{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,18]],"date-time":"2025-10-18T08:10:56Z","timestamp":1760775056616,"version":"build-2065373602"},"reference-count":15,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,7,4]],"date-time":"2023-07-04T00:00:00Z","timestamp":1688428800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bioorganic & Medicinal Chemistry Letters"],"published-print":{"date-parts":[[2023,8]]},"DOI":"10.1016\/j.bmcl.2023.129405","type":"journal-article","created":{"date-parts":[[2023,7,4]],"date-time":"2023-07-04T21:05:45Z","timestamp":1688504745000},"page":"129405","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Novel series of tunable \u00b5OR modulators with enhanced brain penetration for the treatment of opioid use disorder, pain and neuropsychiatric indications"],"prefix":"10.1016","volume":"92","author":[{"given":"Alok","family":"Nerurkar","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Nguyen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sheldon","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ulhas","family":"Bhatt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kevin","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yihong","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pingyu","family":"Ding","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frederick J.","family":"Seidl","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin","family":"Holan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-6009-4824","authenticated-orcid":false,"given":"Tien","family":"Widjaja","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhi-Liang","family":"Wei","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9688-1487","authenticated-orcid":false,"given":"Corinne","family":"Sadlowski","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Sperandio","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lawrence R.","family":"McGee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Beth","family":"Youngblood","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Neil","family":"Schwartz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Donald","family":"Gehlert","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8045-0818","authenticated-orcid":false,"given":"Julio C.","family":"Medina","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.bmcl.2023.129405_b0005","doi-asserted-by":"crossref","unstructured":"Patterson Silver Wolf, D. A.; Gold, M. Treatment resistant opioid use disorder (TROUD): Definition, rationale, and recommendations. J. Neurol. Sci. 2020, 411 (February), 116718.","DOI":"10.1016\/j.jns.2020.116718"},{"key":"10.1016\/j.bmcl.2023.129405_b0010","doi-asserted-by":"crossref","first-page":"S105","DOI":"10.36076\/ppj.2008\/11\/S105","article-title":"Opioid complications and side effects","volume":"11","author":"Benyamin","year":"2008","journal-title":"Pain Physician"},{"key":"10.1016\/j.bmcl.2023.129405_b0015","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1093\/bja\/aen094","article-title":"Opioids and the control of respiration","volume":"100","author":"Pattinson","year":"2008","journal-title":"British Journal of Anaesthesia"},{"key":"10.1016\/j.bmcl.2023.129405_b0020","first-page":"45","article-title":"Pharmacological management of cancer pain","volume":"27","author":"Walsh","year":"2000","journal-title":"Seminars in Oncology"},{"key":"10.1016\/j.bmcl.2023.129405_b0025","first-page":"1347","article-title":"Management of common opioid induced adverse effects","volume":"74","author":"Swegle","year":"2006","journal-title":"American Family Physician"},{"key":"10.1016\/j.bmcl.2023.129405_b0030","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/j.neuropharm.2019.02.008","article-title":"Respiratory depression and brain hypoxia induced by opioid drugs: Morphine, oxycodone, heroin, and fentanyl","volume":"151","author":"Kiyatkin","year":"2019","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.bmcl.2023.129405_b0035","unstructured":"CDC NC for HS. 2, Wide-ranging online data for epidemiologic research (WONDER). [Internet]. Atlanta, GA, (2020) (Available from), https:\/\/wonder.cdc.gov\/."},{"key":"10.1016\/j.bmcl.2023.129405_b0040","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1038\/nature19112","article-title":"Structure-based discovery of opioid analgesics with reduced side effects","volume":"537","author":"Manglik","year":"2016","journal-title":"Nature"},{"key":"10.1016\/j.bmcl.2023.129405_b0045","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1602\/neurorx.2.4.541","article-title":"Medicinal chemical properties of successful central nervous system drugs","volume":"2","author":"Pajouhesh","year":"2005","journal-title":"NeuroRx : the journal of the American Society for Experimental NeuroTherapeutics"},{"key":"10.1016\/j.bmcl.2023.129405_b0050","unstructured":"Medina, J. C.; McGee, L.; Wei, Z-L.; Sadlowski, C.; Seidl, F.; Bhatt, U.; Wang, X.; Nguyen, T.; Sperandio, D.; Ding, P.; Nerurkar, A.; Li, Y.; Duquette, J. Opioid receptor modulators and products and methods related thereto. WO2019\/195634A1, 10 October 2019."},{"key":"10.1016\/j.bmcl.2023.129405_b0055","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1016\/j.tet.2007.11.031","article-title":"Negishi cross-coupling reactions of \u03b1-amino acid-derived organozinc reagents and aromatic bromides","volume":"64","author":"Oswald","year":"2008","journal-title":"Tetrahedron"},{"key":"10.1016\/j.bmcl.2023.129405_b0060","doi-asserted-by":"crossref","first-page":"1389","DOI":"10.1016\/j.lfs.2007.09.005","article-title":"In vivo rat brain opioid receptor binding of LY255582 assessed with a novel method using LC\/MS\/MS and the administration of three tracers simultaneously","volume":"81","author":"Need","year":"2007","journal-title":"Life Sciences"},{"key":"10.1016\/j.bmcl.2023.129405_b0065","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1124\/jpet.120.000214","article-title":"A novel maintenance therapeutic for Opioid Use Disorder","volume":"378","author":"Youngblood","year":"2021","journal-title":"The Journal of Pharmacology and Experimental Therapeutics"},{"key":"10.1016\/j.bmcl.2023.129405_b0070","unstructured":"Drug, A. & Advisory, P. FDA advisory committee on the most appropriate dose or doses of naloxone to reverse the effects of life-threatening opioid overdose in the community settings. (2016)."},{"key":"10.1016\/j.bmcl.2023.129405_b0075","unstructured":"Kim, S.; Wagner, H. N. Jr.; Villemagne, V. L.; Kao, P. F.; Dannals, R. F.; Ravert, H. T.; Joh, T.; Dixon, R. B.; Civelek, A. C. Longer occupancy of opioid receptors by nalmefene compared to naloxone as measured in vivo by a dual-detector system. J Nucl Med. 1997, 38(11), 1726-1731."}],"container-title":["Bioorganic & Medicinal Chemistry Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0960894X23002834?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0960894X23002834?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,18]],"date-time":"2025-10-18T07:48:52Z","timestamp":1760773732000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0960894X23002834"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,8]]},"references-count":15,"alternative-id":["S0960894X23002834"],"URL":"https:\/\/doi.org\/10.1016\/j.bmcl.2023.129405","relation":{},"ISSN":["0960-894X"],"issn-type":[{"type":"print","value":"0960-894X"}],"subject":[],"published":{"date-parts":[[2023,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Novel series of tunable \u00b5OR modulators with enhanced brain penetration for the treatment of opioid use disorder, pain and neuropsychiatric indications","name":"articletitle","label":"Article Title"},{"value":"Bioorganic & Medicinal Chemistry Letters","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bmcl.2023.129405","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 R2M Pharma. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"129405"}}