{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T20:04:38Z","timestamp":1770494678344,"version":"3.49.0"},"reference-count":40,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100000923","name":"Australian Research Council","doi-asserted-by":"publisher","award":["FT16010007"],"award-info":[{"award-number":["FT16010007"]}],"id":[{"id":"10.13039\/501100000923","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bioorganic &amp; Medicinal Chemistry Letters"],"published-print":{"date-parts":[[2023,1]]},"DOI":"10.1016\/j.bmcl.2022.129086","type":"journal-article","created":{"date-parts":[[2022,11,21]],"date-time":"2022-11-21T02:17:20Z","timestamp":1668997040000},"page":"129086","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"special_numbering":"C","title":["Cage hydrocarbons as linkers in dimeric drug design: Case studies with trimethoprim and tedizolid"],"prefix":"10.1016","volume":"80","author":[{"given":"Biljana","family":"Vujcic","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jessica","family":"Wyllie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"family":"Tania","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jed","family":"Burns","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keith F.","family":"White","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simon","family":"Cromwell","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David W.","family":"Lupton","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jason L.","family":"Dutton","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tatiana P.","family":"Soares da Costa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sevan D.","family":"Houston","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.bmcl.2022.129086_b0005","author":"Reardon","year":"2014","journal-title":"Nature"},{"key":"10.1016\/j.bmcl.2022.129086_b0010","unstructured":"2020 Antibacterial Agents in Clinical and Preclinical Development: An Overview and Analysis. Available at: https:\/\/www.who.int\/publications\/i\/item\/9789240021303."},{"key":"10.1016\/j.bmcl.2022.129086_b0015","doi-asserted-by":"crossref","first-page":"971","DOI":"10.2217\/fmb-2018-0054","volume":"13","author":"Patel","year":"2018","journal-title":"Future Microbiol"},{"key":"10.1016\/j.bmcl.2022.129086_b0020","doi-asserted-by":"crossref","first-page":"2757","DOI":"10.1093\/cid\/ciaa336","volume":"71","author":"Watkins","year":"2020","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.bmcl.2022.129086_b0025","article-title":"Tackling drug-resistant infections globally: final report and recommendations","author":"O'Neill","year":"2016","journal-title":"Rev Antimicrob Res"},{"key":"10.1016\/j.bmcl.2022.129086_h0030","doi-asserted-by":"crossref","first-page":"1089","DOI":"10.1126\/science.1176667","volume":"325","author":"Fischbach","year":"2009","journal-title":"Science"},{"key":"10.1016\/j.bmcl.2022.129086_h0035","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1038\/nrd4510","volume":"14","author":"Harvey","year":"2015","journal-title":"Nat Rev Drug Discov"},{"key":"10.1016\/j.bmcl.2022.129086_h0040","doi-asserted-by":"crossref","first-page":"2754","DOI":"10.1002\/(SICI)1521-3773(19981102)37:20<2754::AID-ANIE2754>3.0.CO;2-3","volume":"37","author":"Mammen","year":"1998","journal-title":"Angew Chem, Int Ed"},{"key":"10.1016\/j.bmcl.2022.129086_h0045","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1038\/s41392-019-0101-6","volume":"4","author":"Sun","year":"2019","journal-title":"Signal Trans Targeted Ther"},{"key":"10.1016\/j.bmcl.2022.129086_h0050","doi-asserted-by":"crossref","first-page":"3468","DOI":"10.1016\/j.bmcl.2015.07.010","volume":"25","author":"Ross","year":"2015","journal-title":"Bioorg