{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T00:19:21Z","timestamp":1760833161046,"version":"build-2065373602"},"reference-count":27,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T00:00:00Z","timestamp":1685577600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T00:00:00Z","timestamp":1685577600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T00:00:00Z","timestamp":1685577600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T00:00:00Z","timestamp":1685577600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T00:00:00Z","timestamp":1685577600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T00:00:00Z","timestamp":1685577600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T00:00:00Z","timestamp":1685577600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001409","name":"Department of Science and Technology, Ministry of Science and Technology, India","doi-asserted-by":"publisher","award":["GAP-465"],"award-info":[{"award-number":["GAP-465"]}],"id":[{"id":"10.13039\/501100001409","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001843","name":"Science and Engineering Research Board","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001843","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007854","name":"Central Institute of Medicinal and Aromatic Plants","doi-asserted-by":"publisher","award":["C.R.G.\/2020\/004226"],"award-info":[{"award-number":["C.R.G.\/2020\/004226"]}],"id":[{"id":"10.13039\/501100007854","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bioorganic & Medicinal Chemistry Letters"],"published-print":{"date-parts":[[2023,6]]},"DOI":"10.1016\/j.bmcl.2023.129311","type":"journal-article","created":{"date-parts":[[2023,5,4]],"date-time":"2023-05-04T02:33:33Z","timestamp":1683167613000},"page":"129311","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Synthesis of 6-alkoxy and 6-hydroxy-alkyl amine derivatives of braylin as vasorelaxing agents"],"prefix":"10.1016","volume":"89","author":[{"given":"Kripa Shankar","family":"Nainawat","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarita","family":"Singh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karishma","family":"Agarwal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hina","family":"Iqbal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Poonam","family":"Rani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Divya","family":"Bhatt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sana","family":"Khan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Debabrata","family":"Chanda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dnyaneshwar Umrao","family":"Bawankule","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sudeep","family":"Tandon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2704-5925","authenticated-orcid":false,"given":"Feroz","family":"Khan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anil","family":"Kumar Gupta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Atul","family":"Gupta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.bmcl.2023.129311_b0005","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1007\/s12010-022-04123-z","article-title":"Cardioprotective Role of Scopoletin on Isoproterenol \u2013 Induced Myocardial Infarction in Rats","author":"Rong","year":"2023","journal-title":"Appl Biochem Biotechnol"},{"key":"10.1016\/j.bmcl.2023.129311_b0010","doi-asserted-by":"crossref","DOI":"10.1016\/j.taap.2021.115858","article-title":"Scopoletin and umbelliferone protect hepatocytes against palmitate- and bile acid-induced cell death by reducing endoplasmic reticulum stress and oxidative stress","volume":"436","author":"Wu","year":"2022","journal-title":"Toxicol Appl Pharmacol"},{"key":"10.1016\/j.bmcl.2023.129311_b0015","doi-asserted-by":"crossref","first-page":"1767","DOI":"10.1007\/s00044-021-02775-w","article-title":"Osthole: an overview of its sources, biological activities, and modification development","author":"Sun","year":"2021","journal-title":"Med Chem Res"},{"key":"10.1016\/j.bmcl.2023.129311_b0020","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1002\/ptr.7311","article-title":"Esculetin: A review of its pharmacology and pharmacokinetics","volume":"36","author":"Zhang","year":"2022","journal-title":"Phytother Res"},{"key":"10.1016\/j.bmcl.2023.129311_b0025","doi-asserted-by":"crossref","unstructured":"Zhu J, Jiang J. Pharmacological and Nutritional Effects of Natural Coumarins and Their Structure-Activity Relationships. Mol. Nutr. Food Res. 2018; 62: 1701073. doi: 10.1002\/mnfr.201701073; (b) Lu P, Liao T, Chen Y, Hsu Y, Kuo C, Chan C, Wang L, Chern C, Tsai F. Coumarin Derivatives Inhibit ADP-Induced Platelet Activation and Aggregation. Molecules. 