11094-012-0698-z","article-title":"Synthesis and antiviral activity of 1,2,4-triazine derivatives","volume":"45","author":"Rusinov","year":"2012","journal-title":"Pharm Chem J"},{"key":"10.1016\/j.bmcl.2022.129080_b0115","doi-asserted-by":"crossref","first-page":"1746","DOI":"10.1039\/C8MD00347E","article-title":"Synthesis and antiviral activity of camphor-based 1,3-thiazolidin-4-one and thiazole derivatives as Orthopoxvirus-reproduction inhibitors","volume":"9","author":"Sokolova","year":"2018","journal-title":"Med Chem Comm"},{"key":"10.1016\/j.bmcl.2022.129080_b0120","doi-asserted-by":"crossref","first-page":"e1800153","DOI":"10.1002\/cbdv.201800153","article-title":"Discovery of a new class of inhibitors of vaccinia virus based on (-)-borneol from Abies sibirica and (+)-Camphor","volume":"15","author":"Sokolova","year":"2018","journal-title":"Chem Biodivers"},{"key":"10.1016\/j.bmcl.2022.129080_b0125","doi-asserted-by":"crossref","first-page":"1185","DOI":"10.1039\/D0MD00108B","article-title":"New chemical agents based on adamantane-monoterpene conjugates against orthopoxvirus infections","volume":"11","author":"Suslov","year":"2020","journal-title":"RSC Med Chem"},{"key":"10.1016\/j.bmcl.2022.129080_b0130","doi-asserted-by":"crossref","first-page":"e2100038","DOI":"10.1002\/ardp.202100038","article-title":"(+)-Camphor and (-)-borneol derivatives as potential anti-orthopoxvirus agents","author":"Sokolova","year":"2021","journal-title":"Arch Pharm"},{"key":"10.1016\/j.bmcl.2022.129080_b0135","doi-asserted-by":"crossref","first-page":"2235","DOI":"10.3390\/molecules26082235","article-title":"Synthesis and antiviral activity of camphene derivatives against different types of viruses","volume":"26","author":"Sokolova","year":"2021","journal-title":"Molecules"},{"key":"10.1016\/j.bmcl.2022.129080_b0140","first-page":"e20210071","article-title":"Design, synthesis and biological evaluation of novel (+)-camphor and (-)-fenchone based derivatives as potent orthopoxviruses inhibitors","author":"Sokolova","year":"2022","journal-title":"ChemMedChem"},{"key":"10.1016\/j.bmcl.2022.129080_b0145","doi-asserted-by":"crossref","first-page":"4761","DOI":"10.3390\/molecules27154761","article-title":"Synthesis and antiviral properties of camphor-derived iminothiazolidine-4-ones and 2,3-dihydrothiazoles","volume":"27","author":"Oreshko","year":"2022","journal-title":"Molecules"},{"key":"10.1016\/j.bmcl.2022.129080_b0150","doi-asserted-by":"crossref","first-page":"3147","DOI":"10.1016\/j.bmcl.2015.06.006","article-title":"Design and synthesis of imidazole N-H substituted amide prodrugs as inhibitors of hepatitis C virus replication","volume":"25","author":"Zong","year":"2015","journal-title":"Bioorg Med Chem Lett"},{"key":"10.1016\/j.bmcl.2022.129080_b0155","doi-asserted-by":"crossref","first-page":"3711","DOI":"10.1016\/j.bmcl.2015.06.031","article-title":"Design, synthesis and evaluation of novel anti-HCV molecules that deliver intracellularly three highly potent NS5A inhibitors","volume":"25","author":"Boucle","year":"2015","journal-title":"Bioorg Med Chem Lett"},{"key":"10.1016\/j.bmcl.2022.129080_b0160","doi-asserted-by":"crossref","first-page":"228","DOI":"10.3390\/molecules21020228","article-title":"Synthesis and structure-activity relationships of imidazole-coumarin conjugates against hepatitis C virus","volume":"21","author":"Tsay","year":"2016","journal-title":"Molecules"},{"key":"10.1016\/j.bmcl.2022.129080_b0165","doi-asserted-by":"crossref","first-page":"10228","DOI":"10.1021\/acs.jmedchem.6b01234","article-title":"Discovery of chromane containung hepatitis C virus (HCV) NS5A inhibitors with improved potency against resistance-associated variants","volume":"59","author":"Yu","year":"2016","journal-title":"J Med Chem"},{"key":"10.1016\/j.bmcl.2022.129080_b0170","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1021\/acs.jmedchem.6b01310","article-title":"Discovery of ruzasvir (MK-8408): a potent, pan-genotype HCV NS5A inhibitor with optimized activity against common resistance-associated polymorphisms","volume":"60","author":"Tong","year":"2017","journal-title":"J Med Chem"},{"key":"10.1016\/j.bmcl.2022.129080_b0175","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.ejmech.2016.09.031","article-title":"New potent biaryl sulfate-based hepatitis C virus inhibitors","volume":"125","author":"You","year":"2017","journal-title":"Eur J Med