Med Chem Lett"},{"key":"10.1016\/j.bmcl.2022.129086_h0055","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1002\/chem.201604765","volume":"23","author":"Silverman","year":"2017","journal-title":"Chem\u2014A Eur J"},{"key":"10.1016\/j.bmcl.2022.129086_h0060","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1080\/17460441.2016.1187597","volume":"11","author":"Parkes","year":"2016","journal-title":"Expert Opin Drug Discov"},{"key":"10.1016\/j.bmcl.2022.129086_h0065","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1038\/nrd2202","volume":"6","author":"Silver","year":"2007","journal-title":"Nature Rev Drug Discov"},{"key":"10.1016\/j.bmcl.2022.129086_h0070","doi-asserted-by":"crossref","first-page":"832","DOI":"10.1039\/C7NP00006E","volume":"34","author":"Klahn","year":"2017","journal-title":"Natural Prod Rep"},{"issue":"23","key":"10.1016\/j.bmcl.2022.129086_b0050","doi-asserted-by":"crossref","first-page":"127514","DOI":"10.1016\/j.bmcl.2020.127514","volume":"30","author":"Sampath Kumar","year":"2020","journal-title":"Bioorg Med Chem Lett"},{"key":"10.1016\/j.bmcl.2022.129086_b0055","doi-asserted-by":"crossref","first-page":"2428","DOI":"10.1016\/j.bmcl.2012.02.019","volume":"22","author":"Karoli","year":"2012","journal-title":"Bioorg Med Chem Lett"},{"issue":"19","key":"10.1016\/j.bmcl.2022.129086_b0060","doi-asserted-by":"crossref","first-page":"1712","DOI":"10.2174\/1568026619666190712205025","volume":"19","author":"de Sena","year":"2019","journal-title":"Curr Top Med Chem"},{"key":"10.1016\/j.bmcl.2022.129086_b0065","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1038\/nature22308","volume":"545","author":"Richter","year":"2017","journal-title":"Nature"},{"key":"10.1016\/j.bmcl.2022.129086_b0070","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1038\/ja.2013.27","volume":"66","author":"Shapiro","year":"2013","journal-title":"J Antibiotics"},{"key":"10.1016\/j.bmcl.2022.129086_h0100","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/j.nurt.2008.10.037","volume":"6","author":"Van der Schyf","year":"2009","journal-title":"Neurotherapeutics"},{"key":"10.1016\/j.bmcl.2022.129086_h0105","doi-asserted-by":"crossref","first-page":"2059","DOI":"10.1002\/anie.199420591","volume":"33","author":"Carell","year":"1994","journal-title":"Angew Chem (Int Ed English)"},{"key":"10.1016\/j.bmcl.2022.129086_b0080","doi-asserted-by":"crossref","first-page":"4590","DOI":"10.1002\/chem.201804225","volume":"25","author":"Locke","year":"2019","journal-title":"Chem\u2014A Eur J"},{"key":"10.1016\/j.bmcl.2022.129086_b0085","doi-asserted-by":"crossref","first-page":"3580","DOI":"10.1002\/anie.201510675","volume":"55","author":"Chalmers","year":"2016","journal-title":"Angew Chem, Int Ed"},{"key":"10.1016\/j.bmcl.2022.129086_h0120","doi-asserted-by":"crossref","first-page":"1078","DOI":"10.1021\/acs.jmedchem.8b00888","volume":"62","author":"Reekie","year":"2019","journal-title":"J Med Chem"},{"key":"10.1016\/j.bmcl.2022.129086_h0125","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.1039\/C8OB02959H","volume":"17","author":"Houston","year":"2019","journal-title":"Org Biomol Chem"},{"key":"10.1016\/j.bmcl.2022.129086_h0130","doi-asserted-by":"crossref","first-page":"6790","DOI":"10.1039\/C9OB01238A","volume":"17","author":"Houston","year":"2019","journal-title":"Org Biomol Chem"},{"key":"10.1016\/j.bmcl.2022.129086_h0135","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1586\/eem.10.60","volume":"5","author":"Rosenstock","year":"2010","journal-title":"Expert Rev Endocrinol Metab"},{"key":"10.1016\/j.bmcl.2022.129086_h0140","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1021\/acsmedchemlett.6b00281","volume":"8","author":"Measom","year":"2017","journal-title":"ACS Med Chem Lett"},{"key":"10.1016\/j.bmcl.2022.129086_b0095","unstructured":"Labischinski JCH, Calanasan C, Boyce RS, WO 2010\/025906 A2."