{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,20]],"date-time":"2026-01-20T06:52:42Z","timestamp":1768891962578,"version":"3.49.0"},"reference-count":27,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100018530","name":"Major Science and Technology Projects in Anhui Province","doi-asserted-by":"publisher","award":["202203a07020029"],"award-info":[{"award-number":["202203a07020029"]}],"id":[{"id":"10.13039\/501100018530","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bioorganic & Medicinal Chemistry Letters"],"published-print":{"date-parts":[[2023,1]]},"DOI":"10.1016\/j.bmcl.2022.129101","type":"journal-article","created":{"date-parts":[[2022,12,5]],"date-time":"2022-12-05T14:23:09Z","timestamp":1670250189000},"page":"129101","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":9,"special_numbering":"C","title":["Synthesis and biological evaluation of N-(benzene sulfonyl)acetamide derivatives as anti-inflammatory and analgesic agents with COX-2\/5-LOX\/TRPV1 multifunctional inhibitory activity"],"prefix":"10.1016","volume":"80","author":[{"given":"Wenli","family":"Chen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qinlong","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaodong","family":"Ma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiajia","family":"Mo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gaofeng","family":"Lin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guangwei","family":"He","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhaoxing","family":"Chu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiaming","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.bmcl.2022.129101_b0005","doi-asserted-by":"crossref","first-page":"eabj7360","DOI":"10.1126\/scitranslmed.abj7360","article-title":"Brain circuits for pain and its treatment","volume":"13","author":"Mercer Lindsay","year":"2021","journal-title":"Science Translational Medicine"},{"key":"10.1016\/j.bmcl.2022.129101_b0010","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1186\/s12916-020-01644-4","article-title":"All-cause mortality in patients with long-term opioid therapy compared with non-opioid analgesics for chronic non-cancer pain: a database study","volume":"18","author":"Hauser","year":"2020","journal-title":"BMC Medicine"},{"key":"10.1016\/j.bmcl.2022.129101_b0015","doi-asserted-by":"crossref","first-page":"251","DOI":"10.2147\/DDDT.S342409","article-title":"Less Well-Known Consequences of the Long-Term Use of Opioid Analgesics: A Comprehensive Literature Review","volume":"16","author":"Kotlinska-Lemieszek","year":"2022","journal-title":"Drug Design, Development and Therapy"},{"key":"10.1016\/j.bmcl.2022.129101_b0020","doi-asserted-by":"crossref","unstructured":"Bedini, A., Cuna, E., Baiula, M., Spampinato, S. Quantitative Systems Pharmacology and Biased Agonism at Opioid Receptors: A Potential Avenue for Improved Analgesics. Int J Mol Sci. 2022, 23.","DOI":"10.3390\/ijms23095114"},{"key":"10.1016\/j.bmcl.2022.129101_b0025","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/j.gastrohep.2021.06.003","article-title":"NSAIDs, gastrointestinal toxicity and inflammatory bowel disease","volume":"45","author":"Hijos-Mallada","year":"2022","journal-title":"Gastroenterolog\u00eda y Hepatolog\u00eda"},{"key":"10.1016\/j.bmcl.2022.129101_b0030","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1038\/s41569-020-0366-z","article-title":"Cardiovascular effects and safety of (non-aspirin) NSAIDs","volume":"17","author":"Schjerning","year":"2020","journal-title":"Nature Reviews. Cardiology"},{"key":"10.1016\/j.bmcl.2022.129101_b0035","first-page":"CD012129","article-title":"Aspirin (single dose) for perineal pain in the early postpartum period","volume":"2","author":"Molakatalla","year":"2017","journal-title":"Cochrane Database of Systematic Reviews"},{"key":"10.1016\/j.bmcl.2022.129101_b0040","doi-asserted-by":"crossref","first-page":"257","DOI":"10.3389\/fnmol.2019.00257","article-title":"Indomethacin