Chem"},{"key":"10.1016\/j.bmcl.2022.129080_b0180","doi-asserted-by":"crossref","first-page":"31803","DOI":"10.1039\/C8RA05471A","article-title":"Sulfur(VI) fluoride exchange as a key reaction for synthesizing biaryl sulfate core derivatives as potent hepatitis C virus NS5A inhibitors and their structure-activity relationship studies","volume":"8","author":"You","year":"2018","journal-title":"RSC Adv"},{"key":"10.1016\/j.bmcl.2022.129080_b0185","doi-asserted-by":"crossref","first-page":"632","DOI":"10.3390\/ph15050632","article-title":"Design and synthesis of novel bis-imidazolyl phenyl butadiyne derivatives as HCV NS5A inhibitors","volume":"15","author":"Hamdy","year":"2022","journal-title":"Pharmaceuticals"},{"key":"10.1016\/j.bmcl.2022.129080_b0190","doi-asserted-by":"crossref","DOI":"10.1016\/j.bmc.2020.115952","article-title":"Discovery and structure activity relationship of glyoxamide derivatives as anti-hepatitis B virus agents","volume":"31","author":"Amblard","year":"2021","journal-title":"Bioorg Med Chem"},{"key":"10.1016\/j.bmcl.2022.129080_b0195","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1016\/j.ejmech.2015.12.013","article-title":"Imidazole-based pinanamine derivatives: discovery of dual inhibitors of the wild-type and drug-resistant mutant of the influenza A virus","volume":"108","author":"Dong","year":"2016","journal-title":"Eur J Med Chem"},{"key":"10.1016\/j.bmcl.2022.129080_b0200","doi-asserted-by":"crossref","first-page":"150","DOI":"10.3390\/molecules21020150","article-title":"Imidazole alkaloids from the south china sea sponge Pericharax heteroraphis and their cytotoxic and antiviral activities","volume":"21","author":"Gong","year":"2016","journal-title":"Molecules"},{"key":"10.1016\/j.bmcl.2022.129080_b0205","doi-asserted-by":"crossref","first-page":"2181","DOI":"10.1016\/j.bmc.2019.04.015","article-title":"Synthesis and biological evaluation of novel imidazole nucleosides as potential anti-dengue virus agents","volume":"27","author":"Okano","year":"2019","journal-title":"Bioorg Med Chem"},{"key":"10.1016\/j.bmcl.2022.129080_b0210","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1248\/cpb.c21-01038","article-title":"Synthesis and anti-dengue virus activity of 5-ethynylimidazole-4-carboxamide (EICA) nucleotide prodrugs","volume":"70","author":"Nakamura","year":"2022","journal-title":"Chem Pharm Bull"},{"key":"10.1016\/j.bmcl.2022.129080_b0215","doi-asserted-by":"crossref","first-page":"e202201560","DOI":"10.1002\/slct.202201560","article-title":"Antileishmanial and anti-chikungunya activity of Cu(I)-N-heterocyclic carbenes","volume":"7","author":"Fontes","year":"2022","journal-title":"ChemistrySelect"},{"key":"10.1016\/j.bmcl.2022.129080_b0220","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1016\/j.fsi.2019.07.006","article-title":"Synthesis and antiviral activity of a new arctigenin derivative against IHNV in vitro and in vivo","volume":"92","author":"Hu","year":"2019","journal-title":"Fish Shellfish Immunol"},{"key":"10.1016\/j.bmcl.2022.129080_b0225","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.virusres.2019.05.007","article-title":"Antiviral efficiency of a coumarin derivative on spring viremia of carp virus in vivo","volume":"268","author":"Liu","year":"2019","journal-title":"Virus Res"},{"key":"10.1016\/j.bmcl.2022.129080_b0230","doi-asserted-by":"crossref","first-page":"1749","DOI":"10.1016\/j.bmcl.2019.05.019","article-title":"Synthesis and antiviral activity of coumarin derivatives against infectious hematopoietis necrosis virus","volume":"29","author":"Hu","year":"2019","journal-title":"Bioorg Med Chem Lett"},{"key":"10.1016\/j.bmcl.2022.129080_b0235","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/j.virusres.2019.01.009","article-title":"An imidazole coumarin derivative enhances the antiviral response to spring viremia of carp virus infection in zebrafish","volume":"263","author":"Liu","year":"2019","journal-title":"Virus Res"},{"key":"10.1016\/j.bmcl.2022.129080_b0240","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.ejmech.2018.11.064","article-title":"Synthesis of arctigenin derivatives against infectious hematopoietic necrosis virus","volume":"163","author":"Hu","year":"2019","journal-title":"Eur J Med Chem"},{"key":"10.1016\/j.bmcl.2022.129080_b0245","doi-asserted-by":"crossref","first-page":"3924","DOI":"10.1021\/acs.jmedchem.8b01827","article-title":"Fragment-based discovery of a qualified hit targeting the