2022; 27: 4054. doi: 10.3390\/molecules27134054; (c) Zeng Z, Tian R, Feng J, Yang N, Yuan L. A systematic review on traditional medicine Toddalia asiatica (L.) Lam.: Chemistry and medicinal potential. Saudi Pharm J.2021; 29(8): 781-798. https\/\/doi.org\/10.1016\/j.jsps.2021.05.003; (d) Song F, Huo X, Guo Z. Anti-breast cancer potential of natural and synthetic coumarin derivatives.Curr Top Med Chem. 2021; 21(18):1692-1709. doi: 10.2174\/1568026621666210303145430.","DOI":"10.2174\/1568026621666210303145430"},{"key":"10.1016\/j.bmcl.2023.129311_b0030","doi-asserted-by":"crossref","first-page":"501","DOI":"10.3390\/molecules26020501","article-title":"Trending topics on coumarin and its derivatives in 2020","volume":"26","author":"Carneiro","year":"2021","journal-title":"Molecules"},{"key":"10.1016\/j.bmcl.2023.129311_b0035","doi-asserted-by":"crossref","DOI":"10.4155\/fmc-2018-0375","article-title":"Translational role of natural coumarins and their derivatives as anticancer agents","author":"Menezes","year":"2019","journal-title":"Future Med Chem"},{"key":"#cr-split#-10.1016\/j.bmcl.2023.129311_b0040.1","doi-asserted-by":"crossref","unstructured":"(b) Prabhala P, Sutar SM, Savanur HM, Joshi SD, Kalkhambkar RG. In vitro antimicrobial combat, molecular modeling and structure activity relationship studies of novel class of aryl-ethyne tethered coumarin analogues and some 3-aryl coumarin derivatives. Eur J Med Chem Reports. 2022","DOI":"10.1016\/j.ejmcr.2022.100048"},{"key":"#cr-split#-10.1016\/j.bmcl.2023.129311_b0040.2","doi-asserted-by":"crossref","unstructured":"(c) Sharma M, Vyas VK, Bhatt S, Ghate MD. Therapeutic potential of 4-substituted coumarins\u00a0: A conspectus. Eur J Med Chem Reports. 2022","DOI":"10.1016\/j.ejmcr.2022.100086"},{"key":"#cr-split#-10.1016\/j.bmcl.2023.129311_b0040.3","doi-asserted-by":"crossref","unstructured":"Rawat A, Reddy VB. Recent advances on anticancer activity of coumarin derivatives. Eur J Med Chem Reports. 2022; 5: 100038. doi: 10.1016\/j.ejmcr.2022.100038;","DOI":"10.1016\/j.ejmcr.2022.100038"},{"key":"#cr-split#-10.1016\/j.bmcl.2023.129311_b0040.4","doi-asserted-by":"crossref","unstructured":"(b) Prabhala P, Sutar SM, Savanur HM, Joshi SD, Kalkhambkar RG. In vitro antimicrobial combat, molecular modeling and structure activity relationship studies of novel class of aryl-ethyne tethered coumarin analogues and some 3-aryl coumarin derivatives. Eur J Med Chem Reports. 2022; 5:100048. doi: 10.1016\/j.ejmcr.2022.100048;","DOI":"10.1016\/j.ejmcr.2022.100048"},{"key":"#cr-split#-10.1016\/j.bmcl.2023.129311_b0040.5","doi-asserted-by":"crossref","unstructured":"(c) Sharma M, Vyas VK, Bhatt S, Ghate MD. Therapeutic potential of 4-substituted coumarins\u00a0: A conspectus. Eur J Med Chem Reports. 2022; 6:100086. doi: 10.1016\/j.ejmcr.2022.1000861.","DOI":"10.1016\/j.ejmcr.2022.100086"},{"key":"10.1016\/j.bmcl.2023.129311_b0045","doi-asserted-by":"crossref","first-page":"17020","DOI":"10.1039\/D2RA01029A","article-title":"Coumarin derivatives inhibit the aggregation of \u03b2-lactoglobulin","volume":"12","author":"Parvej","year":"2022","journal-title":"RSC Adv"},{"key":"10.1016\/j.bmcl.2023.129311_b0050","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2020.112832","article-title":"Antibacterial activities with the structure-activity relationship of coumarin derivatives","volume":"207","author":"Qin","year":"2020","journal-title":"Eur J Med Chem"},{"key":"10.1016\/j.bmcl.2023.129311_b0055","doi-asserted-by":"crossref","first-page":"160","DOI":"10.3390\/antibiotics12010160","article-title":"Coumarin Triazoles as Potential Antimicrobial Agents","volume":"12","author":"Patil","year":"2023","journal-title":"Antibiotics"},{"key":"10.1016\/j.bmcl.2023.129311_b0060","doi-asserted-by":"crossref","first-page":"e202200476","DOI":"10.1002\/cmdc.202200476","article-title":"Synthesis and Vasorelaxant Activity of Nitrate-Coumarin Derivatives","volume":"17","author":"Matos","year":"2022","journal-title":"Chem Med Chem."