Enhances Type 1 Cannabinoid Receptor Signaling","volume":"12","author":"Laprairie","year":"2019","journal-title":"Frontiers in Molecular Neuroscience"},{"key":"10.1016\/j.bmcl.2022.129101_b0045","doi-asserted-by":"crossref","first-page":"1879125","DOI":"10.1155\/2020\/1879125","article-title":"Employment of Alginate Floating In Situ Gel for Controlled Delivery of Celecoxib: Solubilization and Formulation Studies","author":"Abdul Rasool","year":"2020","journal-title":"Biomed Research International"},{"key":"10.1016\/j.bmcl.2022.129101_b0050","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1080\/17512433.2018.1516143","article-title":"NSAID induced gastrointestinal damage and designing GI-sparing NSAIDs","volume":"11","author":"Garcia-Rayado","year":"2018","journal-title":"Expert Review of Clinical Pharmacology"},{"key":"10.1016\/j.bmcl.2022.129101_b0055","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1053\/j.gastro.2017.10.049","article-title":"Mechanisms of Damage to the Gastrointestinal Tract From Nonsteroidal Anti-Inflammatory Drugs","volume":"154","author":"Bjarnason","year":"2018","journal-title":"Gastroenterology"},{"key":"10.1016\/j.bmcl.2022.129101_b0060","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1186\/s12876-020-01329-5","article-title":"Non-steroidal anti-inflammatory drug-induced enteropathy as a major risk factor for small bowel bleeding: a retrospective study","volume":"20","author":"Lim","year":"2020","journal-title":"BMC Gastroenterology"},{"key":"10.1016\/j.bmcl.2022.129101_b0065","first-page":"25","article-title":"Natural inhibitors against potential targets of cyclooxygenase, lipoxygenase and leukotrienes","author":"Dey","year":"2021","journal-title":"Combinatorial Chemistry & High Throughput Screening"},{"key":"10.1016\/j.bmcl.2022.129101_b0070","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2020.112066","article-title":"Design, synthesis and biological evaluation of novel pyrazole sulfonamide derivatives as dual COX-2\/5-LOX inhibitors","volume":"189","author":"Gedawy","year":"2020","journal-title":"European Journal of Medicinal Chemistry"},{"key":"10.1016\/j.bmcl.2022.129101_b0075","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1007\/s40265-020-01429-2","article-title":"TRPV1-Targeted Drugs in Development for Human Pain Conditions","volume":"81","author":"Iftinca","year":"2020","journal-title":"Drugs"},{"key":"10.1016\/j.bmcl.2022.129101_b0080","doi-asserted-by":"crossref","first-page":"936","DOI":"10.1002\/med.21427","article-title":"Medicinal Chemistry, Pharmacology, and Clinical Implications of TRPV1 Receptor Antagonists","volume":"37","author":"Aghazadeh Tabrizi","year":"2017","journal-title":"Medicinal Research Reviews"},{"key":"10.1016\/j.bmcl.2022.129101_b0085","doi-asserted-by":"crossref","first-page":"2185","DOI":"10.1111\/bph.14044","article-title":"Targeting nociceptive transient receptor potential channels to treat chronic pain: current state of the field","volume":"175","author":"Moran","year":"2018","journal-title":"British Journal of Pharmacology"},{"key":"10.1016\/j.bmcl.2022.129101_b0090","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2021.675128","article-title":"The Heat Sensing Trpv1 Receptor Is Not a Viable Anticonvulsant Drug Target in the Scn1a (+\/-) Mouse Model of Dravet Syndrome","volume":"12","author":"Satpute Janve","year":"2021","journal-title":"Frontiers in Pharmacology"},{"key":"10.1016\/j.bmcl.2022.129101_b0095","doi-asserted-by":"crossref","DOI":"10.1016\/j.bioorg.2020.104418","article-title":"Synthesis of novel halogenated triarylpyrazoles as selective COX-2 inhibitors: Anti-inflammatory activity, histopatholgical profile and in-silico studies","volume":"105","author":"Abdellatif","year":"2020","journal-title":"Bioorganic Chemistry"},{"key":"10.1016\/j.bmcl.2022.129101_b0100","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2021.113457","article-title":"Novel 