{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,18]],"date-time":"2025-10-18T08:10:56Z","timestamp":1760775056479,"version":"build-2065373602"},"reference-count":15,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,7,1]],"date-time":"2023-07-01T00:00:00Z","timestamp":1688169600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,7,1]],"date-time":"2023-07-01T00:00:00Z","timestamp":1688169600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,7,1]],"date-time":"2023-07-01T00:00:00Z","timestamp":1688169600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,7,1]],"date-time":"2023-07-01T00:00:00Z","timestamp":1688169600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,7,1]],"date-time":"2023-07-01T00:00:00Z","timestamp":1688169600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,7,1]],"date-time":"2023-07-01T00:00:00Z","timestamp":1688169600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,7,1]],"date-time":"2023-07-01T00:00:00Z","timestamp":1688169600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bioorganic & Medicinal Chemistry Letters"],"published-print":{"date-parts":[[2023,7]]},"DOI":"10.1016\/j.bmcl.2023.129362","type":"journal-article","created":{"date-parts":[[2023,6,7]],"date-time":"2023-06-07T23:15:47Z","timestamp":1686179747000},"page":"129362","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Discovery of novel pyridinones as MGAT2 inhibitors for the treatment of metabolic disorders"],"prefix":"10.1016","volume":"91","author":[{"given":"Fang","family":"Moore","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guohua","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James","family":"Mignone","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Meng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ching-Hsuen","family":"Chu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhengping","family":"Ma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anthony","family":"Azzara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mary Jane","family":"Cullen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mary Ann","family":"Pelleymounter","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kingsley","family":"Appiah","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mary Ellen","family":"Cvijic","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elizabeth","family":"Dierks","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shu","family":"Chang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kimberly","family":"Foster","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lisa","family":"Kopcho","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kevin","family":"O'Malley","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi-Xin","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Purnima","family":"Khandelwal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0630-211X","authenticated-orcid":false,"given":"Jean M.","family":"Whaley","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3146-8485","authenticated-orcid":false,"given":"Arvind","family":"Mathur","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoping","family":"Hou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dauh-Rurng","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeffrey A.","family":"Robl","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dong","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pratik","family":"Devasthale","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.bmcl.2023.129362_b0005","doi-asserted-by":"crossref","first-page":"9879","DOI":"10.1021\/acs.jmedchem.8b00864","volume":"61","author":"Devasthale","year":"2018","journal-title":"Journal of Medicinal Chemistry"},{"key":"10.1016\/j.bmcl.2023.129362_b0010","doi-asserted-by":"crossref","first-page":"176","DOI":"10.3390\/diseases3030176","volume":"3","author":"Yang","year":"2015","journal-title":"Diseases"},{"key":"10.1016\/j.bmcl.2023.129362_b0015","doi-asserted-by":"crossref","first-page":"18532","DOI":"10.1074\/jbc.M301633200","volume":"278","author":"Yen","year":"2003","journal-title":"The Journal of Biological Chemistry"},{"key":"10.1016\/j.bmcl.2023.129362_b0020","doi-asserted-by":"crossref","first-page":"13860","DOI":"10.1074\/jbc.M300139200","volume":"278","author":"Cao","year":"2003","journal-title":"The Journal of Biological Chemistry"},{"key":"10.1016\/j.bmcl.2023.129362_b0025","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1038\/nm.1937","volume":"15","author":"Yen","year":"2009","journal-title":"Nature Medicine"},{"key":"10.1016\/j.bmcl.2023.129362_b0030","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1080\/13543776.2020.1815707","volume":"30","author":"Zambre","year":"2020","journal-title":"Expert Opinion on Therapeutic Patents"},{"key":"10.1016\/j.bmcl.2023.129362_b0035","doi-asserted-by":"crossref","first-page":"3892","DOI":"10.1021\/acs.jmedchem.5b00178","volume":"58","author":"Sato","year":"2015","journal-title":"Journal of Medicinal Chemistry"},{"key":"10.1016\/j.bmcl.2023.129362_b0040","doi-asserted-by":"crossref","first-page":"e0150976","DOI":"10.1371\/journal.pone.0150976","volume":"11","author":"Take","year":"2016","journal-title":"PLoS One1"},{"key":"10.1016\/j.bmcl.2023.129362_b0045","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1002\/2211-5463.12778","volume":"10","author":"Mochida","year":"2020","journal-title":"FEBS Open Bio"},{"key":"10.1016\/j.bmcl.2023.129362_b0050","doi-asserted-by":"crossref","unstructured":"Barlind, J. G.; Buckett, L. K.; Crosby, S. G.; Davidsson, \u00d6.; Emten\u00e4s, H.; Ertan, A.; Jurva, U.; Lemurell, M.; Gutierrez, P. M.; Nilsson, K.; O\u2019Mahony, G.; Petersson, A. U.; Redzic, A.; W\u00e5gberg, F.; Yuan, Z.-Q. Bioorg. Med. Chem. Lett. 2013, 23, 2721\u22122726.","DOI":"10.1016\/j.bmcl.2013.02.084"},{"key":"10.1016\/j.bmcl.2023.129362_b0055","doi-asserted-by":"crossref","first-page":"14773","DOI":"10.1021\/acs.jmedchem.1c01356","volume":"64","author":"Turdi","year":"2021","journal-title":"Journal of Medicinal Chemistry"},{"key":"10.1016\/j.bmcl.2023.129362_b0060","doi-asserted-by":"crossref","first-page":"1732","DOI":"10.1016\/j.cmet.2022.10.007","article-title":"A","volume":"34","author":"Cheng","year":"2022","journal-title":"Cell Metabolism"},{"key":"10.1016\/j.bmcl.2023.129362_b0065","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1007\/s10822-010-9359-z","volume":"24","author":"Katritzky","year":"2010","journal-title":"Computer Aided Molecular Design"},{"key":"10.1016\/j.bmcl.2023.129362_b0070","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1194\/jlr.D055020","volume":"56","author":"Onorato","year":"2015","journal-title":"Journal of Lipid Research"},{"key":"10.1016\/j.bmcl.2023.129362_b0075","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1002\/cmdc.201200585","volume":"8","author":"Ballatore","year":"2013","journal-title":"ChemMedChem"}],"container-title":["Bioorganic & Medicinal Chemistry Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0960894X23002408?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0960894X23002408?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,18]],"date-time":"2025-10-18T07:48:19Z","timestamp":1760773699000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0960894X23002408"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,7]]},"references-count":15,"alternative-id":["S0960894X23002408"],"URL":"https:\/\/doi.org\/10.1016\/j.bmcl.2023.129362","relation":{},"ISSN":["0960-894X"],"issn-type":[{"type":"print","value":"0960-894X"}],"subject":[],"published":{"date-parts":[[2023,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Discovery of novel pyridinones as MGAT2 inhibitors for the treatment of metabolic disorders","name":"articletitle","label":"Article Title"},{"value":"Bioorganic & Medicinal Chemistry Letters","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bmcl.2023.129362","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"129362"}}