},{"key":"10.1016\/j.bmcl.2023.129311_b0065","doi-asserted-by":"crossref","first-page":"3135","DOI":"10.3390\/plants11223135","article-title":"Plant Pyranocoumarins: Description, Biosynthesis, Application","volume":"11","author":"Khandy","year":"2022","journal-title":"Plants"},{"key":"#cr-split#-10.1016\/j.bmcl.2023.129311_b0070.1","unstructured":"19(1): 3-27. doi: 10.2174\/1570193X18666210218213410 (c) Moreira ASN, Mathias L, Braz-Filho R, Schripsema J, Vieira I.Two New Diprenylated Coumarins from Flindersia Brayleyana. Nat Prod Lett. 2002"},{"key":"#cr-split#-10.1016\/j.bmcl.2023.129311_b0070.2","doi-asserted-by":"crossref","unstructured":"Anet FAL, Hughes GK, Ritchie E. The Chemical Constituents of Australian Flindersia Species. II. Braylin and Brayleyanin. Aust J Sci Res, Series A: Phy Sci. 1949; 2: 608. doi: 10.1071\/CH9490608","DOI":"10.1071\/CH9490608"},{"key":"#cr-split#-10.1016\/j.bmcl.2023.129311_b0070.3","doi-asserted-by":"crossref","unstructured":"(b) Nascimento LPS,Passos M,Nogueira TSR,Arantes MB;Monteiro NO, Boeno SI;Moreira A SN,Vieira MGC,de Carvalho J\u00fanior AR,Braz-Filho R,Vieira IJC. Chemical Constituents and Biological Activities of Genus Flindersia (Rutaceae). Mini-Rev. Org. Chem. 2022; 19(1): 3-27. doi: 10.2174\/1570193X18666210218213410","DOI":"10.2174\/1570193X18666210218213410"},{"key":"#cr-split#-10.1016\/j.bmcl.2023.129311_b0070.4","doi-asserted-by":"crossref","unstructured":"(c) Moreira ASN, Mathias L, Braz-Filho R, Schripsema J, Vieira I.Two New Diprenylated Coumarins from Flindersia Brayleyana. Nat Prod Lett. 2002; 16(4): 291-295. doi: 10.1080\/ 10575630290020668.","DOI":"10.1080\/10575630290020668"},{"key":"10.1016\/j.bmcl.2023.129311_b0075","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1055\/s-2003-37717","article-title":"Vasorelaxing Properties and Bio-Guided Fractionation of Cedrelopsis grevei","volume":"69","author":"Rakotoarison","year":"2003","journal-title":"Planta Med"},{"key":"10.1016\/j.bmcl.2023.129311_b0080","doi-asserted-by":"crossref","DOI":"10.1016\/j.bmcl.2019.126759","article-title":"Synthesis and evaluation of substituted 8,8-dimethyl-8H-pyrano[2,3-f]chromen-2- one derivatives as vasorelaxing agents","author":"Singh","year":"2020","journal-title":"Bioorg Med Chem Lett"},{"key":"10.1016\/j.bmcl.2023.129311_b0085","doi-asserted-by":"crossref","first-page":"1322","DOI":"10.3390\/molecules21101322","article-title":"Natural and Synthetic Coumarins with Effects on Inflammation","volume":"21","author":"Kirsch","year":"2016","journal-title":"Molecules"},{"key":"10.1016\/j.bmcl.2023.129311_b0090","doi-asserted-by":"crossref","unstructured":"Revankar HM, Bukhari S.N.A., Kumar GB, Qin H. Coumarins scaffolds as COX inhibitors. Bioorg Chem. 2017; 71: 146-15doi: 10.1016\/j.bioorg.2017.02.001.","DOI":"10.1016\/j.bioorg.2017.02.001"},{"key":"10.1016\/j.bmcl.2023.129311_b0095","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1016\/S0960-894X(02)00015-X","article-title":"Synthesis and Vasorelaxant Activity of New Coumarin and Furocoumarin Derivatives","volume":"12","author":"Campos-Toimil","year":"2002","journal-title":"Bioorg Med Chem Lett"},{"key":"10.1016\/j.bmcl.2023.129311_b0100","doi-asserted-by":"crossref","first-page":"6087","DOI":"10.1016\/j.bmc.2011.08.037","article-title":"Design, synthesis and vasorelaxant evaluation of novel coumarins-pyrimidine hybrids","volume":"19","author":"Amin","year":"2011","journal-title":"Bioorg Med Chem"}],"container-title":["Bioorganic & Medicinal Chemistry Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0960894X23001890?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0960894X23001890?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,18]],"date-time":"2025-10-18T07:47:48Z","timestamp":1760773668000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0960894X23001890"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,6]]},"references-count":27,"alternative-id":["S0960894X23001890"],"URL":"https:\/\/doi.org\/10.1016\/j.bmcl.2023.129311","relation":{},"ISSN":["0960-894X"],"issn-type":[{"type":"print","value":"0960-894X"}],"subject":[],"published":{"date-parts":[[2023,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Synthesis of 6-alkoxy and 6-hydroxy-alkyl amine derivatives of braylin as vasorelaxing agents","name":"articletitle","label":"Article Title"},{"value":"Bioorganic & Medicinal Chemistry Letters","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bmcl.2023.129311","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"129311"}}