1,2,4-triazine-quinoline hybrids: The privileged scaffolds as potent multi-target inhibitors of LPS-induced inflammatory response via dual COX-2 and 15-LOX inhibition","volume":"219","author":"Ghanim","year":"2021","journal-title":"European Journal of Medicinal Chemistry"},{"key":"10.1016\/j.bmcl.2022.129101_b0105","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.bioorg.2018.03.011","article-title":"Design, synthesis, analgesic, anti-inflammatory activity of novel pyrazolones possessing aminosulfonyl pharmacophore as inhibitors of COX-2\/5-LOX enzymes: Histopathological and docking studies","volume":"78","author":"Abdelgawad","year":"2018","journal-title":"Bioorganic Chemistry"},{"key":"10.1016\/j.bmcl.2022.129101_b0110","doi-asserted-by":"crossref","first-page":"4195","DOI":"10.1016\/j.bmcl.2008.05.071","article-title":"Synthesis and biological evaluation of 1-(benzenesulfonamido)-2-[5-(N-hydroxypyridin-2(1H)-one)]acetylene regioisomers: a novel class of 5-lipoxygenase inhibitors","volume":"18","author":"Chowdhury","year":"2008","journal-title":"Bioorganic & Medicinal Chemistry Letters"},{"key":"10.1016\/j.bmcl.2022.129101_b0115","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2021.113804","article-title":"Synthetically-tailored and nature-derived dual COX-2\/5-LOX inhibitors: Structural aspects and SAR","volume":"225","author":"Meshram","year":"2021","journal-title":"European Journal of Medicinal Chemistry"},{"key":"10.1016\/j.bmcl.2022.129101_b0120","first-page":"12","article-title":"Preparation and Evaluation of Amino Acid Conjugates of Celecoxib as Prodrugs to Improve the Pharmacokinetic and Therapeutic Properties of Celecoxib","author":"Lee","year":"2020","journal-title":"Pharmaceutics."},{"key":"10.1016\/j.bmcl.2022.129101_b0125","doi-asserted-by":"crossref","DOI":"10.3390\/ijms22052587","article-title":"NFAT5 Deficiency Alleviates Formalin-Induced Inflammatory Pain Through mTOR","volume":"22","author":"Gwon","year":"2021","journal-title":"International Journal of Molecular Sciences"},{"key":"10.1016\/j.bmcl.2022.129101_b0130","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1186\/1744-8069-3-30","article-title":"Roles of TRPV1 and neuropeptidergic receptors in dorsal root reflex-mediated neurogenic inflammation induced by intradermal injection of capsaicin","volume":"3","author":"Lin","year":"2007","journal-title":"Molecular Pain"},{"key":"10.1016\/j.bmcl.2022.129101_b0135","article-title":"Low Energy Shock Wave Therapy Inhibits Inflammatory Molecules and Suppresses Prostatic Pain and Hypersensitivity in a Capsaicin Induced Prostatitis Model in Rats","volume":"20","author":"Wang","year":"2019","journal-title":"International Journal of Molecular Sciences"}],"container-title":["Bioorganic & Medicinal Chemistry Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0960894X22005777?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0960894X22005777?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,18]],"date-time":"2025-10-18T07:46:37Z","timestamp":1760773597000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0960894X22005777"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,1]]},"references-count":27,"alternative-id":["S0960894X22005777"],"URL":"https:\/\/doi.org\/10.1016\/j.bmcl.2022.129101","relation":{},"ISSN":["0960-894X"],"issn-type":[{"value":"0960-894X","type":"print"}],"subject":[],"published":{"date-parts":[[2023,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Synthesis and biological evaluation of N-(benzene sulfonyl)acetamide derivatives as anti-inflammatory and analgesic agents with COX-2\/5-LOX\/TRPV1 multifunctional inhibitory activity","name":"articletitle","label":"Article Title"},{"value":"Bioorganic & Medicinal Chemistry Letters","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bmcl.2022.129101","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"129101"}}