latency-associated nuclear antigen of the oncogenic kaposi\u2019s sarcoma-associated herpesvirus\/human herpesvirus 8","volume":"62","author":"Kirsch","year":"2019","journal-title":"J Med Chem"},{"key":"10.1016\/j.bmcl.2022.129080_b0250","doi-asserted-by":"crossref","first-page":"1177","DOI":"10.1007\/s10822-021-00428-z","article-title":"Design of new imidazole derivatives with anti-HCMV activity: QSAR modeling, synthesis and biological testing","volume":"35","author":"Kovalishyn","year":"2021","journal-title":"J Comput Aided Mol Design"},{"key":"10.1016\/j.bmcl.2022.129080_b0255","doi-asserted-by":"crossref","first-page":"6203","DOI":"10.3390\/molecules26206203","article-title":"Studies towards the design and synthesis of novel 1,5-diaryl-1H-imidazole-4-carboxylic acids and 1,5-Diaryl-1H-imidazole-4-carbohydrazides as host LEDGF\/p75 and HIV-1 integrase interaction inhibitors","volume":"26","author":"Rashamuse","year":"2021","journal-title":"Molecules"},{"key":"10.1016\/j.bmcl.2022.129080_b0260","doi-asserted-by":"crossref","first-page":"2923","DOI":"10.1016\/j.bmcl.2015.05.039","article-title":"Design, synthesis and evaluation of a series of acyclic fleximer nucleoside analogues with anti-coronavirus activity","volume":"25","author":"Peters","year":"2015","journal-title":"Bioorg Med Chem Lett"},{"key":"10.1016\/j.bmcl.2022.129080_b0265","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1007\/s11172-019-2467-6","article-title":"Synthesis and antiviral activity of 1-hydroxy-2-(2-hydroxyphenyl)imidazoles against vaccinia virus","volume":"68","author":"Nikitina","year":"2019","journal-title":"Russ Chem Bull Int Ed"},{"key":"10.1016\/j.bmcl.2022.129080_b0270","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1007\/s10593-017-2030-z","article-title":"Methods of synthesis and physicochemical properties of 1-hydroxyimidazoles, imidazole 3-oxides, and their benzoannulated analogs","volume":"53","author":"Nikitina","year":"2017","journal-title":"Chem Heterocy Compounds"},{"key":"10.1016\/j.bmcl.2022.129080_b0275","doi-asserted-by":"crossref","first-page":"3249","DOI":"10.1016\/j.tet.2013.02.039","article-title":"Synthesis and study of prototropic tautomerism of 2-(3-chromenyl)-1-hydroxyimidazoles","volume":"69","author":"Nikitina","year":"2013","journal-title":"Tetrahedron"},{"key":"10.1016\/j.bmcl.2022.129080_b0280","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1007\/s10593-018-2355-2","article-title":"New 4H-thieno[3,2-b]pyrrole-5-carboxamides","volume":"54","author":"Torosyan","year":"2018","journal-title":"Chem Heterocy Compd."},{"key":"10.1016\/j.bmcl.2022.129080_b0285","doi-asserted-by":"crossref","DOI":"10.1016\/j.bmc.2020.115455","article-title":"Optimization and biological evaluation of imidazopyridine derivatives as a novel scaffold for \u03b3-secretase modulators with oral efficacy against cognitive deficits in Alzheimer\u2019s disease model mice","volume":"28","author":"Sekioka","year":"2020","journal-title":"Bioorg Med Chem"},{"key":"10.1016\/j.bmcl.2022.129080_b0290","doi-asserted-by":"crossref","first-page":"2264","DOI":"10.1016\/j.bmcl.2011.02.108","article-title":"Design and synthesis of isoquinolines and benzimidazoles as RAF kinase inhibitors","volume":"21","author":"Buchstaller","year":"2011","journal-title":"Bioorg Med Chem Lett"}],"container-title":["Bioorganic &amp; Medicinal Chemistry Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0960894X2200556X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0960894X2200556X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,18]],"date-time":"2025-10-18T07:46:52Z","timestamp":1760773612000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0960894X2200556X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,1]]},"references-count":58,"alternative-id":["S0960894X2200556X"],"URL":"https:\/\/doi.org\/10.1016\/j.bmcl.2022.129080","relation":{},"ISSN":["0960-894X"],"issn-type":[{"value":"0960-894X","type":"print"}],"subject":[],"published":{"date-parts":[[2023,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Synthesis of esters and amides of 2-aryl-1-hydroxy-4-methyl-1H-imidazole-5-carboxylic acids and study of their antiviral activity against orthopoxviruses","name":"articletitle","label":"Article Title"},{"value":"Bioorganic & Medicinal Chemistry Letters","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bmcl.2022.129080","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"129080"}}