},{"key":"10.1016\/j.bmcl.2022.129086_b0100","doi-asserted-by":"crossref","first-page":"23","DOI":"10.3390\/antib6040023","volume":"6","author":"Westbroek","year":"2017","journal-title":"Antibodies (Basel)"},{"key":"10.1016\/j.bmcl.2022.129086_h0155","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/S1473-3099(18)30614-5","volume":"19","author":"Gerding","year":"2019","journal-title":"Lancet Infect Dis"},{"key":"10.1016\/j.bmcl.2022.129086_h0160","doi-asserted-by":"crossref","first-page":"5634","DOI":"10.1038\/s41598-019-42155-4","volume":"9","author":"Scaiola","year":"2019","journal-title":"Sci Rep"},{"key":"10.1016\/j.bmcl.2022.129086_b0110","doi-asserted-by":"crossref","first-page":"10006","DOI":"10.1021\/ja202767g","volume":"133","author":"Long","year":"2011","journal-title":"J Am Chem Soc"},{"key":"10.1016\/j.bmcl.2022.129086_b0115","doi-asserted-by":"crossref","first-page":"6719","DOI":"10.1021\/cr500523x","volume":"115","author":"Biegasiewicz","year":"2015","journal-title":"Chem Rev"},{"key":"10.1016\/j.bmcl.2022.129086_b0120","doi-asserted-by":"crossref","first-page":"1641","DOI":"10.3390\/molecules24081641","volume":"24","author":"Liu","year":"2019","journal-title":"Molecules"},{"key":"10.1016\/j.bmcl.2022.129086_h0180","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.1002\/1521-3773(20020315)41:6<1053::AID-ANIE1053>3.0.CO;2-4","volume":"41","author":"Lewis","year":"2002","journal-title":"Angew Chem, Int Ed"},{"key":"10.1016\/j.bmcl.2022.129086_h0185","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1002\/anie.201508330","volume":"55","author":"Gorityala","year":"2016","journal-title":"Angew Chem, Int Ed"},{"key":"10.1016\/j.bmcl.2022.129086_h0190","doi-asserted-by":"crossref","first-page":"6517","DOI":"10.1021\/ja021273s","volume":"125","author":"Griffin","year":"2003","journal-title":"J Am Chem Soc"},{"key":"10.1016\/j.bmcl.2022.129086_h0195","doi-asserted-by":"crossref","first-page":"19688","DOI":"10.1021\/jacs.9b08064","volume":"141","author":"Sarkar","year":"2019","journal-title":"J Am Chem Soc"},{"key":"10.1016\/j.bmcl.2022.129086_h0200","doi-asserted-by":"crossref","first-page":"1954","DOI":"10.1016\/j.bmcl.2019.05.039","volume":"29","author":"Xing","year":"2019","journal-title":"Bioorg Med Chem Lett"}],"container-title":["Bioorganic &amp; Medicinal Chemistry Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0960894X22005625?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0960894X22005625?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,18]],"date-time":"2025-10-18T07:46:22Z","timestamp":1760773582000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0960894X22005625"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,1]]},"references-count":40,"alternative-id":["S0960894X22005625"],"URL":"https:\/\/doi.org\/10.1016\/j.bmcl.2022.129086","relation":{},"ISSN":["0960-894X"],"issn-type":[{"value":"0960-894X","type":"print"}],"subject":[],"published":{"date-parts":[[2023,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Cage hydrocarbons as linkers in dimeric drug design: Case studies with trimethoprim and tedizolid","name":"articletitle","label":"Article Title"},{"value":"Bioorganic & Medicinal Chemistry Letters","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bmcl.2022.129086","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"129086"}}